Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders / Irina MANOUILENKO in Research in Autism Spectrum Disorders, 7-5 (May 2013)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578 Titre : Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Article en page(s) : p.566-578 Mots-clés : Autism spectrum disorder  ADHD  Neurological soft signs  Temporo-parietal junction  Thalamus  Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 [article] Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - p.566-578. in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578 Mots-clés : Autism spectrum disorder  ADHD  Neurological soft signs  Temporo-parietal junction  Thalamus  Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194

Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ / Marco PAGANI in Journal of Autism and Developmental Disorders, 42-2 (February 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.313-318 Titre : Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ Type de document : Texte imprimé et/ou numérique Auteurs : Marco PAGANI, Auteur ; Irina MANOUILENKO, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Dario SALMASO, Auteur ; Robert HATHERLY, Auteur ; Fredrik BROLIN, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Année de publication : 2012 Article en page(s) : p.313-318 Langues : Anglais (eng) Mots-clés : High functioning autism  PET/CT  [1-11C]butanol  Cerebral blood flow Index. décimale : PER Périodiques Résumé : Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1240-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Brief Report: Alterations in Cerebral Blood Flow as Assessed by PET/CT in Adults with Autism Spectrum Disorder with Normal IQ [Texte imprimé et/ou numérique] / Marco PAGANI, Auteur ; Irina MANOUILENKO, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Dario SALMASO, Auteur ; Robert HATHERLY, Auteur ; Fredrik BROLIN, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - 2012 . - p.313-318. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.313-318 Mots-clés : High functioning autism  PET/CT  [1-11C]butanol  Cerebral blood flow Index. décimale : PER Périodiques Résumé : Specific biological markers for Autism Spectrum Disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal “social” brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-11C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD. En ligne : http://dx.doi.org/10.1007/s10803-011-1240-y Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

The Swedish Version of the Ritvo Autism and Asperger Diagnostic Scale: Revised (RAADS-R). A Validation Study of a Rating Scale for Adults / Lisa ANDERSEN in Journal of Autism and Developmental Disorders, 41-12 (December 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1635-1645 Titre : The Swedish Version of the Ritvo Autism and Asperger Diagnostic Scale: Revised (RAADS-R). A Validation Study of a Rating Scale for Adults Type de document : Texte imprimé et/ou numérique Auteurs : Lisa ANDERSEN, Auteur ; Katharina NASWALL, Auteur ; Irina MANOUILENKO, Auteur ; Lena NYLANDER, Auteur ; Johan EDGAR, Auteur ; Riva-Ariella RITVO, Auteur ; Edward R. RITVO, Auteur ; Susanne BEJEROT, Auteur Année de publication : 2011 Article en page(s) : p.1635-1645 Langues : Anglais (eng) Mots-clés : Autistic disorder  Asperger syndrome  Psychiatric status rating scales  Self assessment (Psychology)  Diagnostic techniques and procedures  Adult Index. décimale : PER Périodiques Résumé : There is a paucity of diagnostic instruments for adults with autism spectrum disorder (ASD). This study evaluates the psychometric properties of the Swedish version of the Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), an 80-item self-rating scale designed to assist clinicians diagnosing ASD in adults. It was administered to 75 adults with ASD and 197 comparison cases. Also, a subset completed the Autism Spectrum Quotient (AQ). Three out of four subscales had high internal consistency. Sensitivity was 91% and specificity was 93%. The ASD subjects had significantly higher mean scores on all subscales. ASD females had higher scores than ASD males on the sensory motor subscale, a dimension not included in the AQ. RAADS-R showed promising test re-test reliability. En ligne : http://dx.doi.org/10.1007/s10803-011-1191-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148 [article] The Swedish Version of the Ritvo Autism and Asperger Diagnostic Scale: Revised (RAADS-R). A Validation Study of a Rating Scale for Adults [Texte imprimé et/ou numérique] / Lisa ANDERSEN, Auteur ; Katharina NASWALL, Auteur ; Irina MANOUILENKO, Auteur ; Lena NYLANDER, Auteur ; Johan EDGAR, Auteur ; Riva-Ariella RITVO, Auteur ; Edward R. RITVO, Auteur ; Susanne BEJEROT, Auteur . - 2011 . - p.1635-1645. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-12 (December 2011) . - p.1635-1645 Mots-clés : Autistic disorder  Asperger syndrome  Psychiatric status rating scales  Self assessment (Psychology)  Diagnostic techniques and procedures  Adult Index. décimale : PER Périodiques Résumé : There is a paucity of diagnostic instruments for adults with autism spectrum disorder (ASD). This study evaluates the psychometric properties of the Swedish version of the Ritvo Autism and Asperger Diagnostic Scale-Revised (RAADS-R), an 80-item self-rating scale designed to assist clinicians diagnosing ASD in adults. It was administered to 75 adults with ASD and 197 comparison cases. Also, a subset completed the Autism Spectrum Quotient (AQ). Three out of four subscales had high internal consistency. Sensitivity was 91% and specificity was 93%. The ASD subjects had significantly higher mean scores on all subscales. ASD females had higher scores than ASD males on the sensory motor subscale, a dimension not included in the AQ. RAADS-R showed promising test re-test reliability. En ligne : http://dx.doi.org/10.1007/s10803-011-1191-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=148

---

1 (1 - 3 / 3)