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Auteur Albert HOFMAN |
Documents disponibles écrits par cet auteur (6)



Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects / Maartje P.C.M. LUIJK in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)
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Titre : Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects Type de document : Texte imprimé et/ou numérique Auteurs : Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur Année de publication : 2011 Article en page(s) : p.1295-1307 Langues : Anglais (eng) Mots-clés : Attachment Strange Situation Procedure candidate genes parenting sensitivity G × E Index. décimale : PER Périodiques Résumé : Background and methods: In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure.
Results: We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples.
Conclusions: This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307[article] Dopaminergic, serotonergic, and oxytonergic candidate genes associated with infant attachment security and disorganization? In search of main and interaction effects [Texte imprimé et/ou numérique] / Maartje P.C.M. LUIJK, Auteur ; Glenn I. ROISMAN, Auteur ; John D. HALTIGAN, Auteur ; Henning TIEMEIER, Auteur ; Cathryn BOOTH-LAFORCE, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Jay BELSKY, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Anne THARNER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur . - 2011 . - p.1295-1307.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1295-1307
Mots-clés : Attachment Strange Situation Procedure candidate genes parenting sensitivity G × E Index. décimale : PER Périodiques Résumé : Background and methods: In two birth cohort studies with genetic, sensitive parenting, and attachment data of more than 1,000 infants in total, we tested main and interaction effects of candidate genes involved in the dopamine, serotonin, and oxytocin systems (DRD4, DRD2, COMT, 5-HTT, OXTR) on attachment security and disorganization. Parenting was assessed using observational rating scales for parental sensitivity (Ainsworth, Bell, & Stayton, 1974), and infant attachment was assessed with the Strange Situation Procedure.
Results: We found no consistent additive genetic associations for attachment security and attachment disorganization. However, specific tests revealed evidence for a codominant risk model for COMT Val158Met, consistent across both samples. Children with the Val/Met genotype showed higher disorganization scores (combined effect size d = .22, CI = .10–.34, p < .001). Gene-by-environment interaction effects were not replicable across the two samples.
Conclusions: This unexpected finding might be explained by a broader range of plasticity in heterozygotes, which may increase susceptibility to environmental influences or to dysregulation of emotional arousal. This study is unique in combining the two largest attachment cohorts with molecular genetic and observed rearing environment data to date.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02440.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=147 Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study / Akhgar GHASSABIAN in Journal of Child Psychology and Psychiatry, 54-1 (January 2013)
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Titre : Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study Type de document : Texte imprimé et/ou numérique Auteurs : Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : 96-104 Langues : Anglais (eng) Mots-clés : Brain corpus callosum executive function Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104[article] Infant brain structures, executive function, and attention deficit/hyperactivity problems at preschool age. A prospective study [Texte imprimé et/ou numérique] / Akhgar GHASSABIAN, Auteur ; Catherine M. HERBA, Auteur ; Sabine J. ROZA, Auteur ; Paul GOVAERT, Auteur ; Jacqueline J. SCHENK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Tonya WHITE, Auteur ; Frank C. VERHULST, Auteur ; Henning TIEMEIER, Auteur . - 96-104.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 54-1 (January 2013) . - 96-104
Mots-clés : Brain corpus callosum executive function Attention Deficit/Hyperactivity Disorder Index. décimale : PER Périodiques Résumé : Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2012.02590.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=186 Maternal depressive symptoms and sensitivity are related to young children's facial expression recognition: The Generation R Study / Eszter SZEKELY in Development and Psychopathology, 26-2 (May 2014)
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Titre : Maternal depressive symptoms and sensitivity are related to young children's facial expression recognition: The Generation R Study Type de document : Texte imprimé et/ou numérique Auteurs : Eszter SZEKELY, Auteur ; Nicole LUCASSEN, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Rianne KOK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Catherine M. HERBA, Auteur Article en page(s) : p.333-345 Index. décimale : PER Périodiques Résumé : A vast body of literature shows that maternal depression has long-term adverse consequences for children. However, only very few studies have documented the effect of maternal depression on children's ability to process emotional expressions and even fewer incorporated measures of observed maternal sensitivity to further tease apart whether it is the symptoms per se or the associated impact via maternal sensitivity that affects children's developing emotion-processing abilities. In a large community sample of Dutch preschoolers (N = 770), we examined independent and mediated effects of maternal depressive symptoms and sensitivity on children's ability to recognize emotional expressions using a nonverbal and a verbal task paradigm. Maternal depressive symptoms predicted less accurate emotion labeling in children, while maternal sensitivity was associated with more accurate emotion matching, especially for sadness and anger. Maternal sensitivity did not mediate the observed associations between mothers’ depressive symptoms and children's emotion recognition, and effects were similar for boys and girls. Given that maternal depressive symptoms and sensitivity affected nonoverlapping areas of young children's emotion recognition, prevention and intervention efforts should focus on both alleviating maternal depressive symptoms and improving maternal sensitivity at the same time in order to maximize benefit. En ligne : http://dx.doi.org/10.1017/S0954579413001028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Development and Psychopathology > 26-2 (May 2014) . - p.333-345[article] Maternal depressive symptoms and sensitivity are related to young children's facial expression recognition: The Generation R Study [Texte imprimé et/ou numérique] / Eszter SZEKELY, Auteur ; Nicole LUCASSEN, Auteur ; Henning TIEMEIER, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Rianne KOK, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Catherine M. HERBA, Auteur . - p.333-345.
in Development and Psychopathology > 26-2 (May 2014) . - p.333-345
Index. décimale : PER Périodiques Résumé : A vast body of literature shows that maternal depression has long-term adverse consequences for children. However, only very few studies have documented the effect of maternal depression on children's ability to process emotional expressions and even fewer incorporated measures of observed maternal sensitivity to further tease apart whether it is the symptoms per se or the associated impact via maternal sensitivity that affects children's developing emotion-processing abilities. In a large community sample of Dutch preschoolers (N = 770), we examined independent and mediated effects of maternal depressive symptoms and sensitivity on children's ability to recognize emotional expressions using a nonverbal and a verbal task paradigm. Maternal depressive symptoms predicted less accurate emotion labeling in children, while maternal sensitivity was associated with more accurate emotion matching, especially for sadness and anger. Maternal sensitivity did not mediate the observed associations between mothers’ depressive symptoms and children's emotion recognition, and effects were similar for boys and girls. Given that maternal depressive symptoms and sensitivity affected nonoverlapping areas of young children's emotion recognition, prevention and intervention efforts should focus on both alleviating maternal depressive symptoms and improving maternal sensitivity at the same time in order to maximize benefit. En ligne : http://dx.doi.org/10.1017/S0954579413001028 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 A prospective study of heart rate and externalising behaviours in young children / Bram DIERCKX in Journal of Child Psychology and Psychiatry, 55-4 (April 2014)
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Titre : A prospective study of heart rate and externalising behaviours in young children Type de document : Texte imprimé et/ou numérique Auteurs : Bram DIERCKX, Auteur ; Rianne KOK, Auteur ; Joke H. M. TULEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Henning TIEMEIER, Auteur Article en page(s) : p.402-410 Mots-clés : Child heart rate anxiety externalising behaviour parenting compliance Index. décimale : PER Périodiques Résumé : Background Low heart rate predicts externalising and delinquent behaviour in adults, adolescents and school-age children. In younger children the evidence is less clear. Moreover, the specificity of the relation between the autonomic nervous system and different forms of externalising behaviour is uncertain. We investigated the longitudinal relation between resting mean heart rate and different externalising behaviours. Methods In 412 children of the Generation R Study, we measured resting mean heart rate at 14 months. At 3 years, child problem behaviour was assessed by the mother with the Child Behavior Checklist. In a gift delay task, we observed whether children were compliant and whether they lied about their noncompliance. The association of heart rate with behaviour was contrasted with the effect of harsh parenting. Results In our main analysis, we examined the association between heart rate and reported and observed child behaviour. For comparison, the association of heart rate with behaviour was contrasted with the effect of harsh parenting. Mean heart rate was positively associated with Anxious/Depressed scale scores (? = .1, 95% CI = 0.01; 0.2, p = .04), but not with Aggressive Behaviour (? = .02; 95% CI = ?0.1; 0.1, p = .8) nor Attention Problem scale scores (? = .08, 95% CI = ?0.3; 0.5, p = .8). We could not demonstrate an association between mean heart rate and noncompliance during the gift delay task (OR = 1.14, 95% CI = 0.9; 1.1, p = .2), but lower heart rate predicted higher odds of the child lying (OR = 0.56, 95% CI = 0.3; 0.9, p = .03). In contrast, harsh parenting was associated with mother-reported Aggressive Behaviour (? = .7, 95% CI = 0.4; 0.9, p .001) and Attention Problems (? = .2, 95% CI = 0.1; 0.3, p .001), but not with observed lying (OR = 1.03, 95% CI = 0.8; 1.4, p = .8). Conclusions Lower resting mean heart rate at age 14 months predicts low anxiety symptoms and higher odds of lying at age 3 years. Low resting mean heart rate may be less an indicator of early childhood aggression than of fearless behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230
in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.402-410[article] A prospective study of heart rate and externalising behaviours in young children [Texte imprimé et/ou numérique] / Bram DIERCKX, Auteur ; Rianne KOK, Auteur ; Joke H. M. TULEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; Marian J. BAKERMANS-KRANENBURG, Auteur ; Marinus H. VAN IJZENDOORN, Auteur ; Henning TIEMEIER, Auteur . - p.402-410.
in Journal of Child Psychology and Psychiatry > 55-4 (April 2014) . - p.402-410
Mots-clés : Child heart rate anxiety externalising behaviour parenting compliance Index. décimale : PER Périodiques Résumé : Background Low heart rate predicts externalising and delinquent behaviour in adults, adolescents and school-age children. In younger children the evidence is less clear. Moreover, the specificity of the relation between the autonomic nervous system and different forms of externalising behaviour is uncertain. We investigated the longitudinal relation between resting mean heart rate and different externalising behaviours. Methods In 412 children of the Generation R Study, we measured resting mean heart rate at 14 months. At 3 years, child problem behaviour was assessed by the mother with the Child Behavior Checklist. In a gift delay task, we observed whether children were compliant and whether they lied about their noncompliance. The association of heart rate with behaviour was contrasted with the effect of harsh parenting. Results In our main analysis, we examined the association between heart rate and reported and observed child behaviour. For comparison, the association of heart rate with behaviour was contrasted with the effect of harsh parenting. Mean heart rate was positively associated with Anxious/Depressed scale scores (? = .1, 95% CI = 0.01; 0.2, p = .04), but not with Aggressive Behaviour (? = .02; 95% CI = ?0.1; 0.1, p = .8) nor Attention Problem scale scores (? = .08, 95% CI = ?0.3; 0.5, p = .8). We could not demonstrate an association between mean heart rate and noncompliance during the gift delay task (OR = 1.14, 95% CI = 0.9; 1.1, p = .2), but lower heart rate predicted higher odds of the child lying (OR = 0.56, 95% CI = 0.3; 0.9, p = .03). In contrast, harsh parenting was associated with mother-reported Aggressive Behaviour (? = .7, 95% CI = 0.4; 0.9, p .001) and Attention Problems (? = .2, 95% CI = 0.1; 0.3, p .001), but not with observed lying (OR = 1.03, 95% CI = 0.8; 1.4, p = .8). Conclusions Lower resting mean heart rate at age 14 months predicts low anxiety symptoms and higher odds of lying at age 3 years. Low resting mean heart rate may be less an indicator of early childhood aggression than of fearless behaviour. En ligne : http://dx.doi.org/10.1111/jcpp.12175 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=230 Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study / Eszter SZEKELY in Journal of Child Psychology and Psychiatry, 52-12 (December 2011)
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Titre : Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study Type de document : Texte imprimé et/ou numérique Auteurs : Eszter SZEKELY, Auteur ; Catherine M. HERBA, Auteur ; Pascal P. ARP, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; James J. HUDZIAK, Auteur ; Henning TIEMEIER, Auteur Année de publication : 2011 Article en page(s) : p.1279-1286 Langues : Anglais (eng) Mots-clés : Serotonin transporter gene emotion processing facial expression fear children Index. décimale : PER Périodiques Résumé : Background: Previous research highlights the significance of a functional polymorphism located in the promoter region (5-HTTLPR) of the serotonin transporter gene in emotional behaviour. This study examined the effect of the 5-HTTLPR polymorphism on emotion processing in a large number of healthy preschoolers.
Methods: The 5-HTTLPR genotype was classified in 605 children as homozygous for the short allele (SS), homozygous for the long allele (LL), or heterozygous (LS). Emotion-processing was assessed using age-appropriate computer tasks where children matched happy, sad, angry, and fearful facial expressions preceded by a shape-matching task to assess basic matching ability.
Results: We found that young children could differentiate between emotion categories (F = 12.1, p < .001). The effect of 5-HTTLPR genotype depended on the emotion category presented (F = 2.3, p = .031). This effect was explained by the finding that SS children were less accurate at recognising fearful faces than LL or LS children (F = 5.3, p = .005). We did not find any significant differences as a result of 5-HTTLPR genotype for happy, sad or angry expressions (p > .05).
Conclusions: Results indicate that 5-HTTLPR allele status selectively impacts the processing of fearful but not other facial expressions. This pattern is already apparent in very young typically developing children. Results may signal an early vulnerability for affective problems before disorders emerge.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02423.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1279-1286[article] Recognition of scared faces and the serotonin transporter gene in young children: the Generation R Study [Texte imprimé et/ou numérique] / Eszter SZEKELY, Auteur ; Catherine M. HERBA, Auteur ; Pascal P. ARP, Auteur ; André G. UITTERLINDEN, Auteur ; Vincent W.V. JADDOE, Auteur ; Albert HOFMAN, Auteur ; Frank C. VERHULST, Auteur ; James J. HUDZIAK, Auteur ; Henning TIEMEIER, Auteur . - 2011 . - p.1279-1286.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 52-12 (December 2011) . - p.1279-1286
Mots-clés : Serotonin transporter gene emotion processing facial expression fear children Index. décimale : PER Périodiques Résumé : Background: Previous research highlights the significance of a functional polymorphism located in the promoter region (5-HTTLPR) of the serotonin transporter gene in emotional behaviour. This study examined the effect of the 5-HTTLPR polymorphism on emotion processing in a large number of healthy preschoolers.
Methods: The 5-HTTLPR genotype was classified in 605 children as homozygous for the short allele (SS), homozygous for the long allele (LL), or heterozygous (LS). Emotion-processing was assessed using age-appropriate computer tasks where children matched happy, sad, angry, and fearful facial expressions preceded by a shape-matching task to assess basic matching ability.
Results: We found that young children could differentiate between emotion categories (F = 12.1, p < .001). The effect of 5-HTTLPR genotype depended on the emotion category presented (F = 2.3, p = .031). This effect was explained by the finding that SS children were less accurate at recognising fearful faces than LL or LS children (F = 5.3, p = .005). We did not find any significant differences as a result of 5-HTTLPR genotype for happy, sad or angry expressions (p > .05).
Conclusions: Results indicate that 5-HTTLPR allele status selectively impacts the processing of fearful but not other facial expressions. This pattern is already apparent in very young typically developing children. Results may signal an early vulnerability for affective problems before disorders emerge.En ligne : http://dx.doi.org/10.1111/j.1469-7610.2011.02423.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=146 Variations in maternal 5-HTTLPR affect observed sensitive parenting / Rolieke A. M. CENTS in Journal of Child Psychology and Psychiatry, 55-9 (September 2014)
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