Latent class analysis of early developmental trajectory in baby siblings of children with autism / Rebecca LANDA in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96 Titre : Latent class analysis of early developmental trajectory in baby siblings of children with autism Type de document : texte imprimé Auteurs : Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur Année de publication : 2012 Article en page(s) : p.986-96 Langues : Anglais (eng) Mots-clés : Autism  trajectories  broader autism phenotype Index. décimale : PER Périodiques Résumé : Background:  Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods:  Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results:  A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions:  Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Latent class analysis of early developmental trajectory in baby siblings of children with autism [texte imprimé] / Rebecca LANDA, Auteur ; Alden L. GROSS, Auteur ; Elizabeth A. STUART, Auteur ; Margaret L. BAUMAN, Auteur . - 2012 . - p.986-96. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.986-96 Mots-clés : Autism  trajectories  broader autism phenotype Index. décimale : PER Périodiques Résumé : Background:  Siblings of children with autism (sibs-A) are at increased genetic risk for autism spectrum disorders (ASD) and milder impairments. To elucidate diversity and contour of early developmental trajectories exhibited by sibs-A, regardless of diagnostic classification, latent class modeling was used. Methods:  Sibs-A (N = 204) were assessed with the Mullen Scales of Early Learning from age 6 to 36 months. Mullen T scores served as dependent variables. Outcome classifications at age 36 months included: ASD (N = 52); non-ASD social/communication delay (broader autism phenotype; BAP; N = 31); and unaffected (N = 121). Child-specific patterns of performance were studied using latent class growth analysis. Latent class membership was then related to diagnostic outcome through estimation of within-class proportions of children assigned to each diagnostic classification. Results:  A 4-class model was favored. Class 1 represented accelerated development and consisted of 25.7% of the sample, primarily unaffected children. Class 2 (40.0% of the sample), was characterized by normative development with above-average nonverbal cognitive outcome. Class 3 (22.3% of the sample) was characterized by receptive language, and gross and fine motor delay. Class 4 (12.0% of the sample), was characterized by widespread delayed skill acquisition, reflected by declining trajectories. Children with an outcome diagnosis of ASD were spread across Classes 2, 3, and 4. Conclusions:  Results support a category of ASD that involves slowing in early non-social development. Receptive language and motor development is vulnerable to early delay in sibs-A with and without ASD outcomes. Non-ASD sibs-A are largely distributed across classes depicting average or accelerated development. Developmental trajectories of motor, language, and cognition appear independent of communication and social delays in non-ASD sibs-A. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02558.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants / Marianna PURGATO in Journal of Child Psychology and Psychiatry, 61-5 (May 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.584-593 Titre : Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants Type de document : texte imprimé Auteurs : Marianna PURGATO, Auteur ; Federico TEDESCHI, Auteur ; Theresa S. BETANCOURT, Auteur ; Paul BOLTON, Auteur ; Chiara BONETTO, Auteur ; Chiara GASTALDON, Auteur ; James GORDON, Auteur ; Paul O'CALLAGHAN, Auteur ; Davide PAPOLA, Auteur ; Kirsi PELTONEN, Auteur ; Raija-Leena PUNAMAKI, Auteur ; Justin RICHARDS, Auteur ; Julie K. STAPLES, Auteur ; Johanna UNTERHITZENBERGER, Auteur ; Joop DE JONG, Auteur ; Mark J.D. JORDANS, Auteur ; Alden L. GROSS, Auteur ; Wietse A. TOL, Auteur ; Corrado BARBUI, Auteur Article en page(s) : p.584-593 Langues : Anglais (eng) Mots-clés : Mediation analysis  children  humanitarian setting  individual participant data  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on psychosocial interventions has been focused on the effectiveness of psychosocial interventions on mental health outcomes, without exploring how interventions achieve beneficial effects. Identifying the potential pathways through which interventions work would potentially allow further strengthening of interventions by emphasizing specific components connected with such pathways. METHODS: We conducted a preplanned mediation analysis using individual participant data from a dataset of 11 randomized controlled trials (RCTs) which compared focused psychosocial support interventions versus control conditions for children living in low- and middle-income countries (LMICs) affected by humanitarian crises. Based on an ecological resilience framework, we hypothesized that (a) coping, (b) hope, (c) social support, and (d) functional impairment mediate the relationship between intervention and outcome PTSD symptoms. A systematic search on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, PyscARTICLES, Web of Science, and the main local LMICs databases was conducted up to August 2018. The hypotheses were tested by using individual participant data obtained from study authors of all the studies included in the systematic review. RESULTS: We included 3,143 children from 11 studies (100% of data from included studies), of which 1,877 from six studies contributed to the mediation analysis. Functional impairment was the strongest mediator for focused psychosocial interventions on PTSD (mediation coefficient -0.087, standard error 0.040). The estimated proportion of effect mediated by functional impairment, and adjusted for confounders, was 31%. CONCLUSIONS: Findings did not support the proposed mediation hypotheses for coping, hope, and social support. The mediation through functional impairment may represent unmeasured proxy measures or point to a broader mechanism that impacts self-efficacy and agency. En ligne : http://dx.doi.org/10.1111/jcpp.13151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422 [article] Mediators of focused psychosocial support interventions for children in low-resource humanitarian settings: analysis from an Individual Participant Dataset with 3,143 participants [texte imprimé] / Marianna PURGATO, Auteur ; Federico TEDESCHI, Auteur ; Theresa S. BETANCOURT, Auteur ; Paul BOLTON, Auteur ; Chiara BONETTO, Auteur ; Chiara GASTALDON, Auteur ; James GORDON, Auteur ; Paul O'CALLAGHAN, Auteur ; Davide PAPOLA, Auteur ; Kirsi PELTONEN, Auteur ; Raija-Leena PUNAMAKI, Auteur ; Justin RICHARDS, Auteur ; Julie K. STAPLES, Auteur ; Johanna UNTERHITZENBERGER, Auteur ; Joop DE JONG, Auteur ; Mark J.D. JORDANS, Auteur ; Alden L. GROSS, Auteur ; Wietse A. TOL, Auteur ; Corrado BARBUI, Auteur . - p.584-593. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-5 (May 2020) . - p.584-593 Mots-clés : Mediation analysis  children  humanitarian setting  individual participant data  trauma Index. décimale : PER Périodiques Résumé : BACKGROUND: Research on psychosocial interventions has been focused on the effectiveness of psychosocial interventions on mental health outcomes, without exploring how interventions achieve beneficial effects. Identifying the potential pathways through which interventions work would potentially allow further strengthening of interventions by emphasizing specific components connected with such pathways. METHODS: We conducted a preplanned mediation analysis using individual participant data from a dataset of 11 randomized controlled trials (RCTs) which compared focused psychosocial support interventions versus control conditions for children living in low- and middle-income countries (LMICs) affected by humanitarian crises. Based on an ecological resilience framework, we hypothesized that (a) coping, (b) hope, (c) social support, and (d) functional impairment mediate the relationship between intervention and outcome PTSD symptoms. A systematic search on the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, PubMed, PyscARTICLES, Web of Science, and the main local LMICs databases was conducted up to August 2018. The hypotheses were tested by using individual participant data obtained from study authors of all the studies included in the systematic review. RESULTS: We included 3,143 children from 11 studies (100% of data from included studies), of which 1,877 from six studies contributed to the mediation analysis. Functional impairment was the strongest mediator for focused psychosocial interventions on PTSD (mediation coefficient -0.087, standard error 0.040). The estimated proportion of effect mediated by functional impairment, and adjusted for confounders, was 31%. CONCLUSIONS: Findings did not support the proposed mediation hypotheses for coping, hope, and social support. The mediation through functional impairment may represent unmeasured proxy measures or point to a broader mechanism that impacts self-efficacy and agency. En ligne : http://dx.doi.org/10.1111/jcpp.13151 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=422

Psychometric characteristics of the mental health crisis assessment scale in youth with autism spectrum disorder / Luther G. KALB in Journal of Child Psychology and Psychiatry, 59-1 (January 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.48-56 Titre : Psychometric characteristics of the mental health crisis assessment scale in youth with autism spectrum disorder Type de document : texte imprimé Auteurs : Luther G. KALB, Auteur ; Louis P. HAGOPIAN, Auteur ; Alden L. GROSS, Auteur ; Roma A. VASA, Auteur Article en page(s) : p.48-56 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  challenging behavior  mental health  psychometrics  rating scales Index. décimale : PER Périodiques Résumé : Background Youth with autism spectrum disorder (ASD) exhibit high rates of psychopathology. These symptoms can pose a risk of injury to self or others when the child is in crisis. Despite this danger, there are no instruments available to identify those with ASD who are at risk or actively in crisis. This study examined the psychometric properties of the Mental Health Crisis Assessment Scale (MCAS), a 28 item parent report measure. Methods The MCAS was administered to the parents of 606 children and young adults (aged 3–25 years, M age = 13 years, SD = 5 years) enrolled in the Interactive Autism Network, an online registry of families raising a child with ASD. The MCAS asks parents to rate the severity of various emotional and behavioral symptoms exhibited by their child. The parent then selects the behavior they perceive as the most dangerous behavior and rates the acuity of as well as their efficacy in managing this behavior. The MCAS was tested for internal consistency, construct validity, criterion validity, and convergent validity. Results The MCAS demonstrated strong internal consistency (Total Scale Cronbach's α = .88). The exploratory and confirmatory factor analyses suggested that a two factor (acuity and behavioral efficacy) model fit the data well, providing evidence of construct validity. Criterion validity, which was assessed by comparing the MCAS to clinician determination of crisis, indicated high levels of agreement (ROC = .85). Strong positive relationships emerged between the MCAS and measures of family distress (r = .56), parental stress, and frustration (r = .48), and use of emergency psychiatric services (OR = 24.2, 95% CI: 8.6–68.2), indicating convergent validity of the measure (all p < .05). Conclusions Results of the psychometric analyses suggest the MCAS appears to be a promising tool that can measure mental health crises in youth with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327 [article] Psychometric characteristics of the mental health crisis assessment scale in youth with autism spectrum disorder [texte imprimé] / Luther G. KALB, Auteur ; Louis P. HAGOPIAN, Auteur ; Alden L. GROSS, Auteur ; Roma A. VASA, Auteur . - p.48-56. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-1 (January 2018) . - p.48-56 Mots-clés : Autism spectrum disorders  challenging behavior  mental health  psychometrics  rating scales Index. décimale : PER Périodiques Résumé : Background Youth with autism spectrum disorder (ASD) exhibit high rates of psychopathology. These symptoms can pose a risk of injury to self or others when the child is in crisis. Despite this danger, there are no instruments available to identify those with ASD who are at risk or actively in crisis. This study examined the psychometric properties of the Mental Health Crisis Assessment Scale (MCAS), a 28 item parent report measure. Methods The MCAS was administered to the parents of 606 children and young adults (aged 3–25 years, M age = 13 years, SD = 5 years) enrolled in the Interactive Autism Network, an online registry of families raising a child with ASD. The MCAS asks parents to rate the severity of various emotional and behavioral symptoms exhibited by their child. The parent then selects the behavior they perceive as the most dangerous behavior and rates the acuity of as well as their efficacy in managing this behavior. The MCAS was tested for internal consistency, construct validity, criterion validity, and convergent validity. Results The MCAS demonstrated strong internal consistency (Total Scale Cronbach's α = .88). The exploratory and confirmatory factor analyses suggested that a two factor (acuity and behavioral efficacy) model fit the data well, providing evidence of construct validity. Criterion validity, which was assessed by comparing the MCAS to clinician determination of crisis, indicated high levels of agreement (ROC = .85). Strong positive relationships emerged between the MCAS and measures of family distress (r = .56), parental stress, and frustration (r = .48), and use of emergency psychiatric services (OR = 24.2, 95% CI: 8.6–68.2), indicating convergent validity of the measure (all p < .05). Conclusions Results of the psychometric analyses suggest the MCAS appears to be a promising tool that can measure mental health crises in youth with ASD. En ligne : http://dx.doi.org/10.1111/jcpp.12748 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=327

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