Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis / Manfred LAUCHT in Journal of Child Psychology and Psychiatry, 53-4 (April 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359 Titre : Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis Type de document : Texte imprimé et/ou numérique Auteurs : Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur Année de publication : 2012 Article en page(s) : p.351-359 Langues : Anglais (eng) Mots-clés : Catechol-O-methyltransferase gene  alcohol use  adolescentsparenting  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background:  Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods:  Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results:  Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions:  The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis [Texte imprimé et/ou numérique] / Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur . - 2012 . - p.351-359. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359 Mots-clés : Catechol-O-methyltransferase gene  alcohol use  adolescentsparenting  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background:  Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods:  Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results:  Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions:  The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene / Katrin ZOHSEL in Journal of Child Psychology and Psychiatry, 55-1 (January 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.69-76 Titre : Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene Type de document : Texte imprimé et/ou numérique Auteurs : Katrin ZOHSEL, Auteur ; Arlette F. BUCHMANN, Auteur ; Dorothea BLOMEYER, Auteur ; Erika HOHM, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Daniel BRANDEIS, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur Article en page(s) : p.69-76 Langues : Anglais (eng) Mots-clés : Prenatal stress  antisocial  conduct disorder  DRD4  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background Maternal distress during pregnancy has been linked to aggressive behavior in offspring. This effect has been interpreted in terms of ‘fetal programming’. The 7-repeat (7r) allele of a VNTR polymorphism in exon III of the human dopamine receptor D4 (DRD4) has consistently been associated with externalizing behavior problems, especially in the presence of adverse environmental factors. So far, it is not known whether the DRD4 genotype moderates the effect of prenatal maternal stress on the development of childhood antisocial behavior. Methods As part of an ongoing epidemiological cohort study, prenatal maternal stress was assessed using self-report 3 months following child birth. When children were 8, 11, and 15 years old, mothers rated their children's externalizing behavior, and diagnoses of conduct disorder and/or oppositional defiant disorder (CD/ODD) according to DSM-IV were obtained. In a sample of N = 308 participants, the effects of the DRD4 genotype, prenatal maternal stress, and the interaction thereof on antisocial outcome were tested. Results Under conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. Conclusions This study is the first to report a gene–environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene [Texte imprimé et/ou numérique] / Katrin ZOHSEL, Auteur ; Arlette F. BUCHMANN, Auteur ; Dorothea BLOMEYER, Auteur ; Erika HOHM, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Daniel BRANDEIS, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur . - p.69-76. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.69-76 Mots-clés : Prenatal stress  antisocial  conduct disorder  DRD4  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background Maternal distress during pregnancy has been linked to aggressive behavior in offspring. This effect has been interpreted in terms of ‘fetal programming’. The 7-repeat (7r) allele of a VNTR polymorphism in exon III of the human dopamine receptor D4 (DRD4) has consistently been associated with externalizing behavior problems, especially in the presence of adverse environmental factors. So far, it is not known whether the DRD4 genotype moderates the effect of prenatal maternal stress on the development of childhood antisocial behavior. Methods As part of an ongoing epidemiological cohort study, prenatal maternal stress was assessed using self-report 3 months following child birth. When children were 8, 11, and 15 years old, mothers rated their children's externalizing behavior, and diagnoses of conduct disorder and/or oppositional defiant disorder (CD/ODD) according to DSM-IV were obtained. In a sample of N = 308 participants, the effects of the DRD4 genotype, prenatal maternal stress, and the interaction thereof on antisocial outcome were tested. Results Under conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. Conclusions This study is the first to report a gene–environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

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