A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder / Philip SHAW in Journal of Child Psychology and Psychiatry, 59-10 (October 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123 Titre : A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder Type de document : texte imprimé Auteurs : Philip SHAW, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Min Tae PARK, Auteur ; Gabriel A. DEVENYI, Auteur ; Chava ZIBMAN, Auteur ; Steven W. KASPAREK, Auteur ; Gustavo SUDRE, Auteur ; Aman MANGALMURTI, Auteur ; Martine HOOGMAN, Auteur ; Henning TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; Devon SHOOK, Auteur ; Ryan L. MUETZEL, Auteur ; M. Mallar CHAKRAVARTY, Auteur ; Kerstin KONRAD, Auteur ; Sarah DURSTON, Auteur ; Tiffany C. WHITE, Auteur Article en page(s) : p.1114-1123 Langues : Anglais (eng) Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369 [article] A multicohort, longitudinal study of cerebellar development in attention deficit hyperactivity disorder [texte imprimé] / Philip SHAW, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Min Tae PARK, Auteur ; Gabriel A. DEVENYI, Auteur ; Chava ZIBMAN, Auteur ; Steven W. KASPAREK, Auteur ; Gustavo SUDRE, Auteur ; Aman MANGALMURTI, Auteur ; Martine HOOGMAN, Auteur ; Henning TIEMEIER, Auteur ; Georg G. VON POLIER, Auteur ; Devon SHOOK, Auteur ; Ryan L. MUETZEL, Auteur ; M. Mallar CHAKRAVARTY, Auteur ; Kerstin KONRAD, Auteur ; Sarah DURSTON, Auteur ; Tiffany C. WHITE, Auteur . - p.1114-1123. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-10 (October 2018) . - p.1114-1123 Mots-clés : Cerebellum attention deficit hyperactivity disorder growth meta-analysis neuroanatomy white matter Index. décimale : PER Périodiques Résumé : BACKGROUND: The cerebellum supports many cognitive functions disrupted in attention deficit hyperactivity disorder (ADHD). Prior neuroanatomic studies have been often limited by small sample sizes, inconsistent findings, and a reliance on cross-sectional data, limiting inferences about cerebellar development. Here, we conduct a multicohort study using longitudinal data, to characterize cerebellar development. METHODS: Growth trajectories of the cerebellar vermis, hemispheres and white matter were estimated using piecewise linear regression from 1,656 youth; of whom 63% had longitudinal data, totaling 2,914 scans. Four cohorts participated, all contained childhood data (age 4-12 years); two had adolescent data (12-25 years). Growth parameters were combined using random-effects meta-analysis. RESULTS: Diagnostic differences in growth were confined to the corpus medullare (cerebellar white matter). Here, the ADHD group showed slower growth in early childhood compared to the typically developing group (left corpus medullare z = 2.49, p = .01; right z = 2.03, p = .04). This reversed in late childhood, with faster growth in ADHD in the left corpus medullare (z = 2.06, p = .04). Findings held when gender, intelligence, comorbidity, and psychostimulant medication were considered. DISCUSSION: Across four independent cohorts, containing predominately longitudinal data, we found diagnostic differences in the growth of cerebellar white matter. In ADHD, slower white matter growth in early childhood was followed by faster growth in late childhood. The findings are consistent with the concept of ADHD as a disorder of the brain's structural connections, formed partly by developing cortico-cerebellar white matter tracts. En ligne : http://dx.doi.org/10.1111/jcpp.12920 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=369

Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population / Takafumi SHIMADA in Research in Autism Spectrum Disorders, 6-1 (January-March 2012)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507 Titre : Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population Type de document : texte imprimé Auteurs : Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur Année de publication : 2012 Article en page(s) : p.500-507 Langues : Anglais (eng) Mots-clés : Autism  Attention deficit hyperactivity disorder  Tourette syndrome  Parental age  Assisted reproductive technology  Japanese population Index. décimale : PER Périodiques Résumé : We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 [article] Parental age and assisted reproductive technology in autism spectrum disorders, attention deficit hyperactivity disorder, and Tourette syndrome in a Japanese population [texte imprimé] / Takafumi SHIMADA, Auteur ; Atsushi KITAMOTO, Auteur ; Ayako TODOKORO, Auteur ; Ayaka ISHII-TAKAHASHI, Auteur ; Hitoshi KAWAMURA, Auteur ; Soo-Yung KIM, Auteur ; Kei-ichiro WATANABE, Auteur ; Iwao MINOWA, Auteur ; Toshikazu SOMEYA, Auteur ; Hiroshi OHTSU, Auteur ; Yutaka OSUGA, Auteur ; Yukiko KANO, Auteur ; Kiyoto KASAI, Auteur ; Nobumasa KATO, Auteur ; Tsukasa SASAKI, Auteur . - 2012 . - p.500-507. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 6-1 (January-March 2012) . - p.500-507 Mots-clés : Autism  Attention deficit hyperactivity disorder  Tourette syndrome  Parental age  Assisted reproductive technology  Japanese population Index. décimale : PER Périodiques Résumé : We investigated whether advanced parental age and assisted reproductive technology (ART) are risk factors in autism spectrum disorders (ASDs), attention deficit hyperactivity disorder (ADHD), and Tourette syndrome (TS). Clinical charts of Japanese outpatients with ASD (n = 552), ADHD (n = 87), and TS (n = 123) were reviewed. Parental age of individuals with ASD, ADHD, or TS was compared with parental age in the general population (GP) of Tokyo after adjusting for year of birth. Paternal and maternal ages were significantly higher in persons with ASD and ADHD, but not those with TS. In final steps of stepwise logistic regression analysis, both maternal and paternal age were associated with ASD after controlling for the other parent's age, gender, and birth order. In cases where the presence or absence of ART could be ascertained (ASD n = 467; ADHD n = 64; TS n = 83), the rate of ART in cases of persons with ASD (4.5%) was 1.8 times the frequency expected in the GP, while ART was not present in cases of persons with ADHD and TS. These preliminary results remain tentative pending replication with larger, community-based samples. En ligne : http://dx.doi.org/10.1016/j.rasd.2011.07.010 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146

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