A Pilot Study of Abnormal Growth in Autism Spectrum Disorders and Other Childhood Psychiatric Disorders / Nanda N. ROMMELSE in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.44-54 Titre : A Pilot Study of Abnormal Growth in Autism Spectrum Disorders and Other Childhood Psychiatric Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Nanda N. ROMMELSE, Auteur ; Cindy T. R. PETERS, Auteur ; Iris J. OOSTERLING, Auteur ; Janne C. VISSER, Auteur ; Daniëlle M. A. BONS, Auteur ; Daphne J. VAN STEIJN, Auteur ; Jos DRAAISMA, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur Année de publication : 2011 Article en page(s) : p.44-54 Langues : Anglais (eng) Mots-clés : Autism  Growth  Head circumference  Height  Weight  Endophenotype Index. décimale : PER Périodiques Résumé : The aims of the current study were to examine whether early growth abnormalities are (a) comparable in autism spectrum disorders (ASD) and other childhood psychiatric disorders, and (b) specific to the brain or generalized to the whole body. Head circumference, height, and weight were measured during the first 19 months of life in 129 children with ASD and 59 children with non-ASD psychiatric disorders. Both groups showed comparable abnormal patterns of growth compared to population norms, especially regarding height and head circumference in relation to height. Thus abnormal growth appears to be related to psychiatric disorders in general and is mainly expressed as an accelerated growth of height not matched by an increase in weight or head circumference. En ligne : http://dx.doi.org/10.1007/s10803-010-1026-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] A Pilot Study of Abnormal Growth in Autism Spectrum Disorders and Other Childhood Psychiatric Disorders [Texte imprimé et/ou numérique] / Nanda N. ROMMELSE, Auteur ; Cindy T. R. PETERS, Auteur ; Iris J. OOSTERLING, Auteur ; Janne C. VISSER, Auteur ; Daniëlle M. A. BONS, Auteur ; Daphne J. VAN STEIJN, Auteur ; Jos DRAAISMA, Auteur ; Rutger Jan VAN DER GAAG, Auteur ; Jan K. BUITELAAR, Auteur . - 2011 . - p.44-54. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.44-54 Mots-clés : Autism  Growth  Head circumference  Height  Weight  Endophenotype Index. décimale : PER Périodiques Résumé : The aims of the current study were to examine whether early growth abnormalities are (a) comparable in autism spectrum disorders (ASD) and other childhood psychiatric disorders, and (b) specific to the brain or generalized to the whole body. Head circumference, height, and weight were measured during the first 19 months of life in 129 children with ASD and 59 children with non-ASD psychiatric disorders. Both groups showed comparable abnormal patterns of growth compared to population norms, especially regarding height and head circumference in relation to height. Thus abnormal growth appears to be related to psychiatric disorders in general and is mainly expressed as an accelerated growth of height not matched by an increase in weight or head circumference. En ligne : http://dx.doi.org/10.1007/s10803-010-1026-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

Simplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD? / Anoek M. OERLEMANS in Journal of Autism and Developmental Disorders, 45-3 (March 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.645-657 Titre : Simplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD? Type de document : Texte imprimé et/ou numérique Auteurs : Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Yvette G. E. DE BRUIJN, Auteur ; Daphne J. VAN STEIJN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Article en page(s) : p.645-657 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Attention-deficit/hyperactivity disorder (ADHD)  Simplex–multiplex stratification  Family  Unaffected relative Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are highly heterogeneous neuropsychiatric disorders, that frequently co-occur. This study examined whether stratification into single-incidence (SPX) and multi-incidence (MPX) is helpful in (a) parsing heterogeneity and (b) detecting overlapping and unique underpinnings of the disorders. ASD and ADHD traits were measured in 56 ASD/31 ADHD SPX families, 59 ASD/171 ADHD MPX families and 203 control families. In ASD but not ADHD, behavioral traits were less elevated in SPX than MPX unaffected relatives, suggesting that SPX–MPX stratification may thus help parse ASD, but not ADHD heterogeneity. Particularly unaffected relatives from MPX ASD/ADHD families displayed elevated trait levels of both disorders, indicating shared (multifactorial) underpinnings underlying ASD and ADHD in these families. Cross-disorder traits were highest in MPX ASD unaffected siblings. En ligne : http://dx.doi.org/10.1007/s10803-014-2220-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Simplex and Multiplex Stratification in ASD and ADHD Families: A Promising Approach for Identifying Overlapping and Unique Underpinnings of ASD and ADHD? [Texte imprimé et/ou numérique] / Anoek M. OERLEMANS, Auteur ; Catharina A. HARTMAN, Auteur ; Yvette G. E. DE BRUIJN, Auteur ; Daphne J. VAN STEIJN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - p.645-657. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.645-657 Mots-clés : Autism spectrum disorders (ASD)  Attention-deficit/hyperactivity disorder (ADHD)  Simplex–multiplex stratification  Family  Unaffected relative Index. décimale : PER Périodiques Résumé : Autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD) are highly heterogeneous neuropsychiatric disorders, that frequently co-occur. This study examined whether stratification into single-incidence (SPX) and multi-incidence (MPX) is helpful in (a) parsing heterogeneity and (b) detecting overlapping and unique underpinnings of the disorders. ASD and ADHD traits were measured in 56 ASD/31 ADHD SPX families, 59 ASD/171 ADHD MPX families and 203 control families. In ASD but not ADHD, behavioral traits were less elevated in SPX than MPX unaffected relatives, suggesting that SPX–MPX stratification may thus help parse ASD, but not ADHD heterogeneity. Particularly unaffected relatives from MPX ASD/ADHD families displayed elevated trait levels of both disorders, indicating shared (multifactorial) underpinnings underlying ASD and ADHD in these families. Cross-disorder traits were highest in MPX ASD unaffected siblings. En ligne : http://dx.doi.org/10.1007/s10803-014-2220-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD / Daphne J. VAN STEIJN in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.954-63 Titre : The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Daphne J. VAN STEIJN, Auteur ; Jennifer S. RICHARDS, Auteur ; Anoek M. OERLEMANS, Auteur ; Saskia W. DE RUITER, Auteur ; Marcel A. G. VAN AKEN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur Année de publication : 2012 Article en page(s) : p.954-63 Langues : Anglais (eng) Mots-clés : Assortative mating  parent-of-origin effect  autism spectrum disorder  attention-deficit/hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share about 50–72% of their genetic factors, which is the most likely explanation for their frequent co-occurrence within the same patient or family. An additional or alternative explanation for the co-occurrence may be (cross-)assortative mating, e.g., the tendency to choose a partner that is similar or dissimilar to oneself. Another issue is that of parent-of-origin effect which refers to the possibility of parents differing in the relative quantity of risk factors they transmit to the offspring. The current study sets out to examine (cross-)assortative mating and (cross-)parent-of-origin effects of ASD and ADHD in parents of children with either ASD or ASD with ADHD diagnosis. Methods:  In total, 121 families were recruited in an ongoing autism-ADHD family genetics project. Participating families consisted of parents and at least one child aged between 2 and 20 years, with either autistic disorder, Asperger disorder or PDD-NOS, and one or more biological siblings. All children and parents were carefully screened for the presence of ASD and ADHD. Results:  No correlations were found between maternal and paternal ASD and ADHD symptoms. Parental ASD and ADHD symptoms were predictive for similar symptoms in the offspring, but with maternal hyperactive-impulsive symptoms, but not paternal symptoms, predicting similar symptoms in daughters. ASD pathology in the parents was not predictive for ADHD pathology in the offspring, but mother’s ADHD pathology was predictive for offspring ASD pathology even when corrected for maternal ASD pathology. Conclusions:  Cross-assortative mating for ASD and ADHD does not form an explanation for the frequent co-occurrence of these disorders within families. Given that parental ADHD is predictive of offspring’ ASD but not vice versa, risk factors underlying ASD may overlap to a larger degree with risk factors underlying ADHD than vice versa. However, future research is needed to clarify this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] The co-occurrence of autism spectrum disorder and attention-deficit/hyperactivity disorder symptoms in parents of children with ASD or ASD with ADHD [Texte imprimé et/ou numérique] / Daphne J. VAN STEIJN, Auteur ; Jennifer S. RICHARDS, Auteur ; Anoek M. OERLEMANS, Auteur ; Saskia W. DE RUITER, Auteur ; Marcel A. G. VAN AKEN, Auteur ; Barbara FRANKE, Auteur ; Jan K. BUITELAAR, Auteur ; Nanda N. ROMMELSE, Auteur . - 2012 . - p.954-63. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.954-63 Mots-clés : Assortative mating  parent-of-origin effect  autism spectrum disorder  attention-deficit/hyperactivity disorder Index. décimale : PER Périodiques Résumé : Background:  Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) share about 50–72% of their genetic factors, which is the most likely explanation for their frequent co-occurrence within the same patient or family. An additional or alternative explanation for the co-occurrence may be (cross-)assortative mating, e.g., the tendency to choose a partner that is similar or dissimilar to oneself. Another issue is that of parent-of-origin effect which refers to the possibility of parents differing in the relative quantity of risk factors they transmit to the offspring. The current study sets out to examine (cross-)assortative mating and (cross-)parent-of-origin effects of ASD and ADHD in parents of children with either ASD or ASD with ADHD diagnosis. Methods:  In total, 121 families were recruited in an ongoing autism-ADHD family genetics project. Participating families consisted of parents and at least one child aged between 2 and 20 years, with either autistic disorder, Asperger disorder or PDD-NOS, and one or more biological siblings. All children and parents were carefully screened for the presence of ASD and ADHD. Results:  No correlations were found between maternal and paternal ASD and ADHD symptoms. Parental ASD and ADHD symptoms were predictive for similar symptoms in the offspring, but with maternal hyperactive-impulsive symptoms, but not paternal symptoms, predicting similar symptoms in daughters. ASD pathology in the parents was not predictive for ADHD pathology in the offspring, but mother’s ADHD pathology was predictive for offspring ASD pathology even when corrected for maternal ASD pathology. Conclusions:  Cross-assortative mating for ASD and ADHD does not form an explanation for the frequent co-occurrence of these disorders within families. Given that parental ADHD is predictive of offspring’ ASD but not vice versa, risk factors underlying ASD may overlap to a larger degree with risk factors underlying ADHD than vice versa. However, future research is needed to clarify this issue. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02556.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

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