Genomic structural variation in psychiatric disorders / James J. H. RUCKER in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1335-1344 Titre : Genomic structural variation in psychiatric disorders Type de document : Texte imprimé et/ou numérique Auteurs : James J. H. RUCKER, Auteur ; Peter MCGUFFIN, Auteur Année de publication : 2012 Article en page(s) : p.1335-1344 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Copy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders. A complex picture is emerging of a polygenic, heterogeneous model of disease, with CNVs conferring broad susceptibility to a variety of neurodevelopmental disorders, rather than specific disorders per se. Although the insights gleaned thus far only represent a small piece of a much larger puzzle, progress has been rapid and new technologies promise even more insights into these hitherto opaque brain disorders. We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings. En ligne : http://dx.doi.org/10.1017/S0954579412000740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Genomic structural variation in psychiatric disorders [Texte imprimé et/ou numérique] / James J. H. RUCKER, Auteur ; Peter MCGUFFIN, Auteur . - 2012 . - p.1335-1344. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1335-1344 Index. décimale : PER Périodiques Résumé : Copy number variants (CNVs) are submicroscopic deletions and duplications of genomic material that were previously thought to be rare phenomena. They have now been robustly associated with a variety of disorders such as autism, schizophrenia, and attention-deficit/hyperactivity disorder through an emerging research base in affective disorders. A complex picture is emerging of a polygenic, heterogeneous model of disease, with CNVs conferring broad susceptibility to a variety of neurodevelopmental disorders, rather than specific disorders per se. Although the insights gleaned thus far only represent a small piece of a much larger puzzle, progress has been rapid and new technologies promise even more insights into these hitherto opaque brain disorders. We will discuss CNVs, the current state of evidence for their role in the pathogenesis of classical psychiatric disorders, and the application of such knowledge in clinical settings. En ligne : http://dx.doi.org/10.1017/S0954579412000740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Life Events and Depressive Symptoms in Childhood—Shared Genes or Shared Adversity? A Research Note / Anita THAPAR in Journal of Child Psychology and Psychiatry, 39-8 (November 1998)

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 39-8 (November 1998) . - p.1153-1158 Titre : Life Events and Depressive Symptoms in Childhood—Shared Genes or Shared Adversity? A Research Note Type de document : Texte imprimé et/ou numérique Auteurs : Anita THAPAR, Auteur ; Gordon T. HAROLD, Auteur ; Peter MCGUFFIN, Auteur Année de publication : 1998 Article en page(s) : p.1153-1158 Langues : Anglais (eng) Mots-clés : Depression  twins  life events  genetics Index. décimale : PER Périodiques Résumé : A twin study design was used to examine to what extent genetic and environmental factors mediate the association between life events and depressive symptoms. Questionnaire measures (maternally rated) of depressive symptoms and life events were obtained for a systematically ascertained sample of 270 twin pairs aged 8 to 17 years. Bivariate genetic model fitting showed that depressive symptoms and some life events (total events, negative impact) share a common genetic influence. The covariation of independent life events and depressive symptoms was explained by a shared environmental influence common to both. At least part of the association between life events and depressive symptoms is mediated by familial factors that include both genes and shared environment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124 [article] Life Events and Depressive Symptoms in Childhood—Shared Genes or Shared Adversity? A Research Note [Texte imprimé et/ou numérique] / Anita THAPAR, Auteur ; Gordon T. HAROLD, Auteur ; Peter MCGUFFIN, Auteur . - 1998 . - p.1153-1158. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 39-8 (November 1998) . - p.1153-1158 Mots-clés : Depression  twins  life events  genetics Index. décimale : PER Périodiques Résumé : A twin study design was used to examine to what extent genetic and environmental factors mediate the association between life events and depressive symptoms. Questionnaire measures (maternally rated) of depressive symptoms and life events were obtained for a systematically ascertained sample of 270 twin pairs aged 8 to 17 years. Bivariate genetic model fitting showed that depressive symptoms and some life events (total events, negative impact) share a common genetic influence. The covariation of independent life events and depressive symptoms was explained by a shared environmental influence common to both. At least part of the association between life events and depressive symptoms is mediated by familial factors that include both genes and shared environment. Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=124

---

1 (1 - 2 / 2)