Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts / Amy Krain ROY in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.571-579 Titre : Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts Type de document : Texte imprimé et/ou numérique Auteurs : Amy Krain ROY, Auteur ; Randi BENNETT, Auteur ; Jonathan POSNER, Auteur ; Leslie HULVERSHORN, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Rachel G. KLEIN, Auteur Article en page(s) : p.571-579 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO. En ligne : http://dx.doi.org/10.1017/S0954579417001080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Altered intrinsic functional connectivity of the cingulate cortex in children with severe temper outbursts [Texte imprimé et/ou numérique] / Amy Krain ROY, Auteur ; Randi BENNETT, Auteur ; Jonathan POSNER, Auteur ; Leslie HULVERSHORN, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; Rachel G. KLEIN, Auteur . - p.571-579. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.571-579 Index. décimale : PER Périodiques Résumé : Severe temper outbursts (STO) in children are associated with impaired school and family functioning and may contribute to negative outcomes. These outbursts can be conceptualized as excessive frustration responses reflecting reduced emotion regulation capacity. The anterior cingulate cortex (ACC) has been implicated in negative affect as well as emotional control, and exhibits disrupted function in children with elevated irritability and outbursts. This study examined the intrinsic functional connectivity (iFC) of a region of the ACC, the anterior midcingulate cortex (aMCC), in 5- to 9-year-old children with STO (n = 20), comparing them to children with attention-deficit/hyperactivity disorder (ADHD) without outbursts (ADHD; n = 18). Additional analyses compared results to a sample of healthy children (HC; n = 18) and examined specific associations with behavioral and emotional dysregulation. Compared to the ADHD group, STO children exhibited reduced iFC between the aMCC and surrounding regions of the ACC, and increased iFC between the aMCC and precuneus. These differences were also seen between the STO and HC groups; ADHD and HC groups did not differ. Specificity analyses found associations between aMCC–ACC connectivity and hyperactivity, and between aMCC–precuneus iFC and emotion dysregulation. Disruption in aMCC networks may underlie the behavioral and emotional dysregulation characteristic of children with STO. En ligne : http://dx.doi.org/10.1017/S0954579417001080 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making / Amy L. KRAIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030 Titre : An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur Année de publication : 2007 Article en page(s) : p.1023–1030 Langues : Anglais (eng) Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits. Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task. Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback. Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792 [article] An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making [Texte imprimé et/ou numérique] / Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur . - 2007 . - p.1023–1030. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030 Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits. Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task. Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback. Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792

Anxiety disorders / Rachel G. KLEIN in Journal of Child Psychology and Psychiatry, 50-1-2 (January/February 2009)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.153-162 Titre : Anxiety disorders Type de document : Texte imprimé et/ou numérique Auteurs : Rachel G. KLEIN, Auteur Année de publication : 2009 Article en page(s) : p.153-162 Langues : Anglais (eng) Mots-clés : Anxiety-disorders normal-vs.-pathological-anxiety validity-of-child-anxiety-disorders need-for-precision-for-impairment ADHD hormones personality mediation Index. décimale : PER Périodiques Résumé : Because of their high prevalence and their negative long-term consequences, child anxiety disorders have become an important focus of interest. Whether pathological anxiety and normal fear are similar processes continues to be controversial. Comparative studies of child anxiety disorders are scarce, but there is some support for the current classification of anxiety disorders in children and adolescents, except for generalized anxiety disorder. The greatly differing rates of anxiety disorders in child population studies, and of specific disorders in clinical samples, inconsistent findings regarding course, and disparate placebo response rates all suggest a need for more precise, validated, criteria for symptoms, distress, and impairment. Several treatments have documented efficacy, and promising prevention efforts are encouraging. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02061.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695 [article] Anxiety disorders [Texte imprimé et/ou numérique] / Rachel G. KLEIN, Auteur . - 2009 . - p.153-162. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 50-1-2 (January/February 2009) . - p.153-162 Mots-clés : Anxiety-disorders normal-vs.-pathological-anxiety validity-of-child-anxiety-disorders need-for-precision-for-impairment ADHD hormones personality mediation Index. décimale : PER Périodiques Résumé : Because of their high prevalence and their negative long-term consequences, child anxiety disorders have become an important focus of interest. Whether pathological anxiety and normal fear are similar processes continues to be controversial. Comparative studies of child anxiety disorders are scarce, but there is some support for the current classification of anxiety disorders in children and adolescents, except for generalized anxiety disorder. The greatly differing rates of anxiety disorders in child population studies, and of specific disorders in clinical samples, inconsistent findings regarding course, and disparate placebo response rates all suggest a need for more precise, validated, criteria for symptoms, distress, and impairment. Several treatments have documented efficacy, and promising prevention efforts are encouraging. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.02061.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=695

Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial / Carrie MASIA WARNER in Journal of Child Psychology and Psychiatry, 57-11 (November 2016)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1229-1238 Titre : Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial Type de document : Texte imprimé et/ou numérique Auteurs : Carrie MASIA WARNER, Auteur ; Daniela COLOGNORI, Auteur ; Chad BRICE, Auteur ; Kathleen HERZIG, Auteur ; Laura MUFSON, Auteur ; Chelsea LYNCH, Auteur ; Philip T. REISS, Auteur ; Eva PETKOVA, Auteur ; Jeremy FOX, Auteur ; Dominic C. MOCERI, Auteur ; Julie RYAN, Auteur ; Rachel G. KLEIN, Auteur Article en page(s) : p.1229-1238 Langues : Anglais (eng) Mots-clés : Social anxiety  school counselors  adolescents  SASS Index. décimale : PER Périodiques Résumé : Background Social anxiety disorder (SAD) typically onsets in adolescence and is associated with multiple impairments. Despite promising clinical interventions, most socially anxious adolescents remain untreated. To address this clinical neglect, we developed a school-based, 12-week group intervention for youth with SAD, Skills for Academic and Social Success (SASS). When implemented by psychologists, SASS has been found effective. To promote dissemination and optimize treatment access, we tested whether school counselors could be effective treatment providers. Method We randomized 138, ninth through 11th graders with SAD to one of three conditions: (a) SASS delivered by school counselors (C-SASS), (b) SASS delivered by psychologists (P-SASS), or (c) a control condition, Skills for Life (SFL), a nonspecific counseling program. Blind, independent, evaluations were conducted with parents and adolescents at baseline, post-intervention, and 5 months beyond treatment completion. We hypothesized that C-SASS and P-SASS would be superior to the control, immediately after treatment and at follow-up. No prediction was made about the relative efficacy of C-SASS and P-SASS. Results Compared to controls, adolescents treated with C-SASS or P-SASS experienced significantly greater improvement and reductions of anxiety at the end of treatment and follow-up. There were no significant differences between SASS delivered by school counselors and psychologists. Conclusion With training, school counselors are effective treatment providers to adolescents with social anxiety, yielding benefits comparable to those obtained by specialized psychologists. Questions remain regarding means to maintain counselors’ practice standards without external support. En ligne : http://dx.doi.org/10.1111/jcpp.12550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295 [article] Can school counselors deliver cognitive-behavioral treatment for social anxiety effectively? A randomized controlled trial [Texte imprimé et/ou numérique] / Carrie MASIA WARNER, Auteur ; Daniela COLOGNORI, Auteur ; Chad BRICE, Auteur ; Kathleen HERZIG, Auteur ; Laura MUFSON, Auteur ; Chelsea LYNCH, Auteur ; Philip T. REISS, Auteur ; Eva PETKOVA, Auteur ; Jeremy FOX, Auteur ; Dominic C. MOCERI, Auteur ; Julie RYAN, Auteur ; Rachel G. KLEIN, Auteur . - p.1229-1238. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 57-11 (November 2016) . - p.1229-1238 Mots-clés : Social anxiety  school counselors  adolescents  SASS Index. décimale : PER Périodiques Résumé : Background Social anxiety disorder (SAD) typically onsets in adolescence and is associated with multiple impairments. Despite promising clinical interventions, most socially anxious adolescents remain untreated. To address this clinical neglect, we developed a school-based, 12-week group intervention for youth with SAD, Skills for Academic and Social Success (SASS). When implemented by psychologists, SASS has been found effective. To promote dissemination and optimize treatment access, we tested whether school counselors could be effective treatment providers. Method We randomized 138, ninth through 11th graders with SAD to one of three conditions: (a) SASS delivered by school counselors (C-SASS), (b) SASS delivered by psychologists (P-SASS), or (c) a control condition, Skills for Life (SFL), a nonspecific counseling program. Blind, independent, evaluations were conducted with parents and adolescents at baseline, post-intervention, and 5 months beyond treatment completion. We hypothesized that C-SASS and P-SASS would be superior to the control, immediately after treatment and at follow-up. No prediction was made about the relative efficacy of C-SASS and P-SASS. Results Compared to controls, adolescents treated with C-SASS or P-SASS experienced significantly greater improvement and reductions of anxiety at the end of treatment and follow-up. There were no significant differences between SASS delivered by school counselors and psychologists. Conclusion With training, school counselors are effective treatment providers to adolescents with social anxiety, yielding benefits comparable to those obtained by specialized psychologists. Questions remain regarding means to maintain counselors’ practice standards without external support. En ligne : http://dx.doi.org/10.1111/jcpp.12550 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=295

Parent training for preschool ADHD: a randomized controlled trial of specialized and generic programs / Howard B. ABIKOFF in Journal of Child Psychology and Psychiatry, 56-6 (June 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.618-631 Titre : Parent training for preschool ADHD: a randomized controlled trial of specialized and generic programs Type de document : Texte imprimé et/ou numérique Auteurs : Howard B. ABIKOFF, Auteur ; Margaret THOMPSON, Auteur ; Cathy LAVER-BRADBURY, Auteur ; Nicholas LONG, Auteur ; Rex L. FOREHAND, Auteur ; Laurie MILLER BROTMAN, Auteur ; Rachel G. KLEIN, Auteur ; Philip REISS, Auteur ; Lan HUO, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur Article en page(s) : p.618-631 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity disorder  preschool  parent training  generalization Index. décimale : PER Périodiques Résumé : Background The ‘New Forest Parenting Package’ (NFPP), an 8-week home-based intervention for parents of preschoolers with attention-deficit/hyperactivity disorder (ADHD), fosters constructive parenting to target ADHD-related dysfunctions in attention and impulse control. Although NFPP has improved parent and laboratory measures of ADHD in community samples of children with ADHD-like problems, its efficacy in a clinical sample, and relative to an active treatment comparator, is unknown. The aims are to evaluate the short- and long-term efficacy and generalization effects of NFPP compared to an established clinic-based parenting intervention for treating noncompliant behavior [‘Helping the Noncompliant Child’ (HNC)] in young children with ADHD. Methods A randomized controlled trial with three parallel arms was the design for this study. A total of 164 3–4-year-olds, 73.8% male, meeting DSM-IV ADHD diagnostic criteria were randomized to NFPP (N = 67), HNC (N = 63), or wait-list control (WL, N = 34). All participants were assessed at post-treatment. NFPP and HNC participants were assessed at follow-up in the next school year. Primary outcomes were ADHD ratings by teachers blind to and uninvolved in treatment, and by parents. Secondary ADHD outcomes included clinician assessments, and laboratory measures of on-task behavior and delay of gratification. Other outcomes included parent and teacher ratings of oppositional behavior, and parenting measures. (Trial name: Home-Based Parent Training in ADHD Preschoolers; Registry: ClinicalTrials.gov Identifier: NCT01320098; URL: http://www/clinicaltrials.gov/ct2/show/NCT01320098). Results In both treatment groups, children's ADHD and ODD behaviors, as well as aspects of parenting, were rated improved by parents at the end of treatment compared to controls. Most of these gains in the children's behavior and in some parenting practices were sustained at follow-up. However, these parent-reported improvements were not corroborated by teacher ratings or objective observations. NFPP was not significantly better, and on a few outcomes significantly less effective, than HNC. Conclusions The results do not support the claim that NFPP addresses putative dysfunctions underlying ADHD, bringing about generalized change in ADHD, and its underpinning self-regulatory processes. The findings support documented difficulties in achieving generalization across nontargeted settings, and the importance of using blinded measures to provide meaningful assessments of treatment effects. En ligne : http://dx.doi.org/10.1111/jcpp.12346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Parent training for preschool ADHD: a randomized controlled trial of specialized and generic programs [Texte imprimé et/ou numérique] / Howard B. ABIKOFF, Auteur ; Margaret THOMPSON, Auteur ; Cathy LAVER-BRADBURY, Auteur ; Nicholas LONG, Auteur ; Rex L. FOREHAND, Auteur ; Laurie MILLER BROTMAN, Auteur ; Rachel G. KLEIN, Auteur ; Philip REISS, Auteur ; Lan HUO, Auteur ; Edmund J. S. SONUGA-BARKE, Auteur . - p.618-631. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-6 (June 2015) . - p.618-631 Mots-clés : Attention-deficit/hyperactivity disorder  preschool  parent training  generalization Index. décimale : PER Périodiques Résumé : Background The ‘New Forest Parenting Package’ (NFPP), an 8-week home-based intervention for parents of preschoolers with attention-deficit/hyperactivity disorder (ADHD), fosters constructive parenting to target ADHD-related dysfunctions in attention and impulse control. Although NFPP has improved parent and laboratory measures of ADHD in community samples of children with ADHD-like problems, its efficacy in a clinical sample, and relative to an active treatment comparator, is unknown. The aims are to evaluate the short- and long-term efficacy and generalization effects of NFPP compared to an established clinic-based parenting intervention for treating noncompliant behavior [‘Helping the Noncompliant Child’ (HNC)] in young children with ADHD. Methods A randomized controlled trial with three parallel arms was the design for this study. A total of 164 3–4-year-olds, 73.8% male, meeting DSM-IV ADHD diagnostic criteria were randomized to NFPP (N = 67), HNC (N = 63), or wait-list control (WL, N = 34). All participants were assessed at post-treatment. NFPP and HNC participants were assessed at follow-up in the next school year. Primary outcomes were ADHD ratings by teachers blind to and uninvolved in treatment, and by parents. Secondary ADHD outcomes included clinician assessments, and laboratory measures of on-task behavior and delay of gratification. Other outcomes included parent and teacher ratings of oppositional behavior, and parenting measures. (Trial name: Home-Based Parent Training in ADHD Preschoolers; Registry: ClinicalTrials.gov Identifier: NCT01320098; URL: http://www/clinicaltrials.gov/ct2/show/NCT01320098). Results In both treatment groups, children's ADHD and ODD behaviors, as well as aspects of parenting, were rated improved by parents at the end of treatment compared to controls. Most of these gains in the children's behavior and in some parenting practices were sustained at follow-up. However, these parent-reported improvements were not corroborated by teacher ratings or objective observations. NFPP was not significantly better, and on a few outcomes significantly less effective, than HNC. Conclusions The results do not support the claim that NFPP addresses putative dysfunctions underlying ADHD, bringing about generalized change in ADHD, and its underpinning self-regulatory processes. The findings support documented difficulties in achieving generalization across nontargeted settings, and the importance of using blinded measures to provide meaningful assessments of treatment effects. En ligne : http://dx.doi.org/10.1111/jcpp.12346 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Preventive Intervention for Preschoolers at High Risk for Antisocial Behavior: Long-Term Effects on Child Physical Aggression and Parenting Practices / Laurie MILLER BROTMAN in Journal of Clinical Child & Adolescent Psychology, 37-2 (April-June 2008)  

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The possible role of the kynurenine pathway in adolescent depression with melancholic features / Vilma GABBAY in Journal of Child Psychology and Psychiatry, 51-8 (August 2010)  

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Treating adolescents with social anxiety disorder in school: an attention control trial / Carrie MASIA WARNER in Journal of Child Psychology and Psychiatry, 48-7 (July 2007)  

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