Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders / Mikle SOUTH in Autism Research, 4-6 (December 2011)  

Public ISBD [article]  inAutism Research > 4-6 (December 2011) . - p.412-421 Titre : Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2012 Article en page(s) : p.412-421 Langues : Anglais (eng) Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Better fear conditioning is associated with reduced symptom severity in autism spectrum disorders [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Michael J. LARSON, Auteur ; Sarah E. WHITE, Auteur ; Julianne DANA, Auteur ; Michael J. CROWLEY, Auteur . - 2012 . - p.412-421. Langues : Anglais (eng) in Autism Research > 4-6 (December 2011) . - p.412-421 Mots-clés : autism spectrum disorders  amygdala  anxiety  fear conditioning  dimensional measures Index. décimale : PER Périodiques Résumé : Evidence from behavioral and neuroimaging studies suggest that atypical amygdala function plays a critical role in the development of autism spectrum disorders (ASD). The handful of psychophysiological studies examining amygdala function in ASD using classical fear conditioning paradigms have yielded discordant results. We recorded skin conductance response (SCR) during a simple discrimination conditioning task in 30 children and adolescents (ages 8–18) diagnosed with high-functioning ASD and 30 age- and IQ-matched, typically developing controls. SCR response in the ASD group was uniquely and positively associated with social anxiety; and negatively correlated with autism symptom severity, in particular with social functioning. Fear conditioning studies have tremendous potential to aid understanding regarding the amygdale's role in the varied symptom profile of ASD. Our data demonstrate that such studies require careful attention to task-specific factors, including task complexity; and also to contributions of dimensional, within-group factors that contribute to ASD heterogeneity. En ligne : http://dx.doi.org/10.1002/aur.221 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder / Mikle SOUTH in Journal of Autism and Developmental Disorders, 41-1 (January 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.55-65 Titre : Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mikle SOUTH, Auteur ; Julianne DANA, Auteur ; Sarah WHITE, Auteur ; Michael J. CROWLEY, Auteur Année de publication : 2011 Article en page(s) : p.55-65 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Anxiety  Risk-taking  Decision-making  Amygdala  Orbitofrontal cortex Index. décimale : PER Périodiques Résumé : Understanding hetereogeneity in symptom expression across the autism spectrum disorders (ASD) is a major challenge for identifying causes and effective treatments. In 40 children and adolescents diagnosed with ASD and 37 IQ—and age-matched comparison participants (the TYP group), we found no differences in summary measures on an experimental risk-taking task. However, anxiety and IQ predicted risk-taking only in the ASD group. Risk-taking was correlated with behavioral inhibition in the ASD group and behavioral activation in the TYP group. We suggest that performance on the task was motivated by fear of failure in the ASD group and by sensitivity to reward in the TYP group. Behavioral markers of anxiety and cognitive ability may improve conceptualization of heterogeneity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114 [article] Failure is Not an Option: Risk-Taking is Moderated by Anxiety and Also by Cognitive Ability in Children and Adolescents Diagnosed with an Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mikle SOUTH, Auteur ; Julianne DANA, Auteur ; Sarah WHITE, Auteur ; Michael J. CROWLEY, Auteur . - 2011 . - p.55-65. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-1 (January 2011) . - p.55-65 Mots-clés : Autism spectrum disorders  Anxiety  Risk-taking  Decision-making  Amygdala  Orbitofrontal cortex Index. décimale : PER Périodiques Résumé : Understanding hetereogeneity in symptom expression across the autism spectrum disorders (ASD) is a major challenge for identifying causes and effective treatments. In 40 children and adolescents diagnosed with ASD and 37 IQ—and age-matched comparison participants (the TYP group), we found no differences in summary measures on an experimental risk-taking task. However, anxiety and IQ predicted risk-taking only in the ASD group. Risk-taking was correlated with behavioral inhibition in the ASD group and behavioral activation in the TYP group. We suggest that performance on the task was motivated by fear of failure in the ASD group and by sensitivity to reward in the TYP group. Behavioral markers of anxiety and cognitive ability may improve conceptualization of heterogeneity in ASD. En ligne : http://dx.doi.org/10.1007/s10803-010-1021-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=114

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