Assessing phenotypic and polygenic models of ADHD to identify mechanisms of risk for longitudinal trajectories of externalizing behaviors / James J. LI in Journal of Child Psychology and Psychiatry, 60-11 (November 2019)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1191-1199 Titre : Assessing phenotypic and polygenic models of ADHD to identify mechanisms of risk for longitudinal trajectories of externalizing behaviors Type de document : texte imprimé Auteurs : James J. LI, Auteur Article en page(s) : p.1191-1199 Langues : Anglais (eng) Mots-clés : Adhd  antisocial behavior  longitudinal studies  mediation  molecular genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with ADHD frequently engage in higher rates of externalizing behaviors in adulthood relative to children without. However, externalizing behaviors vary across development. Little is known about how this risk unfolds across development. Phenotypic and polygenic models of childhood ADHD were used to predict individual differences in adult externalizing trajectories. Supportive parenting, school connectedness, and peer closeness were then examined as causal mechanisms. METHODS: Data were from the National Longitudinal Study of Adolescent to Adult Health (N = 7,674). Externalizing behavior was measured using data from age 18 to 32 and modeled using latent class growth analysis. Child ADHD was measured using retrospective self-report (phenotypic model) and genome-wide polygenic risk scores (polygenic model). Multiple mediation models examined the direct and indirect effects of the phenotypic and polygenic models (separately) on externalizing trajectories through the effects of adolescent supportive parenting, school connectedness, and peer closeness. RESULTS: Phenotypic and polygenic models of ADHD were associated with being in the High Decreasing (3.2% of sample) and Moderate (16.1%) adult externalizing trajectories, but not the severe Low Increasing trajectory (2.6%), relative to the Normal trajectory (78.2%). Associations between both models of ADHD on the High Decreasing and Moderate trajectories were partially mediated through the effects of school connectedness, but not supportive parenting or peer closeness. CONCLUSIONS: Findings shed light on how childhood ADHD affects downstream psychosocial processes that then predict specific externalizing outcomes in adulthood. They also reinforce the importance of fostering a strong school environment for adolescents with (and without) ADHD, as this context plays a critical role in shaping the development of externalizing behaviors in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408 [article] Assessing phenotypic and polygenic models of ADHD to identify mechanisms of risk for longitudinal trajectories of externalizing behaviors [texte imprimé] / James J. LI, Auteur . - p.1191-1199. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 60-11 (November 2019) . - p.1191-1199 Mots-clés : Adhd  antisocial behavior  longitudinal studies  mediation  molecular genetics Index. décimale : PER Périodiques Résumé : BACKGROUND: Children with ADHD frequently engage in higher rates of externalizing behaviors in adulthood relative to children without. However, externalizing behaviors vary across development. Little is known about how this risk unfolds across development. Phenotypic and polygenic models of childhood ADHD were used to predict individual differences in adult externalizing trajectories. Supportive parenting, school connectedness, and peer closeness were then examined as causal mechanisms. METHODS: Data were from the National Longitudinal Study of Adolescent to Adult Health (N = 7,674). Externalizing behavior was measured using data from age 18 to 32 and modeled using latent class growth analysis. Child ADHD was measured using retrospective self-report (phenotypic model) and genome-wide polygenic risk scores (polygenic model). Multiple mediation models examined the direct and indirect effects of the phenotypic and polygenic models (separately) on externalizing trajectories through the effects of adolescent supportive parenting, school connectedness, and peer closeness. RESULTS: Phenotypic and polygenic models of ADHD were associated with being in the High Decreasing (3.2% of sample) and Moderate (16.1%) adult externalizing trajectories, but not the severe Low Increasing trajectory (2.6%), relative to the Normal trajectory (78.2%). Associations between both models of ADHD on the High Decreasing and Moderate trajectories were partially mediated through the effects of school connectedness, but not supportive parenting or peer closeness. CONCLUSIONS: Findings shed light on how childhood ADHD affects downstream psychosocial processes that then predict specific externalizing outcomes in adulthood. They also reinforce the importance of fostering a strong school environment for adolescents with (and without) ADHD, as this context plays a critical role in shaping the development of externalizing behaviors in adulthood. En ligne : http://dx.doi.org/10.1111/jcpp.13071 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=408

Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors / James J. LI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Titre : Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors Type de document : texte imprimé Auteurs : James J. LI, Auteur Article en page(s) : p.1947-1967 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors [texte imprimé] / James J. LI, Auteur . - p.1947-1967. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Associations of polygenic scores and developmental trajectories of externalizing behaviors / A. Brooke SASIA in Development and Psychopathology, 37-5 (December 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-5 (December 2025) . - p.2356-2370 Titre : Associations of polygenic scores and developmental trajectories of externalizing behaviors Type de document : texte imprimé Auteurs : A. Brooke SASIA, Auteur ; Katherine G. JONAS, Auteur ; Monika A. WASZCZUK, Auteur ; James J. LI, Auteur Article en page(s) : p.2356-2370 Langues : Anglais (eng) Mots-clés : antisocial behaviors  development  externalizing  polygenic scores  substance use Index. décimale : PER Périodiques Résumé : Polygenic scores (PGSs) have garnered increasing attention in the clinical sciences due to their robust prediction signals for psychopathology, including externalizing (EXT) behaviors. However, studies leveraging PGSs have rarely accounted for the phenotypic and developmental heterogeneity in EXT outcomes. We used the National Longitudinal Study of Adolescent to Adult Health (analytic N = 4,416), spanning ages 13 to 41, to examine associations between EXT PGSs and trajectories of antisocial behaviors (ASB) and substance use behaviors (SUB) identified via growth mixture modeling. Four trajectories of ASB were identified: High Decline (3.6% of the sample), Moderate (18.9%), Adolescence-Peaked (10.6%), and Low (67%), while three were identified for SUB: High Use (35.2%), Typical Use (41.7%), and Low Use (23%). EXT PGSs were consistently associated with persistent trajectories of ASB and SUB (High Decline and High Use, respectively), relative to comparison groups. EXT PGSs were also associated with the Low Use trajectory of SUB, relative to the comparison group. Results suggest PGSs may be sensitive to developmental typologies of EXT, where PGSs are more strongly predictive of chronicity in addition to (or possibly rather than) absolute severity. En ligne : https://dx.doi.org/10.1017/S0954579424001962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572 [article] Associations of polygenic scores and developmental trajectories of externalizing behaviors [texte imprimé] / A. Brooke SASIA, Auteur ; Katherine G. JONAS, Auteur ; Monika A. WASZCZUK, Auteur ; James J. LI, Auteur . - p.2356-2370. Langues : Anglais (eng) in Development and Psychopathology > 37-5 (December 2025) . - p.2356-2370 Mots-clés : antisocial behaviors  development  externalizing  polygenic scores  substance use Index. décimale : PER Périodiques Résumé : Polygenic scores (PGSs) have garnered increasing attention in the clinical sciences due to their robust prediction signals for psychopathology, including externalizing (EXT) behaviors. However, studies leveraging PGSs have rarely accounted for the phenotypic and developmental heterogeneity in EXT outcomes. We used the National Longitudinal Study of Adolescent to Adult Health (analytic N = 4,416), spanning ages 13 to 41, to examine associations between EXT PGSs and trajectories of antisocial behaviors (ASB) and substance use behaviors (SUB) identified via growth mixture modeling. Four trajectories of ASB were identified: High Decline (3.6% of the sample), Moderate (18.9%), Adolescence-Peaked (10.6%), and Low (67%), while three were identified for SUB: High Use (35.2%), Typical Use (41.7%), and Low Use (23%). EXT PGSs were consistently associated with persistent trajectories of ASB and SUB (High Decline and High Use, respectively), relative to comparison groups. EXT PGSs were also associated with the Low Use trajectory of SUB, relative to the comparison group. Results suggest PGSs may be sensitive to developmental typologies of EXT, where PGSs are more strongly predictive of chronicity in addition to (or possibly rather than) absolute severity. En ligne : https://dx.doi.org/10.1017/S0954579424001962 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=572

Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD / Kelly R. BARRY ; Elizabeth DENNIS ; Ryan DONNELLY ; Celina HUERTA ; Andrez JONES ; Kate SCHMIDT ; Sabrina KABAKOV ; Karla K. AUSDERAU ; James J. LI ; Brittany G. TRAVERS in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2784-2785 Titre : Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD Type de document : texte imprimé Auteurs : Kelly R. BARRY, Auteur ; Elizabeth DENNIS, Auteur ; Ryan DONNELLY, Auteur ; Celina HUERTA, Auteur ; Andrez JONES, Auteur ; Kate SCHMIDT, Auteur ; Sabrina KABAKOV, Auteur ; Karla K. AUSDERAU, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : p.2784-2785 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06394-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD [texte imprimé] / Kelly R. BARRY, Auteur ; Elizabeth DENNIS, Auteur ; Ryan DONNELLY, Auteur ; Celina HUERTA, Auteur ; Andrez JONES, Auteur ; Kate SCHMIDT, Auteur ; Sabrina KABAKOV, Auteur ; Karla K. AUSDERAU, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur . - p.2784-2785. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2784-2785 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06394-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression / James J. LI in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.991-1003 Titre : Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression Type de document : texte imprimé Auteurs : James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur Article en page(s) : p.991-1003 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression [texte imprimé] / James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur . - p.991-1003. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.991-1003 Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Enhancing the discriminatory power of polygenic scores for ADHD and autism in clinical and non-clinical samples / James J. LI in Journal of Neurodevelopmental Disorders, 17 (2025)  

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Factorial invariance in hierarchical factor models of mental disorders in African American and European American youths / Quanfa HE in Journal of Child Psychology and Psychiatry, 62-3 (March 2021)  

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Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis / James J. LI in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

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Neurogenetic mechanisms of risk for ADHD: Examining associations of polygenic scores and brain volumes in a population cohort / Quanfa HE in Journal of Neurodevelopmental Disorders, 15 (2023)  

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A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories / Kate WALSH ; James J. LI in Development and Psychopathology, 36-2 (May 2024)  

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Quality of Life in Autistic Children: Discrepancies Between Self- and Caregiver-Proxy Reports and Associations With Individual Characteristics / Emily C. SKALETSKI in Autism Research, 18-10 (October 2025)  

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Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD / Emily C. SKALETSKI in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

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The influence of parents and schools on developmental trajectories of antisocial behaviors in Caucasian and African American youths / Ryann A. MORRISON in Development and Psychopathology, 31-4 (October 2019)  

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