[article] 
inResearch in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50

Titre :	Effects of age and symptomatology on cortical thickness in autism spectrum disorders
Type de document :	Texte imprimé et/ou numérique
Auteurs :	Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur
Année de publication :	2013
Article en page(s) :	p.141-50
Langues :	Anglais (eng)
Mots-clés :	Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes
Index. décimale :	PER Périodiques
Résumé :	Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2012.08.004
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

[article] Effects of age and symptomatology on cortical thickness in autism spectrum disorders [Texte imprimé et/ou numérique] / Krissy A. R. DOYLE-THOMAS, Auteur ; Emma G. DUERDEN, Auteur ; Margot J. TAYLOR, Auteur ; Jason LERCH, Auteur ; Latha V. SOORYA, Auteur ; A. Ting WANG, Auteur ; Jin FAN, Auteur ; Eric HOLLANDER, Auteur ; Evdokia ANAGNOSTOU, Auteur . - 2013 . - p.141-50.
Langues : Anglais (eng)
in Research in Autism Spectrum Disorders > 7-1 (January 2013) . - p.141-50

Mots-clés :	Autism spectrum disorders  Structural MRI  Cortical thickness  Social impairment  Developmental changes
Index. décimale :	PER Périodiques
Résumé :	Several brain regions show structural and functional abnormalities in individuals with autism spectrum disorders (ASD), but the developmental trajectory of abnormalities in these structures and how they may relate to social and communicative impairments are still unclear. We assessed the effects of age on cortical thickness in individuals with ASD, between the ages of 7 and 39 years in comparison to typically developing controls. Additionally, we examined differences in cortical thickness in relation to symptomatology in the ASD group, and their association with age. Analyses were conducted using a general linear model, controlling for sex. Social and communication scores from the Autism Diagnostic Interview-Revised (ADI-R) were correlated with the thickness of regions implicated in those functions. Controls showed widespread cortical thinning relative to the ASD group. Within regions-of-interest, increased thickness in the rostral anterior cingulate cortex was associated with poorer social scores. Additionally, a significant interaction between age and social impairment was found in the orbitofrontal cortex, with more impaired younger children having decreased thickness in this region. These results suggest that differential neurodevelopmental trajectories are present in individuals with ASD and some differences are associated with diagnostic behaviours.
En ligne :	http://dx.doi.org/10.1016/j.rasd.2012.08.004
Permalink :	https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179