Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study / Lindsay C. HANFORD ; Steven W. KASPAREK ; Liliana J. LENGUA ; Katie A. MCLAUGHLIN ; Margaret A. SHERIDAN in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2338-2351 Titre : Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay C. HANFORD, Auteur ; Steven W. KASPAREK, Auteur ; Liliana J. LENGUA, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur Article en page(s) : p.2338-2351 Mots-clés : depression  deprivation  externalizing  reward processing  threat Index. décimale : PER Périodiques Résumé : Childhood adversity is common and associated with elevated risk for transdiagnostic psychopathology. Reward processing has been implicated in the link between adversity and psychopathology, but whether it serves as a mediator or moderator is unclear. This study examined whether alterations in behavioral and neural reward processing function as a mechanism or moderator of psychopathology outcomes following adversity experiences, including threat (i.e., trauma) and deprivation. A longitudinal community sample of 10?15-year-old youths was assessed across two waves (Wave 1: n = 228; Wave 2: n = 206). Wave 1 assessed adverse experiences, psychopathology symptoms, reward processing on a monetary incentive delay task, and resting-state fMRI. At Wave 2, psychopathology symptoms were reassessed. Greater threat experiences were associated with blunted behavioral reward sensitivity, which, in turn, predicted increases in depression symptoms over time and mediated the prospective association between threat and depression symptoms. In contrast, reward sensitivity moderated the association between deprivation experiences and prospective externalizing symptoms such that the positive association of deprivation with increasing externalizing symptoms was absent for children with high levels of reward sensitivity. En ligne : https://dx.doi.org/10.1017/S0954579423000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Does reward processing moderate or mediate the link between childhood adversity and psychopathology: A longitudinal study [Texte imprimé et/ou numérique] / Lindsay C. HANFORD, Auteur ; Steven W. KASPAREK, Auteur ; Liliana J. LENGUA, Auteur ; Katie A. MCLAUGHLIN, Auteur ; Margaret A. SHERIDAN, Auteur . - p.2338-2351. in Development and Psychopathology > 35-5 (December 2023) . - p.2338-2351 Mots-clés : depression  deprivation  externalizing  reward processing  threat Index. décimale : PER Périodiques Résumé : Childhood adversity is common and associated with elevated risk for transdiagnostic psychopathology. Reward processing has been implicated in the link between adversity and psychopathology, but whether it serves as a mediator or moderator is unclear. This study examined whether alterations in behavioral and neural reward processing function as a mechanism or moderator of psychopathology outcomes following adversity experiences, including threat (i.e., trauma) and deprivation. A longitudinal community sample of 10?15-year-old youths was assessed across two waves (Wave 1: n = 228; Wave 2: n = 206). Wave 1 assessed adverse experiences, psychopathology symptoms, reward processing on a monetary incentive delay task, and resting-state fMRI. At Wave 2, psychopathology symptoms were reassessed. Greater threat experiences were associated with blunted behavioral reward sensitivity, which, in turn, predicted increases in depression symptoms over time and mediated the prospective association between threat and depression symptoms. In contrast, reward sensitivity moderated the association between deprivation experiences and prospective externalizing symptoms such that the positive association of deprivation with increasing externalizing symptoms was absent for children with high levels of reward sensitivity. En ligne : https://dx.doi.org/10.1017/S0954579423000962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

Early adolescent alcohol use in context: How neighborhoods, parents, and peers impact youth / Elisa M. TRUCCO in Development and Psychopathology, 26-2 (May 2014)  

Public ISBD [article]  inDevelopment and Psychopathology > 26-2 (May 2014) . - p.425-436 Titre : Early adolescent alcohol use in context: How neighborhoods, parents, and peers impact youth Type de document : Texte imprimé et/ou numérique Auteurs : Elisa M. TRUCCO, Auteur ; Craig R. COLDER, Auteur ; William F. WIECZOREK, Auteur ; Liliana J. LENGUA, Auteur ; Larry W. HAWK, Auteur Article en page(s) : p.425-436 Index. décimale : PER Périodiques Résumé : Developmental–ecological models are useful for integrating risk factors across multiple contexts and conceptualizing mediational pathways for adolescent alcohol use, yet these comprehensive models are rarely tested. This study used a developmental–ecological framework to investigate the influence of neighborhood, family, and peer contexts on alcohol use in early adolescence (N = 387). Results from a multi-informant longitudinal cross-lagged mediation path model suggested that high levels of neighborhood disadvantage were associated with high levels of alcohol use 2 years later via an indirect pathway that included exposure to delinquent peers and adolescent delinquency. Results also indicated that adolescent involvement with delinquent peers and alcohol use led to decrements in parenting, rather than being consequences of poor parenting. Overall, the study supported hypothesized relationships among key microsystems thought to influence adolescent alcohol use, and thus findings underscore the utility of developmental–ecological models of alcohol use. En ligne : http://dx.doi.org/10.1017/S0954579414000042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 [article] Early adolescent alcohol use in context: How neighborhoods, parents, and peers impact youth [Texte imprimé et/ou numérique] / Elisa M. TRUCCO, Auteur ; Craig R. COLDER, Auteur ; William F. WIECZOREK, Auteur ; Liliana J. LENGUA, Auteur ; Larry W. HAWK, Auteur . - p.425-436. in Development and Psychopathology > 26-2 (May 2014) . - p.425-436 Index. décimale : PER Périodiques Résumé : Developmental–ecological models are useful for integrating risk factors across multiple contexts and conceptualizing mediational pathways for adolescent alcohol use, yet these comprehensive models are rarely tested. This study used a developmental–ecological framework to investigate the influence of neighborhood, family, and peer contexts on alcohol use in early adolescence (N = 387). Results from a multi-informant longitudinal cross-lagged mediation path model suggested that high levels of neighborhood disadvantage were associated with high levels of alcohol use 2 years later via an indirect pathway that included exposure to delinquent peers and adolescent delinquency. Results also indicated that adolescent involvement with delinquent peers and alcohol use led to decrements in parenting, rather than being consequences of poor parenting. Overall, the study supported hypothesized relationships among key microsystems thought to influence adolescent alcohol use, and thus findings underscore the utility of developmental–ecological models of alcohol use. En ligne : http://dx.doi.org/10.1017/S0954579414000042 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230

Effortful control as a moderator of the relation between contextual risk factors and growth in adjustment problems / Liliana J. LENGUA in Development and Psychopathology, 20-2 (Spring 2008)  

Public ISBD [article]  inDevelopment and Psychopathology > 20-2 (Spring 2008) . - p.509-528 Titre : Effortful control as a moderator of the relation between contextual risk factors and growth in adjustment problems Type de document : Texte imprimé et/ou numérique Auteurs : Liliana J. LENGUA, Auteur ; Anna C. LONG, Auteur ; Nicole R. BUSH, Auteur ; Erica A. KOVACS, Auteur ; Anika M. TRANCIK, Auteur Année de publication : 2008 Article en page(s) : p.509-528 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Effortful control was examined as a moderator of the relations of three domains of contextual risk factors to growth in internalizing and externalizing problems in a community sample (N = 189) of children (8–12 years at Time 1). Socioeconomic, maternal, and environmental risk factors were examined as predictors of initial levels and growth in children's adjustment problems across 3 years. The effects of the risk factors depended on children's level of effortful control. For children lower in effortful control, socioeconomic risk was related to significantly higher initial levels of internalizing and externalizing problems and decreases over time. However, children lower in effortful control had higher levels of problems at all three time points than children higher in effortful control. Maternal risk was associated with increases in internalizing for children lower in effortful control, and environmental risk was related to increases in internalizing and externalizing problems for children lower in effortful control, but not those higher in effortful control. Children who were lower in effortful control appeared to experience more adverse effects of contextual risk than those higher in effortful control, suggesting that interventions aimed at improving children's effortful control might serve to protect children from increased risk of adjustment problems associated with contextual risk factors. En ligne : http://dx.doi.org/10.1017/s0954579408000254 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412 [article] Effortful control as a moderator of the relation between contextual risk factors and growth in adjustment problems [Texte imprimé et/ou numérique] / Liliana J. LENGUA, Auteur ; Anna C. LONG, Auteur ; Nicole R. BUSH, Auteur ; Erica A. KOVACS, Auteur ; Anika M. TRANCIK, Auteur . - 2008 . - p.509-528. Langues : Anglais (eng) in Development and Psychopathology > 20-2 (Spring 2008) . - p.509-528 Index. décimale : PER Périodiques Résumé : Effortful control was examined as a moderator of the relations of three domains of contextual risk factors to growth in internalizing and externalizing problems in a community sample (N = 189) of children (8–12 years at Time 1). Socioeconomic, maternal, and environmental risk factors were examined as predictors of initial levels and growth in children's adjustment problems across 3 years. The effects of the risk factors depended on children's level of effortful control. For children lower in effortful control, socioeconomic risk was related to significantly higher initial levels of internalizing and externalizing problems and decreases over time. However, children lower in effortful control had higher levels of problems at all three time points than children higher in effortful control. Maternal risk was associated with increases in internalizing for children lower in effortful control, and environmental risk was related to increases in internalizing and externalizing problems for children lower in effortful control, but not those higher in effortful control. Children who were lower in effortful control appeared to experience more adverse effects of contextual risk than those higher in effortful control, suggesting that interventions aimed at improving children's effortful control might serve to protect children from increased risk of adjustment problems associated with contextual risk factors. En ligne : http://dx.doi.org/10.1017/s0954579408000254 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=412

Identifying cognitive, affective, and developmental mechanisms linking threat and deprivation with adolescent psychopathology / David G. WEISSMAN ; Maya L. ROSEN ; Elise ROBINSON ; Liliana J. LENGUA ; Margaret A. SHERIDAN ; Henning TIEMEIER ; Katie A. MCLAUGHLIN in Journal of Child Psychology and Psychiatry, 66-5 (May 2025)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.612-623 Titre : Identifying cognitive, affective, and developmental mechanisms linking threat and deprivation with adolescent psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : David G. WEISSMAN, Auteur ; Maya L. ROSEN, Auteur ; Elise ROBINSON, Auteur ; Liliana J. LENGUA, Auteur ; Margaret A. SHERIDAN, Auteur ; Henning TIEMEIER, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.612-623 Langues : Anglais (eng) Mots-clés : Adversity  threat  deprivation  psychopathology  high dimensional mediation analysis  reward sensitivity  pubertal development Index. décimale : PER Périodiques Résumé : Background The mechanisms linking early-life adversity with psychopathology over the life-course are complex. In this prospective study, we collectively examined cognitive, affective, and developmental mediators previously found to individually link childhood threat and deprivation experiences to adolescent psychopathology to identify the most potent mechanisms. Methods Data came from a community sample of 227 children (mean child age 11.5?+?0.5?years, 48.5% female) from the Seattle metro area with recruitment designed to reflect diversity in family income. Candidate mechanisms included self-rated pubertal development and task-measured attention bias to threat, emotion regulation, theory of mind, fear learning, inhibitory control, language ability, reasoning, and reward sensitivity. Using a high-dimensional mediation approach, we determined which mediating pathways linking threat and deprivation to psychopathology persisted after controlling for all candidate mechanisms associated with psychopathology. Models additionally controlled for the child's age, sex, early-childhood emotional and behavioral symptoms, poverty, and maternal depression. Results Blunted reward sensitivity mediated the prospective relationship between threat and internalizing psychopathology, explaining 17.25% (95% CI 1.08%, 69.96%) of this association. Advanced pubertal development was associated with increases in internalizing and externalizing symptoms (standardized associations of 0.16 (95% CI 0.03, 0.29) and 0.17 (95% CI 0.05, 0.29), respectively), but not with adversity. Although deprivation was strongly related to psychopathology, no mechanisms were empirically identified. Conclusions In a well-characterized community sample, we isolated reward sensitivity as a robust mediator of the prospective association between early-life threat and adolescent internalizing psychopathology. Interventions aimed at bolstering reward sensitivity may mitigate the impact of early-life threat experiences on internalizing problems. En ligne : https://doi.org/10.1111/jcpp.14067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554 [article] Identifying cognitive, affective, and developmental mechanisms linking threat and deprivation with adolescent psychopathology [Texte imprimé et/ou numérique] / David G. WEISSMAN, Auteur ; Maya L. ROSEN, Auteur ; Elise ROBINSON, Auteur ; Liliana J. LENGUA, Auteur ; Margaret A. SHERIDAN, Auteur ; Henning TIEMEIER, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.612-623. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 66-5 (May 2025) . - p.612-623 Mots-clés : Adversity  threat  deprivation  psychopathology  high dimensional mediation analysis  reward sensitivity  pubertal development Index. décimale : PER Périodiques Résumé : Background The mechanisms linking early-life adversity with psychopathology over the life-course are complex. In this prospective study, we collectively examined cognitive, affective, and developmental mediators previously found to individually link childhood threat and deprivation experiences to adolescent psychopathology to identify the most potent mechanisms. Methods Data came from a community sample of 227 children (mean child age 11.5?+?0.5?years, 48.5% female) from the Seattle metro area with recruitment designed to reflect diversity in family income. Candidate mechanisms included self-rated pubertal development and task-measured attention bias to threat, emotion regulation, theory of mind, fear learning, inhibitory control, language ability, reasoning, and reward sensitivity. Using a high-dimensional mediation approach, we determined which mediating pathways linking threat and deprivation to psychopathology persisted after controlling for all candidate mechanisms associated with psychopathology. Models additionally controlled for the child's age, sex, early-childhood emotional and behavioral symptoms, poverty, and maternal depression. Results Blunted reward sensitivity mediated the prospective relationship between threat and internalizing psychopathology, explaining 17.25% (95% CI 1.08%, 69.96%) of this association. Advanced pubertal development was associated with increases in internalizing and externalizing symptoms (standardized associations of 0.16 (95% CI 0.03, 0.29) and 0.17 (95% CI 0.05, 0.29), respectively), but not with adversity. Although deprivation was strongly related to psychopathology, no mechanisms were empirically identified. Conclusions In a well-characterized community sample, we isolated reward sensitivity as a robust mediator of the prospective association between early-life threat and adolescent internalizing psychopathology. Interventions aimed at bolstering reward sensitivity may mitigate the impact of early-life threat experiences on internalizing problems. En ligne : https://doi.org/10.1111/jcpp.14067 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=554

Income, cumulative risk, and longitudinal profiles of hypothalamic–pituitary–adrenal axis activity in preschool-age children / Maureen ZALEWSKI in Development and Psychopathology, 28-2 (May 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-2 (May 2016) . - p.341-353 Titre : Income, cumulative risk, and longitudinal profiles of hypothalamic–pituitary–adrenal axis activity in preschool-age children Type de document : Texte imprimé et/ou numérique Auteurs : Maureen ZALEWSKI, Auteur ; Liliana J. LENGUA, Auteur ; Stephanie F. THOMPSON, Auteur ; Cara J. KIFF, Auteur Article en page(s) : p.341-353 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Environmental risk predicts disrupted basal cortisol levels in preschool children. However, little is known about the stability or variability of diurnal cortisol morning levels or slope patterns over time in young children. This study used latent profile analysis to identify patterns of the hypothalamic–pituitary–adrenal axis activity during the preschool period. Using a community sample (N = 306), this study measured income, cumulative risk, and children's diurnal cortisol (morning level and slope) four times across 2.5 years, starting when children were 36 months old. Latent profile analysis profiles indicated that there were predominantly stable patterns of diurnal cortisol level and slope over time and that these patterns were predicted by income and cumulative risk. In addition, there were curvilinear relations of income and cumulative risk to profiles of low morning cortisol level and flattened diurnal slope across time, suggesting that both lower and higher levels of income and cumulative risk were associated with a stress-sensitive physiological system. Overall, this study provides initial evidence for the role of environmental risk in predicting lower, flattened basal cortisol patterns that remain stable over time. En ligne : http://dx.doi.org/10.1017/S0954579415000474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288 [article] Income, cumulative risk, and longitudinal profiles of hypothalamic–pituitary–adrenal axis activity in preschool-age children [Texte imprimé et/ou numérique] / Maureen ZALEWSKI, Auteur ; Liliana J. LENGUA, Auteur ; Stephanie F. THOMPSON, Auteur ; Cara J. KIFF, Auteur . - p.341-353. Langues : Anglais (eng) in Development and Psychopathology > 28-2 (May 2016) . - p.341-353 Index. décimale : PER Périodiques Résumé : Environmental risk predicts disrupted basal cortisol levels in preschool children. However, little is known about the stability or variability of diurnal cortisol morning levels or slope patterns over time in young children. This study used latent profile analysis to identify patterns of the hypothalamic–pituitary–adrenal axis activity during the preschool period. Using a community sample (N = 306), this study measured income, cumulative risk, and children's diurnal cortisol (morning level and slope) four times across 2.5 years, starting when children were 36 months old. Latent profile analysis profiles indicated that there were predominantly stable patterns of diurnal cortisol level and slope over time and that these patterns were predicted by income and cumulative risk. In addition, there were curvilinear relations of income and cumulative risk to profiles of low morning cortisol level and flattened diurnal slope across time, suggesting that both lower and higher levels of income and cumulative risk were associated with a stress-sensitive physiological system. Overall, this study provides initial evidence for the role of environmental risk in predicting lower, flattened basal cortisol patterns that remain stable over time. En ligne : http://dx.doi.org/10.1017/S0954579415000474 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=288

Income, neural executive processes, and preschool children's executive control / Erika J. RUBERRY in Development and Psychopathology, 29-1 (February 2017)  

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Maternal mental health mediates the effects of pandemic-related stressors on adolescent psychopathology during COVID-19 / Liliana J. LENGUA in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)  

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Parenting and Temperament Prior to September 11, 2001, and Parenting Specific to 9/11 as Predictors of Children's Posttraumatic Stress Symptoms Following 9/11 / Anna WILSON in Journal of Clinical Child & Adolescent Psychology, 39-4 (July-August 2010)  

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Pathways from early adversity to later adjustment: Tests of the additive and bidirectional effects of executive control and diurnal cortisol in early childhood – Corrigendum / Liliana J. LENGUA in Development and Psychopathology, 33-3 (August 2021)  

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Pre-attack stress-load, appraisals, and coping in children's responses to the 9/11 terrorist attacks / Liliana J. LENGUA in Journal of Child Psychology and Psychiatry, 47-12 (December 2006)  

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