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Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study / Alessandra PIATTI in Research in Autism Spectrum Disorders, 86 (August 2021)
[article]
Titre : Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study Type de document : Texte imprimé et/ou numérique Auteurs : Alessandra PIATTI, Auteur ; Sara VAN DER PAELT, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur Article en page(s) : 101805 Langues : Anglais (eng) Mots-clés : Auditory oddball MMN P3a ASD Developmental delay Neural adaptation Index. décimale : PER Périodiques Résumé : Background Sound perception in autism spectrum disorder (ASD) is usually at typical levels, even when auditory stimuli carry a social value, as it is the case for speech. Nevertheless, orienting to sounds in a speech context might be atypical in some individuals with ASD, which in ERP studies is reflected by a diminished P3a component. As P3 values and cognitive abilities seem to be inversely related under some circumstances, the current study investigates whether diminished attentional orienting to sounds in speech is equally observable in children with ASD with and without developmental delay (DD). Method Children with typical development (TD, n = 17) or ASD, with or without comorbid DD (ASD/DD, n = 22, and ASD/noDD, n = 12), aged 1.5 through 4 years took part in a passive auditory oddball task while EEG data were recorded. The paradigm consisted in the presentation of two deviant stimuli (one vowel sound and one complex tone) either in a speech or in a non-speech context. Results We found overall more negative MMN voltages in both ASD groups compared to TD. For P3a mean voltages, we found an attenuated response in children ASD/noDD when deviant tones were presented in speech, but not in other conditions. Children with ASD/DD did not differ from TD in P3a mean voltages. Conclusion Atypical speech sound processing might be more accentuated in children with ASD/noDD than in their peers with comorbid DD. This finding is interpreted within the theoretical framework of neural adaptation. En ligne : https://doi.org/10.1016/j.rasd.2021.101805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458
in Research in Autism Spectrum Disorders > 86 (August 2021) . - 101805[article] Atypical attention to voice in toddlers and pre-schoolers with autism spectrum disorder is related to unimpaired cognitive abilities. An ERP study [Texte imprimé et/ou numérique] / Alessandra PIATTI, Auteur ; Sara VAN DER PAELT, Auteur ; Petra WARREYN, Auteur ; Herbert ROEYERS, Auteur . - 101805.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 86 (August 2021) . - 101805
Mots-clés : Auditory oddball MMN P3a ASD Developmental delay Neural adaptation Index. décimale : PER Périodiques Résumé : Background Sound perception in autism spectrum disorder (ASD) is usually at typical levels, even when auditory stimuli carry a social value, as it is the case for speech. Nevertheless, orienting to sounds in a speech context might be atypical in some individuals with ASD, which in ERP studies is reflected by a diminished P3a component. As P3 values and cognitive abilities seem to be inversely related under some circumstances, the current study investigates whether diminished attentional orienting to sounds in speech is equally observable in children with ASD with and without developmental delay (DD). Method Children with typical development (TD, n = 17) or ASD, with or without comorbid DD (ASD/DD, n = 22, and ASD/noDD, n = 12), aged 1.5 through 4 years took part in a passive auditory oddball task while EEG data were recorded. The paradigm consisted in the presentation of two deviant stimuli (one vowel sound and one complex tone) either in a speech or in a non-speech context. Results We found overall more negative MMN voltages in both ASD groups compared to TD. For P3a mean voltages, we found an attenuated response in children ASD/noDD when deviant tones were presented in speech, but not in other conditions. Children with ASD/DD did not differ from TD in P3a mean voltages. Conclusion Atypical speech sound processing might be more accentuated in children with ASD/noDD than in their peers with comorbid DD. This finding is interpreted within the theoretical framework of neural adaptation. En ligne : https://doi.org/10.1016/j.rasd.2021.101805 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 Auditory processing in autism spectrum disorder: Mismatch negativity deficits / Chantal VLASKAMP in Autism Research, 10-11 (November 2017)
[article]
Titre : Auditory processing in autism spectrum disorder: Mismatch negativity deficits Type de document : Texte imprimé et/ou numérique Auteurs : Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur Article en page(s) : p.1857-1865 Langues : Anglais (eng) Mots-clés : auditory processing ASD MMN P3a schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322
in Autism Research > 10-11 (November 2017) . - p.1857-1865[article] Auditory processing in autism spectrum disorder: Mismatch negativity deficits [Texte imprimé et/ou numérique] / Chantal VLASKAMP, Auteur ; Bob ORANJE, Auteur ; Gitte Falcher MADSEN, Auteur ; Jens Richardt MØLLEGAARD JEPSEN, Auteur ; Sarah DURSTON, Auteur ; Cathriona CANTIO, Auteur ; Birte GLENTHØJ, Auteur ; Niels BILENBERG, Auteur . - p.1857-1865.
Langues : Anglais (eng)
in Autism Research > 10-11 (November 2017) . - p.1857-1865
Mots-clés : auditory processing ASD MMN P3a schizophrenia Index. décimale : PER Périodiques Résumé : Children with autism spectrum disorders (ASD) often show changes in (automatic) auditory processing. Electrophysiology provides a method to study auditory processing, by investigating event-related potentials such as mismatch negativity (MMN) and P3a-amplitude. However, findings on MMN in autism are highly inconsistent, partly due to small sample sizes in the studies and differences in MMN paradigms. Therefore, in the current study, MMN and P3a amplitude were assessed in a relatively large sample of children with ASD, using a more extensive MMN paradigm and compared with that of typically developing children (TDC). Thirty-five children (aged 8–12 years) with ASD and 38 age and gender matched TDC were assessed with a MMN paradigm with three types of deviants, i.e., frequency, duration and a combination of these two. MMN elicited by duration and frequency-duration deviants was significantly reduced in the ASD group. P3a-amplitude elicited by duration deviants was significantly increased in the ASD group. Reduced MMN in children with ASD suggests that children with ASD may be less responsive to environmentally deviant stimuli at an early (sensory) level. P3a-amplitude was increased in ASD, implying a hyper-responsivity at the attentional level. In addition, as similar MMN deficits are found in schizophrenia, these MMN results may explain some of the frequently reported increased risk of children with ASD to develop schizophrenia later in life. Autism Res 2017, 10: 1857–1865. © 2017 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Automatic detection of deviant sounds in the environment, such as upcoming traffic, is often affected in children with autism spectrum disorders (ASD). Mismatch negativity (MMN) is a way to quantify automatic deviancy detection, using electroencephalography. In this study, auditory MMN was assessed in 35 children with ASD and 38 matched control children, revealing significantly reduced MMN in the ASD group. This may indicate that children with ASD are less able to automatically detect environmentally deviant stimuli. En ligne : http://dx.doi.org/10.1002/aur.1821 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=322 Automatic cortical representation of auditory pitch changes in Rett syndrome / J. J. FOXE in Journal of Neurodevelopmental Disorders, 8-1 (December 2016)
[article]
Titre : Automatic cortical representation of auditory pitch changes in Rett syndrome Type de document : Texte imprimé et/ou numérique Auteurs : J. J. FOXE, Auteur ; K. M. BURKE, Auteur ; G. N. ANDRADE, Auteur ; A. DJUKIC, Auteur ; H. P. FREY, Auteur ; S. MOLHOLM, Auteur Article en page(s) : p.34 Langues : Anglais (eng) Mots-clés : Aep Auditory evoked potential Eeg Erp Event-related potential Females High-density electrical mapping Mecp2 Mmn Mismatch negativity Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones. METHODS: Fourteen girls with genetically confirmed Rett syndrome and 22 age-matched neurotypical controls participated (ages 3.9-21.1 years). High-density electrophysiological recordings from 64 scalp electrodes were made while participants passively listened to a regularly occurring stream of 503-Hz auditory tone pips that was occasionally (15 % of presentations) interrupted by a higher-pitched deviant tone of 996 Hz. The MMN was derived by subtracting the AEP to these deviants from the AEP produced to the standard. RESULTS: Despite clearly anomalous morphology and latency of the AEP to simple pure-tone inputs in Rett syndrome, the MMN response was evident in both neurotypicals and Rett patients. However, we found that the pitch-evoked MMN was both delayed and protracted in duration in Rett, pointing to slowing of auditory responsiveness. CONCLUSIONS: The presence of the MMN in Rett patients suggests preserved abilities to process pitch changes in auditory sensory memory. This work represents a beginning step in an effort to comprehensively map the extent of auditory cortical functioning in Rett syndrome. These easily obtained objective brain measures of auditory processing have promise as biomarkers against which future therapeutic efforts can be assayed. En ligne : http://dx.doi.org/10.1186/s11689-016-9166-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.34[article] Automatic cortical representation of auditory pitch changes in Rett syndrome [Texte imprimé et/ou numérique] / J. J. FOXE, Auteur ; K. M. BURKE, Auteur ; G. N. ANDRADE, Auteur ; A. DJUKIC, Auteur ; H. P. FREY, Auteur ; S. MOLHOLM, Auteur . - p.34.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 8-1 (December 2016) . - p.34
Mots-clés : Aep Auditory evoked potential Eeg Erp Event-related potential Females High-density electrical mapping Mecp2 Mmn Mismatch negativity Index. décimale : PER Périodiques Résumé : BACKGROUND: Over the typical course of Rett syndrome, initial language and communication abilities deteriorate dramatically between the ages of 1 and 4 years, and a majority of these children go on to lose all oral communication abilities. It becomes extremely difficult for clinicians and caretakers to accurately assess the level of preserved auditory functioning in these children, an issue of obvious clinical import. Non-invasive electrophysiological techniques allow for the interrogation of auditory cortical processing without the need for overt behavioral responses. In particular, the mismatch negativity (MMN) component of the auditory evoked potential (AEP) provides an excellent and robust dependent measure of change detection and auditory sensory memory. Here, we asked whether females with Rett syndrome would produce the MMN to occasional changes in pitch in a regularly occurring stream of auditory tones. METHODS: Fourteen girls with genetically confirmed Rett syndrome and 22 age-matched neurotypical controls participated (ages 3.9-21.1 years). High-density electrophysiological recordings from 64 scalp electrodes were made while participants passively listened to a regularly occurring stream of 503-Hz auditory tone pips that was occasionally (15 % of presentations) interrupted by a higher-pitched deviant tone of 996 Hz. The MMN was derived by subtracting the AEP to these deviants from the AEP produced to the standard. RESULTS: Despite clearly anomalous morphology and latency of the AEP to simple pure-tone inputs in Rett syndrome, the MMN response was evident in both neurotypicals and Rett patients. However, we found that the pitch-evoked MMN was both delayed and protracted in duration in Rett, pointing to slowing of auditory responsiveness. CONCLUSIONS: The presence of the MMN in Rett patients suggests preserved abilities to process pitch changes in auditory sensory memory. This work represents a beginning step in an effort to comprehensively map the extent of auditory cortical functioning in Rett syndrome. These easily obtained objective brain measures of auditory processing have promise as biomarkers against which future therapeutic efforts can be assayed. En ligne : http://dx.doi.org/10.1186/s11689-016-9166-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=349 Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder / Melissa LORTIE in Journal of Autism and Developmental Disorders, 47-6 (June 2017)
[article]
Titre : Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa LORTIE, Auteur ; Léa PROULX-BEGIN, Auteur ; Dave SAINT-AMOUR, Auteur ; Dominique COUSINEAU, Auteur ; Hugo THEORET, Auteur ; Jean-François LEPAGE, Auteur Article en page(s) : p.1904-1909 Langues : Anglais (eng) Mots-clés : Social impairments Event related potentials EEG Biological actions Auditory Attention Novelty detection MMN P3 Index. décimale : PER Périodiques Résumé : There is debate whether social impairments in autism spectrum disorder (ASD) are truly domain-specific, or if they reflect generalized deficits in lower-level cognitive processes. To solve this issue, we used auditory-evoked EEG responses to assess novelty detection (MMN component) and involuntary attentional orientation (P3 component) induced by socially-relevant, human-produced, biological sounds and acoustically-matched control stimuli in children with ASD and controls. Results show that early sensory and novelty processing of biological stimuli are preserved in ASD, but that automatic attentional orientation for biological sounds is markedly altered. These results support the notion that at least some cognitive processes of ASD are specifically altered when it comes to processing social stimuli. En ligne : http://dx.doi.org/10.1007/s10803-017-3093-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308
in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1904-1909[article] Brief Report: Biological Sound Processing in Children with Autistic Spectrum Disorder [Texte imprimé et/ou numérique] / Melissa LORTIE, Auteur ; Léa PROULX-BEGIN, Auteur ; Dave SAINT-AMOUR, Auteur ; Dominique COUSINEAU, Auteur ; Hugo THEORET, Auteur ; Jean-François LEPAGE, Auteur . - p.1904-1909.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 47-6 (June 2017) . - p.1904-1909
Mots-clés : Social impairments Event related potentials EEG Biological actions Auditory Attention Novelty detection MMN P3 Index. décimale : PER Périodiques Résumé : There is debate whether social impairments in autism spectrum disorder (ASD) are truly domain-specific, or if they reflect generalized deficits in lower-level cognitive processes. To solve this issue, we used auditory-evoked EEG responses to assess novelty detection (MMN component) and involuntary attentional orientation (P3 component) induced by socially-relevant, human-produced, biological sounds and acoustically-matched control stimuli in children with ASD and controls. Results show that early sensory and novelty processing of biological stimuli are preserved in ASD, but that automatic attentional orientation for biological sounds is markedly altered. These results support the notion that at least some cognitive processes of ASD are specifically altered when it comes to processing social stimuli. En ligne : http://dx.doi.org/10.1007/s10803-017-3093-5 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=308 Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study / L. F. HALLIDAY in Journal of Neurodevelopmental Disorders, 6-1 (December 2014)
[article]
Titre : Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study Type de document : Texte imprimé et/ou numérique Auteurs : L. F. HALLIDAY, Auteur ; Johanna G. BARRY, Auteur ; M. J. HARDIMAN, Auteur ; Dorothy V. M. BISHOP, Auteur Article en page(s) : p.21 Langues : Anglais (eng) Mots-clés : Dyslexia Event-related desynchronization Event-related spectral perturbation Frequency discrimination Inter-trial coherence Ldn Late discriminative negativity Mmn Mismatch negativity Phase locking Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. METHODS: In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with developmental dyslexia and 20 age-matched controls, divided into younger (6-11 years, n = 10) and older (11-14 years, n = 10) age bands. We focused on early (mismatch negativity; MMN) and late (late discriminative negativity; LDN) conventional mismatch responses and associated measures derived from time-frequency analysis (inter-trial coherence and event-related spectral perturbation). Responses were elicited using an auditory oddball task, whereby a stream of 1000-Hz standards was interspersed with rare large (1,200 Hz) and small (1,030 Hz) frequency deviants. RESULTS: Conventional analyses revealed no significant differences between groups in the size of the MMN to either large or small frequency deviants. However, the younger age band of children with dyslexia showed an enhanced inter-trial coherence in the theta frequency band over the time window corresponding to the MMN to small deviants. By contrast, these same children showed a reduced-amplitude LDN for the small deviants relative to their age-matched controls, whilst the older children with dyslexia showed a shorter and less intense period of event-related desynchronization over this time window. CONCLUSIONS: Initial detection and discrimination of auditory frequency change appears normal or even enhanced in children with dyslexia. Rather, deficits in late-stage auditory processing appear to be a feature of this population. En ligne : http://dx.doi.org/10.1186/1866-1955-6-21 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.21[article] Late, not early mismatch responses to changes in frequency are reduced or deviant in children with dyslexia: an event-related potential study [Texte imprimé et/ou numérique] / L. F. HALLIDAY, Auteur ; Johanna G. BARRY, Auteur ; M. J. HARDIMAN, Auteur ; Dorothy V. M. BISHOP, Auteur . - p.21.
Langues : Anglais (eng)
in Journal of Neurodevelopmental Disorders > 6-1 (December 2014) . - p.21
Mots-clés : Dyslexia Event-related desynchronization Event-related spectral perturbation Frequency discrimination Inter-trial coherence Ldn Late discriminative negativity Mmn Mismatch negativity Phase locking Index. décimale : PER Périodiques Résumé : BACKGROUND: Developmental disorders of oral and written language have been linked to deficits in the processing of auditory information. However, findings have been inconsistent, both for behavioural and electrophysiological measures. METHODS: In this study, we examined event-related potentials (ERPs) in 20 6- to 14-year-old children with developmental dyslexia and 20 age-matched controls, divided into younger (6-11 years, n = 10) and older (11-14 years, n = 10) age bands. We focused on early (mismatch negativity; MMN) and late (late discriminative negativity; LDN) conventional mismatch responses and associated measures derived from time-frequency analysis (inter-trial coherence and event-related spectral perturbation). Responses were elicited using an auditory oddball task, whereby a stream of 1000-Hz standards was interspersed with rare large (1,200 Hz) and small (1,030 Hz) frequency deviants. RESULTS: Conventional analyses revealed no significant differences between groups in the size of the MMN to either large or small frequency deviants. However, the younger age band of children with dyslexia showed an enhanced inter-trial coherence in the theta frequency band over the time window corresponding to the MMN to small deviants. By contrast, these same children showed a reduced-amplitude LDN for the small deviants relative to their age-matched controls, whilst the older children with dyslexia showed a shorter and less intense period of event-related desynchronization over this time window. CONCLUSIONS: Initial detection and discrimination of auditory frequency change appears normal or even enhanced in children with dyslexia. Rather, deficits in late-stage auditory processing appear to be a feature of this population. En ligne : http://dx.doi.org/10.1186/1866-1955-6-21 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=346 Increased context adjustment is associated with auditory sensitivities but not with autistic traits / Roshini RANDENIYA in Autism Research, 15-8 (August 2022)
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