Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder / Laura C. ERICKSON in Journal of Autism and Developmental Disorders, 42-6 (June 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1120-1126 Titre : Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laura C. ERICKSON, Auteur ; Ashley A. SCOTT VAN ZEELAND, Auteur ; Gavin HAMILTON, Auteur ; Alan J. LINCOLN, Auteur ; Beatrice A. GOLOMB, Auteur Année de publication : 2012 Article en page(s) : p.1120-1126 Langues : Anglais (eng) Mots-clés : Autism  ASD  Magnetic resonance  Energetics  Muscle  Brain  Awake Index. décimale : PER Périodiques Résumé : We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle 31Phosphorus-Magnetic Resonance Spectroscopy (31P-MRS) scans performed in one session in 12 awake, non-sedated subjects (ages 6–18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced preparation, parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement of future MR studies in pediatric subjects with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1359-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156 [article] Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children with and without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Laura C. ERICKSON, Auteur ; Ashley A. SCOTT VAN ZEELAND, Auteur ; Gavin HAMILTON, Auteur ; Alan J. LINCOLN, Auteur ; Beatrice A. GOLOMB, Auteur . - 2012 . - p.1120-1126. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-6 (June 2012) . - p.1120-1126 Mots-clés : Autism  ASD  Magnetic resonance  Energetics  Muscle  Brain  Awake Index. décimale : PER Périodiques Résumé : We piloted a suite of approaches aimed to facilitate a successful series of up to four brain and muscle 31Phosphorus-Magnetic Resonance Spectroscopy (31P-MRS) scans performed in one session in 12 awake, non-sedated subjects (ages 6–18), 6 with autism spectrum disorders (ASD) and 6 controls. We targeted advanced preparation, parental input, physical comfort, short scan protocols, allocation of extra time, and subject emotional support. 100% of subjects completed at least one brain scan and one leg muscle scan: 42 of 46 attempted scans were completed (91%), with failures dominated by exercise muscle scans (completed in 6/6 controls but 3/6 cases). One completed scan lacked usable data unrelated to subject/scan procedure (orthodonture affected a frontal brain scan). As a group, these methods provide a foundation for conduct and enhancement of future MR studies in pediatric subjects with ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1359-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=156

Erratum to: Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children With and Without Autism Spectrum Disorder / Laura C. ERICKSON in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2671-2677 Titre : Erratum to: Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children With and Without Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Laura C. ERICKSON, Auteur ; Ashley A. SCOTT VAN ZEELAND, Auteur ; Gavin HAMILTON, Auteur ; Alan LINCOLN, Auteur ; Beatrice A. GOLOMB, Auteur Article en page(s) : p.2671-2677 Langues : Anglais (eng) Mots-clés : Autism  ASD  Magnetic resonance  Energetics  Muscle  Brain  Awake Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-013-1821-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241 [article] Erratum to: Brief Report: Approaches to 31P-MRS in Awake, Non-Sedated Children With and Without Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Laura C. ERICKSON, Auteur ; Ashley A. SCOTT VAN ZEELAND, Auteur ; Gavin HAMILTON, Auteur ; Alan LINCOLN, Auteur ; Beatrice A. GOLOMB, Auteur . - p.2671-2677. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2671-2677 Mots-clés : Autism  ASD  Magnetic resonance  Energetics  Muscle  Brain  Awake Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-013-1821-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=241

Reward processing in autism / Ashley A. SCOTT VAN ZEELAND in Autism Research, 3-2 (April 2010)  

Public ISBD [article]  inAutism Research > 3-2 (April 2010) . - p.53-67 Titre : Reward processing in autism Type de document : Texte imprimé et/ou numérique Auteurs : Ashley A. SCOTT VAN ZEELAND, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Dara G. GHAHREMANI, Auteur ; Russell A. POLDRACK, Auteur Année de publication : 2010 Article en page(s) : p.53-67 Langues : Anglais (eng) Mots-clés : functional-MRI-(fMRI) social-cognition reward learning Index. décimale : PER Périodiques Résumé : The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments. En ligne : http://dx.doi.org/10.1002/aur.122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 [article] Reward processing in autism [Texte imprimé et/ou numérique] / Ashley A. SCOTT VAN ZEELAND, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur ; Dara G. GHAHREMANI, Auteur ; Russell A. POLDRACK, Auteur . - 2010 . - p.53-67. Langues : Anglais (eng) in Autism Research > 3-2 (April 2010) . - p.53-67 Mots-clés : functional-MRI-(fMRI) social-cognition reward learning Index. décimale : PER Périodiques Résumé : The social motivation hypothesis of autism posits that infants with autism do not experience social stimuli as rewarding, thereby leading to a cascade of potentially negative consequences for later development. While possible downstream effects of this hypothesis such as altered face and voice processing have been examined, there has not been a direct investigation of social reward processing in autism. Here we use functional magnetic resonance imaging to examine social and monetary rewarded implicit learning in children with and without autism spectrum disorders (ASD). Sixteen males with ASD and sixteen age- and IQ-matched typically developing (TD) males were scanned while performing two versions of a rewarded implicit learning task. In addition to examining responses to reward, we investigated the neural circuitry supporting rewarded learning and the relationship between these factors and social development. We found diminished neural responses to both social and monetary rewards in ASD, with a pronounced reduction in response to social rewards (SR). Children with ASD also demonstrated a further deficit in frontostriatal response during social, but not monetary, rewarded learning. Moreover, we show a relationship between ventral striatum activity and social reciprocity in TD children. Together, these data support the hypothesis that children with ASD have diminished neural responses to SR, and that this deficit relates to social learning impairments. En ligne : http://dx.doi.org/10.1002/aur.122 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102

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