Dépouillements

Editorial: The difficulties and privileges of the editor / Daniel Samuel PINE in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.897-899 Titre : Editorial: The difficulties and privileges of the editor Type de document : Texte imprimé et/ou numérique Auteurs : Daniel Samuel PINE, Auteur Année de publication : 2008 Article en page(s) : p.897-899 Langues : Anglais (eng) Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01993.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=557 [article] Editorial: The difficulties and privileges of the editor [Texte imprimé et/ou numérique] / Daniel Samuel PINE, Auteur . - 2008 . - p.897-899. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.897-899 Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01993.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=557

Practitioner Review: How can epidemiology help us plan and deliver effective child and adolescent mental health services? / Tamsin FORD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.900-914 Titre : Practitioner Review: How can epidemiology help us plan and deliver effective child and adolescent mental health services? Type de document : Texte imprimé et/ou numérique Auteurs : Tamsin FORD, Auteur Année de publication : 2008 Article en page(s) : p.900-914 Langues : Anglais (eng) Mots-clés : Epidemiology childhood-psychiatric-disorder impairing-psychopathology-in-childhood service-delivery service-use service-planning Index. décimale : PER Périodiques Résumé : This review focuses on ways in which epidemiological research can inform mental health service development and clinical practice. Data from epidemiological studies can provide cross-sectional and secular estimates of the prevalence of psychopathology to support rational service development. Epidemiological surveys have difficulties in finding large enough samples of children with rare disorders, although these disorders are often severely debilitating and require extensive service input. Systematic surveillance provides a rigorous method for studying rare disorders and events. Only a minority of children with impairing psychopathology reach mental health services, although a larger proportion have mental health related contacts with other services. The gap in provision is such that an expansion of mental health services is unlikely to reach all children who could benefit, suggesting that mental health professionals need to develop innovative strategies to increase the number of children seen and the effectiveness of interventions that they receive. Training and supervision of non-mental-health professionals working with children in the identification and management of mental health problems is also extremely important. Most studies suggest that the children with the severest problems are getting to specialist mental health services, and service contact is more likely if important adults can perceive the child's difficulty or find it to be burdensome. The latter suggests that education of key adults would improve detection if services had the capacity to cope. Studies consistently suggest that the region in which the child lives affects the likelihood of service contact, but studies of other characteristics predicting service contact are so contradictory that studies should only be (cautiously) applied to similar populations to assess which types of children may currently be falling through gaps in service provision. Academics are beginning to explore the use of structured measures developed for epidemiological studies in clinical assessment and outcome monitoring. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01927.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Practitioner Review: How can epidemiology help us plan and deliver effective child and adolescent mental health services? [Texte imprimé et/ou numérique] / Tamsin FORD, Auteur . - 2008 . - p.900-914. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.900-914 Mots-clés : Epidemiology childhood-psychiatric-disorder impairing-psychopathology-in-childhood service-delivery service-use service-planning Index. décimale : PER Périodiques Résumé : This review focuses on ways in which epidemiological research can inform mental health service development and clinical practice. Data from epidemiological studies can provide cross-sectional and secular estimates of the prevalence of psychopathology to support rational service development. Epidemiological surveys have difficulties in finding large enough samples of children with rare disorders, although these disorders are often severely debilitating and require extensive service input. Systematic surveillance provides a rigorous method for studying rare disorders and events. Only a minority of children with impairing psychopathology reach mental health services, although a larger proportion have mental health related contacts with other services. The gap in provision is such that an expansion of mental health services is unlikely to reach all children who could benefit, suggesting that mental health professionals need to develop innovative strategies to increase the number of children seen and the effectiveness of interventions that they receive. Training and supervision of non-mental-health professionals working with children in the identification and management of mental health problems is also extremely important. Most studies suggest that the children with the severest problems are getting to specialist mental health services, and service contact is more likely if important adults can perceive the child's difficulty or find it to be burdensome. The latter suggests that education of key adults would improve detection if services had the capacity to cope. Studies consistently suggest that the region in which the child lives affects the likelihood of service contact, but studies of other characteristics predicting service contact are so contradictory that studies should only be (cautiously) applied to similar populations to assess which types of children may currently be falling through gaps in service provision. Academics are beginning to explore the use of structured measures developed for epidemiological studies in clinical assessment and outcome monitoring. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01927.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents / Dean W. BEEBE in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.915-923 Titre : Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents Type de document : Texte imprimé et/ou numérique Auteurs : Dean W. BEEBE, Auteur ; Gahan FALLONE, Auteur ; Neha GODIWALA, Auteur ; Matt FLANIGAN, Auteur ; David MARTIN, Auteur ; Laura SCHAFFNER, Auteur ; Raouf AMIN, Auteur Année de publication : 2008 Article en page(s) : p.915-923 Langues : Anglais (eng) Mots-clés : Adolescence attention executive-function pediatrics sleep-deprivation sleep-debt sleepiness teenagers Index. décimale : PER Périodiques Résumé : Background: Sleep deprivation is common among adolescents and has been associated with adverse behavioral and educational outcomes. However, it is difficult to draw strong causal conclusions because of a dearth of experimental sleep research. In part, this appears related to methodological challenges when working with this population. This study tested the feasibility and behavioral effects of a multi-night, at-home experimental sleep restriction protocol in a sample of adolescents. Methods: Twenty healthy adolescents aged 13.9–16.9 years were enrolled in a three-week sleep manipulation protocol using a counterbalanced cross-over experimental design. The protocol included a baseline week, followed in random order by a short sleep week (Monday–Friday nights limited to 6.5 hours time in bed) and an extended sleep week (10 hours lights-out time in bed Monday–Friday nights). Sleep was monitored via self-report and objective actigraphy. These were reviewed with participants and parents on the Saturdays at the end of each week, when parents and participants also completed behavior rating questionnaires. Results: One participant dropped out of the study, but each of the remaining 19 displayed markedly less sleep in the short sleep condition than the extended sleep condition (average nightly gap ∼2.5 hours). Data also reflected indirect effects of sleep deprivation that are consistent with an increase in homeostatic sleep drive. Compared to the extended sleep week, parents during the short sleep week reported that the participants displayed significantly greater problems with sleepiness, attention, oppositionality/irritability, behavior regulation, and metacognition. Participant self-report results were similar, though less robust. Conclusions: A multi-night, at-home sleep manipulation protocol for use with adolescents is indeed feasible. This study also provided the first experimental evidence that chronic sleep restriction during adolescence is causally related to a wide range of behavioral deficits. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01885.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Feasibility and behavioral effects of an at-home multi-night sleep restriction protocol for adolescents [Texte imprimé et/ou numérique] / Dean W. BEEBE, Auteur ; Gahan FALLONE, Auteur ; Neha GODIWALA, Auteur ; Matt FLANIGAN, Auteur ; David MARTIN, Auteur ; Laura SCHAFFNER, Auteur ; Raouf AMIN, Auteur . - 2008 . - p.915-923. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.915-923 Mots-clés : Adolescence attention executive-function pediatrics sleep-deprivation sleep-debt sleepiness teenagers Index. décimale : PER Périodiques Résumé : Background: Sleep deprivation is common among adolescents and has been associated with adverse behavioral and educational outcomes. However, it is difficult to draw strong causal conclusions because of a dearth of experimental sleep research. In part, this appears related to methodological challenges when working with this population. This study tested the feasibility and behavioral effects of a multi-night, at-home experimental sleep restriction protocol in a sample of adolescents. Methods: Twenty healthy adolescents aged 13.9–16.9 years were enrolled in a three-week sleep manipulation protocol using a counterbalanced cross-over experimental design. The protocol included a baseline week, followed in random order by a short sleep week (Monday–Friday nights limited to 6.5 hours time in bed) and an extended sleep week (10 hours lights-out time in bed Monday–Friday nights). Sleep was monitored via self-report and objective actigraphy. These were reviewed with participants and parents on the Saturdays at the end of each week, when parents and participants also completed behavior rating questionnaires. Results: One participant dropped out of the study, but each of the remaining 19 displayed markedly less sleep in the short sleep condition than the extended sleep condition (average nightly gap ∼2.5 hours). Data also reflected indirect effects of sleep deprivation that are consistent with an increase in homeostatic sleep drive. Compared to the extended sleep week, parents during the short sleep week reported that the participants displayed significantly greater problems with sleepiness, attention, oppositionality/irritability, behavior regulation, and metacognition. Participant self-report results were similar, though less robust. Conclusions: A multi-night, at-home sleep manipulation protocol for use with adolescents is indeed feasible. This study also provided the first experimental evidence that chronic sleep restriction during adolescence is causally related to a wide range of behavioral deficits. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01885.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Does self-directed and web-based support for parents enhance the effects of viewing a reality television series based on the Triple P – Positive Parenting Programme? / Matthew R. SANDERS in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.924-932 Titre : Does self-directed and web-based support for parents enhance the effects of viewing a reality television series based on the Triple P – Positive Parenting Programme? Type de document : Texte imprimé et/ou numérique Auteurs : Matthew R. SANDERS, Auteur ; Rachel CALAM, Auteur ; Marianne DURAND, Auteur ; Tom LIVERSIDGE, Auteur ; Sue Ann CARMONT, Auteur Année de publication : 2008 Article en page(s) : p.924-932 Langues : Anglais (eng) Mots-clés : Parent-training conduct-problems media-intervention prevention Index. décimale : PER Périodiques Résumé : Background: This study investigated whether providing self-directed and web-based support for parents enhanced the effects of viewing a reality television series based on the Triple P – Positive Parenting Programme. Method: Parents with a child aged 2 to 9 (N = 454) were randomly assigned to either a standard or enhanced intervention condition. In the standard television alone viewing condition, parents watched the six-episode weekly television series, 'Driving Mum and Dad Mad'. Parents in the enhanced television viewing condition received a self-help workbook, extra web support involving downloadable parenting tip sheets, audio and video streaming of positive parenting messages and email support, in addition to viewing the television series. Results: Parents in both conditions reported significant improvements in their child's disruptive behaviour and improvements in dysfunctional parenting practices. Effects were greater for the enhanced condition as seen on the ECBI, two of the three parenting indicators and overall programme satisfaction. However, no significant differences were seen on other measures, including parent affect indicators. The level of improvement was related to number of episodes watched, with greatest changes occurring in families who watched each episode. Improvements achieved at post-intervention by parents in both groups were maintained at six-month follow-up. Online tip sheets were frequently accessed; uptake of web-based resources was highest early in the series. Conclusions: The value of combining self-help approaches, technology and media as part of a comprehensive public health approach to providing parenting support is discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01901.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Does self-directed and web-based support for parents enhance the effects of viewing a reality television series based on the Triple P – Positive Parenting Programme? [Texte imprimé et/ou numérique] / Matthew R. SANDERS, Auteur ; Rachel CALAM, Auteur ; Marianne DURAND, Auteur ; Tom LIVERSIDGE, Auteur ; Sue Ann CARMONT, Auteur . - 2008 . - p.924-932. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.924-932 Mots-clés : Parent-training conduct-problems media-intervention prevention Index. décimale : PER Périodiques Résumé : Background: This study investigated whether providing self-directed and web-based support for parents enhanced the effects of viewing a reality television series based on the Triple P – Positive Parenting Programme. Method: Parents with a child aged 2 to 9 (N = 454) were randomly assigned to either a standard or enhanced intervention condition. In the standard television alone viewing condition, parents watched the six-episode weekly television series, 'Driving Mum and Dad Mad'. Parents in the enhanced television viewing condition received a self-help workbook, extra web support involving downloadable parenting tip sheets, audio and video streaming of positive parenting messages and email support, in addition to viewing the television series. Results: Parents in both conditions reported significant improvements in their child's disruptive behaviour and improvements in dysfunctional parenting practices. Effects were greater for the enhanced condition as seen on the ECBI, two of the three parenting indicators and overall programme satisfaction. However, no significant differences were seen on other measures, including parent affect indicators. The level of improvement was related to number of episodes watched, with greatest changes occurring in families who watched each episode. Improvements achieved at post-intervention by parents in both groups were maintained at six-month follow-up. Online tip sheets were frequently accessed; uptake of web-based resources was highest early in the series. Conclusions: The value of combining self-help approaches, technology and media as part of a comprehensive public health approach to providing parenting support is discussed. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01901.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Adolescent borderline symptoms in the community: prognosis for functioning over 20 years / Greta WINOGRAD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.933-941 Titre : Adolescent borderline symptoms in the community: prognosis for functioning over 20 years Type de document : Texte imprimé et/ou numérique Auteurs : Greta WINOGRAD, Auteur ; Patricia COHEN, Auteur ; Henian CHEN, Auteur Année de publication : 2008 Article en page(s) : p.933-941 Langues : Anglais (eng) Mots-clés : Adolescence adulthood prognosis borderline-personality-disorder functioning Index. décimale : PER Périodiques Résumé : Background: The long-term prognosis associated with adolescent symptoms of borderline personality disorder (BPD) in the general population is virtually unknown. In this study, the relationship of early borderline symptoms to subsequent psychosocial functioning and attainment was investigated based on data from the Children in the Community cohort. Method: Using multilevel linear regression, symptoms of BPD at mean age 14 were employed as predictors of work/school/homemaker role function, social function (social support, relationship quality), and life satisfaction over the subsequent 20 years. Borderline symptoms were also employed as predictors of attainment at 20-year follow-up. Results: On average, those with higher levels of early adolescent borderline symptoms scored consistently lower in role function, social function, and life satisfaction from mid-adolescence through mid-adulthood. Borderline symptoms predicted lower academic and occupational attainment, less partner involvement, and fewer attained adult developmental milestones. Adolescent borderline symptoms were also associated with adult borderline symptoms, borderline diagnosis, general impairment, and need for services at mean age 33. These effects were evident despite symptom decline with age and were independent of adolescent Axis I disorders. Conclusions: Adverse prognosis associated with youth symptoms of BPD appeared early and persisted in important and interrelated life domains. These findings lend support to the utility of DSM-IV BPD symptoms assessed by self-report in early adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01930.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Adolescent borderline symptoms in the community: prognosis for functioning over 20 years [Texte imprimé et/ou numérique] / Greta WINOGRAD, Auteur ; Patricia COHEN, Auteur ; Henian CHEN, Auteur . - 2008 . - p.933-941. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.933-941 Mots-clés : Adolescence adulthood prognosis borderline-personality-disorder functioning Index. décimale : PER Périodiques Résumé : Background: The long-term prognosis associated with adolescent symptoms of borderline personality disorder (BPD) in the general population is virtually unknown. In this study, the relationship of early borderline symptoms to subsequent psychosocial functioning and attainment was investigated based on data from the Children in the Community cohort. Method: Using multilevel linear regression, symptoms of BPD at mean age 14 were employed as predictors of work/school/homemaker role function, social function (social support, relationship quality), and life satisfaction over the subsequent 20 years. Borderline symptoms were also employed as predictors of attainment at 20-year follow-up. Results: On average, those with higher levels of early adolescent borderline symptoms scored consistently lower in role function, social function, and life satisfaction from mid-adolescence through mid-adulthood. Borderline symptoms predicted lower academic and occupational attainment, less partner involvement, and fewer attained adult developmental milestones. Adolescent borderline symptoms were also associated with adult borderline symptoms, borderline diagnosis, general impairment, and need for services at mean age 33. These effects were evident despite symptom decline with age and were independent of adolescent Axis I disorders. Conclusions: Adverse prognosis associated with youth symptoms of BPD appeared early and persisted in important and interrelated life domains. These findings lend support to the utility of DSM-IV BPD symptoms assessed by self-report in early adolescence. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01930.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11 / Richard D. TODD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.942-949 Titre : Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11 Type de document : Texte imprimé et/ou numérique Auteurs : Richard D. TODD, Auteur ; Hongyan HUANG, Auteur ; Cynthia A. HENDERSON, Auteur Année de publication : 2008 Article en page(s) : p.942-949 Langues : Anglais (eng) Mots-clés : Attention-deficit/hyperactivity-disorder age-of-onset twin-study follow-up-study disruptive-behavior-disorders Index. décimale : PER Périodiques Résumé : Background: To test whether the retrospective reporting of the age of onset impairment criterion for attention deficit/hyperactivity disorder (ADHD) required in the Diagnostic and Statistical Manual of Mental Disorders – IV (DSM-IV) complicates identification of new and known child and adolescent cases later in life. Methods: A birth-records-based cohort of twins assessed at ages 7 to 19 years were blindly reassessed five years later using the MAGIC interview. Study outcome measures were differences in reported ages of onset for attention deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD) and major depressive disorder (MDD). Results: For all age groups and respondents (parent on youth or youth self-report), later ages of ADHD onset were reported five years later. The same phenomenon was also present for the other diagnostic groups. Of the initial ADHD individuals who continued to meet all other ADHD criteria at follow-up, 46% failed the age of onset criterion five years later. When ignoring the age of onset criterion, late onsets of ages 7–16 years accounted for about 10% of all ADHD. Conclusions: Use of the DSM-IV age of onset criterion for attention deficit/hyperactivity disorder in the assessment of adolescents and young adults results in under-identification of affected individuals. Consideration should be given to revising the current nomenclatures to reflect the reality of retrospective reporting errors in age of onset as well as the presence of late onset cases. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01892.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Poor utility of the age of onset criterion for DSM-IV attention deficit/hyperactivity disorder: recommendations for DSM-V and ICD-11 [Texte imprimé et/ou numérique] / Richard D. TODD, Auteur ; Hongyan HUANG, Auteur ; Cynthia A. HENDERSON, Auteur . - 2008 . - p.942-949. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.942-949 Mots-clés : Attention-deficit/hyperactivity-disorder age-of-onset twin-study follow-up-study disruptive-behavior-disorders Index. décimale : PER Périodiques Résumé : Background: To test whether the retrospective reporting of the age of onset impairment criterion for attention deficit/hyperactivity disorder (ADHD) required in the Diagnostic and Statistical Manual of Mental Disorders – IV (DSM-IV) complicates identification of new and known child and adolescent cases later in life. Methods: A birth-records-based cohort of twins assessed at ages 7 to 19 years were blindly reassessed five years later using the MAGIC interview. Study outcome measures were differences in reported ages of onset for attention deficit/hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD) and major depressive disorder (MDD). Results: For all age groups and respondents (parent on youth or youth self-report), later ages of ADHD onset were reported five years later. The same phenomenon was also present for the other diagnostic groups. Of the initial ADHD individuals who continued to meet all other ADHD criteria at follow-up, 46% failed the age of onset criterion five years later. When ignoring the age of onset criterion, late onsets of ages 7–16 years accounted for about 10% of all ADHD. Conclusions: Use of the DSM-IV age of onset criterion for attention deficit/hyperactivity disorder in the assessment of adolescents and young adults results in under-identification of affected individuals. Consideration should be given to revising the current nomenclatures to reflect the reality of retrospective reporting errors in age of onset as well as the presence of late onset cases. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01892.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes / Sandra K. LOO in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Titre : Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes Type de document : Texte imprimé et/ou numérique Auteurs : Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur Année de publication : 2008 Article en page(s) : p.950-957 Langues : Anglais (eng) Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Cognitive functioning in affected sibling pairs with ADHD: familial clustering and dopamine genes [Texte imprimé et/ou numérique] / Sandra K. LOO, Auteur ; Erika CARPENTER RICH, Auteur ; Janeen ISHII, Auteur ; James MCGOUGH, Auteur ; Stanley NELSON, Auteur ; Susan L. SMALLEY, Auteur ; James T. MCCRACKEN, Auteur . - 2008 . - p.950-957. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.950-957 Mots-clés : Endophenotype working-memory DRD4 genetics executive-function neuropsychology parent-psychopathology Index. décimale : PER Périodiques Résumé : Background: This paper examines familiality and candidate gene associations of cognitive measures as potential endophenotypes in attention-deficit/hyperactivity disorder (ADHD). Methods: The sample consists of 540 participants, aged 6 to 18, who were diagnosed with ADHD from 251 families recruited for a larger genetic study of ADHD. All members of the family underwent psychiatric interviews and children were administered a large battery of cognitive tasks. Subjects were genotyped for several dopaminergic candidate genes (DAT1, DRD4, and DRD5). Results: Performance on measures of intelligence, working memory, and set-shifting had the highest sibling correlations and exhibited significant familial clustering. The 7-repeat allele of the dopamine receptor D4 (DRD4) gene was associated with poor performance on measures of intelligence, color naming, interference control, and working memory. There were no significant associations with DAT1 and DRD5. Conclusions: Sibling correlations, familial clustering and candidate gene associations provide strong support for verbal working memory as a candidate endophenotype for ADHD. More complex models of, and larger sample sizes for, genetic association with cognitive functions are encouraged for future study. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01928.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls / Jeffrey M. HALPERIN in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.958-966 Titre : Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls Type de document : Texte imprimé et/ou numérique Auteurs : Jeffrey M. HALPERIN, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur Année de publication : 2008 Article en page(s) : p.958-966 Langues : Anglais (eng) Mots-clés : Activity-level ADD/ADHD adolescence executive-function longitudinal-studies neuropsychology Index. décimale : PER Périodiques Résumé : Background: This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures of executive processes would parallel adolescent clinical status, with ADHD-persisters, but not remitters, differing significantly from controls. In contrast, persisters and remitters were hypothesized to perform similarly, and different from controls, on tasks requiring less effortful processing. Methods: Ninety-eight participants diagnosed with ADHD in childhood were reevaluated approximately 10 years later. Eighty-five never-ADHD controls similar in age, IQ, and sex distribution served as a comparison group. Participants were administered a psychiatric interview and neuropsychological test battery. Results: Those with childhood ADHD demonstrated broad neuropsychological deficits relative to controls. When the group with childhood ADHD was subdivided based on adolescent ADHD status, compared to controls, both persisters and remitters showed deficient perceptual sensitivity and response variability, and increased ankle movements recorded by a solid-state actigraph. Only persisters differed from controls on several measures of more effortful executive processes. Conclusions: Findings provide preliminary support to the hypothesis that ADHD is associated with early-appearing and enduring subcortical dysfunction, while recovery over the course of development is associated with improvements in executive control functions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01926.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Neuropsychological outcome in adolescents/young adults with childhood ADHD: profiles of persisters, remitters and controls [Texte imprimé et/ou numérique] / Jeffrey M. HALPERIN, Auteur ; Jeffrey H. NEWCORN, Auteur ; David J. MARKS, Auteur ; Joey W. TRAMPUSH, Auteur ; Carlin J. MILLER, Auteur . - 2008 . - p.958-966. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.958-966 Mots-clés : Activity-level ADD/ADHD adolescence executive-function longitudinal-studies neuropsychology Index. décimale : PER Périodiques Résumé : Background: This study examined neuropsychological functioning in a longitudinal sample of adolescents/young adults with attention deficit/hyperactivity disorder (ADHD) and controls as a function of the persistence of ADHD. We hypothesized that measures of executive processes would parallel adolescent clinical status, with ADHD-persisters, but not remitters, differing significantly from controls. In contrast, persisters and remitters were hypothesized to perform similarly, and different from controls, on tasks requiring less effortful processing. Methods: Ninety-eight participants diagnosed with ADHD in childhood were reevaluated approximately 10 years later. Eighty-five never-ADHD controls similar in age, IQ, and sex distribution served as a comparison group. Participants were administered a psychiatric interview and neuropsychological test battery. Results: Those with childhood ADHD demonstrated broad neuropsychological deficits relative to controls. When the group with childhood ADHD was subdivided based on adolescent ADHD status, compared to controls, both persisters and remitters showed deficient perceptual sensitivity and response variability, and increased ankle movements recorded by a solid-state actigraph. Only persisters differed from controls on several measures of more effortful executive processes. Conclusions: Findings provide preliminary support to the hypothesis that ADHD is associated with early-appearing and enduring subcortical dysfunction, while recovery over the course of development is associated with improvements in executive control functions. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01926.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Fetal origins of child non-right-handedness and mental health / Alina RODRIGUEZ in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.967-976 Titre : Fetal origins of child non-right-handedness and mental health Type de document : Texte imprimé et/ou numérique Auteurs : Alina RODRIGUEZ, Auteur ; Ulla WALDENSTROM, Auteur Année de publication : 2008 Article en page(s) : p.967-976 Langues : Anglais (eng) Mots-clés : ADHD atypical-laterality child-mental-health handedness language-difficulties prenatal Index. décimale : PER Périodiques Résumé : Background: Environmental risk during fetal development for non-right-handedness, an index of brain asymmetry, and its relevance for child mental health is not fully understood. Methods: A Swedish population-based prospective pregnancy–offspring cohort was followed-up when children were five years old (N = 1714). Prenatal environmental risk exposures were the number of ultrasound examinations and maternal distress during pregnancy. Child mental health, including symptoms of attention deficit hyperactivity disorder (ADHD), language difficulties, and care-seeking for child behavior problems, was assessed via maternal and/or kindergarten teacher's ratings. Results: Prenatal exposure to maternal depressive symptoms and critical life events were associated with increased risk of child non-right-handedness and mixed handedness, after adjustment for parity, maternal age, birth outcomes, infant sex, and parental handedness. No association was found between handedness and number of ultrasound examinations. Non-right and mixed-handedness, rather than left-handedness, were associated with increased risk of language difficulties and particularly with ADHD symptoms, after adjustment for current parental ADHD symptoms, current maternal depressive symptoms, birth outcomes, smoking during pregnancy, depressive symptoms and critical life events. Problems were significant enough to prompt mothers to seek care for children's behavioral problems, and parents were more likely to have received advice from the children's kindergarten teachers to seek care. Conclusions: This study suggests that mixed-handedness, i.e., reflecting atypical brain laterality, can be a marker of both severity of prenatal exposure to maternal distress and of increased risk of ADHD symptoms in childhood. Our results support the idea that the fetal environment plays a role in subsequent child mental health. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01923.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Fetal origins of child non-right-handedness and mental health [Texte imprimé et/ou numérique] / Alina RODRIGUEZ, Auteur ; Ulla WALDENSTROM, Auteur . - 2008 . - p.967-976. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.967-976 Mots-clés : ADHD atypical-laterality child-mental-health handedness language-difficulties prenatal Index. décimale : PER Périodiques Résumé : Background: Environmental risk during fetal development for non-right-handedness, an index of brain asymmetry, and its relevance for child mental health is not fully understood. Methods: A Swedish population-based prospective pregnancy–offspring cohort was followed-up when children were five years old (N = 1714). Prenatal environmental risk exposures were the number of ultrasound examinations and maternal distress during pregnancy. Child mental health, including symptoms of attention deficit hyperactivity disorder (ADHD), language difficulties, and care-seeking for child behavior problems, was assessed via maternal and/or kindergarten teacher's ratings. Results: Prenatal exposure to maternal depressive symptoms and critical life events were associated with increased risk of child non-right-handedness and mixed handedness, after adjustment for parity, maternal age, birth outcomes, infant sex, and parental handedness. No association was found between handedness and number of ultrasound examinations. Non-right and mixed-handedness, rather than left-handedness, were associated with increased risk of language difficulties and particularly with ADHD symptoms, after adjustment for current parental ADHD symptoms, current maternal depressive symptoms, birth outcomes, smoking during pregnancy, depressive symptoms and critical life events. Problems were significant enough to prompt mothers to seek care for children's behavioral problems, and parents were more likely to have received advice from the children's kindergarten teachers to seek care. Conclusions: This study suggests that mixed-handedness, i.e., reflecting atypical brain laterality, can be a marker of both severity of prenatal exposure to maternal distress and of increased risk of ADHD symptoms in childhood. Our results support the idea that the fetal environment plays a role in subsequent child mental health. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01923.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination / Anna B. SMITH in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.977-985 Titre : Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination Type de document : Texte imprimé et/ou numérique Auteurs : Anna B. SMITH, Auteur ; Michael BRAMMER, Auteur ; Eric TAYLOR, Auteur ; Rozmin HALARI, Auteur ; Katya RUBIA, Auteur Année de publication : 2008 Article en page(s) : p.977-985 Langues : Anglais (eng) Mots-clés : ADHD time-discrimination fMRI anterior-cingulate dorsolateral-prefrontal-cortex Index. décimale : PER Périodiques Résumé : Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during executive tasks. We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI). Methods: Twenty-one male medication-naïve adolescents aged 10–15 years with a DSM-IV diagnosis of ADHD (combined subtype) and without comorbid Axis I disorders (except conduct disorder) were compared to a group of 17 age- and IQ-matched healthy adolescents. Using fMRI on a 1.5T scanner, we compared brain activation and performance between adolescents with ADHD and controls during a time discrimination task contrasted with a temporal order task. Results: Despite comparable performance, patients with ADHD showed decreased activation in right dorsolateral and inferior prefrontal cortex and AC during time discrimination compared with controls. Conclusions: Right hemispheric fronto-cingulate abnormalities in ADHD, previously observed during inhibitory and executive functions, are also associated with temporal perception. Furthermore, recruitment of medication-naïve patients precludes the possibility that deficits are attributable to stimulant exposure. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01870.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination [Texte imprimé et/ou numérique] / Anna B. SMITH, Auteur ; Michael BRAMMER, Auteur ; Eric TAYLOR, Auteur ; Rozmin HALARI, Auteur ; Katya RUBIA, Auteur . - 2008 . - p.977-985. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.977-985 Mots-clés : ADHD time-discrimination fMRI anterior-cingulate dorsolateral-prefrontal-cortex Index. décimale : PER Périodiques Résumé : Background: Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during executive tasks. We investigated the neuro-anatomical substrates mediating fine temporal discrimination in adolescents with ADHD compared with controls, using functional magnetic resonance imaging (fMRI). Methods: Twenty-one male medication-naïve adolescents aged 10–15 years with a DSM-IV diagnosis of ADHD (combined subtype) and without comorbid Axis I disorders (except conduct disorder) were compared to a group of 17 age- and IQ-matched healthy adolescents. Using fMRI on a 1.5T scanner, we compared brain activation and performance between adolescents with ADHD and controls during a time discrimination task contrasted with a temporal order task. Results: Despite comparable performance, patients with ADHD showed decreased activation in right dorsolateral and inferior prefrontal cortex and AC during time discrimination compared with controls. Conclusions: Right hemispheric fronto-cingulate abnormalities in ADHD, previously observed during inhibitory and executive functions, are also associated with temporal perception. Furthermore, recruitment of medication-naïve patients precludes the possibility that deficits are attributable to stimulant exposure. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01870.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth / Kate DIMOND FITZGERALD in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.986-994 Titre : Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth Type de document : Texte imprimé et/ou numérique Auteurs : Kate DIMOND FITZGERALD, Auteur ; Christopher D. ZBROZEK, Auteur ; Robert C. WELSH, Auteur ; Jennifer C. BRITTON, Auteur ; Israel LIBERZON, Auteur ; Stephan F. TAYLOR, Auteur Année de publication : 2008 Article en page(s) : p.986-994 Langues : Anglais (eng) Mots-clés : Antisaccade response-inhibition error-processing anterior-cingulate developmental-neuroimaging Index. décimale : PER Périodiques Résumé : Background: Recent neuroimaging work suggests that inhibitory and error processing in healthy adults share overlapping, but functionally distinct neural circuitries within the posterior medial frontal cortex (pMFC); however, it remains unknown whether the pMFC is differentially engaged by response inhibition compared to error commission in the developing brain. Developmental neuroimaging studies of response inhibition have found pMFC activation, but the possible contribution of error-related activation during inhibitory processing has not been well studied in youth. Method: To examine the processing of correct response inhibition compared to errors in the developing brain, we performed functional magnetic resonance imaging scans in 11 healthy subjects, ages 8–14 years, during an antisaccade task while performance was monitored. Results: Successful antisaccades activated the pre-supplementary motor area. In contrast, errors on the antisaccade task activated the dorsal anterior cingulate cortex. Conclusion: The findings suggest the functional sub-specialization of inhibitory and error processing within the pMFC in this pilot sample of children and adolescents. Future neuroimaging studies of developing inhibitory control should examine both between correct and error trials. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01906.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Pilot study of response inhibition and error processing in the posterior medial prefrontal cortex in healthy youth [Texte imprimé et/ou numérique] / Kate DIMOND FITZGERALD, Auteur ; Christopher D. ZBROZEK, Auteur ; Robert C. WELSH, Auteur ; Jennifer C. BRITTON, Auteur ; Israel LIBERZON, Auteur ; Stephan F. TAYLOR, Auteur . - 2008 . - p.986-994. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.986-994 Mots-clés : Antisaccade response-inhibition error-processing anterior-cingulate developmental-neuroimaging Index. décimale : PER Périodiques Résumé : Background: Recent neuroimaging work suggests that inhibitory and error processing in healthy adults share overlapping, but functionally distinct neural circuitries within the posterior medial frontal cortex (pMFC); however, it remains unknown whether the pMFC is differentially engaged by response inhibition compared to error commission in the developing brain. Developmental neuroimaging studies of response inhibition have found pMFC activation, but the possible contribution of error-related activation during inhibitory processing has not been well studied in youth. Method: To examine the processing of correct response inhibition compared to errors in the developing brain, we performed functional magnetic resonance imaging scans in 11 healthy subjects, ages 8–14 years, during an antisaccade task while performance was monitored. Results: Successful antisaccades activated the pre-supplementary motor area. In contrast, errors on the antisaccade task activated the dorsal anterior cingulate cortex. Conclusion: The findings suggest the functional sub-specialization of inhibitory and error processing within the pMFC in this pilot sample of children and adolescents. Future neuroimaging studies of developing inhibitory control should examine both between correct and error trials. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01906.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Audiovisual speech integration in pervasive developmental disorder: evidence from event-related potentials / Maurice J.C.M. MAGNEE in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.995-1000 Titre : Audiovisual speech integration in pervasive developmental disorder: evidence from event-related potentials Type de document : Texte imprimé et/ou numérique Auteurs : Maurice J.C.M. MAGNEE, Auteur ; Herman VAN ENGELAND, Auteur ; Béatrice DE GELDER, Auteur ; Chantal KEMNER, Auteur Année de publication : 2008 Article en page(s) : p.995-1000 Langues : Anglais (eng) Mots-clés : Multisensory-integration language-and-communication autism EEG visual auditory Index. décimale : PER Périodiques Résumé : Background: Integration of information from multiple sensory sources is an important prerequisite for successful social behavior, especially during face-to-face conversation. It has been suggested that communicative impairments among individuals with pervasive developmental disorders (PDD) might be caused by an inability to integrate synchronously presented visual and auditory cues. Method: We investigated audiovisual integration of speech stimuli among a group of high-functioning adult PDD individuals and age- and IQ-matched controls using electroencephalography, measuring both early pre-phonological, as well as late phonologically driven integration. Results: Pre-phonological AV interactions are intact, while AV interactions corresponding to more complex phonological processes are impaired in individuals with PDD. Conclusions: The present findings argue for a pattern of impairments on tasks related to complex audiovisual integration combined with relative sparing of low-level integrational abilities. This combination may very well contribute to the communicative disabilities which are typical for the disorder. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01902.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Audiovisual speech integration in pervasive developmental disorder: evidence from event-related potentials [Texte imprimé et/ou numérique] / Maurice J.C.M. MAGNEE, Auteur ; Herman VAN ENGELAND, Auteur ; Béatrice DE GELDER, Auteur ; Chantal KEMNER, Auteur . - 2008 . - p.995-1000. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.995-1000 Mots-clés : Multisensory-integration language-and-communication autism EEG visual auditory Index. décimale : PER Périodiques Résumé : Background: Integration of information from multiple sensory sources is an important prerequisite for successful social behavior, especially during face-to-face conversation. It has been suggested that communicative impairments among individuals with pervasive developmental disorders (PDD) might be caused by an inability to integrate synchronously presented visual and auditory cues. Method: We investigated audiovisual integration of speech stimuli among a group of high-functioning adult PDD individuals and age- and IQ-matched controls using electroencephalography, measuring both early pre-phonological, as well as late phonologically driven integration. Results: Pre-phonological AV interactions are intact, while AV interactions corresponding to more complex phonological processes are impaired in individuals with PDD. Conclusions: The present findings argue for a pattern of impairments on tasks related to complex audiovisual integration combined with relative sparing of low-level integrational abilities. This combination may very well contribute to the communicative disabilities which are typical for the disorder. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01902.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559

Behavior in Prader-Willi syndrome: relationship to genetic subtypes and age / Elisabeth M. DYKENS in Journal of Child Psychology and Psychiatry, 49-9 (September 2008)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.1001-1008 Titre : Behavior in Prader-Willi syndrome: relationship to genetic subtypes and age Type de document : Texte imprimé et/ou numérique Auteurs : Elisabeth M. DYKENS, Auteur ; Elizabeth ROOF, Auteur Année de publication : 2008 Article en page(s) : p.1001-1008 Langues : Anglais (eng) Mots-clés : Prader-Willi-syndrome genetic-subtypes age CYFIP1 Index. décimale : PER Périodiques Résumé : Background: Some behavioral features of Prader-Willi syndrome (PWS) are associated with the major genetic subtypes of this disorder. While most agree that those with maternal uniparental disomy (UPD) have a distinctive cognitive and psychiatric profile, findings are more controversial regarding possible differences among persons who vary in paternal deletion size. Methods: Caregivers of 88 persons with PWS aged 5 to 51 years (M = 22 years) were administered measures of problem behavior, compulsivity, hyperphagia, and adaptive skills. The sample was well characterized as having relatively large, Type I (n = 26) or smaller, Type II (n = 29) deletions, or UPD (n = 33). Results: No significant behavioral differences were found between the Type I versus Type II deletion groups. Within each genetic subtype, however, differences emerged in how advancing age related to behavior. Although age did not emerge as a significant correlate of behavior in the Type II or UPD groups, in the Type I group age was consistently associated with lower problem behaviors, adaptive skills, and externalizing symptoms. Conclusion: Although differences between deletion subtypes were not found, significant within-subtype differences emerged in relationships between age and behavior. Negative associations between age and behavior in the Type I group only may relate to non-imprinted genes that are deleted in Type I but not Type II cases, including CYFIP1. Altered expression of CYFIP1 is seen in other developmental disabilities, including 15q disorders, and haploinsufficiency of CYFIP1 in Type I PWS cases may be associated with age-related phenotypic effects. Findings underscore the importance of a life-span perspective in phenotypic research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01913.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559 [article] Behavior in Prader-Willi syndrome: relationship to genetic subtypes and age [Texte imprimé et/ou numérique] / Elisabeth M. DYKENS, Auteur ; Elizabeth ROOF, Auteur . - 2008 . - p.1001-1008. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 49-9 (September 2008) . - p.1001-1008 Mots-clés : Prader-Willi-syndrome genetic-subtypes age CYFIP1 Index. décimale : PER Périodiques Résumé : Background: Some behavioral features of Prader-Willi syndrome (PWS) are associated with the major genetic subtypes of this disorder. While most agree that those with maternal uniparental disomy (UPD) have a distinctive cognitive and psychiatric profile, findings are more controversial regarding possible differences among persons who vary in paternal deletion size. Methods: Caregivers of 88 persons with PWS aged 5 to 51 years (M = 22 years) were administered measures of problem behavior, compulsivity, hyperphagia, and adaptive skills. The sample was well characterized as having relatively large, Type I (n = 26) or smaller, Type II (n = 29) deletions, or UPD (n = 33). Results: No significant behavioral differences were found between the Type I versus Type II deletion groups. Within each genetic subtype, however, differences emerged in how advancing age related to behavior. Although age did not emerge as a significant correlate of behavior in the Type II or UPD groups, in the Type I group age was consistently associated with lower problem behaviors, adaptive skills, and externalizing symptoms. Conclusion: Although differences between deletion subtypes were not found, significant within-subtype differences emerged in relationships between age and behavior. Negative associations between age and behavior in the Type I group only may relate to non-imprinted genes that are deleted in Type I but not Type II cases, including CYFIP1. Altered expression of CYFIP1 is seen in other developmental disabilities, including 15q disorders, and haploinsufficiency of CYFIP1 in Type I PWS cases may be associated with age-related phenotypic effects. Findings underscore the importance of a life-span perspective in phenotypic research. En ligne : http://dx.doi.org/10.1111/j.1469-7610.2008.01913.x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=559