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Détail de l'auteur
Auteur Michael P. MILHAM |
Documents disponibles écrits par cet auteur (3)



An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making / Amy L. KRAIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)
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[article]
Titre : An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making Type de document : Texte imprimé et/ou numérique Auteurs : Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur Année de publication : 2007 Article en page(s) : p.1023–1030 Langues : Anglais (eng) Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits.
Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task.
Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback.
Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030[article] An fMRI examination of developmental differences in the neural correlates of uncertainty and decision-making [Texte imprimé et/ou numérique] / Amy L. KRAIN, Auteur ; Daniel Samuel PINE, Auteur ; Sara HEFTON, Auteur ; Monique ERNST, Auteur ; Rachel G. KLEIN, Auteur ; Michael P. MILHAM, Auteur ; Francisco Xavier CASTELLANOS, Auteur . - 2007 . - p.1023–1030.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1023–1030
Mots-clés : Adolescence anxiety brain-imaging development Index. décimale : PER Périodiques Résumé : Background: Maturation of prefrontal circuits during adolescence contributes to the development of cognitive processes such as decision-making. Recent theories suggest that these neural changes also play a role in the shift from generalized anxiety disorder (GAD) to depression that often occurs during this developmental period. Cognitive models of the development of GAD highlight the role of intolerance of uncertainty (IU), which can be characterized behaviorally by impairments in decision-making. The present study examines potential developmental differences in frontal regions associated with uncertain decision-making, and tests the impact of IU on these circuits.
Methods: Twelve healthy adults (ages 19–36) and 12 healthy adolescents (ages 13–17) completed a decision-making task with conditions of varied uncertainty while fMRI scans were acquired. They also completed measures of worry and IU, and a questionnaire about their levels of anxiety and certainty during the task.
Results: Combined group analyses demonstrated significant linear effects of uncertainty on activity within anterior cingulate cortex (ACC). Region of interest (ROI)-based analysis found a significant interaction of group and IU ratings in ACC. Increased IU was associated with robust linear increases in ACC activity only in adolescents. An ROI analysis of feedback-related processing found that adolescents demonstrated greater activation during incorrect trials relative to correct trials, while the adults showed no difference in neural activity associated with incorrect and correct feedback.
Conclusions: This decision-making task was shown to be effective at eliciting uncertainty-related ACC activity in adults and adolescents. Further, IU impacts ACC activity in adolescents during uncertain decision-making, providing preliminary support for a developmental model of GAD.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01677.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=792 Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes / Aki NIKOLAIDIS in Development and Psychopathology, 34-2 (May 2022)
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Titre : Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes Type de document : Texte imprimé et/ou numérique Auteurs : Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur Article en page(s) : 621-634 Langues : Anglais (eng) Mots-clés : caregiving related early adversities heterogeneity prediction subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744
in Development and Psychopathology > 34-2 (May 2022) . - 621-634[article] Heterogeneity in caregiving-related early adversity: Creating stable dimensions and subtypes [Texte imprimé et/ou numérique] / Aki NIKOLAIDIS, Auteur ; Charlotte HELENIAK, Auteur ; Andrea FIELDS, Auteur ; Paul A. BLOOM, Auteur ; Michelle VANTIEGHEM, Auteur ; Anna VANNUCCI, Auteur ; Nicolas L. CAMACHO, Auteur ; Tricia CHOY, Auteur ; Lisa GIBSON, Auteur ; Chelsea HARMON, Auteur ; Syntia S. HADIS, Auteur ; Ian J. DOUGLAS, Auteur ; Michael P. MILHAM, Auteur ; Nim TOTTENHAM, Auteur . - 621-634.
Langues : Anglais (eng)
in Development and Psychopathology > 34-2 (May 2022) . - 621-634
Mots-clés : caregiving related early adversities heterogeneity prediction subtyping Index. décimale : PER Périodiques Résumé : Early psychosocial adversities exist at many levels, including caregiving-related, extrafamilial, and sociodemographic, which despite their high interrelatedness may have unique impacts on development. In this paper, we focus on caregiving-related early adversities (crEAs) and parse the heterogeneity of crEAs via data reduction techniques that identify experiential cooccurrences. Using network science, we characterized crEA cooccurrences to represent the comorbidity of crEA experiences across a sample of school-age children (n = 258; 6?12 years old) with a history of crEAs. crEA dimensions (variable level) and crEA subtypes (subject level) were identified using parallel factor analysis/principal component analysis and graph-based Louvain community detection. Bagging enhancement with cross-validation provided estimates of robustness. These data-driven dimensions/subtypes showed evidence of stability, transcended traditional sociolegally defined groups, were more homogenous than sociolegally defined groups, and reduced statistical correlations with sociodemographic factors. Finally, random forests showed both unique and common predictive importance of the crEA dimensions/subtypes for childhood mental health symptoms and academic skills. These data-driven outcomes provide additional tools and recommendations for crEA data reduction to inform precision medicine efforts in this area. En ligne : http://dx.doi.org/10.1017/s0954579421001668 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4744 The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis / Steven G. DICKSTEIN in Journal of Child Psychology and Psychiatry, 47-10 (October 2006)
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[article]
Titre : The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis Type de document : Texte imprimé et/ou numérique Auteurs : Steven G. DICKSTEIN, Auteur ; Michael P. MILHAM, Auteur ; Katie BANNON, Auteur ; Francisco Xavier CASTELLANOS, Auteur Année de publication : 2007 Article en page(s) : p.1051–1062 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity-disorder-(ADHD) meta-analysis neuroimaging functional-magnetic-resonance-imaging-(fMRI) positron-emission-tomography-(PET) executive-function Index. décimale : PER Périodiques Résumé : Background: Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent and commonly studied forms of psychopathology in children and adolescents. Causal models of ADHD have long implicated dysfunction in fronto-striatal and frontal-parietal networks supporting executive function, a hypothesis that can now be examined systematically using functional neuroimaging. The present work provides an objective, unbiased statistically-based meta-analysis of published functional neuroimaging studies of ADHD.
Methods: A recently developed voxel-wise quantitative meta-analytic technique known as activation likelihood estimation (ALE) was applied to 16 neuroimaging studies examining and contrasting patterns of neural activity in patients with ADHD and healthy controls. Voxel-wise results are reported using a statistical threshold of p < .05, corrected. Given the large number of studies examining response inhibition, additional meta-analyses focusing specifically on group differences in the neural correlates of inhibition were included.
Results: Across studies, significant patterns of frontal hypoactivity were detected in patients with ADHD, affecting anterior cingulate, dorsolateral prefrontal, and inferior prefrontal cortices, as well as related regions including basal ganglia, thalamus, and portions of parietal cortex. When focusing on studies of response inhibition alone, a more limited set of group differences were observed, including inferior prefrontal cortex, medial wall regions, and the precentral gyrus. In contrast, analyses focusing on studies of constructs other than response inhibition revealed a more extensive pattern of hypofunction in patients with ADHD than those of response inhibition.
Conclusions: To date, the most consistent findings in the neuroimaging literature of ADHD are deficits in neural activity within fronto-striatal and fronto-parietal circuits. The distributed nature of these results fails to support models emphasizing dysfunction in any one frontal sub-region. While our findings are suggestive of the primacy of deficits in frontal-based neural circuitry underlying ADHD, we discuss potential biases in the literature that need to be addressed before such a conclusion can be fully embraced.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01671.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=795
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1051–1062[article] The neural correlates of attention deficit hyperactivity disorder: an ALE meta-analysis [Texte imprimé et/ou numérique] / Steven G. DICKSTEIN, Auteur ; Michael P. MILHAM, Auteur ; Katie BANNON, Auteur ; Francisco Xavier CASTELLANOS, Auteur . - 2007 . - p.1051–1062.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 47-10 (October 2006) . - p.1051–1062
Mots-clés : Attention-deficit/hyperactivity-disorder-(ADHD) meta-analysis neuroimaging functional-magnetic-resonance-imaging-(fMRI) positron-emission-tomography-(PET) executive-function Index. décimale : PER Périodiques Résumé : Background: Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent and commonly studied forms of psychopathology in children and adolescents. Causal models of ADHD have long implicated dysfunction in fronto-striatal and frontal-parietal networks supporting executive function, a hypothesis that can now be examined systematically using functional neuroimaging. The present work provides an objective, unbiased statistically-based meta-analysis of published functional neuroimaging studies of ADHD.
Methods: A recently developed voxel-wise quantitative meta-analytic technique known as activation likelihood estimation (ALE) was applied to 16 neuroimaging studies examining and contrasting patterns of neural activity in patients with ADHD and healthy controls. Voxel-wise results are reported using a statistical threshold of p < .05, corrected. Given the large number of studies examining response inhibition, additional meta-analyses focusing specifically on group differences in the neural correlates of inhibition were included.
Results: Across studies, significant patterns of frontal hypoactivity were detected in patients with ADHD, affecting anterior cingulate, dorsolateral prefrontal, and inferior prefrontal cortices, as well as related regions including basal ganglia, thalamus, and portions of parietal cortex. When focusing on studies of response inhibition alone, a more limited set of group differences were observed, including inferior prefrontal cortex, medial wall regions, and the precentral gyrus. In contrast, analyses focusing on studies of constructs other than response inhibition revealed a more extensive pattern of hypofunction in patients with ADHD than those of response inhibition.
Conclusions: To date, the most consistent findings in the neuroimaging literature of ADHD are deficits in neural activity within fronto-striatal and fronto-parietal circuits. The distributed nature of these results fails to support models emphasizing dysfunction in any one frontal sub-region. While our findings are suggestive of the primacy of deficits in frontal-based neural circuitry underlying ADHD, we discuss potential biases in the literature that need to be addressed before such a conclusion can be fully embraced.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2006.01671.x Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=795