Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study / Akhgar GHASSABIAN in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104 Titre : Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : 96-104 Langues : Anglais (eng) Mots-clés : Brain  corpus callosum  executive function  Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 [article] Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study [Texte imprimé et/ou numérique] / Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - 96-104. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104 Mots-clés : Brain  corpus callosum  executive function  Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186

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