Biobehavioral profiles of arousal and social motivation in autism spectrum disorders / Blythe A. CORBETT in Journal of Child Psychology and Psychiatry, 55-8 (August 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.924-934 Titre : Biobehavioral profiles of arousal and social motivation in autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Deanna M. SWAIN, Auteur ; Cassandra NEWSOM, Auteur ; Lily WANG, Auteur ; Yanna SONG, Auteur ; Dale EDGERTON, Auteur Article en page(s) : p.924-934 Langues : Anglais (eng) Mots-clés : Autism  cortisol  play  stress  social  interaction  behavior Index. décimale : PER Périodiques Résumé : Background Children with autism spectrum disorder (ASD) are impaired in social communication and interaction with peers, which may reflect diminished social motivation. Many children with ASD show enhanced stress when playing with other children. This study investigated social and stress profiles of children with ASD during play. Methods We utilized a peer interaction paradigm in a natural playground setting with 66 unmedicated, prepubertal, children aged 8–12 years [38 with ASD, 28 with typical development (TD)]. Salivary cortisol was collected before and after a 20-min playground interaction that was divided into periods of free and solicited play facilitated by a confederate child. Statistical analyses included Wilcoxon rank-sum tests, mixed effects models, and Spearman correlations to assess the between-group differences in social and stress functioning, identify stress responders, and explore associations between variables, respectively. Results There were no differences between the groups during unsolicited free play; however, during solicited play by the confederate, significant differences emerged such that children with ASD engaged in fewer verbal interactions and more self-play than the TD group. Regarding physiological arousal, children with ASD as a group showed relatively higher cortisol in response to social play; however, there was a broad range of responses. Moreover, those with the highest cortisol levels engaged in less social communication. Conclusions The social interaction of children with ASD can be facilitated by peer solicitation; however, it may be accompanied by increased stress. The children with ASD that have the highest level of cortisol show less social motivation; yet, it is unclear if it reflects an underlying state of heightened arousal or enhanced reactivity to social engagement, or both. En ligne : http://dx.doi.org/10.1111/jcpp.12184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237 [article] Biobehavioral profiles of arousal and social motivation in autism spectrum disorders [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Deanna M. SWAIN, Auteur ; Cassandra NEWSOM, Auteur ; Lily WANG, Auteur ; Yanna SONG, Auteur ; Dale EDGERTON, Auteur . - p.924-934. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-8 (August 2014) . - p.924-934 Mots-clés : Autism  cortisol  play  stress  social  interaction  behavior Index. décimale : PER Périodiques Résumé : Background Children with autism spectrum disorder (ASD) are impaired in social communication and interaction with peers, which may reflect diminished social motivation. Many children with ASD show enhanced stress when playing with other children. This study investigated social and stress profiles of children with ASD during play. Methods We utilized a peer interaction paradigm in a natural playground setting with 66 unmedicated, prepubertal, children aged 8–12 years [38 with ASD, 28 with typical development (TD)]. Salivary cortisol was collected before and after a 20-min playground interaction that was divided into periods of free and solicited play facilitated by a confederate child. Statistical analyses included Wilcoxon rank-sum tests, mixed effects models, and Spearman correlations to assess the between-group differences in social and stress functioning, identify stress responders, and explore associations between variables, respectively. Results There were no differences between the groups during unsolicited free play; however, during solicited play by the confederate, significant differences emerged such that children with ASD engaged in fewer verbal interactions and more self-play than the TD group. Regarding physiological arousal, children with ASD as a group showed relatively higher cortisol in response to social play; however, there was a broad range of responses. Moreover, those with the highest cortisol levels engaged in less social communication. Conclusions The social interaction of children with ASD can be facilitated by peer solicitation; however, it may be accompanied by increased stress. The children with ASD that have the highest level of cortisol show less social motivation; yet, it is unclear if it reflects an underlying state of heightened arousal or enhanced reactivity to social engagement, or both. En ligne : http://dx.doi.org/10.1111/jcpp.12184 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=237

Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1738 Titre : Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur Année de publication : 2012 Article en page(s) : p.1738 Langues : Anglais (eng) Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1507-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Erratum to: Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes [Texte imprimé et/ou numérique] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur . - 2012 . - p.1738. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1738 Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1007/s10803-012-1507-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Improvement in Social Deficits in Autism Spectrum Disorders Using a Theatre-Based, Peer-Mediated Intervention / Blythe A. CORBETT in Autism Research, 7-1 (February 2014)  

Public ISBD [article]  inAutism Research > 7-1 (February 2014) . - p.4-16 Titre : Improvement in Social Deficits in Autism Spectrum Disorders Using a Theatre-Based, Peer-Mediated Intervention Type de document : Texte imprimé et/ou numérique Auteurs : Blythe A. CORBETT, Auteur ; Deanna M. SWAIN, Auteur ; Catherine COKE, Auteur ; David SIMON, Auteur ; Cassandra NEWSOM, Auteur ; Nea HOUCHINS-JUAREZ, Auteur ; Ashley JENSON, Auteur ; Lily WANG, Auteur ; Yanna SONG, Auteur Article en page(s) : p.4-16 Langues : Anglais (eng) Mots-clés : autism  social interaction  face processing  theatre  cortisol Index. décimale : PER Périodiques Résumé : Social Emotional NeuroScience Endocrinology Theatre is a novel intervention program aimed at improving reciprocal social interaction in youth with autism spectrum disorder (ASD) using behavioral strategies and theatrical techniques in a peer-mediated model. Previous research using a 3-month model showed improvement in face perception, social interaction, and reductions in stress. The current study assessed a 2-week summer camp model. Typically developing peers were trained and paired with ASD youth (8–17 years). Social perception and interaction skills were measured before and after treatment using neuropsychological and parental measures. Behavioral coding by reliable, independent raters was conducted within the treatment context (theatre) and outside the setting (playground). Salivary cortisol levels to assess physiological arousal were measured across contexts (home, theatre, and playground). A pretest–posttest design for within-group comparisons was used, and prespecified pairwise comparisons were achieved using a nonparametric Wilcoxon signed-rank test. Significant differences were observed in face processing, social awareness, and social cognition (P??0.05). Duration of interaction with familiar peers increased significantly over the course of treatment (P??0.05), while engagement with novel peers outside the treatment setting remained stable. Cortisol levels rose on the first day of camp compared with home values yet declined by the end of treatment and further reduced during posttreatment play with peers. Results corroborate previous findings that the peer-mediated theatre program contributes to improvement in core social deficits in ASD using a short-term, summer camp treatment model. Future studies will explore treatment length and peer familiarity to optimize and generalize gains. En ligne : http://dx.doi.org/10.1002/aur.1341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Improvement in Social Deficits in Autism Spectrum Disorders Using a Theatre-Based, Peer-Mediated Intervention [Texte imprimé et/ou numérique] / Blythe A. CORBETT, Auteur ; Deanna M. SWAIN, Auteur ; Catherine COKE, Auteur ; David SIMON, Auteur ; Cassandra NEWSOM, Auteur ; Nea HOUCHINS-JUAREZ, Auteur ; Ashley JENSON, Auteur ; Lily WANG, Auteur ; Yanna SONG, Auteur . - p.4-16. Langues : Anglais (eng) in Autism Research > 7-1 (February 2014) . - p.4-16 Mots-clés : autism  social interaction  face processing  theatre  cortisol Index. décimale : PER Périodiques Résumé : Social Emotional NeuroScience Endocrinology Theatre is a novel intervention program aimed at improving reciprocal social interaction in youth with autism spectrum disorder (ASD) using behavioral strategies and theatrical techniques in a peer-mediated model. Previous research using a 3-month model showed improvement in face perception, social interaction, and reductions in stress. The current study assessed a 2-week summer camp model. Typically developing peers were trained and paired with ASD youth (8–17 years). Social perception and interaction skills were measured before and after treatment using neuropsychological and parental measures. Behavioral coding by reliable, independent raters was conducted within the treatment context (theatre) and outside the setting (playground). Salivary cortisol levels to assess physiological arousal were measured across contexts (home, theatre, and playground). A pretest–posttest design for within-group comparisons was used, and prespecified pairwise comparisons were achieved using a nonparametric Wilcoxon signed-rank test. Significant differences were observed in face processing, social awareness, and social cognition (P??0.05). Duration of interaction with familiar peers increased significantly over the course of treatment (P??0.05), while engagement with novel peers outside the treatment setting remained stable. Cortisol levels rose on the first day of camp compared with home values yet declined by the end of treatment and further reduced during posttreatment play with peers. Results corroborate previous findings that the peer-mediated theatre program contributes to improvement in core social deficits in ASD using a short-term, summer camp treatment model. Future studies will explore treatment length and peer familiarity to optimize and generalize gains. En ligne : http://dx.doi.org/10.1002/aur.1341 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes / Beth A. MALOW in Journal of Autism and Developmental Disorders, 42-8 (August 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737 Titre : Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes Type de document : Texte imprimé et/ou numérique Auteurs : Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur Année de publication : 2012 Article en page(s) : p.1729-1737 Langues : Anglais (eng) Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques Résumé : Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population. En ligne : http://dx.doi.org/10.1007/s10803-011-1418-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178 [article] Melatonin for Sleep in Children with Autism: A Controlled Trial Examining Dose, Tolerability, and Outcomes [Texte imprimé et/ou numérique] / Beth A. MALOW, Auteur ; Karen W. ADKINS, Auteur ; Susan G. MCGREW, Auteur ; Lily WANG, Auteur ; Suzanne E. GOLDMAN, Auteur ; Diane FAWKES, Auteur ; Courtney BURNETTE, Auteur . - 2012 . - p.1729-1737. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-8 (August 2012) . - p.1729-1737 Mots-clés : Melatonin  Insomnia  Actigraphy  Clinical trial  Children’s sleep habits questionnaire  Child behavior checklist  Autism diagnostic observation schedule Index. décimale : PER Périodiques Résumé : Supplemental melatonin has shown promise in treating sleep onset insomnia in children with autism spectrum disorders (ASD). Twenty-four children, free of psychotropic medications, completed an open-label dose-escalation study to assess dose–response, tolerability, safety, feasibility of collecting actigraphy data, and ability of outcome measures to detect change during a 14-week intervention. Supplemental melatonin improved sleep latency, as measured by actigraphy, in most children at 1 or 3 mg dosages. It was effective in week 1 of treatment, maintained effects over several months, was well tolerated and safe, and showed improvement in sleep, behavior, and parenting stress. Our findings contribute to the growing literature on supplemental melatonin for insomnia in ASD and inform planning for a large randomized trial in this population. En ligne : http://dx.doi.org/10.1007/s10803-011-1418-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=178

Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep / Suzanne E. GOLDMAN in Journal of Autism and Developmental Disorders, 44-10 (October 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2525-2535 Titre : Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep Type de document : Texte imprimé et/ou numérique Auteurs : Suzanne E. GOLDMAN, Auteur ; Karen W. ADKINS, Auteur ; M. Wade CALCUTT, Auteur ; Melissa D. CARTER, Auteur ; Robert L. GOODPASTER, Auteur ; Lily WANG, Auteur ; Yaping SHI, Auteur ; Helen J. BURGESS, Auteur ; David L. HACHEY, Auteur ; Beth A. MALOW, Auteur Article en page(s) : p.2525-2535 Langues : Anglais (eng) Mots-clés : Insomnia  N-acetylserotonin  Dim light melatonin onset Index. décimale : PER Périodiques Résumé : Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C max) and time to peak concentration (T max) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin. En ligne : http://dx.doi.org/10.1007/s10803-014-2123-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240 [article] Melatonin in Children with Autism Spectrum Disorders: Endogenous and Pharmacokinetic Profiles in Relation to Sleep [Texte imprimé et/ou numérique] / Suzanne E. GOLDMAN, Auteur ; Karen W. ADKINS, Auteur ; M. Wade CALCUTT, Auteur ; Melissa D. CARTER, Auteur ; Robert L. GOODPASTER, Auteur ; Lily WANG, Auteur ; Yaping SHI, Auteur ; Helen J. BURGESS, Auteur ; David L. HACHEY, Auteur ; Beth A. MALOW, Auteur . - p.2525-2535. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-10 (October 2014) . - p.2525-2535 Mots-clés : Insomnia  N-acetylserotonin  Dim light melatonin onset Index. décimale : PER Périodiques Résumé : Supplemental melatonin has been used to treat sleep onset insomnia in children with autism spectrum disorders (ASD), although the mechanism of action is uncertain. We assessed endogenous and supplemental melatonin profiles in relation to sleep in nine children with ASD. In endogenous samples, maximal melatonin concentration (C max) and time to peak concentration (T max) were comparable to those previously published in the literature for typically developing children, and dim light melatonin onsets were captured in the majority of children. In treatment samples (supplemental melatonin), melatonin parameters were also comparable to those previously published for typically developing children. Our findings support that children with ASD and insomnia responsive to low dose melatonin treatment have relatively normal profiles of endogenous and supplemental melatonin. En ligne : http://dx.doi.org/10.1007/s10803-014-2123-9 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=240

Relation of Melatonin to Sleep Architecture in Children with Autism / Roberta M. LEU in Journal of Autism and Developmental Disorders, 41-4 (April 2011)  

Permalink

---

1 (1 - 6 / 6)