Brief Report: Impaired Differentiation of Vegetative/Affective and Intentional Nonverbal Vocalizations in a Subject with Asperger Syndrome (AS) / Susanne DIETRICH in Journal of Autism and Developmental Disorders, 42-10 (October 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2219-2224 Titre : Brief Report: Impaired Differentiation of Vegetative/Affective and Intentional Nonverbal Vocalizations in a Subject with Asperger Syndrome (AS) Type de document : Texte imprimé et/ou numérique Auteurs : Susanne DIETRICH, Auteur ; Ingo HERTRICH, Auteur ; Andreas RIEDEL, Auteur ; Hermann ACKERMANN, Auteur Année de publication : 2012 Article en page(s) : p.2219-2224 Langues : Anglais (eng) Mots-clés : Theory of mind  Affective system  Nonverbal vocalization Index. décimale : PER Périodiques Résumé : The Asperger syndrome (AS) includes impaired recognition of other people’s mental states. Since language-based diagnostic procedures may be confounded by cognitive-linguistic compensation strategies, nonverbal test materials were created, including human affective and vegetative sounds. Depending on video context, each sound could be interpreted either as direct expression of an agent’s affective/vegetative state or as result of intentional-executive mental operations. “Situational relevance” and “intentionality” ratings by a group of twelve healthy subjects nicely differentiated between context types. By contrast, an AS subject showed a systematic overinterpretation of vegetative/affective signals in terms of planned activities. Such overestimation of intentional motivation, leading to impaired social cognition, might be due to the inability to utilize “affective resonance” mechanisms for the interpretation of an individual’s internal state. En ligne : http://dx.doi.org/10.1007/s10803-012-1455-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180 [article] Brief Report: Impaired Differentiation of Vegetative/Affective and Intentional Nonverbal Vocalizations in a Subject with Asperger Syndrome (AS) [Texte imprimé et/ou numérique] / Susanne DIETRICH, Auteur ; Ingo HERTRICH, Auteur ; Andreas RIEDEL, Auteur ; Hermann ACKERMANN, Auteur . - 2012 . - p.2219-2224. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-10 (October 2012) . - p.2219-2224 Mots-clés : Theory of mind  Affective system  Nonverbal vocalization Index. décimale : PER Périodiques Résumé : The Asperger syndrome (AS) includes impaired recognition of other people’s mental states. Since language-based diagnostic procedures may be confounded by cognitive-linguistic compensation strategies, nonverbal test materials were created, including human affective and vegetative sounds. Depending on video context, each sound could be interpreted either as direct expression of an agent’s affective/vegetative state or as result of intentional-executive mental operations. “Situational relevance” and “intentionality” ratings by a group of twelve healthy subjects nicely differentiated between context types. By contrast, an AS subject showed a systematic overinterpretation of vegetative/affective signals in terms of planned activities. Such overestimation of intentional motivation, leading to impaired social cognition, might be due to the inability to utilize “affective resonance” mechanisms for the interpretation of an individual’s internal state. En ligne : http://dx.doi.org/10.1007/s10803-012-1455-6 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=180

Exploring autistic traits in adults with chronic depression: A clinical study / Martina RADTKE in Research in Autism Spectrum Disorders, 65 (September 2019)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 65 (September 2019) . - p.34-45 Titre : Exploring autistic traits in adults with chronic depression: A clinical study Type de document : Texte imprimé et/ou numérique Auteurs : Martina RADTKE, Auteur ; Denisa WIECZOREKOVA, Auteur ; Claus NORMANN, Auteur ; Pavel HUMPOLICEK, Auteur ; Eva-Lotta BRAKEMEIER, Auteur ; Emanuel BUBL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Andreas RIEDEL, Auteur Article en page(s) : p.34-45 Langues : Anglais (eng) Mots-clés : Autistic traits  Chronic depression  Broader autistic phenotype  Autism spectrum disorder  Autism spectrum quotient  Empathy quotient Index. décimale : PER Périodiques Résumé : Background Chronic depression is characterized by persistent or recurrent depressive symptoms, defined according to DSM criteria, and is associated with lack of empathy; deficits in social perception, interaction, and communication; and social withdrawal. These symptoms are reminiscent of autism spectrum disorders, yet the co-occurrence of autistic traits and chronic depression has been rarely explored. We explored measures of autistic traits in chronically depressed adult patients in order to further define and delineate the overlap of symptoms between chronic depression and autism spectrum disorders. Method Three groups were tested: 31 patients with chronic depression, 27 patients with autism spectrum disorder, and 31 healthy controls. The Autism Spectrum Quotient (AQ) and the Empathy Quotient (EQ) were used to measure autistic traits. The severity of depression was measured by Beck’s Depression Inventory. Results The group of chronically depressed patients showed significantly elevated autistic traits according to both AQ and EQ measures. In addition, 48.4% of the patients with chronic depression showed AQ scores within the range of the broader autistic phenotype. Similar scores were found among 3.2% of the healthy controls and 100% of the patients with autism spectrum disorder. Conclusions About half of the chronically depressed patients showed elevated autistic or autism-like traits. It remained unclear whether this was due to the state of chronic depression or a kind of premorbid autistic personality trait. The findings illustrate the need for further research to clarify the possible role of autistic traits in the development of chronic depression. Furthermore, they reveal that it might be clinically useful to focus on autism-like social impairments in therapy for chronic depression. En ligne : https://doi.org/10.1016/j.rasd.2019.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401 [article] Exploring autistic traits in adults with chronic depression: A clinical study [Texte imprimé et/ou numérique] / Martina RADTKE, Auteur ; Denisa WIECZOREKOVA, Auteur ; Claus NORMANN, Auteur ; Pavel HUMPOLICEK, Auteur ; Eva-Lotta BRAKEMEIER, Auteur ; Emanuel BUBL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur ; Andreas RIEDEL, Auteur . - p.34-45. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 65 (September 2019) . - p.34-45 Mots-clés : Autistic traits  Chronic depression  Broader autistic phenotype  Autism spectrum disorder  Autism spectrum quotient  Empathy quotient Index. décimale : PER Périodiques Résumé : Background Chronic depression is characterized by persistent or recurrent depressive symptoms, defined according to DSM criteria, and is associated with lack of empathy; deficits in social perception, interaction, and communication; and social withdrawal. These symptoms are reminiscent of autism spectrum disorders, yet the co-occurrence of autistic traits and chronic depression has been rarely explored. We explored measures of autistic traits in chronically depressed adult patients in order to further define and delineate the overlap of symptoms between chronic depression and autism spectrum disorders. Method Three groups were tested: 31 patients with chronic depression, 27 patients with autism spectrum disorder, and 31 healthy controls. The Autism Spectrum Quotient (AQ) and the Empathy Quotient (EQ) were used to measure autistic traits. The severity of depression was measured by Beck’s Depression Inventory. Results The group of chronically depressed patients showed significantly elevated autistic traits according to both AQ and EQ measures. In addition, 48.4% of the patients with chronic depression showed AQ scores within the range of the broader autistic phenotype. Similar scores were found among 3.2% of the healthy controls and 100% of the patients with autism spectrum disorder. Conclusions About half of the chronically depressed patients showed elevated autistic or autism-like traits. It remained unclear whether this was due to the state of chronic depression or a kind of premorbid autistic personality trait. The findings illustrate the need for further research to clarify the possible role of autistic traits in the development of chronic depression. Furthermore, they reveal that it might be clinically useful to focus on autism-like social impairments in therapy for chronic depression. En ligne : https://doi.org/10.1016/j.rasd.2019.04.006 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=401

Increased prefrontal GABA concentrations in adults with autism spectrum disorders / Simon MAIER in Autism Research, 15-7 (July 2022)  

Public ISBD [article]  inAutism Research > 15-7 (July 2022) . - p.1222-1236 Titre : Increased prefrontal GABA concentrations in adults with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Simon MAIER, Auteur ; Ansgard Lena DÜPPERS, Auteur ; Kimon RUNGE, Auteur ; Michael DACKO, Auteur ; Thomas LANGE, Auteur ; Thomas FANGMEIER, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Dominique ENDRES, Auteur ; Katharina DOMSCHKE, Auteur ; Evgeniy PERLOV, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur Article en page(s) : p.1222-1236 Langues : Anglais (eng) Mots-clés : Gaba  anterior cingulate cortex  autism spectrum disorder  dorsolateral prefrontal cortex  gamma-aminobutyric acid  glutamate Index. décimale : PER Périodiques Résumé : The excitatory-inhibitory imbalance hypothesis postulates dysregulation of the gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common underlying deficit in individuals with autism spectrum disorders (ASD). Previous studies suggest an important role of these systems in the pathophysiology of ASD, including a study of our group reporting decreased glutamate concentrations in the pregenual anterior cingulate cortex (ACC) of adults with ASD. The aim of this study was to replicate our previous findings of impaired glutamate metabolism in ASD in a new sample and to additionally quantify GABA in the ACC and dorsolateral prefrontal cortex (dlPFC). Concentrations of GABA and glutamate-glutamine (Glx; combined glutamate and glutamine signal) were quantified in the ACC and dlPFC of 43 adults with ASD and 43 neurotypical controls (NTC) by magnetic resonance spectroscopy (MRS). The ASD group showed increased absolute GABA concentrations and elevated GABA/creatine ratios in the left dlPFC compared to NTC, while no group differences were detected in the pregenual and dorsal ACC. Previous findings of altered Glx concentration in the pregenual ACC of the ASD group could not be replicated. Regarding Glx concentrations and Glx/creatine ratios, there were no significant differences in the dlPFC and ACC either. The study supports the hypothesis of an altered GABA and glutamate equilibrium, indicating an imbalance between excitatory and inhibitory metabolism in ASD patients. However, inconsistent results across studies and brain regions suggest a complex underlying phenomenon. LAY SUMMARY: Adults of the autism spectrum exhibit elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476 [article] Increased prefrontal GABA concentrations in adults with autism spectrum disorders [Texte imprimé et/ou numérique] / Simon MAIER, Auteur ; Ansgard Lena DÜPPERS, Auteur ; Kimon RUNGE, Auteur ; Michael DACKO, Auteur ; Thomas LANGE, Auteur ; Thomas FANGMEIER, Auteur ; Andreas RIEDEL, Auteur ; Dieter EBERT, Auteur ; Dominique ENDRES, Auteur ; Katharina DOMSCHKE, Auteur ; Evgeniy PERLOV, Auteur ; Kathrin NICKEL, Auteur ; Ludger TEBARTZ VAN ELST, Auteur . - p.1222-1236. Langues : Anglais (eng) in Autism Research > 15-7 (July 2022) . - p.1222-1236 Mots-clés : Gaba  anterior cingulate cortex  autism spectrum disorder  dorsolateral prefrontal cortex  gamma-aminobutyric acid  glutamate Index. décimale : PER Périodiques Résumé : The excitatory-inhibitory imbalance hypothesis postulates dysregulation of the gamma-aminobutyric acid (GABA) and glutamate (Glu) neurotransmitter systems as a common underlying deficit in individuals with autism spectrum disorders (ASD). Previous studies suggest an important role of these systems in the pathophysiology of ASD, including a study of our group reporting decreased glutamate concentrations in the pregenual anterior cingulate cortex (ACC) of adults with ASD. The aim of this study was to replicate our previous findings of impaired glutamate metabolism in ASD in a new sample and to additionally quantify GABA in the ACC and dorsolateral prefrontal cortex (dlPFC). Concentrations of GABA and glutamate-glutamine (Glx; combined glutamate and glutamine signal) were quantified in the ACC and dlPFC of 43 adults with ASD and 43 neurotypical controls (NTC) by magnetic resonance spectroscopy (MRS). The ASD group showed increased absolute GABA concentrations and elevated GABA/creatine ratios in the left dlPFC compared to NTC, while no group differences were detected in the pregenual and dorsal ACC. Previous findings of altered Glx concentration in the pregenual ACC of the ASD group could not be replicated. Regarding Glx concentrations and Glx/creatine ratios, there were no significant differences in the dlPFC and ACC either. The study supports the hypothesis of an altered GABA and glutamate equilibrium, indicating an imbalance between excitatory and inhibitory metabolism in ASD patients. However, inconsistent results across studies and brain regions suggest a complex underlying phenomenon. LAY SUMMARY: Adults of the autism spectrum exhibit elevated levels of the inhibitory neurotransmitter GABA in the left dorsolateral prefrontal cortex. This finding supports the hypothesis of an imbalance between excitatory and inhibitory equilibrium in patients with autism spectrum disorders. En ligne : http://dx.doi.org/10.1002/aur.2740 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=476

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