Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world / Scott I. VRIEZE in Development and Psychopathology, 24-4 (November 2012)  

Public ISBD [article]  inDevelopment and Psychopathology > 24-4 (November 2012) . - p.1195-1214 Titre : Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world Type de document : Texte imprimé et/ou numérique Auteurs : Scott I. VRIEZE, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur Année de publication : 2012 Article en page(s) : p.1195-1214 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : This article serves to outline a research paradigm to investigate main effects and interactions of genes, environment, and development on behavior and psychiatric illness. We provide a historical context for candidate gene studies and genome-wide association studies, including benefits, limitations, and expected payoffs. Using substance use and abuse as our driving example, we then turn to the importance of etiological psychological theory in guiding genetic, environmental, and developmental research, as well as the utility of refined phenotypic measures, such as endophenotypes, in the pursuit of etiological understanding and focused tests of genetic and environmental associations. Phenotypic measurement has received considerable attention in the history of psychology and is informed by psychometrics, whereas the environment remains relatively poorly measured and is often confounded with genetic effects (i.e., gene–environment correlation). Genetically informed designs, which are no longer limited to twin and adoption studies thanks to ever-cheaper genotyping, are required to understand environmental influences. Finally, we outline the vast amount of individual difference in structural genomic variation, most of which remains to be leveraged in genetic association tests. Although the genetic data can be massive and burdensome (tens of millions of variants per person), we argue that improved understanding of genomic structure and function will provide investigators with new tools to test specific a priori hypotheses derived from etiological psychological theory, much like current candidate gene research but with less confusion and more payoff than candidate gene research has to date. En ligne : http://dx.doi.org/10.1017/S0954579412000648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182 [article] Confluence of genes, environment, development, and behavior in a post Genome-Wide Association Study world [Texte imprimé et/ou numérique] / Scott I. VRIEZE, Auteur ; William G. IACONO, Auteur ; Matt MCGUE, Auteur . - 2012 . - p.1195-1214. Langues : Anglais (eng) in Development and Psychopathology > 24-4 (November 2012) . - p.1195-1214 Index. décimale : PER Périodiques Résumé : This article serves to outline a research paradigm to investigate main effects and interactions of genes, environment, and development on behavior and psychiatric illness. We provide a historical context for candidate gene studies and genome-wide association studies, including benefits, limitations, and expected payoffs. Using substance use and abuse as our driving example, we then turn to the importance of etiological psychological theory in guiding genetic, environmental, and developmental research, as well as the utility of refined phenotypic measures, such as endophenotypes, in the pursuit of etiological understanding and focused tests of genetic and environmental associations. Phenotypic measurement has received considerable attention in the history of psychology and is informed by psychometrics, whereas the environment remains relatively poorly measured and is often confounded with genetic effects (i.e., gene–environment correlation). Genetically informed designs, which are no longer limited to twin and adoption studies thanks to ever-cheaper genotyping, are required to understand environmental influences. Finally, we outline the vast amount of individual difference in structural genomic variation, most of which remains to be leveraged in genetic association tests. Although the genetic data can be massive and burdensome (tens of millions of variants per person), we argue that improved understanding of genomic structure and function will provide investigators with new tools to test specific a priori hypotheses derived from etiological psychological theory, much like current candidate gene research but with less confusion and more payoff than candidate gene research has to date. En ligne : http://dx.doi.org/10.1017/S0954579412000648 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=182

Why does perceived parenting in adolescence predict maladaptive personality in adulthood? Evidence for substantial genetic mediation / Kelsey A. HOBBS in Development and Psychopathology, 37-3 (August 2025)  

Public ISBD [article]  inDevelopment and Psychopathology > 37-3 (August 2025) . - p.1505-1514 Titre : Why does perceived parenting in adolescence predict maladaptive personality in adulthood? Evidence for substantial genetic mediation Type de document : Texte imprimé et/ou numérique Auteurs : Kelsey A. HOBBS, Auteur ; Sylia WILSON, Auteur ; Scott I. VRIEZE, Auteur ; Glenn I. ROISMAN, Auteur ; Matt MCGUE, Auteur ; Robert F. KRUEGER, Auteur Article en page(s) : p.1505-1514 Langues : Anglais (eng) Mots-clés : Genetics  maladaptive personality  parenting  personality disorders Index. décimale : PER Périodiques Résumé : Why is parenting in adolescence predictive of maladaptive personality in adulthood? This study sets out to investigate environmental and genetic factors underlying the association between parenting and maladaptive personality longitudinally in a large sample of twins. The present study addressed this question via a longitudinal study focused on two cohorts of twins assessed on aspects of perceived parenting (parent- and adolescent-reported) at age 14 years (n =1,094 pairs). Participants were followed to adulthood, and maladaptive personality traits were self-reported using the Personality Inventory for DSM-5 (PID-5) at age 24 or 34 years. We then modeled these data using a bivariate biometric model, decomposing parenting-maladaptive personality associations into additive genetic, shared environmental, and nonshared environmental factors. Numerous domains of adolescent-reported parenting predicted adult maladaptive personality. Further, we found evidence for substantial additive genetic (ra ranging from 0.22 to 0.55) and (to a lesser extent) nonshared environmental factors (re ranging from 0.10 to 0.15) that accounted for the association between perceived parenting reported in adolescence and adult personality. Perceived parenting in adolescence and maladaptive personality in adulthood may be related due to some of the same genetic factors contributing to both phenotypes at different developmental periods. En ligne : https://www.cambridge.org/core/product/338B7B3B07E5099616D4D728502AFA88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564 [article] Why does perceived parenting in adolescence predict maladaptive personality in adulthood? Evidence for substantial genetic mediation [Texte imprimé et/ou numérique] / Kelsey A. HOBBS, Auteur ; Sylia WILSON, Auteur ; Scott I. VRIEZE, Auteur ; Glenn I. ROISMAN, Auteur ; Matt MCGUE, Auteur ; Robert F. KRUEGER, Auteur . - p.1505-1514. Langues : Anglais (eng) in Development and Psychopathology > 37-3 (August 2025) . - p.1505-1514 Mots-clés : Genetics  maladaptive personality  parenting  personality disorders Index. décimale : PER Périodiques Résumé : Why is parenting in adolescence predictive of maladaptive personality in adulthood? This study sets out to investigate environmental and genetic factors underlying the association between parenting and maladaptive personality longitudinally in a large sample of twins. The present study addressed this question via a longitudinal study focused on two cohorts of twins assessed on aspects of perceived parenting (parent- and adolescent-reported) at age 14 years (n =1,094 pairs). Participants were followed to adulthood, and maladaptive personality traits were self-reported using the Personality Inventory for DSM-5 (PID-5) at age 24 or 34 years. We then modeled these data using a bivariate biometric model, decomposing parenting-maladaptive personality associations into additive genetic, shared environmental, and nonshared environmental factors. Numerous domains of adolescent-reported parenting predicted adult maladaptive personality. Further, we found evidence for substantial additive genetic (ra ranging from 0.22 to 0.55) and (to a lesser extent) nonshared environmental factors (re ranging from 0.10 to 0.15) that accounted for the association between perceived parenting reported in adolescence and adult personality. Perceived parenting in adolescence and maladaptive personality in adulthood may be related due to some of the same genetic factors contributing to both phenotypes at different developmental periods. En ligne : https://www.cambridge.org/core/product/338B7B3B07E5099616D4D728502AFA88 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=564

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