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Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 46-3 (March 2016)
[article]
Titre : Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur Article en page(s) : p.954-963 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Theory of mind Mentalizing network Sex differences Medial prefrontal cortex Temporo-parietal junction Superior temporal sulcus Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963[article] Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur . - p.954-963.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963
Mots-clés : Autism spectrum disorder Theory of mind Mentalizing network Sex differences Medial prefrontal cortex Temporo-parietal junction Superior temporal sulcus Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders / Irina MANOUILENKO in Research in Autism Spectrum Disorders, 7-5 (May 2013)
[article]
Titre : Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Article en page(s) : p.566-578 Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578[article] Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - p.566-578.
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578
Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194