Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors / James J. LI in Development and Psychopathology, 29-5 (December 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Titre : Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur Article en page(s) : p.1947-1967 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324 [article] Assessing the interplay between multigenic and environmental influences on adolescent to adult pathways of antisocial behaviors [Texte imprimé et/ou numérique] / James J. LI, Auteur . - p.1947-1967. Langues : Anglais (eng) in Development and Psychopathology > 29-5 (December 2017) . - p.1947-1967 Index. décimale : PER Périodiques Résumé : The current investigation utilized a developmental psychopathology approach to test the hypothesis that multigenic (i.e., dopaminergic and serotonergic genes) and multienvironmental factors interactively contribute to developmental pathways of antisocial behavior (ASB). A sample of 8,834 Caucasian individuals from the National Longitudinal Study of Adolescent to Adult Health (Add Health) were used to (a) examine the developmental pathways of ASB from age 13 to 32 using growth mixture modeling, (b) compute weighted multigenic risk scores (Add Health MRS) for ASB from six well-characterized polymorphisms in dopamine and serotonin genes, and (c) test the interaction between the Add Health MRS and a measures of support (incorporating indicators of both positive and negative support from parents and schools). Four pathways of adolescent to adult ASB emerged from the growth mixture models: low, adolescence-peaked, high decline, and persistent. Add Health MRS predicted the persistent ASB pathway, but not other ASB pathways. Males with high Add Health MRS, but not low MRS, had significantly greater odds of being in the adolescence-peaked pathway relative to the low pathway at low levels of school connectedness. Nonfamilial environmental influences during adolescence may have a cumulative impact on the development of ASB, particularly among males with greater underlying genetic risks. En ligne : http://dx.doi.org/10.1017/S0954579417001511 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=324

Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD / Kelly BARRY ; Elizabeth DENNIS ; Ryan DONNELLY ; Celina HUERTA ; Andrez JONES ; Kate SCHMIDT ; Sabrina KABAKOV ; Karla K. AUSDERAU ; James J. LI ; Brittany G. TRAVERS in Journal of Autism and Developmental Disorders, 54-7 (July 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2784-2785 Titre : Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD Type de document : Texte imprimé et/ou numérique Auteurs : Kelly BARRY, Auteur ; Elizabeth DENNIS, Auteur ; Ryan DONNELLY, Auteur ; Celina HUERTA, Auteur ; Andrez JONES, Auteur ; Kate SCHMIDT, Auteur ; Sabrina KABAKOV, Auteur ; Karla K. AUSDERAU, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur Article en page(s) : p.2784-2785 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06394-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533 [article] Correction: Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD [Texte imprimé et/ou numérique] / Kelly BARRY, Auteur ; Elizabeth DENNIS, Auteur ; Ryan DONNELLY, Auteur ; Celina HUERTA, Auteur ; Andrez JONES, Auteur ; Kate SCHMIDT, Auteur ; Sabrina KABAKOV, Auteur ; Karla K. AUSDERAU, Auteur ; James J. LI, Auteur ; Brittany G. TRAVERS, Auteur . - p.2784-2785. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 54-7 (July 2024) . - p.2784-2785 Index. décimale : PER Périodiques En ligne : https://doi.org/10.1007/s10803-024-06394-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=533

Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression / James J. LI in Development and Psychopathology, 25-4 (November 2013)  

Public ISBD [article]  inDevelopment and Psychopathology > 25-4 (November 2013) . - p.991-1003 Titre : Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur Article en page(s) : p.991-1003 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219 [article] Differential susceptibility in longitudinal models of gene–environment interaction for adolescent depression [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Michele S. BERK, Auteur ; Steve S. LEE, Auteur . - p.991-1003. Langues : Anglais (eng) in Development and Psychopathology > 25-4 (November 2013) . - p.991-1003 Index. décimale : PER Périodiques Résumé : Although family support reliably predicts the development of adolescent depression and suicidal behaviors, relatively little is known about the interplay of family support with potential genetic factors. We tested the association of the 44 base pair polymorphism in the serotonin transporter linked promoter region gene (5-HTTLPR), family support (i.e., cohesion, communication, and warmth), and their interaction with self-reported depression symptoms and risk for suicide in 1,030 Caucasian adolescents and young adults from the National Longitudinal Study of Adolescent Health. High-quality family support predicted fewer symptoms of depression and reduced risk for suicidality. There was also a significant interaction between 5-HTTLPR and family support for boys and a marginally significant interaction for girls. Among boys with poor family support, youth with at least one short allele had more symptoms of depression and a higher risk for suicide attempts relative to boys homozygous for the long allele. However, in the presence of high family support, boys with the short allele had the fewest depression symptoms (but not suicide attempts). Results suggest that the short allele may increase reactivity to both negative and positive family influences in the development of depression. We discuss the potential role of interactive exchanges between family support and offspring genotype in the development of adolescent depression and suicidal behaviors. En ligne : http://dx.doi.org/10.1017/S0954579413000321 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=219

Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis / James J. LI in Journal of Child Psychology and Psychiatry, 53-9 (September 2012)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005 Titre : Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis Type de document : Texte imprimé et/ou numérique Auteurs : James J. LI, Auteur ; Steve S. LEE, Auteur Année de publication : 2012 Article en page(s) : p.997-1005 Langues : Anglais (eng) Mots-clés : ADHD  latent class analysis  gene-environment interaction  DAT1  maltreatment Index. décimale : PER Périodiques Résumé : Background:  Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method:  We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results:  In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions:  The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179 [article] Interaction of dopamine transporter (DAT1) genotype and maltreatment for ADHD: a latent class analysis [Texte imprimé et/ou numérique] / James J. LI, Auteur ; Steve S. LEE, Auteur . - 2012 . - p.997-1005. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 53-9 (September 2012) . - p.997-1005 Mots-clés : ADHD  latent class analysis  gene-environment interaction  DAT1  maltreatment Index. décimale : PER Périodiques Résumé : Background:  Although the association of the dopamine transporter (DAT1) gene and attention-deficit/hyperactivity disorder (ADHD) has been widely studied, far less is known about its potential interaction with environmental risk factors. Given that maltreatment is a replicated risk factor for ADHD, we explored the interaction between DAT1 and maltreatment with ADHD symptoms defined dimensionally and using latent class analysis (LCA). Method:  We tested the association of the 40 base-pair variable number of tandem repeats polymorphism in DAT1, maltreatment, and their interaction in 2,488 boys and girls from the National Longitudinal Study of Adolescent Health. Results:  In boys, ADHD symptoms were optimally defined by four classes (Combined, Hyperactive/Impulsive, Inattentive, and Normal), whereas in girls, ADHD symptoms were defined by three classes (Combined, Combined-Mild, Normal). A significant DAT1 × maltreatment interaction revealed that maltreated girls homozygous for the 10-repeat allele had more symptoms of ADHD, and were also 2.5 times more likely to be classified in the Combined ADHD group than in the Normal Group. Conclusions:  The underlying structure of ADHD symptoms differed between boys and girls and DAT1 interacted with maltreatment to predict ADHD symptoms and ADHD status derived from LCA. Interactive exchanges between maltreatment and DAT1 for ADHD symptoms, and their implications for intervention, are discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02563.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=179

A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories / Kate WALSH ; James J. LI in Development and Psychopathology, 36-2 (May 2024)  

Public ISBD [article]  inDevelopment and Psychopathology > 36-2 (May 2024) . - p.750-764 Titre : A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories Type de document : Texte imprimé et/ou numérique Auteurs : Kate WALSH, Auteur ; James J. LI, Auteur Article en page(s) : p.750-764 Langues : Anglais (eng) Mots-clés : add health  depression  growth mixture modeling  maltreatment  resilience Index. décimale : PER Périodiques Résumé : The majority of children with maltreatment histories do not go on to develop depression in their adolescent and adult years. These individuals are often identified as being "resilient", but this characterization may conceal difficulties that individuals with maltreatment histories might face in their interpersonal relationships, substance use, physical health, and/or socioeconomic outcomes in their later lives. This study examined how adolescents with maltreatment histories who exhibit low levels of depression function in other domains during their adult years. Longitudinal trajectories of depression (across ages 13-32) in individuals with (n = 3,809) and without (n = 8,249) maltreatment histories were modeled in the National Longitudinal Study of Adolescent to Adult Health. The same "Low," "increasing," and "declining" depression trajectories in both individuals with and without maltreatment histories were identified. Youths with maltreatment histories in the "low" depression trajectory reported lower romantic relationship satisfaction, more exposure to intimate partner and sexual violence, more alcohol abuse/dependency, and poorer general physical health compared to individuals without maltreatment histories in the same "low" depression trajectory in adulthood. Findings add further caution against labeling individuals as "resilient" based on a just single domain of functioning (low depression), as childhood maltreatment has harmful effects on a broad spectrum of functional domains. En ligne : https://dx.doi.org/10.1017/S0954579423000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528 [article] A prospective longitudinal study of multidomain resilience among youths with and without maltreatment histories [Texte imprimé et/ou numérique] / Kate WALSH, Auteur ; James J. LI, Auteur . - p.750-764. Langues : Anglais (eng) in Development and Psychopathology > 36-2 (May 2024) . - p.750-764 Mots-clés : add health  depression  growth mixture modeling  maltreatment  resilience Index. décimale : PER Périodiques Résumé : The majority of children with maltreatment histories do not go on to develop depression in their adolescent and adult years. These individuals are often identified as being "resilient", but this characterization may conceal difficulties that individuals with maltreatment histories might face in their interpersonal relationships, substance use, physical health, and/or socioeconomic outcomes in their later lives. This study examined how adolescents with maltreatment histories who exhibit low levels of depression function in other domains during their adult years. Longitudinal trajectories of depression (across ages 13-32) in individuals with (n = 3,809) and without (n = 8,249) maltreatment histories were modeled in the National Longitudinal Study of Adolescent to Adult Health. The same "Low," "increasing," and "declining" depression trajectories in both individuals with and without maltreatment histories were identified. Youths with maltreatment histories in the "low" depression trajectory reported lower romantic relationship satisfaction, more exposure to intimate partner and sexual violence, more alcohol abuse/dependency, and poorer general physical health compared to individuals without maltreatment histories in the same "low" depression trajectory in adulthood. Findings add further caution against labeling individuals as "resilient" based on a just single domain of functioning (low depression), as childhood maltreatment has harmful effects on a broad spectrum of functional domains. En ligne : https://dx.doi.org/10.1017/S0954579423000032 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=528

Sensorimotor Features and Daily Living Skills in Autistic Children With and Without ADHD / Emily C. SKALETSKI in Journal of Autism and Developmental Disorders, 55-3 (March 2025)  

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