Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents / Oksana Yu NAUMOVA in Development and Psychopathology, 24-1 (January 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-1 (January 2012) . - p.143-155 Titre : Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents Type de document : Texte imprimé et/ou numérique Auteurs : Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur Année de publication : 2012 Article en page(s) : p.143-155 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Differential patterns of whole-genome DNA methylation in institutionalized children and children raised by their biological parents [Texte imprimé et/ou numérique] / Oksana Yu NAUMOVA, Auteur ; Maria LEE, Auteur ; Roman A. KOPOSOV, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur ; Elena L. GRIGORENKO, Auteur . - 2012 . - p.143-155. Langues : Anglais (eng) in Development and Psychopathology > 24-1 (January 2012) . - p.143-155 Index. décimale : PER Périodiques Résumé : Previous studies with nonhuman species have shown that animals exposed to early adversity show differential DNA methylation relative to comparison animals. The current study examined differential methylation among 14 children raised since birth in institutional care and 14 comparison children raised by their biological parents. Blood samples were taken from children in middle childhood. Analysis of whole-genome methylation patterns was performed using the Infinium HumanMethylation27 BeadChip assay (Illumina), which contains 27,578 CpG sites, covering approximately 14,000 gene promoters. Group differences were registered, which were characterized primarily by greater methylation in the institutionalized group relative to the comparison group, with most of these differences in genes involved in the control of immune response and cellular signaling systems, including a number of crucial players important for neural communication and brain development and functioning. The findings suggest that patterns of differential methylation seen in nonhuman species with altered maternal care are also characteristic of children who experience early maternal separation. En ligne : http://dx.doi.org/10.1017/S0954579411000605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151

Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation / Renaud MASSART in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272 Titre : Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation Type de document : Texte imprimé et/ou numérique Auteurs : Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur Article en page(s) : p.1259-1272 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] Early life adversity alters normal sex-dependent developmental dynamics of DNA methylation [Texte imprimé et/ou numérique] / Renaud MASSART, Auteur ; Zsofia NEMODA, Auteur ; Matthew J. SUDERMAN, Auteur ; Sheila SUTTI, Auteur ; Angela M. RUGGIERO, Auteur ; Amanda M. DETTMER, Auteur ; Stephen J. SUOMI, Auteur ; Moshe SZYF, Auteur . - p.1259-1272. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1259-1272 Index. décimale : PER Périodiques Résumé : Studies in rodents, nonhuman primates, and humans suggest that epigenetic processes mediate between early life experiences and adult phenotype. However, the normal evolution of epigenetic programs during child development, the effect of sex, and the impact of early life adversity on these trajectories are not well understood. This study mapped the genome-wide DNA methylation changes in CD3+ T lymphocytes from rhesus monkeys from postnatal day 14 through 2 years of age in both males and females and determined the impact of maternal deprivation on the DNA methylation profile. We show here that DNA methylation profiles evolve from birth to adolescence and are sex dependent. DNA methylation changes accompany imposed weaning, attenuating the difference between males and females. Maternal separation at birth alters the normal evolution of DNA methylation profiles and targets genes that are also affected by a later stage maternal separation, that is, weaning. Our results suggest that early life events dynamically interfere with the normal developmental evolution of the DNA methylation profile and that these changes are highly effected by sex. En ligne : http://dx.doi.org/10.1017/s0954579416000833 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children / Julie R. HOYE in Development and Psychopathology, 32-4 (October 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-4 (October 2020) . - p.1486-1494 Titre : Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children Type de document : Texte imprimé et/ou numérique Auteurs : Julie R. HOYE, Auteur ; David CHEISHVILI, Auteur ; Heather A. YARGER, Auteur ; Tania L. ROTH, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur Article en page(s) : p.1486-1494 Langues : Anglais (eng) Mots-clés : DNA methylation  epigenetics  intervention  maltreatment  parenting Index. décimale : PER Périodiques Résumé : Maltreatment during development is associated with epigenetic changes to the genome. Enhancing caregiving may mitigate these effects. Attachment and Biobehavioral Catch-Up (ABC) is an intervention that has been shown to improve parent-child relationships and a variety of biological and behavioral outcomes among children that are involved in Child Protective Services. This preliminary study, using a small sample size, explored whether children who received ABC exhibit different methylation patterns than those who received a control intervention. The participants included 23 children aged 6-21 months who were randomized to receive ABC (n = 12) or a control intervention (n = 11). While the children displayed similar methylation patterns preintervention, DNA methylation varied between the ABC and control groups at 14,828 sites postintervention. Functional pathway analyses indicated that these differences were associated with gene pathways that are involved in cell signaling, metabolism, and neuronal development. This study is one of the first to explore parenting intervention effects on children's DNA methylation at the whole genome level in infancy. These preliminary findings provide a basis for hypothesis generation in further research with larger-scale studies regarding the malleability of epigenetic states that are associated with maltreatment. En ligne : http://dx.doi.org/10.1017/s0954579419001421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433 [article] Preliminary indications that the Attachment and Biobehavioral Catch-up Intervention alters DNA methylation in maltreated children [Texte imprimé et/ou numérique] / Julie R. HOYE, Auteur ; David CHEISHVILI, Auteur ; Heather A. YARGER, Auteur ; Tania L. ROTH, Auteur ; Moshe SZYF, Auteur ; Mary DOZIER, Auteur . - p.1486-1494. Langues : Anglais (eng) in Development and Psychopathology > 32-4 (October 2020) . - p.1486-1494 Mots-clés : DNA methylation  epigenetics  intervention  maltreatment  parenting Index. décimale : PER Périodiques Résumé : Maltreatment during development is associated with epigenetic changes to the genome. Enhancing caregiving may mitigate these effects. Attachment and Biobehavioral Catch-Up (ABC) is an intervention that has been shown to improve parent-child relationships and a variety of biological and behavioral outcomes among children that are involved in Child Protective Services. This preliminary study, using a small sample size, explored whether children who received ABC exhibit different methylation patterns than those who received a control intervention. The participants included 23 children aged 6-21 months who were randomized to receive ABC (n = 12) or a control intervention (n = 11). While the children displayed similar methylation patterns preintervention, DNA methylation varied between the ABC and control groups at 14,828 sites postintervention. Functional pathway analyses indicated that these differences were associated with gene pathways that are involved in cell signaling, metabolism, and neuronal development. This study is one of the first to explore parenting intervention effects on children's DNA methylation at the whole genome level in infancy. These preliminary findings provide a basis for hypothesis generation in further research with larger-scale studies regarding the malleability of epigenetic states that are associated with maltreatment. En ligne : http://dx.doi.org/10.1017/s0954579419001421 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=433

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