A cascade model connecting life stress to risk behavior among rural African American emerging adults / Gene H. BRODY in Development and Psychopathology, 22-3 (August 2010)  

Public ISBD [article]  inDevelopment and Psychopathology > 22-3 (August 2010) . - p.667-678 Titre : A cascade model connecting life stress to risk behavior among rural African American emerging adults Type de document : texte imprimé Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven M. KOGAN, Auteur Année de publication : 2010 Article en page(s) : p.667-678 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : A three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk behavior as African Americans transitioned out of secondary school. The cascade model indicated that life stress fostered increases in negative emotions. Negative emotions, in turn, were linked to increases in affiliations with deviant peers and romantic partners; this forecast increases in risk behavior. The findings supported a stress proliferation framework, in which primary stressors affect increases in secondary stressors that carry forward to influence changes in risk behaviors that can potentially compromise mental health. En ligne : http://dx.doi.org/10.1017/s0954579410000350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108 [article] A cascade model connecting life stress to risk behavior among rural African American emerging adults [texte imprimé] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Steven M. KOGAN, Auteur . - 2010 . - p.667-678. Langues : Anglais (eng) in Development and Psychopathology > 22-3 (August 2010) . - p.667-678 Index. décimale : PER Périodiques Résumé : A three-wave cascade model linking life stress to increases in risk behavior was tested with 347 African American emerging adults living in the rural South. Data analyses using structural equation modeling and latent growth curve modeling demonstrated that life stress was linked to increases in risk behavior as African Americans transitioned out of secondary school. The cascade model indicated that life stress fostered increases in negative emotions. Negative emotions, in turn, were linked to increases in affiliations with deviant peers and romantic partners; this forecast increases in risk behavior. The findings supported a stress proliferation framework, in which primary stressors affect increases in secondary stressors that carry forward to influence changes in risk behaviors that can potentially compromise mental health. En ligne : http://dx.doi.org/10.1017/s0954579410000350 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=108

Childhood exposure to danger increases Black youths’ alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis / Steven R. H. BEACH in Development and Psychopathology, 38-1 (February 2026)  

Public ISBD [article]  inDevelopment and Psychopathology > 38-1 (February 2026) . - p.156-171 Titre : Childhood exposure to danger increases Black youths’ alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis Type de document : texte imprimé Auteurs : Steven R. H. BEACH, Auteur ; Sierra E. CARTER, Auteur ; Mei Ling ONG, Auteur ; Justin A. LAVNER, Auteur ; Steven M. KOGAN, Auteur ; Katherine B. EHRLICH, Auteur ; Man-Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Olutosin ADESOGAN, Auteur ; Frederick X. GIBBONS, Auteur ; Meg GERRARD, Auteur ; Robert A. PHILIBERT, Auteur Article en page(s) : p.156-171 Langues : Anglais (eng) Mots-clés : DNAm-based aging Danger Inflammation alcohol cardiac risk Index. décimale : PER Périodiques Résumé : Using the dual-pathway framework (Beach et al., a), we tested a Neuro-immune Network (NIN) hypothesis: i.e., that chronically elevated inflammatory processes may have delayed (i.e., incubation) effects on young adult substance use, leading to negative health outcomes. In a sample of 449 participants in the Family and Community Health Study who were followed from age 10 to age 29, we examined a non-self-report index of young adult elevated alcohol consumption (EAC). By controlling self-reported substance use at the transition to adulthood, we were able to isolate a significant delayed (incubation) effect from childhood exposure to danger to EAC (β = −.157, p = .006), which contributed to significantly worse aging outomes. Indirect effects from danger to aging outcomes via EAC were: GrimAge (IE = .010, [.002, .024]), Cardiac Risk (IE = −.004, [−.011, −.001]), DunedinPACE (IE = .002, [.000, .008]). In exploratory analyses we examined potential sex differences in effects, showing slightly stronger incubation effects for men and slightly stronger effects of EAC on aging outcomes for women. Results support the NIN hypothesis that incubation of immune pathway effects contributes to elevated alcohol consumption in young adulthood, resulting in accelerated aging and elevated cardiac risk outcomes via health behavior. En ligne : https://dx.doi.org/10.1017/S0954579425000264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579 [article] Childhood exposure to danger increases Black youths’ alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis [texte imprimé] / Steven R. H. BEACH, Auteur ; Sierra E. CARTER, Auteur ; Mei Ling ONG, Auteur ; Justin A. LAVNER, Auteur ; Steven M. KOGAN, Auteur ; Katherine B. EHRLICH, Auteur ; Man-Kit LEI, Auteur ; Ronald L. SIMONS, Auteur ; Olutosin ADESOGAN, Auteur ; Frederick X. GIBBONS, Auteur ; Meg GERRARD, Auteur ; Robert A. PHILIBERT, Auteur . - p.156-171. Langues : Anglais (eng) in Development and Psychopathology > 38-1 (February 2026) . - p.156-171 Mots-clés : DNAm-based aging Danger Inflammation alcohol cardiac risk Index. décimale : PER Périodiques Résumé : Using the dual-pathway framework (Beach et al., a), we tested a Neuro-immune Network (NIN) hypothesis: i.e., that chronically elevated inflammatory processes may have delayed (i.e., incubation) effects on young adult substance use, leading to negative health outcomes. In a sample of 449 participants in the Family and Community Health Study who were followed from age 10 to age 29, we examined a non-self-report index of young adult elevated alcohol consumption (EAC). By controlling self-reported substance use at the transition to adulthood, we were able to isolate a significant delayed (incubation) effect from childhood exposure to danger to EAC (β = −.157, p = .006), which contributed to significantly worse aging outomes. Indirect effects from danger to aging outcomes via EAC were: GrimAge (IE = .010, [.002, .024]), Cardiac Risk (IE = −.004, [−.011, −.001]), DunedinPACE (IE = .002, [.000, .008]). In exploratory analyses we examined potential sex differences in effects, showing slightly stronger incubation effects for men and slightly stronger effects of EAC on aging outcomes for women. Results support the NIN hypothesis that incubation of immune pathway effects contributes to elevated alcohol consumption in young adulthood, resulting in accelerated aging and elevated cardiac risk outcomes via health behavior. En ligne : https://dx.doi.org/10.1017/S0954579425000264 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=579

Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood / Assaf OSHRI in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.417-435 Titre : Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood Type de document : texte imprimé Auteurs : Assaf OSHRI, Auteur ; Steve M. KOGAN, Auteur ; Josephine A. KWON, Auteur ; Kandauda A.S. WICKRAMA, Auteur ; Lauren VANDERBROEK, Auteur ; Abraham A. PALMER, Auteur ; James MACKILLOP, Auteur Article en page(s) : p.417-435 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Emerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1, N = 9,421) and (b) a cross-sectional sample of adults (Study 2, N = 1,011). In Study 1, the links between child abuse and neglect and young adult smoking and marijuana use were mediated by increases in adolescent impulsivity. In Study 2, indirect links between child abuse and neglect and substance use were evidenced via delayed reward discounting and impulsivity traits. Among impulsivity subcomponents, robust indirect effects connecting childhood experiences to cigarette use emerged for negative urgency. Negative urgency, positive urgency, and sensation seeking mediated the effect of child abuse and neglect on cannabis and alcohol use. Results suggest that child abuse and neglect increases risk for substance use in part, due to effects on impulsivity. Individuals with adverse childhood experiences may benefit from substance use preventive intervention programs that target impulsive behaviors. En ligne : http://dx.doi.org/10.1017/S0954579417000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358 [article] Impulsivity as a mechanism linking child abuse and neglect with substance use in adolescence and adulthood [texte imprimé] / Assaf OSHRI, Auteur ; Steve M. KOGAN, Auteur ; Josephine A. KWON, Auteur ; Kandauda A.S. WICKRAMA, Auteur ; Lauren VANDERBROEK, Auteur ; Abraham A. PALMER, Auteur ; James MACKILLOP, Auteur . - p.417-435. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.417-435 Index. décimale : PER Périodiques Résumé : Emerging developmental perspectives suggest that adverse rearing environments promote neurocognitive adaptations that heighten impulsivity and increase vulnerability to risky behavior. Although studies document links between harsh rearing environments and impulsive behavior on substance use, the developmental hypothesis that impulsivity acts as mechanism linking adverse rearing environments to downstream substance use remains to be investigated. The present study investigated the role of impulsivity in linking child abuse and neglect with adult substance use using data from (a) a longitudinal sample of youth (Study 1, N = 9,421) and (b) a cross-sectional sample of adults (Study 2, N = 1,011). In Study 1, the links between child abuse and neglect and young adult smoking and marijuana use were mediated by increases in adolescent impulsivity. In Study 2, indirect links between child abuse and neglect and substance use were evidenced via delayed reward discounting and impulsivity traits. Among impulsivity subcomponents, robust indirect effects connecting childhood experiences to cigarette use emerged for negative urgency. Negative urgency, positive urgency, and sensation seeking mediated the effect of child abuse and neglect on cannabis and alcohol use. Results suggest that child abuse and neglect increases risk for substance use in part, due to effects on impulsivity. Individuals with adverse childhood experiences may benefit from substance use preventive intervention programs that target impulsive behaviors. En ligne : http://dx.doi.org/10.1017/S0954579417000943 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=358

Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis / Gene H. BRODY in Development and Psychopathology, 24-3 (August 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-3 (August 2012) . - p.941-51 Titre : Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis Type de document : texte imprimé Auteurs : Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R.H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur Année de publication : 2012 Article en page(s) : p.941-51 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes. En ligne : http://dx.doi.org/10.1017/S0954579412000466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Life stress, the dopamine receptor gene, and emerging adult drug use trajectories: A longitudinal, multilevel, mediated moderation analysis [texte imprimé] / Gene H. BRODY, Auteur ; Yi-Fu CHEN, Auteur ; Tianyi YU, Auteur ; Steven R.H. BEACH, Auteur ; Steven M. KOGAN, Auteur ; Ronald L. SIMONS, Auteur ; Michael WINDLE, Auteur ; Robert A. PHILIBERT, Auteur . - 2012 . - p.941-51. Langues : Anglais (eng) in Development and Psychopathology > 24-3 (August 2012) . - p.941-51 Index. décimale : PER Périodiques Résumé : This study was designed to examine the prospective relations of life stress and genetic status with increases in drug use. African Americans (N = 399) in rural Georgia (Wave 1 mean age = 17 years) provided three waves of data across 27.5 months and a saliva sample from which the dopamine receptor D4 (DRD4) gene was genotyped. Multilevel growth curve modeling analysis indicated that emerging adults manifested the highest escalations in drug use when they reported high life stress and carried an allele of DRD4 with 7 or more repeats (7 + R allele). In addition, emerging adults who reported high life stress and carried the 7 + R allele evinced the largest increases in two proximal risk factors for drug use: affiliations with drug-using companions and drug use vulnerability cognitions. Furthermore, when the Gene × Environment interaction effects on the increases in affiliations with drug-using companions and vulnerability cognitions were entered into the model forecasting drug use, the Life Stress × DRD4 Status interaction on drug use became nonsignificant in the presence of the risk mechanisms. This finding provides an example of “second generation” Gene × Environment interaction research in which the interaction's effects on proximal risk mechanisms account for its effects on outcomes. En ligne : http://dx.doi.org/10.1017/S0954579412000466 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children / Michael WINDLE in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.415-431 Titre : Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children Type de document : texte imprimé Auteurs : Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R.H. BEACH, Auteur ; Tianyi YU, Auteur Article en page(s) : p.415-431 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Neighborhood × Serotonin Transporter Linked Polymorphic Region (5-HTTLPR) interactions for substance use from ages 10 to 24 years using a harmonized data set of African American children [texte imprimé] / Michael WINDLE, Auteur ; Steven M. KOGAN, Auteur ; Sunbok LEE, Auteur ; Yi-Fu CHEN, Auteur ; Karlo Mankit LEI, Auteur ; Gene H. BRODY, Auteur ; Steven R.H. BEACH, Auteur ; Tianyi YU, Auteur . - p.415-431. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.415-431 Index. décimale : PER Périodiques Résumé : This study investigated the influences of neighborhood factors (residential stability and neighborhood disadvantage) and variants of the serotonin transporter linked polymorphic region (5-HTTLPR) genotype on the development of substance use among African American children aged 10–24 years. To accomplish this, a harmonized data set of five longitudinal studies was created via pooling overlapping age cohorts to establish a database with 2,689 children and 12,474 data points to span ages 10–24 years. A description of steps used in the development of the harmonized data set is provided, including how issues such as the measurement equivalence of constructs were addressed. A sequence of multilevel models was specified to evaluate Gene × Environment effects on growth of substance use across time. Findings indicated that residential instability was associated with higher levels and a steeper gradient of growth in substance use across time. The inclusion of the 5-HTTLPR genotype provided greater precision to the relationships in that higher residential instability, in conjunction with the risk variant of 5-HTTLPR (i.e., the short allele), was associated with the highest level and steepest gradient of growth in substance use across ages 10–24 years. The findings demonstrated how the creation of a harmonized data set increased statistical power to test Gene × Environment interactions for an under studied sample. En ligne : http://dx.doi.org/10.1017/S095457941500053X Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Parent and youth dopamine D4 receptor genotypes moderate multilevel contextual effects on rural African American youth's risk behavior / Junhan CHO in Development and Psychopathology, 28-2 (May 2016)  

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Pathways linking adverse environments to emerging adults’ substance abuse and depressive symptoms: A prospective analysis of rural African American men / Steven M. KOGAN in Development and Psychopathology, 33-4 (October 2021)  

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Perceived discrimination, serotonin transporter linked polymorphic region status, and the development of conduct problems / Gene H. BRODY in Development and Psychopathology, 23-2 (May 2011)  

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