Brief Report: Risk and Protective Factors Associated with Depressive Symptoms among Autistic Adults / Petya D. RADOEVA in Journal of Autism and Developmental Disorders, 52-6 (June 2022)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2819-2824 Titre : Brief Report: Risk and Protective Factors Associated with Depressive Symptoms among Autistic Adults Type de document : Texte imprimé et/ou numérique Auteurs : Petya D. RADOEVA, Auteur ; Kristen BALLINGER, Auteur ; Theodore HO, Auteur ; Sara J. WEBB, Auteur ; Gary A. STOBBE, Auteur Article en page(s) : p.2819-2824 Langues : Anglais (eng) Mots-clés : Adulthood  Autism spectrum disorder  Community activities  Depression  Phq-9 Index. décimale : PER Périodiques Résumé : Autistic individuals are at risk for developing depression though the risk and protective factors for co-occurring depression in autistic individuals are not yet fully characterized. In this retrospective medical chart review study, we explored factors associated with self-reported depressive symptoms (Patient Health Questionnaire-9) in autistic adults (N=58). For autistic adults, engagement in one or more activities (recreational, educational and/or vocational) was associated with less severe depressive symptoms (Mann-Whitney U test, p=0.006); and reported family history of depression/anxiety was associated with increased likelihood of suicidal ideation (Chi-square test, p=0.027). Promotion of community-based activities and family support systems may be an integral part of creating effective treatment plans for depressive symptoms in autistic adults. En ligne : http://dx.doi.org/10.1007/s10803-021-05085-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474 [article] Brief Report: Risk and Protective Factors Associated with Depressive Symptoms among Autistic Adults [Texte imprimé et/ou numérique] / Petya D. RADOEVA, Auteur ; Kristen BALLINGER, Auteur ; Theodore HO, Auteur ; Sara J. WEBB, Auteur ; Gary A. STOBBE, Auteur . - p.2819-2824. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 52-6 (June 2022) . - p.2819-2824 Mots-clés : Adulthood  Autism spectrum disorder  Community activities  Depression  Phq-9 Index. décimale : PER Périodiques Résumé : Autistic individuals are at risk for developing depression though the risk and protective factors for co-occurring depression in autistic individuals are not yet fully characterized. In this retrospective medical chart review study, we explored factors associated with self-reported depressive symptoms (Patient Health Questionnaire-9) in autistic adults (N=58). For autistic adults, engagement in one or more activities (recreational, educational and/or vocational) was associated with less severe depressive symptoms (Mann-Whitney U test, p=0.006); and reported family history of depression/anxiety was associated with increased likelihood of suicidal ideation (Chi-square test, p=0.027). Promotion of community-based activities and family support systems may be an integral part of creating effective treatment plans for depressive symptoms in autistic adults. En ligne : http://dx.doi.org/10.1007/s10803-021-05085-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=474

Deficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (Velo-Cardio-Facial Syndrome) / Jennifer S. HO in Autism Research, 5-6 (December 2012)  

Public ISBD [article]  inAutism Research > 5-6 (December 2012) . - p.407-418 Titre : Deficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (Velo-Cardio-Facial Syndrome) Type de document : Texte imprimé et/ou numérique Auteurs : Jennifer S. HO, Auteur ; Petya D. RADOEVA, Auteur ; Maria JALBRZIKOWSKI, Auteur ; Carolyn CHOW, Auteur ; Jessica HOPKINS, Auteur ; Wen-Ching TRAN, Auteur ; Ami MEHTA, Auteur ; Nicole ENRIQUE, Auteur ; Chelsea GILBERT, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda P. FREMONT, Auteur ; Wendy R. KATES, Auteur ; Carrie E. BEARDEN, Auteur Article en page(s) : p.407-418 Mots-clés : 22q11.2 deletion syndrome  Velo-cardio-facial syndrome  Theory of Mind  Autism Spectrum Disorders  reciprocal social behavior  social cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187 [article] Deficits in Mental State Attributions in Individuals with 22q11.2 Deletion Syndrome (Velo-Cardio-Facial Syndrome) [Texte imprimé et/ou numérique] / Jennifer S. HO, Auteur ; Petya D. RADOEVA, Auteur ; Maria JALBRZIKOWSKI, Auteur ; Carolyn CHOW, Auteur ; Jessica HOPKINS, Auteur ; Wen-Ching TRAN, Auteur ; Ami MEHTA, Auteur ; Nicole ENRIQUE, Auteur ; Chelsea GILBERT, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda P. FREMONT, Auteur ; Wendy R. KATES, Auteur ; Carrie E. BEARDEN, Auteur . - p.407-418. in Autism Research > 5-6 (December 2012) . - p.407-418 Mots-clés : 22q11.2 deletion syndrome  Velo-cardio-facial syndrome  Theory of Mind  Autism Spectrum Disorders  reciprocal social behavior  social cognition Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1002/aur.1252 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=187

Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis / Petya D. RADOEVA in Journal of Child Psychology and Psychiatry, 58-3 (March 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Titre : Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.305-314 Langues : Anglais (eng) Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Longitudinal study of cerebral surface morphology in youth with 22q11.2 deletion syndrome, and association with positive symptoms of psychosis [Texte imprimé et/ou numérique] / Petya D. RADOEVA, Auteur ; Ravi BANSAL, Auteur ; Kevin M. ANTSHEL, Auteur ; Wanda FREMONT, Auteur ; Bradley S. PETERSON, Auteur ; Wendy R. KATES, Auteur . - p.305-314. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-3 (March 2017) . - p.305-314 Mots-clés : Velo-cardio-facial syndrome  psychosis  ‘cortical morphology’  prodromal Index. décimale : PER Périodiques Résumé : Background 22q11.2 deletion syndrome (22q11DS) is a genetic disorder that greatly increases risk of developing schizophrenia. We previously characterized cerebral surface morphology trajectories from late childhood to mid adolescence in a cohort of youth with 22q11DS. Herein, we extend the study period into early adulthood, and describe further the trajectories associated with severe psychiatric symptoms in this cohort. Methods Participants included 76 youth with 22q11DS and 30 unaffected siblings, assessed at three timepoints, during which high resolution, anatomic magnetic resonance images were acquired. High-dimensional, nonlinear warping algorithms were applied to images in order to derive characteristics of cerebral surface morphology for each participant at each timepoint. Repeated-measures, linear regressions using a mixed model were conducted, while covarying for age and sex. Results Alterations in cerebral surface morphology during late adolescence/early adulthood in individuals with 22q11DS were observed in the lateral frontal, orbitofrontal, temporal, parietal, occipital, and cerebellar regions. An Age x Diagnosis interaction revealed that relative to unaffected siblings, individuals with 22q11DS showed age-related surface protrusions in the prefrontal cortex (which remained stable or increased during early adulthood), and surface indentations in posterior regions (which seemed to level off during late adolescence). Symptoms of psychosis were associated with a trajectory of surface indentations in the orbitofrontal and parietal regions. Conclusions These results advance our understanding of cerebral maturation in individuals with 22q11DS, and provide clinically relevant information about the psychiatric phenotype associated with the longitudinal trajectory of cortical surface morphology in youth with this genetic syndrome. En ligne : http://dx.doi.org/10.1111/jcpp.12657 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Longitudinal study of premorbid adjustment in 22q11.2 deletion (velocardiofacial) syndrome and association with psychosis / Petya D. RADOEVA in Development and Psychopathology, 29-1 (February 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-1 (February 2017) . - p.93-106 Titre : Longitudinal study of premorbid adjustment in 22q11.2 deletion (velocardiofacial) syndrome and association with psychosis Type de document : Texte imprimé et/ou numérique Auteurs : Petya D. RADOEVA, Auteur ; Wanda FREMONT, Auteur ; Kevin M. ANTSHEL, Auteur ; Wendy R. KATES, Auteur Article en page(s) : p.93-106 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : AbstractVelocardiofacial syndrome, also known as 22q11.2 deletion syndrome (22q11DS), is associated with an increased risk of major psychiatric disorders, including schizophrenia. The emergence of psychotic symptoms in individuals with schizophrenia in the general population is often preceded by a premorbid period of poor or worsening social and/or academic functioning. Our current study evaluated premorbid adjustment (via the Cannon–Spoor Premorbid Adjustment Scale [PAS]) and psychotic symptoms (via the Structured Interview for Prodromal Symptoms and the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version) in youth with 22q11DS (N = 96), unaffected siblings (N = 40), and community controls (N = 50). The PAS scores indicated greater maladjustment during all developmental periods in individuals with 22q11DS compared to the controls. Many participants with 22q11DS had chronically poor (n = 33) or deteriorating (n = 6) PAS scores. In 22q11DS, chronically poor PAS trajectories and poor childhood and early adolescence academic domain and total PAS scores significantly increased the risk of prodromal symptoms or overt psychosis. Taking into account the catechol-O-methyltransferase (COMT) genotype, the best predictor of (prodromal) psychosis was the early adolescence academic domain score, which yielded higher sensitivity and specificity in the subgroup of youth with 22q11DS and the high-activity (valine) allele. PAS scores may help identify individuals at higher risk for psychosis. En ligne : http://dx.doi.org/10.1017/s0954579416000018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298 [article] Longitudinal study of premorbid adjustment in 22q11.2 deletion (velocardiofacial) syndrome and association with psychosis [Texte imprimé et/ou numérique] / Petya D. RADOEVA, Auteur ; Wanda FREMONT, Auteur ; Kevin M. ANTSHEL, Auteur ; Wendy R. KATES, Auteur . - p.93-106. Langues : Anglais (eng) in Development and Psychopathology > 29-1 (February 2017) . - p.93-106 Index. décimale : PER Périodiques Résumé : AbstractVelocardiofacial syndrome, also known as 22q11.2 deletion syndrome (22q11DS), is associated with an increased risk of major psychiatric disorders, including schizophrenia. The emergence of psychotic symptoms in individuals with schizophrenia in the general population is often preceded by a premorbid period of poor or worsening social and/or academic functioning. Our current study evaluated premorbid adjustment (via the Cannon–Spoor Premorbid Adjustment Scale [PAS]) and psychotic symptoms (via the Structured Interview for Prodromal Symptoms and the Kiddie Schedule for Affective Disorders and Schizophrenia for School-Age Children—Present and Lifetime Version) in youth with 22q11DS (N = 96), unaffected siblings (N = 40), and community controls (N = 50). The PAS scores indicated greater maladjustment during all developmental periods in individuals with 22q11DS compared to the controls. Many participants with 22q11DS had chronically poor (n = 33) or deteriorating (n = 6) PAS scores. In 22q11DS, chronically poor PAS trajectories and poor childhood and early adolescence academic domain and total PAS scores significantly increased the risk of prodromal symptoms or overt psychosis. Taking into account the catechol-O-methyltransferase (COMT) genotype, the best predictor of (prodromal) psychosis was the early adolescence academic domain score, which yielded higher sensitivity and specificity in the subgroup of youth with 22q11DS and the high-activity (valine) allele. PAS scores may help identify individuals at higher risk for psychosis. En ligne : http://dx.doi.org/10.1017/s0954579416000018 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=298

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