Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis / Manfred LAUCHT in Journal of Child Psychology and Psychiatry, 53-4 (April 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359 Titre : Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis Type de document : Texte imprimé et/ou numérique Auteurs : Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur Année de publication : 2012 Article en page(s) : p.351-359 Langues : Anglais (eng) Mots-clés : Catechol-O-methyltransferase gene  alcohol use  adolescentsparenting  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background:  Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods:  Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results:  Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions:  The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152 [article] Catechol-O-methyltransferase Val158Met genotype, parenting practices and adolescent alcohol use: testing the differential susceptibility hypothesis [Texte imprimé et/ou numérique] / Manfred LAUCHT, Auteur ; Dorothea BLOMEYER, Auteur ; Arlette F. BUCHMANN, Auteur ; Jens TREUTLEIN, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Christine JENNEN-STEINMETZ, Auteur ; Marcella RIETSCHEL, Auteur ; Ulrich S. ZIMMERMANN, Auteur ; Tobias BANASCHEWSKI, Auteur . - 2012 . - p.351-359. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-4 (April 2012) . - p.351-359 Mots-clés : Catechol-O-methyltransferase gene  alcohol use  adolescentsparenting  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background:  Recently, first evidence has been reported for a gene–parenting interaction (G × E) with regard to adolescent alcohol use. The present investigation set out to extend this research using the catechol-O-methyltransferase (COMT) Val158Met polymorphism as a genetic susceptibility factor. Moreover, the current study examined whether a potential G×E would be consistent with one of two models of gene–environment interplay (genetic vulnerability vs. differential susceptibility). Methods:  Data were collected as part of an ongoing epidemiological cohort study following the outcome of early risk factors from birth into adulthood. Two hundred and eighty-five participants (130 males, 155 females) were genotyped for the COMT Val158Met polymorphism and were administered an alcohol interview, providing measures of current frequency and amount of drinking at ages 15 and 19 years. Information on three dimensions of perceived parenting behavior was obtained from the 15-year-olds. Results:  Adolescents homozygous for the Met allele showed higher drinking activity at age 19 years when their parents had engaged in less supervision or were less involved, while their drinking activity was reduced under conditions of favorable parenting. No such relationship was found in individuals carrying the Val allele. Conclusions:  The present findings correspond with the pattern of results predicted by the differential susceptibility hypothesis, suggesting that environmental variation would have a greater impact in individuals carrying a genetic susceptibility such that, in this group, exposure to negative environmental conditions would result in more adverse outcomes and the experience of favorable conditions would lead to more positive outcomes. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02408.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=152

Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene / Katrin ZOHSEL in Journal of Child Psychology and Psychiatry, 55-1 (January 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.69-76 Titre : Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene Type de document : Texte imprimé et/ou numérique Auteurs : Katrin ZOHSEL, Auteur ; Arlette F. BUCHMANN, Auteur ; Dorothea BLOMEYER, Auteur ; Erika HOHM, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Daniel BRANDEIS, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur Article en page(s) : p.69-76 Langues : Anglais (eng) Mots-clés : Prenatal stress  antisocial  conduct disorder  DRD4  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background Maternal distress during pregnancy has been linked to aggressive behavior in offspring. This effect has been interpreted in terms of ‘fetal programming’. The 7-repeat (7r) allele of a VNTR polymorphism in exon III of the human dopamine receptor D4 (DRD4) has consistently been associated with externalizing behavior problems, especially in the presence of adverse environmental factors. So far, it is not known whether the DRD4 genotype moderates the effect of prenatal maternal stress on the development of childhood antisocial behavior. Methods As part of an ongoing epidemiological cohort study, prenatal maternal stress was assessed using self-report 3 months following child birth. When children were 8, 11, and 15 years old, mothers rated their children's externalizing behavior, and diagnoses of conduct disorder and/or oppositional defiant disorder (CD/ODD) according to DSM-IV were obtained. In a sample of N = 308 participants, the effects of the DRD4 genotype, prenatal maternal stress, and the interaction thereof on antisocial outcome were tested. Results Under conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. Conclusions This study is the first to report a gene–environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220 [article] Mothers' prenatal stress and their children's antisocial outcomes – a moderating role for the Dopamine D4 Receptor (DRD4) gene [Texte imprimé et/ou numérique] / Katrin ZOHSEL, Auteur ; Arlette F. BUCHMANN, Auteur ; Dorothea BLOMEYER, Auteur ; Erika HOHM, Auteur ; Martin H. SCHMIDT, Auteur ; Günter ESSER, Auteur ; Daniel BRANDEIS, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur . - p.69-76. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-1 (January 2014) . - p.69-76 Mots-clés : Prenatal stress  antisocial  conduct disorder  DRD4  gene–environment interaction Index. décimale : PER Périodiques Résumé : Background Maternal distress during pregnancy has been linked to aggressive behavior in offspring. This effect has been interpreted in terms of ‘fetal programming’. The 7-repeat (7r) allele of a VNTR polymorphism in exon III of the human dopamine receptor D4 (DRD4) has consistently been associated with externalizing behavior problems, especially in the presence of adverse environmental factors. So far, it is not known whether the DRD4 genotype moderates the effect of prenatal maternal stress on the development of childhood antisocial behavior. Methods As part of an ongoing epidemiological cohort study, prenatal maternal stress was assessed using self-report 3 months following child birth. When children were 8, 11, and 15 years old, mothers rated their children's externalizing behavior, and diagnoses of conduct disorder and/or oppositional defiant disorder (CD/ODD) according to DSM-IV were obtained. In a sample of N = 308 participants, the effects of the DRD4 genotype, prenatal maternal stress, and the interaction thereof on antisocial outcome were tested. Results Under conditions of elevated prenatal maternal stress, children carrying one or two DRD4 7r alleles were at increased risk of a diagnosis of CD/ODD. Moreover, homozygous carriers of the DRD4 7r allele displayed more externalizing behavior following exposure to higher levels of prenatal maternal stress, while homozygous carriers of the DRD4 4r allele turned out to be insensitive to the effects of prenatal stress. Conclusions This study is the first to report a gene–environment interaction related to DRD4 and prenatal maternal stress using data from a prospective study, which extends earlier findings on the impact of prenatal maternal stress with respect to childhood antisocial behavior. En ligne : http://dx.doi.org/10.1111/jcpp.12138 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=220

The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis / Martin HOLTMANN in Journal of Child Psychology and Psychiatry, 52-2 (February 2011)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147 Titre : The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis Type de document : Texte imprimé et/ou numérique Auteurs : Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur Année de publication : 2011 Article en page(s) : p.139-147 Langues : Anglais (eng) Mots-clés : Dysregulation  childhood  comorbidity  longitudinal  irritability  depression  ADHD  substance use  suicidality  CBCL  bipolar Index. décimale : PER Périodiques Résumé : Background:  Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods:  We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results:  Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions:  Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115 [article] The Child Behavior Checklist-Dysregulation Profile predicts substance use, suicidality, and functional impairment: a longitudinal analysis [Texte imprimé et/ou numérique] / Martin HOLTMANN, Auteur ; Arlette F. BUCHMANN, Auteur ; Guenter ESSER, Auteur ; Martin H. SCHMIDT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Manfred LAUCHT, Auteur . - 2011 . - p.139-147. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 52-2 (February 2011) . - p.139-147 Mots-clés : Dysregulation  childhood  comorbidity  longitudinal  irritability  depression  ADHD  substance use  suicidality  CBCL  bipolar Index. décimale : PER Périodiques Résumé : Background:  Recent studies have identified a Child Behavior Checklist profile that characterizes children with severe affective and behavioral dysregulation (CBCL-dysregulation profile, CBCL-DP). In two recent longitudinal studies the CBCL-DP in childhood was associated with heightened rates of comorbid psychiatric disorders, among them bipolar disorder, an increased risk for suicidality, and marked psychosocial impairment at young-adult follow-up. This is the first study outside the US that examines the longitudinal course of the CBCL-DP. Methods:  We studied the diagnostic and functional trajectories and the predictive utility of the CBCL-DP in the Mannheim Study of Children at Risk, an epidemiological cohort study on the outcome of early risk factors from birth into adulthood. A total of 325 young adults (151 males, 174 females) participated in the 19-year assessment. Results:  Young adults with a higher CBCL-DP score in childhood were at increased risk for substance use disorders, suicidality and poorer overall functioning at age 19, even after adjustment for parental education, family income, impairment and psychiatric disorders at baseline. Childhood dysregulation was not related to bipolar disorder in young adulthood. The CBCL-DP was neither a precursor of a specific pattern of comorbidity nor of comorbidity in general. Conclusions:  Children with high CBCL-DP values are at risk for later severe, psychiatric symptomatology. The different developmental trajectories suggest that the CBCL-DP is not simply an early manifestation of a single disease process but might rather be an early developmental risk marker of a persisting deficit of self-regulation of affect and behavior. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2010.02309.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=115

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