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Résultat de la recherche
7 recherche sur le mot-clé 'Thalamus'




Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder / Heng CHEN in Autism Research, 9-11 (November 2016)
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Titre : Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Youxue ZHANG, Auteur ; Xujun DUAN, Auteur ; Huafu CHEN, Auteur Article en page(s) : p.1183-1190 Langues : Anglais (eng) Mots-clés : autism spectrum disorder thalamus brain development granger causality analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by atypical connectivity within and across multiple brain systems. We aimed to explore information transmission from the sensory periphery to information processing centers of the brain across thalamo-cortical circuits in ASD. A large multicenter dataset from the autism brain imaging data exchange was utilized. A thalamus template derived from the Automatic Anatomic Labeling atlas was subdivided into six subregions corresponding to six cortical regions using a “winner-takes-all” strategy. Granger causality analysis (GCA) was then applied to calculate effective connectivity from subregions of the thalamus to the corresponding cortical regions. Results demonstrate reduced effective connectivity from the thalamus to left prefrontal cortex (P?=?0.023), right posterior parietal cortex (P?=?0.03), and bilateral temporal cortex (left: P?=?0.014; right: P?=?0.015) in ASD compared with healthy control (HC) participants. The GCA values of the thalamus-bilateral temporal cortex connections were significantly negatively correlated with communication scores as assessed by the autism diagnostic observation schedule in the ASD group (left: P?=?0.037; right: P?=?0.007). Age-related analyses showed that the strengths of the thalamus-bilateral temporal cortex connections were significantly positively correlated with age in the HC group (left: P?=?0.013; right: P?=?0.016), but not in the ASD group (left: P?=?0.506; right: P?=?0.219). These results demonstrate impaired thalamo-cortical information transmission in ASD and suggest that atypical development of thalamus-temporal cortex connections may relate to communication deficits in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297
in Autism Research > 9-11 (November 2016) . - p.1183-1190[article] Atypical effective connectivity of thalamo-cortical circuits in autism spectrum disorder [Texte imprimé et/ou numérique] / Heng CHEN, Auteur ; Lucina Q. UDDIN, Auteur ; Youxue ZHANG, Auteur ; Xujun DUAN, Auteur ; Huafu CHEN, Auteur . - p.1183-1190.
Langues : Anglais (eng)
in Autism Research > 9-11 (November 2016) . - p.1183-1190
Mots-clés : autism spectrum disorder thalamus brain development granger causality analysis Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is a neurodevelopment disorder characterized by atypical connectivity within and across multiple brain systems. We aimed to explore information transmission from the sensory periphery to information processing centers of the brain across thalamo-cortical circuits in ASD. A large multicenter dataset from the autism brain imaging data exchange was utilized. A thalamus template derived from the Automatic Anatomic Labeling atlas was subdivided into six subregions corresponding to six cortical regions using a “winner-takes-all” strategy. Granger causality analysis (GCA) was then applied to calculate effective connectivity from subregions of the thalamus to the corresponding cortical regions. Results demonstrate reduced effective connectivity from the thalamus to left prefrontal cortex (P?=?0.023), right posterior parietal cortex (P?=?0.03), and bilateral temporal cortex (left: P?=?0.014; right: P?=?0.015) in ASD compared with healthy control (HC) participants. The GCA values of the thalamus-bilateral temporal cortex connections were significantly negatively correlated with communication scores as assessed by the autism diagnostic observation schedule in the ASD group (left: P?=?0.037; right: P?=?0.007). Age-related analyses showed that the strengths of the thalamus-bilateral temporal cortex connections were significantly positively correlated with age in the HC group (left: P?=?0.013; right: P?=?0.016), but not in the ASD group (left: P?=?0.506; right: P?=?0.219). These results demonstrate impaired thalamo-cortical information transmission in ASD and suggest that atypical development of thalamus-temporal cortex connections may relate to communication deficits in the disorder. En ligne : http://dx.doi.org/10.1002/aur.1614 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=297 Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders / Irina MANOUILENKO in Research in Autism Spectrum Disorders, 7-5 (May 2013)
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Titre : Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur Article en page(s) : p.566-578 Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578[article] Autistic traits, ADHD symptoms, neurological soft signs and regional cerebral blood flow in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Irina MANOUILENKO, Auteur ; Marco PAGANI, Auteur ; Sharon STONE-ELANDER, Auteur ; Richard ODH, Auteur ; Fredrik BROLIN, Auteur ; Robert HATHERLY, Auteur ; Hans JACOBSSON, Auteur ; Stig A. LARSSON, Auteur ; Susanne BEJEROT, Auteur . - p.566-578.
in Research in Autism Spectrum Disorders > 7-5 (May 2013) . - p.566-578
Mots-clés : Autism spectrum disorder ADHD Neurological soft signs Temporo-parietal junction Thalamus Caudate Index. décimale : PER Périodiques Résumé : The resting regional cerebral blood flow (rCBF) patterns related to co-occurring symptoms such as inattention, hyperactivity, neurological soft signs and motor problems have not yet been disclosed in autism spectrum disorders (ASD). In this study thirteen adults with ASD and ten matched neurotypical controls underwent PET. The scores of rating scales for autistic traits, attention deficit hyperactivity disorder (ADHD) and neurological soft signs were included in a factorial analysis and correlated with rCBF. Factors corresponding to “autistic/ADHD traits”, “sensory-motor integration” and “Intelligence/Motor sequencing” were identified. In the ASD group, positive correlations with CBF were found for “autistic/ADHD traits” in caudate bilaterally and the inferior parietal lobule, for “sensory-motor integration” in parieto-occipital cortex and for “Intelligence/Motor sequencing” in the right temporal cortex. Notably, CBF in the left thalamus correlated negatively with all three factors. Autistic traits and ADHD symptoms were associated with shared neural substrates. The correlation between “autistic/ADHD traits” and rCBF in the caudate is possibly associated with the executive impairments and ritualistic/stereotyped behaviors apparent in ASD. Furthermore, sensory-motor deficits were correlated with rCBF in the occipital visual cortex, involved in atypical visual perception in ASD. Various behavioral and neurological symptoms are suggested to converge into the ASD phenotype. En ligne : http://dx.doi.org/10.1016/j.rasd.2012.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=194 Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder / K. MCLAUGHLIN in Autism Research, 11-3 (March 2018)
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Titre : Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : K. MCLAUGHLIN, Auteur ; B. G. TRAVERS, Auteur ; O. I. DADALKO, Auteur ; D. C. DEAN, Auteur ; D. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; A. FREEMAN, Auteur ; M. D. PRIGGE, Auteur ; A. FROEHLICH, Auteur ; T. C. DUFFIELD, Auteur ; B. A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; N. LANGE, Auteur ; Jeffrey S. ANDERSON, Auteur ; A. L. ALEXANDER, Auteur ; J. E. LAINHART, Auteur Article en page(s) : p.450-462 Langues : Anglais (eng) Mots-clés : autism spectrum disorder diffusion magnetic resonance imaging internal capsule thalamus white matter Index. décimale : PER Périodiques Résumé : The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal). Our results showed that the group with ASD exhibited different developmental trajectories of microstructure in all regions, demonstrating childhood group differences that appeared to approach and, in some cases, surpass the typically developing group in adolescence and adulthood. The PLIC (but not ALIC nor thalamus) mediated the relation between age and finger-tapping speed in both groups. Yet, the gap in finger-tapping speed appeared to widen at the same time that the between-group gap in the PLIC appeared to narrow. Overall, these results suggest that childhood group differences in microstructure of the thalamus and PLIC become less robust in adolescence and adulthood. Further, finger-tapping speed appears to be mediated by the PLIC in both groups, but group differences in motor speed that widen during adolescence and adulthood suggest that factors beyond the microstructure of the thalamus and internal capsule may contribute to atypical motor profiles in ASD. Autism Res 2018, 11: 450-462. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Microstructure of the thalamus, a key sensory and motor brain area, appears to develop differently in individuals with autism spectrum disorder (ASD). Microstructure is important because it informs us of the density and organization of different brain tissues. During childhood, thalamic microstructure was distinct in the ASD group compared to the typically developing group. However, these group differences appeared to narrow with age, suggesting that the thalamus continues to dynamically change in ASD into adulthood. En ligne : http://dx.doi.org/10.1002/aur.1909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352
in Autism Research > 11-3 (March 2018) . - p.450-462[article] Longitudinal development of thalamic and internal capsule microstructure in autism spectrum disorder [Texte imprimé et/ou numérique] / K. MCLAUGHLIN, Auteur ; B. G. TRAVERS, Auteur ; O. I. DADALKO, Auteur ; D. C. DEAN, Auteur ; D. TROMP, Auteur ; Nagesh ADLURU, Auteur ; Dan DESTICHE, Auteur ; A. FREEMAN, Auteur ; M. D. PRIGGE, Auteur ; A. FROEHLICH, Auteur ; T. C. DUFFIELD, Auteur ; B. A. ZIELINSKI, Auteur ; Erin D. BIGLER, Auteur ; N. LANGE, Auteur ; Jeffrey S. ANDERSON, Auteur ; A. L. ALEXANDER, Auteur ; J. E. LAINHART, Auteur . - p.450-462.
Langues : Anglais (eng)
in Autism Research > 11-3 (March 2018) . - p.450-462
Mots-clés : autism spectrum disorder diffusion magnetic resonance imaging internal capsule thalamus white matter Index. décimale : PER Périodiques Résumé : The thalamus is a key sensorimotor relay area that is implicated in autism spectrum disorder (ASD). However, it is unknown how the thalamus and white-matter structures that contain thalamo-cortical fiber connections (e.g., the internal capsule) develop from childhood into adulthood and whether this microstructure relates to basic motor challenges in ASD. We used diffusion weighted imaging in a cohort-sequential design to assess longitudinal development of the thalamus, and posterior- and anterior-limbs of the internal capsule (PLIC and ALIC, respectively) in 89 males with ASD and 56 males with typical development (3-41 years; all verbal). Our results showed that the group with ASD exhibited different developmental trajectories of microstructure in all regions, demonstrating childhood group differences that appeared to approach and, in some cases, surpass the typically developing group in adolescence and adulthood. The PLIC (but not ALIC nor thalamus) mediated the relation between age and finger-tapping speed in both groups. Yet, the gap in finger-tapping speed appeared to widen at the same time that the between-group gap in the PLIC appeared to narrow. Overall, these results suggest that childhood group differences in microstructure of the thalamus and PLIC become less robust in adolescence and adulthood. Further, finger-tapping speed appears to be mediated by the PLIC in both groups, but group differences in motor speed that widen during adolescence and adulthood suggest that factors beyond the microstructure of the thalamus and internal capsule may contribute to atypical motor profiles in ASD. Autism Res 2018, 11: 450-462. (c) 2017 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Microstructure of the thalamus, a key sensory and motor brain area, appears to develop differently in individuals with autism spectrum disorder (ASD). Microstructure is important because it informs us of the density and organization of different brain tissues. During childhood, thalamic microstructure was distinct in the ASD group compared to the typically developing group. However, these group differences appeared to narrow with age, suggesting that the thalamus continues to dynamically change in ASD into adulthood. En ligne : http://dx.doi.org/10.1002/aur.1909 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=352 Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD / Shulamite A. GREEN in Autism Research, 10-5 (May 2017)
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Titre : Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD Type de document : Texte imprimé et/ou numérique Auteurs : Shulamite A. GREEN, Auteur ; Leanna HERNANDEZ, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur Article en page(s) : p.801-809 Langues : Anglais (eng) Mots-clés : sensory over responsivity thalamus amygdala functional connectivity fMRI Index. décimale : PER Périodiques Résumé : Recent evidence for abnormal thalamic connectivity in autism spectrum disorders (ASD) and sensory processing disorders suggests the thalamus may play a role in sensory over-responsivity (SOR), an extreme negative response to sensory stimuli, which is common in ASD. However, there is yet little understanding of changes in thalamic connectivity during exposure to aversive sensory inputs in individuals with ASD. In particular, the pulvinar nucleus of the thalamus is implicated in atypical sensory processing given its role in selective attention, regulation, and sensory integration. This study aimed to examine the role of pulvinar connectivity in ASD during mildly aversive sensory input. Functional magnetic resonance imaging was used to examine connectivity with the pulvinar during exposure to mildly aversive auditory and tactile stimuli in 38 youth (age 9–17; 19 ASD, 19 IQ-matched typically developing (TD)). Parents rated children's SOR severity on two standard scales. Compared to TD, ASD participants displayed aberrant modulation of connectivity between pulvinar and cortex (including sensory-motor and prefrontal regions) during sensory stimulation. In ASD participants, pulvinar-amygdala connectivity was correlated with severity of SOR symptoms. Deficits in modulation of thalamocortical connectivity in youth with ASD may reflect reduced thalamo-cortical inhibition in response to sensory stimulation, which could lead to difficulty filtering out and/or integrating sensory information. An increase in amygdala connectivity with the pulvinar might be partially responsible for deficits in selective attention as the amygdala signals the brain to attend to distracting sensory stimuli. En ligne : http://dx.doi.org/10.1002/aur.1726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307
in Autism Research > 10-5 (May 2017) . - p.801-809[article] Reduced modulation of thalamocortical connectivity during exposure to sensory stimuli in ASD [Texte imprimé et/ou numérique] / Shulamite A. GREEN, Auteur ; Leanna HERNANDEZ, Auteur ; Susan Y. BOOKHEIMER, Auteur ; Mirella DAPRETTO, Auteur . - p.801-809.
Langues : Anglais (eng)
in Autism Research > 10-5 (May 2017) . - p.801-809
Mots-clés : sensory over responsivity thalamus amygdala functional connectivity fMRI Index. décimale : PER Périodiques Résumé : Recent evidence for abnormal thalamic connectivity in autism spectrum disorders (ASD) and sensory processing disorders suggests the thalamus may play a role in sensory over-responsivity (SOR), an extreme negative response to sensory stimuli, which is common in ASD. However, there is yet little understanding of changes in thalamic connectivity during exposure to aversive sensory inputs in individuals with ASD. In particular, the pulvinar nucleus of the thalamus is implicated in atypical sensory processing given its role in selective attention, regulation, and sensory integration. This study aimed to examine the role of pulvinar connectivity in ASD during mildly aversive sensory input. Functional magnetic resonance imaging was used to examine connectivity with the pulvinar during exposure to mildly aversive auditory and tactile stimuli in 38 youth (age 9–17; 19 ASD, 19 IQ-matched typically developing (TD)). Parents rated children's SOR severity on two standard scales. Compared to TD, ASD participants displayed aberrant modulation of connectivity between pulvinar and cortex (including sensory-motor and prefrontal regions) during sensory stimulation. In ASD participants, pulvinar-amygdala connectivity was correlated with severity of SOR symptoms. Deficits in modulation of thalamocortical connectivity in youth with ASD may reflect reduced thalamo-cortical inhibition in response to sensory stimulation, which could lead to difficulty filtering out and/or integrating sensory information. An increase in amygdala connectivity with the pulvinar might be partially responsible for deficits in selective attention as the amygdala signals the brain to attend to distracting sensory stimuli. En ligne : http://dx.doi.org/10.1002/aur.1726 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=307 Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume / J. Christopher EDGAR in Journal of Autism and Developmental Disorders, 45-3 (March 2015)
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Titre : Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume Type de document : Texte imprimé et/ou numérique Auteurs : J. Christopher EDGAR, Auteur ; Kory HEIKEN, Auteur ; Yu-Han CHEN, Auteur ; John D. HERRINGTON, Auteur ; Vivian CHOW, Auteur ; Song LIU, Auteur ; Luke BLOY, Auteur ; Mingxiong HUANG, Auteur ; Juhi PANDEY, Auteur ; Katelyn M. CANNON, Auteur ; Saba QASMIEH, Auteur ; Susan E. LEVY, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P L. ROBERTS, Auteur Article en page(s) : p.795-804 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder Alpha Resting-state Magnetoencephalography Thalamus Index. décimale : PER Périodiques Résumé : Alpha circuits (8–12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas—with increased alpha thought to reflect greater inhibition—might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2236-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258
in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.795-804[article] Resting-State Alpha in Autism Spectrum Disorder and Alpha Associations with Thalamic Volume [Texte imprimé et/ou numérique] / J. Christopher EDGAR, Auteur ; Kory HEIKEN, Auteur ; Yu-Han CHEN, Auteur ; John D. HERRINGTON, Auteur ; Vivian CHOW, Auteur ; Song LIU, Auteur ; Luke BLOY, Auteur ; Mingxiong HUANG, Auteur ; Juhi PANDEY, Auteur ; Katelyn M. CANNON, Auteur ; Saba QASMIEH, Auteur ; Susan E. LEVY, Auteur ; Robert T. SCHULTZ, Auteur ; Timothy P L. ROBERTS, Auteur . - p.795-804.
Langues : Anglais (eng)
in Journal of Autism and Developmental Disorders > 45-3 (March 2015) . - p.795-804
Mots-clés : Autism spectrum disorder Alpha Resting-state Magnetoencephalography Thalamus Index. décimale : PER Périodiques Résumé : Alpha circuits (8–12 Hz), necessary for basic and complex brain processes, are abnormal in autism spectrum disorder (ASD). The present study obtained estimates of resting-state (RS) alpha activity in children with ASD and examined associations between alpha activity, age, and clinical symptoms. Given that the thalamus modulates cortical RS alpha rhythms, associations between thalamic structure and alpha activity were examined. RS magnetoencephalography was obtained from 47 typically-developing children (TDC) and 41 children with ASD. RS alpha activity was measured using distributed source localization. Left and right thalamic volume measurements were also obtained. In both groups, the strongest alpha activity was observed in Calcarine Sulcus regions. In Calcarine regions, only TDC showed the expected association between age and alpha peak frequency. ASD had more alpha activity than TDC in regions bordering the Central Sulcus as well as parietal association cortices. In ASD, whereas greater left Central Sulcus relative alpha activity was associated with higher Social Responsiveness Scale (SRS) scores, greater Calcarine region relative alpha activity was associated with lower SRS scores. Although thalamic volume group differences were not observed, relationships between thalamic volume and Calcarine alpha power were unique to TDC. The present study also identified a failure to shift peak alpha frequency as a function of age in primary alpha-generating areas in children with ASD. Findings suggested that increased RS alpha activity in primary motor and somatosensory as well as parietal multimodal areas—with increased alpha thought to reflect greater inhibition—might impair the ability to identify or interpret social cues. Finally, to our knowledge, this is the first study to report associations between thalamic volume and alpha power, an association observed only in TDC. The lack of thalamic and alpha associations in ASD suggests thalamic contributions to RS alpha abnormalities in ASD. En ligne : http://dx.doi.org/10.1007/s10803-014-2236-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 Causal effects of psychostimulants on neural connectivity: a mechanistic, randomized clinical trial / Yun WANG in Journal of Child Psychology and Psychiatry, 63-11 (November 2022)
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PermalinkPrenatal exposure to hypoxic risk conditions in autistic and neurotypical youth: Associated ventricular differences, sleep disturbance, and sensory processing / Cristian PRECIADO in Autism Research, 17-12 (December 2024)
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