An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents / Charlotte RHIND in Molecular Autism, (December 2014)  

Public ISBD [article]  inMolecular Autism > (December 2014) . - p.1-9 Titre : An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents Type de document : Texte imprimé et/ou numérique Auteurs : Charlotte RHIND, Auteur ; Elena BONFIOLI, Auteur ; Rebecca HIBBS, Auteur ; Elizabeth GODDARD, Auteur ; Pamela MACDONALD, Auteur ; Simon GOWERS, Auteur ; Ulrike SCHMIDT, Auteur ; Kate TCHANTURIA, Auteur ; Nadia MICALI, Auteur ; Janet TREASURE, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive traits, how many would meet diagnostic criteria for autism spectrum disorder, and whether these traits are shared by parents. En ligne : http://dx.doi.org/10.1186/2040-2392-5-56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277 [article] An examination of autism spectrum traits in adolescents with anorexia nervosa and their parents [Texte imprimé et/ou numérique] / Charlotte RHIND, Auteur ; Elena BONFIOLI, Auteur ; Rebecca HIBBS, Auteur ; Elizabeth GODDARD, Auteur ; Pamela MACDONALD, Auteur ; Simon GOWERS, Auteur ; Ulrike SCHMIDT, Auteur ; Kate TCHANTURIA, Auteur ; Nadia MICALI, Auteur ; Janet TREASURE, Auteur . - p.1-9. Langues : Anglais (eng) in Molecular Autism > (December 2014) . - p.1-9 Index. décimale : PER Périodiques Résumé : There may be a link between anorexia nervosa and autism spectrum disorders. The aims of this study were to examine whether adolescents with anorexia nervosa have autism spectrum and/or obsessive-compulsive traits, how many would meet diagnostic criteria for autism spectrum disorder, and whether these traits are shared by parents. En ligne : http://dx.doi.org/10.1186/2040-2392-5-56 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=277

Childhood psychopathology in children of women with eating disorders: understanding risk mechanisms / Nadia MICALI in Journal of Child Psychology and Psychiatry, 55-2 (February 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.124-134 Titre : Childhood psychopathology in children of women with eating disorders: understanding risk mechanisms Type de document : Texte imprimé et/ou numérique Auteurs : Nadia MICALI, Auteur ; Daniel STAHL, Auteur ; Janet TREASURE, Auteur ; Emily SIMONOFF, Auteur Article en page(s) : p.124-134 Langues : Anglais (eng) Mots-clés : ALSPAC  child psychopathology  eating disorders  parental mental health  risk mechanisms Index. décimale : PER Périodiques Résumé : Background Very few studies have investigated psychopathology in children of mothers with eating disorders (ED). We aimed to determine the effect of maternal ED on childhood psychopathology in a large population-based cohort and investigate relevant risk pathways using structural equation modeling (SEM). Methods Data on emotional and behavioral problems at 3½ years were obtained prospectively on 8,622 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Children of exposed women who self-reported lifetime anorexia nervosa (AN, N = 193) or bulimia nervosa (BN, N = 158) in pregnancy were compared with children of unexposed women (N = 8,271) using linear and logistic regression models. SEM was used to determine best-fitting risk models by child gender. Results There was evidence that girls of AN women were more likely to have emotional, conduct, and hyperactivity disorders [Odds Ratio (OR): 1.7 (95% Confidence Intervals 1.0–3.0); OR: 2.2 (1.2–4.0); OR: 1.8 (1.1–3.1), respectively] and boys of AN women to have emotional disorders compared with unexposed [OR: 2.0(1.2–3.4)]. Girls of women with BN were more likely to show hyperactivity [OR: 1.7 (1.0–3.1)]; and boys to show emotional and conduct disorders compared with unexposed [OR: 2.2 (1.2–3.9); OR: 2.4 (1.4–4.2), respectively]. SEM models showed that pregnancy anxiety and depression mediated the effect of maternal ED on child psychopathology. Conclusions Maternal ED are associated with different childhood psychopathology outcomes in boys and girls. Pregnancy anxiety and depression and active ED symptoms are important mediators of risk and are preventable; the direct effect of maternal lifetime ED was small. En ligne : http://dx.doi.org/10.1111/jcpp.12112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221 [article] Childhood psychopathology in children of women with eating disorders: understanding risk mechanisms [Texte imprimé et/ou numérique] / Nadia MICALI, Auteur ; Daniel STAHL, Auteur ; Janet TREASURE, Auteur ; Emily SIMONOFF, Auteur . - p.124-134. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-2 (February 2014) . - p.124-134 Mots-clés : ALSPAC  child psychopathology  eating disorders  parental mental health  risk mechanisms Index. décimale : PER Périodiques Résumé : Background Very few studies have investigated psychopathology in children of mothers with eating disorders (ED). We aimed to determine the effect of maternal ED on childhood psychopathology in a large population-based cohort and investigate relevant risk pathways using structural equation modeling (SEM). Methods Data on emotional and behavioral problems at 3½ years were obtained prospectively on 8,622 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). Children of exposed women who self-reported lifetime anorexia nervosa (AN, N = 193) or bulimia nervosa (BN, N = 158) in pregnancy were compared with children of unexposed women (N = 8,271) using linear and logistic regression models. SEM was used to determine best-fitting risk models by child gender. Results There was evidence that girls of AN women were more likely to have emotional, conduct, and hyperactivity disorders [Odds Ratio (OR): 1.7 (95% Confidence Intervals 1.0–3.0); OR: 2.2 (1.2–4.0); OR: 1.8 (1.1–3.1), respectively] and boys of AN women to have emotional disorders compared with unexposed [OR: 2.0(1.2–3.4)]. Girls of women with BN were more likely to show hyperactivity [OR: 1.7 (1.0–3.1)]; and boys to show emotional and conduct disorders compared with unexposed [OR: 2.2 (1.2–3.9); OR: 2.4 (1.4–4.2), respectively]. SEM models showed that pregnancy anxiety and depression mediated the effect of maternal ED on child psychopathology. Conclusions Maternal ED are associated with different childhood psychopathology outcomes in boys and girls. Pregnancy anxiety and depression and active ED symptoms are important mediators of risk and are preventable; the direct effect of maternal lifetime ED was small. En ligne : http://dx.doi.org/10.1111/jcpp.12112 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=221

Exploring autistic traits in anorexia: a clinical study / Kate TCHANTURIA in Molecular Autism, (November 2013)  

Public ISBD [article]  inMolecular Autism > (November 2013) Titre : Exploring autistic traits in anorexia: a clinical study Type de document : Texte imprimé et/ou numérique Auteurs : Kate TCHANTURIA, Auteur ; Emma SMITH, Auteur ; Felicitas WEINECK, Auteur ; Eliz FIDANBOYLU, Auteur ; Nikola KERN, Auteur ; Janet TREASURE, Auteur ; Simon BARON-COHEN, Auteur Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The objectives of this study were to explore associations between autistic traits and self-reported clinical symptoms in a population with anorexia nervosa (AN). Experimental and self-report evidence reveals similarities between AN and autism spectrum condition (ASC) populations in socio-emotional and cognitive domains; this includes difficulties with empathy, set-shifting and global processing. Focusing on these similarities may lead to better tailored interventions for both conditions. A cross-sectional independent-groups design was employed. Participants with AN (n = 66) and typical controls (n = 66) completed self-report questionnaires including the Short (10-Item) Version Autism Spectrum Quotient (AQ-10) questionnaire (the first time this has been implemented in this population), the Eating Disorder Examination Questionnaire, the Hospital Anxiety and Depression Scale and the Work and Social Adjustment Scale. Group differences and the relationship between autistic traits and other questionnaire measures were investigated. The AN group had a significantly higher AQ-10 total score and a greater proportion scored above the clinical cut-off than the control group. Seven out of ten AQ-10 items significantly discriminated between groups. In the AN group, levels of autistic traits correlated with a greater self-reported anxiety and depression and a lower ability to maintain close relationships; however, eating disorder symptoms were not associated with autistic traits. Women with anorexia possess a greater number of autistic traits than typical women. AQ-10 items that discriminated between groups related to 'bigger picture' (global) thinking, inflexibility of thinking and problems with social interactions, suggesting that autistic traits may exacerbate factors that maintain the eating disorder rather than cause the eating disorder directly. Using screening instruments may improve understanding of patients' problems, leading to better tailoring of intervention. We conclude that further investigation of autistic traits in AN could inform new intervention approaches based on joint working between ASC and eating disorder services. En ligne : http://dx.doi.org/10.1186/2040-2392-4-44 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227 [article] Exploring autistic traits in anorexia: a clinical study [Texte imprimé et/ou numérique] / Kate TCHANTURIA, Auteur ; Emma SMITH, Auteur ; Felicitas WEINECK, Auteur ; Eliz FIDANBOYLU, Auteur ; Nikola KERN, Auteur ; Janet TREASURE, Auteur ; Simon BARON-COHEN, Auteur. Langues : Anglais (eng) in Molecular Autism > (November 2013) Index. décimale : PER Périodiques Résumé : The objectives of this study were to explore associations between autistic traits and self-reported clinical symptoms in a population with anorexia nervosa (AN). Experimental and self-report evidence reveals similarities between AN and autism spectrum condition (ASC) populations in socio-emotional and cognitive domains; this includes difficulties with empathy, set-shifting and global processing. Focusing on these similarities may lead to better tailored interventions for both conditions. A cross-sectional independent-groups design was employed. Participants with AN (n = 66) and typical controls (n = 66) completed self-report questionnaires including the Short (10-Item) Version Autism Spectrum Quotient (AQ-10) questionnaire (the first time this has been implemented in this population), the Eating Disorder Examination Questionnaire, the Hospital Anxiety and Depression Scale and the Work and Social Adjustment Scale. Group differences and the relationship between autistic traits and other questionnaire measures were investigated. The AN group had a significantly higher AQ-10 total score and a greater proportion scored above the clinical cut-off than the control group. Seven out of ten AQ-10 items significantly discriminated between groups. In the AN group, levels of autistic traits correlated with a greater self-reported anxiety and depression and a lower ability to maintain close relationships; however, eating disorder symptoms were not associated with autistic traits. Women with anorexia possess a greater number of autistic traits than typical women. AQ-10 items that discriminated between groups related to 'bigger picture' (global) thinking, inflexibility of thinking and problems with social interactions, suggesting that autistic traits may exacerbate factors that maintain the eating disorder rather than cause the eating disorder directly. Using screening instruments may improve understanding of patients' problems, leading to better tailoring of intervention. We conclude that further investigation of autistic traits in AN could inform new intervention approaches based on joint working between ASC and eating disorder services. En ligne : http://dx.doi.org/10.1186/2040-2392-4-44 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=227

Maternal eating disorders and infant feeding difficulties: maternal and child mediators in a longitudinal general population study / Nadia MICALI in Journal of Child Psychology and Psychiatry, 52-7 (July 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.800-807 Titre : Maternal eating disorders and infant feeding difficulties: maternal and child mediators in a longitudinal general population study Type de document : Texte imprimé et/ou numérique Auteurs : Nadia MICALI, Auteur ; Emily SIMONOFF, Auteur ; Daniel STAHL, Auteur ; Janet TREASURE, Auteur Année de publication : 2011 Article en page(s) : p.800-807 Langues : Anglais (eng) Mots-clés : ALSPAC  eating disorders  feeding  anxiety  depression;infants Index. décimale : PER Périodiques Résumé : Background:  Maternal eating disorders (ED) have been shown to increase the risk of feeding difficulties in the offspring. Very few studies, however, have investigated whether the effect of a maternal ED on childhood feeding is a direct effect or whether it can be ascribed to other child or maternal factors. We aimed to determine the role of maternal anxiety and depression in mediating the risk for feeding difficulties in infants of women with ED. Methods:  A prospective study comparing women with lifetime ED (441) and without any lifetime psychiatric disorder (10,461) and their infants from the Avon Longitudinal Study of Parents and Children (ALSPAC). We investigated the effect of: maternal anxiety and depression in late pregnancy (32 weeks) and the post-partum (8 weeks), child temperament and developmental status on infant feeding difficulties at 1 and 6 months. We also investigated the effect of active pregnancy ED symptoms. We tested 3 models and their fit to the data using structured equation modelling: a direct effect model, a fully mediational model and an integrated (partial meditational) model. Results:  The integrated model including a direct effect of maternal lifetime ED on infant feeding and a mediational path via maternal distress (a latent variable combining anxiety and depression) fitted the data best. This also applied to maternal pregnancy ED symptoms. Feeding difficulties in turn increased maternal distress over time. Conclusions:  Lifetime ED and active pregnancy ED increase the risk for infant feeding difficulties and do so via maternal distress (i.e., depression and anxiety). This has important implications for prevention and early intervention in relation to infant feeding difficulties, as well as for future research in the field. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02341.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126 [article] Maternal eating disorders and infant feeding difficulties: maternal and child mediators in a longitudinal general population study [Texte imprimé et/ou numérique] / Nadia MICALI, Auteur ; Emily SIMONOFF, Auteur ; Daniel STAHL, Auteur ; Janet TREASURE, Auteur . - 2011 . - p.800-807. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-7 (July 2011) . - p.800-807 Mots-clés : ALSPAC  eating disorders  feeding  anxiety  depression;infants Index. décimale : PER Périodiques Résumé : Background:  Maternal eating disorders (ED) have been shown to increase the risk of feeding difficulties in the offspring. Very few studies, however, have investigated whether the effect of a maternal ED on childhood feeding is a direct effect or whether it can be ascribed to other child or maternal factors. We aimed to determine the role of maternal anxiety and depression in mediating the risk for feeding difficulties in infants of women with ED. Methods:  A prospective study comparing women with lifetime ED (441) and without any lifetime psychiatric disorder (10,461) and their infants from the Avon Longitudinal Study of Parents and Children (ALSPAC). We investigated the effect of: maternal anxiety and depression in late pregnancy (32 weeks) and the post-partum (8 weeks), child temperament and developmental status on infant feeding difficulties at 1 and 6 months. We also investigated the effect of active pregnancy ED symptoms. We tested 3 models and their fit to the data using structured equation modelling: a direct effect model, a fully mediational model and an integrated (partial meditational) model. Results:  The integrated model including a direct effect of maternal lifetime ED on infant feeding and a mediational path via maternal distress (a latent variable combining anxiety and depression) fitted the data best. This also applied to maternal pregnancy ED symptoms. Feeding difficulties in turn increased maternal distress over time. Conclusions:  Lifetime ED and active pregnancy ED increase the risk for infant feeding difficulties and do so via maternal distress (i.e., depression and anxiety). This has important implications for prevention and early intervention in relation to infant feeding difficulties, as well as for future research in the field. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02341.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=126

Neurobehavioural and cognitive development in infants born to mothers with eating disorders / Manuela BARONA in Journal of Child Psychology and Psychiatry, 58-8 (August 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.931-938 Titre : Neurobehavioural and cognitive development in infants born to mothers with eating disorders Type de document : Texte imprimé et/ou numérique Auteurs : Manuela BARONA, Auteur ; Emma TABORELLI, Auteur ; Freya CORFIELD, Auteur ; Susan PAWLBY, Auteur ; Abigail EASTER, Auteur ; Ulrike SCHMIDT, Auteur ; Janet TREASURE, Auteur ; Nadia MICALI, Auteur Article en page(s) : p.931-938 Langues : Anglais (eng) Mots-clés : Brazelton Neonatal Behavioural Assessment Scale  Bayley Scales of Infant and Toddler Development  eating disorders  child development Index. décimale : PER Périodiques Résumé : Introduction Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. Methods Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy. Newborns and infants of mothers with ED were compared with newborns and infants of healthy controls on (a) neurobehavioural dysregulation using the Brazelton Neonatal Behavioural Assessment Scale at 8 days postpartum (active ED, n = 15; past ED, n = 20; healthy controls, n = 28); and (b) cognitive development using the Bayley Scales of Infant and Toddler Development at 1-year postpartum (active ED, n = 18; past ED, n = 19; healthy controls, n = 28). In order to maintain the largest possible sample at each time point, sample size varied across time points. Results Newborns of mothers with an active ED had worse autonomic stability when compared with newborns of healthy controls [B = ?0.34 (?1.81, ?0.26)]. Infants of mothers with a past ED had poorer language [B = ?0.33 (?13.6, ?1.9)] and motor development [B = ?0.32 (?18.4, ?1.3)] compared with healthy controls. Conclusions Children of mothers with ED display neurobehavioural dysregulation early after birth and poorer language and motor development at 1 year. These characteristics suggest evidence of early neurobiological markers in children at risk. Differential outcomes in children of women with active versus past ED suggest that active symptomatology during pregnancy might have an effect on physiological reactivity while cognitive characteristics might be more stable markers of risk for ED. En ligne : http://dx.doi.org/10.1111/jcpp.12736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316 [article] Neurobehavioural and cognitive development in infants born to mothers with eating disorders [Texte imprimé et/ou numérique] / Manuela BARONA, Auteur ; Emma TABORELLI, Auteur ; Freya CORFIELD, Auteur ; Susan PAWLBY, Auteur ; Abigail EASTER, Auteur ; Ulrike SCHMIDT, Auteur ; Janet TREASURE, Auteur ; Nadia MICALI, Auteur . - p.931-938. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-8 (August 2017) . - p.931-938 Mots-clés : Brazelton Neonatal Behavioural Assessment Scale  Bayley Scales of Infant and Toddler Development  eating disorders  child development Index. décimale : PER Périodiques Résumé : Introduction Although recent research has focused on the effects of maternal eating disorders (EDs) on children, little is known about the effect of maternal EDs on neurobiological outcomes in newborns and infants. This study is the first to investigate neurobehavioural regulation and cognitive development in newborns and infants of mothers with EDs. Methods Women with an active and past ED and healthy controls were recruited to a prospective longitudinal study during their first trimester or second trimester of pregnancy. Newborns and infants of mothers with ED were compared with newborns and infants of healthy controls on (a) neurobehavioural dysregulation using the Brazelton Neonatal Behavioural Assessment Scale at 8 days postpartum (active ED, n = 15; past ED, n = 20; healthy controls, n = 28); and (b) cognitive development using the Bayley Scales of Infant and Toddler Development at 1-year postpartum (active ED, n = 18; past ED, n = 19; healthy controls, n = 28). In order to maintain the largest possible sample at each time point, sample size varied across time points. Results Newborns of mothers with an active ED had worse autonomic stability when compared with newborns of healthy controls [B = ?0.34 (?1.81, ?0.26)]. Infants of mothers with a past ED had poorer language [B = ?0.33 (?13.6, ?1.9)] and motor development [B = ?0.32 (?18.4, ?1.3)] compared with healthy controls. Conclusions Children of mothers with ED display neurobehavioural dysregulation early after birth and poorer language and motor development at 1 year. These characteristics suggest evidence of early neurobiological markers in children at risk. Differential outcomes in children of women with active versus past ED suggest that active symptomatology during pregnancy might have an effect on physiological reactivity while cognitive characteristics might be more stable markers of risk for ED. En ligne : http://dx.doi.org/10.1111/jcpp.12736 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=316

Prevalence of purging at age 16 and associations with negative outcomes among girls in three community-based cohorts / Francesca SOLMI in Journal of Child Psychology and Psychiatry, 56-1 (January 2015)  

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Using the Autism-Spectrum Quotient to Measure Autistic Traits in Anorexia Nervosa: A Systematic Review and Meta-Analysis / Heather WESTWOOD in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

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