Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children / Maureen SAMMS-VAUGHAN ; Jan BRESSLER ; MinJae LEE ; Courtney BYRD-WILLIAMS ; Manouchehr HESSABI ; Megan L. GROVE ; Sydonnie SHAKESPEARE-PELLINGTON ; Katherine A. LOVELAND ; Mohammad H. RAHBAR in Journal of Autism and Developmental Disorders, 54-2 (February 2024)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 54-2 (February 2024) . - p.704-724 Titre : Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children Type de document : Texte imprimé et/ou numérique Auteurs : Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : p.704-724 Index. décimale : PER Périodiques Résumé : To investigate additive and interactive associations of food allergies with three glutathione S-transferase (GST) genes in relation to ASD and ASD severity in Jamaican children. Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of food allergies with polymorphisms in GST genes (GSTM1, GSTP1 and GSTT1) in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domains specific comparison scores (CSs) by fitting general linear models. Although food allergies and GST genes were not associated with ASD, ASD cases allergic to non-dairy food had higher mean ADOS-2 Restricted and Repetitive Behaviors (RRB) CS (8.8 vs. 8.0, P?=?0.04). In addition, allergy to dairy was associated with higher mean RRB CS only among ASD cases with GSTT1 DD genotype (9.9 vs. 7.8, P? En ligne : https://doi.org/10.1007/s10803-022-05813-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520 [article] Additive or Interactive Associations of Food Allergies with Glutathione S-Transferase Genes in Relation to ASD and ASD Severity in Jamaican Children [Texte imprimé et/ou numérique] / Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - p.704-724. in Journal of Autism and Developmental Disorders > 54-2 (February 2024) . - p.704-724 Index. décimale : PER Périodiques Résumé : To investigate additive and interactive associations of food allergies with three glutathione S-transferase (GST) genes in relation to ASD and ASD severity in Jamaican children. Using data from 344 1:1 age- and sex-matched ASD cases and typically developing controls, we assessed additive and interactive associations of food allergies with polymorphisms in GST genes (GSTM1, GSTP1 and GSTT1) in relation to ASD by applying conditional logistic regression models, and in relation to ASD severity in ASD cases as measured by the Autism Diagnostic Observation Schedule-2nd Edition (ADOS-2) total and domains specific comparison scores (CSs) by fitting general linear models. Although food allergies and GST genes were not associated with ASD, ASD cases allergic to non-dairy food had higher mean ADOS-2 Restricted and Repetitive Behaviors (RRB) CS (8.8 vs. 8.0, P?=?0.04). In addition, allergy to dairy was associated with higher mean RRB CS only among ASD cases with GSTT1 DD genotype (9.9 vs. 7.8, P? En ligne : https://doi.org/10.1007/s10803-022-05813-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=520

Are there sex differences in interactive associations of environmental exposure to Lead (Pb), Mercury (Hg), and Manganese (Mn) with GST Genes (GSTP1, GSTT1, and GSTM1) in relation to ASD in Jamaican children? / Hiba T. ZWIYA in Research in Autism Spectrum Disorders, 105 (July 2023)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 105 (July 2023) . - 102162 Titre : Are there sex differences in interactive associations of environmental exposure to Lead (Pb), Mercury (Hg), and Manganese (Mn) with GST Genes (GSTP1, GSTT1, and GSTM1) in relation to ASD in Jamaican children? Type de document : Texte imprimé et/ou numérique Auteurs : Hiba T. ZWIYA, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : 102162 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder (ASD)  Sex Differences  Interaction  Glutathione S-transferase (GST) genes  Heavy metals (Lead, Mercury, Manganese) Index. décimale : PER Périodiques Résumé : Background Male preponderance is well-established in children with autism spectrum disorder (ASD). Glutathione S-transferase (GST) genes play a crucial role in suppressing oxidative stress triggered by environmental stressors. Objective To determine whether the association between metals and ASD differs by sex and by GST genes. Methods Using data from 344 pairs of sex-and age-matched cases and controls, we assessed the association of each metal with ASD or ASD severity, by applying conditional logistic regression (CLR) or general linear models (GLM). Sex was assessed as an effect modifier in separate GST genetic models. Results For Pb exposure, using a recessive model for the GSTP1 Ile105Val polymorphism, CLR revealed significant overall interaction between sex and GSTP1 (P = 0.04). However, sex-specific matched odds ratios revealed marginally lower odds of the Val/Val genotype among ASD cases than controls in females (MORfemales= 0.23 (95 % CI): 0.05-1.11, P = 0.06), but not among males (MORmales= 1.18 (95 % CI): 0.66-2.16, P = 0.57) in the adjusted model. GLMs for Hg exposure detected significant overall interactions in GSTP1 co-dominant and recessive genetic models. For example, the mean difference in ASD severity among children with Val/Val genotype compared to those with Ile/Ile or Ile/Val were MORfemales= ?0.26 and MORmales= 1.30, respectively, in the adjusted model. Conclusion The association of Pb and Hg with ASD significantly differed by sex under the GSTP1 co-dominant and recessive genetic models. Such findings reflect potential sex differences in metal detoxification mechanisms. Replication is warranted due to the limited sample size of female participants. En ligne : https://doi.org/10.1016/j.rasd.2023.102162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508 [article] Are there sex differences in interactive associations of environmental exposure to Lead (Pb), Mercury (Hg), and Manganese (Mn) with GST Genes (GSTP1, GSTT1, and GSTM1) in relation to ASD in Jamaican children? [Texte imprimé et/ou numérique] / Hiba T. ZWIYA, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Courtney BYRD-WILLIAMS, Auteur ; Manouchehr HESSABI, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - 102162. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 105 (July 2023) . - 102162 Mots-clés : Autism Spectrum Disorder (ASD)  Sex Differences  Interaction  Glutathione S-transferase (GST) genes  Heavy metals (Lead, Mercury, Manganese) Index. décimale : PER Périodiques Résumé : Background Male preponderance is well-established in children with autism spectrum disorder (ASD). Glutathione S-transferase (GST) genes play a crucial role in suppressing oxidative stress triggered by environmental stressors. Objective To determine whether the association between metals and ASD differs by sex and by GST genes. Methods Using data from 344 pairs of sex-and age-matched cases and controls, we assessed the association of each metal with ASD or ASD severity, by applying conditional logistic regression (CLR) or general linear models (GLM). Sex was assessed as an effect modifier in separate GST genetic models. Results For Pb exposure, using a recessive model for the GSTP1 Ile105Val polymorphism, CLR revealed significant overall interaction between sex and GSTP1 (P = 0.04). However, sex-specific matched odds ratios revealed marginally lower odds of the Val/Val genotype among ASD cases than controls in females (MORfemales= 0.23 (95 % CI): 0.05-1.11, P = 0.06), but not among males (MORmales= 1.18 (95 % CI): 0.66-2.16, P = 0.57) in the adjusted model. GLMs for Hg exposure detected significant overall interactions in GSTP1 co-dominant and recessive genetic models. For example, the mean difference in ASD severity among children with Val/Val genotype compared to those with Ile/Ile or Ile/Val were MORfemales= ?0.26 and MORmales= 1.30, respectively, in the adjusted model. Conclusion The association of Pb and Hg with ASD significantly differed by sex under the GSTP1 co-dominant and recessive genetic models. Such findings reflect potential sex differences in metal detoxification mechanisms. Replication is warranted due to the limited sample size of female participants. En ligne : https://doi.org/10.1016/j.rasd.2023.102162 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=508

Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children / MacKinsey A. BACH in Research in Autism Spectrum Disorders, 76 (August 2020)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 76 (August 2020) . - p.101587 Titre : Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children Type de document : Texte imprimé et/ou numérique Auteurs : MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur Article en page(s) : p.101587 Langues : Anglais (eng) Mots-clés : Polychlorinated biphenyls (PCBs)  Organochlorine (OC) pesticides  Autism spectrum disorder (ASD)  Glutathione S-transferase (GST) genes  Interaction  Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Association of polychlorinated biphenyls and organochlorine pesticides with autism spectrum disorder in Jamaican children [Texte imprimé et/ou numérique] / MacKinsey A. BACH, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Manouchehr HESSABI, Auteur ; Jan BRESSLER, Auteur ; MinJae LEE, Auteur ; Jing ZHANG, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Megan L. GROVE, Auteur ; Katherine A. LOVELAND, Auteur ; Mohammad H. RAHBAR, Auteur . - p.101587. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 76 (August 2020) . - p.101587 Mots-clés : Polychlorinated biphenyls (PCBs)  Organochlorine (OC) pesticides  Autism spectrum disorder (ASD)  Glutathione S-transferase (GST) genes  Interaction  Jamaica Index. décimale : PER Périodiques Résumé : Background Polychlorinated biphenyls (PCBs) and organochlorine (OC) pesticides are suspected to play a role in autism spectrum disorder (ASD). Objectives To investigate associations of PCBs and OC pesticides with ASD in Jamaican children and explore possible interaction between PCBs or OC pesticides with glutathione S-transferase (GST) genes (GSTT1, GSTM1, GSTP1) in relation to ASD. Methods Participants included n?=?169 age- and sex-matched case-control pairs of Jamaican children 2?8?years old. Socioeconomic status and food frequency data were self-reported by the parents/guardians. Blood from each participant was analyzed for 100 PCB congeners and 17 OC pesticides and genotyped for three GST genes. PCBs and OC pesticides concentrations below the limit of detection (LoD) were replaced with (LoD/?2). We used conditional logistic regression (CLR) models to assess associations of PCBs and OC pesticides with ASD, individually or interactively with GST genes (GSTT1, GSTM1, GSTP1). Results We found inverse associations of PCB-153 [adjusted MOR (95 % CI)?=?0.44 (0.23, 0.86)] and PCB-180 [adjusted MOR (95 % CI)?=?0.52 (0.28, 0.95)] with ASD. When adjusted for covariates in a CLR the interaction between GSTM1 and PCB-153 became significant (P? En ligne : https://doi.org/10.1016/j.rasd.2020.101587 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Commentary: Issues in Defining the Core Features of Autism through the Lifespan / Katherine A. LOVELAND

Public ISBD in Autism Spectrum Disorders / David G. AMARAL Titre : Commentary: Issues in Defining the Core Features of Autism through the Lifespan Type de document : Texte imprimé et/ou numérique Auteurs : Katherine A. LOVELAND, Auteur Année de publication : 2011 Importance : p.253-259 Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139 in Autism Spectrum Disorders / David G. AMARAL Commentary: Issues in Defining the Core Features of Autism through the Lifespan [Texte imprimé et/ou numérique] / Katherine A. LOVELAND, Auteur . - 2011 . - p.253-259. Langues : Anglais (eng) Index. décimale : AUT-B AUT-B - L'Autisme - Ouvrages généraux et scientifiques Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=139

Exemplaires

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Detecting Social and Non-Social Changes in Natural Scenes: Performance of Children with and Without Autism Spectrum Disorders and Typical Adults / Bhavin R. SHETH in Journal of Autism and Developmental Disorders, 41-4 (April 2011)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.434-446 Titre : Detecting Social and Non-Social Changes in Natural Scenes: Performance of Children with and Without Autism Spectrum Disorders and Typical Adults Type de document : Texte imprimé et/ou numérique Auteurs : Bhavin R. SHETH, Auteur ; James LIU, Auteur ; Olayemi OLAGBAJU, Auteur ; Larry VARGHESE, Auteur ; Rosleen MANSOUR, Auteur ; Stacy REDDOCH, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur Année de publication : 2011 Article en page(s) : p.434-446 Langues : Anglais (eng) Mots-clés : Social attention  Development  Change detection  Change blindness  Naturalistic scenes  Visual perception Index. décimale : PER Périodiques Résumé : We probed differences in the ability to detect and interpret social cues in adults and in children and young adolescents with and without autism spectrum disorders (ASD) by investigating the effect of various social and non-social contexts on the visual exploration of pictures of natural scenes. Children and adolescents relied more on social referencing cues in the scene as compared to adults, and in the presence of such cues, were less able to use other kinds of cues. Typically developing children and adolescents were no better than those with ASD at detecting changes within the various social contexts. Results suggest children and adolescents with ASD use relevant social cues while searching a scene just as typical children do. En ligne : http://dx.doi.org/10.1007/s10803-010-1062-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119 [article] Detecting Social and Non-Social Changes in Natural Scenes: Performance of Children with and Without Autism Spectrum Disorders and Typical Adults [Texte imprimé et/ou numérique] / Bhavin R. SHETH, Auteur ; James LIU, Auteur ; Olayemi OLAGBAJU, Auteur ; Larry VARGHESE, Auteur ; Rosleen MANSOUR, Auteur ; Stacy REDDOCH, Auteur ; Deborah A. PEARSON, Auteur ; Katherine A. LOVELAND, Auteur . - 2011 . - p.434-446. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 41-4 (April 2011) . - p.434-446 Mots-clés : Social attention  Development  Change detection  Change blindness  Naturalistic scenes  Visual perception Index. décimale : PER Périodiques Résumé : We probed differences in the ability to detect and interpret social cues in adults and in children and young adolescents with and without autism spectrum disorders (ASD) by investigating the effect of various social and non-social contexts on the visual exploration of pictures of natural scenes. Children and adolescents relied more on social referencing cues in the scene as compared to adults, and in the presence of such cues, were less able to use other kinds of cues. Typically developing children and adolescents were no better than those with ASD at detecting changes within the various social contexts. Results suggest children and adolescents with ASD use relevant social cues while searching a scene just as typical children do. En ligne : http://dx.doi.org/10.1007/s10803-010-1062-3 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=119

Executive Function in Autism: Association with ADHD and ASD Symptoms / Anthony R. WARD ; David M. LANE ; Michael G. AMAN ; Katherine A. LOVELAND ; Rosleen MANSOUR ; Deborah A. PEARSON in Journal of Autism and Developmental Disorders, 53-2 (February 2023)  

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Functional Assays of Local Connectivity in the Somatosensory Cortex of Individuals with Autism / Mehmet Akif COSKUN in Autism Research, 6-3 (June 2013)  

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Improving the Reliability of Autism Diagnoses: Examining the Utility of Adaptive Behavior / Stacey S. TOMANIK in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

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Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 12 (April 2015)  

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Interaction between manganese and GSTP1 in relation to autism spectrum disorder while controlling for exposure to mixture of lead, mercury, arsenic, and cadmium / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 55 (November 2018)  

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Interaction between a mixture of heavy metals (lead, mercury, arsenic, cadmium, manganese, aluminum) and GSTP1, GSTT1, and GSTM1 in relation to autism spectrum disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 79 (November 2020)  

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Interaction of Finger Representations in the Cortex of Individuals with Autism: A Functional Window into Cortical Inhibition / Mehmet Akif COSKUN in Autism Research, 6-6 (December 2013)  

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Interactive associations of eczema with glutathione S-transferase genes in relation to autism spectrum disorder and its severity in Jamaican children / Sepideh SAROUKHANI in Research in Autism Spectrum Disorders, 105 (July 2023)  

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Maternal and Paternal Age are Jointly Associated with Childhood Autism in Jamaica / Mohammad Hossein RAHBAR in Journal of Autism and Developmental Disorders, 42-9 (September 2012)  

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Parent-reported problematic sleep behaviors in children with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder / Katharine C. REYNOLDS in Research in Autism Spectrum Disorders, 39 (July 2017)  

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