Autistic features in girls from a psychiatric sample are strongly associated with a low 2D:4D ratio / Esther I. DE BRUIN in Autism, 13-5 (September 2009)  

Public ISBD [article]  inAutism > 13-5 (September 2009) . - p.511-521 Titre : Autistic features in girls from a psychiatric sample are strongly associated with a low 2D:4D ratio Type de document : Texte imprimé et/ou numérique Auteurs : Esther I. DE BRUIN, Auteur ; Robert F. FERDINAND, Auteur ; Fop VERHEIJ, Auteur ; Debora H. VERHAGEN, Auteur ; Pieter F.A. DE NIJS, Auteur Année de publication : 2009 Article en page(s) : p.511-521 Langues : Anglais (eng) Mots-clés : autism diagnosis digit-ratio Index. décimale : PER Périodiques Résumé : Autistic features such as deficits in social interactions and communication have been associated with a low 2D:4D ratio in normal children.This study assessed this association in a large sample of children with a variety of psychiatric disorders (n = 35 girls and n = 147 boys). Autistic features were assessed with a highly valid and reliable measure (Autism Diagnostic Observation Schedule—Generic). Correlations between the 2D:4D ratio and autistic features were computed separately for boys and girls. Some small negative correlations (r = —0.17 and r = —0.19) were found in the right hand for boys; however, particularly in girls, large negative correlations (r = —0.51 to r = —0.64) were found in the left hand. A low 2D:4D ratio in girls was highly predictive of the presence of autistic features. Thus, a low ratio could possibly be used as a diagnostic predictor in clinical practice. En ligne : http://dx.doi.org/10.1177/1362361309335720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=833 [article] Autistic features in girls from a psychiatric sample are strongly associated with a low 2D:4D ratio [Texte imprimé et/ou numérique] / Esther I. DE BRUIN, Auteur ; Robert F. FERDINAND, Auteur ; Fop VERHEIJ, Auteur ; Debora H. VERHAGEN, Auteur ; Pieter F.A. DE NIJS, Auteur . - 2009 . - p.511-521. Langues : Anglais (eng) in Autism > 13-5 (September 2009) . - p.511-521 Mots-clés : autism diagnosis digit-ratio Index. décimale : PER Périodiques Résumé : Autistic features such as deficits in social interactions and communication have been associated with a low 2D:4D ratio in normal children.This study assessed this association in a large sample of children with a variety of psychiatric disorders (n = 35 girls and n = 147 boys). Autistic features were assessed with a highly valid and reliable measure (Autism Diagnostic Observation Schedule—Generic). Correlations between the 2D:4D ratio and autistic features were computed separately for boys and girls. Some small negative correlations (r = —0.17 and r = —0.19) were found in the right hand for boys; however, particularly in girls, large negative correlations (r = —0.51 to r = —0.64) were found in the left hand. A low 2D:4D ratio in girls was highly predictive of the presence of autistic features. Thus, a low ratio could possibly be used as a diagnostic predictor in clinical practice. En ligne : http://dx.doi.org/10.1177/1362361309335720 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=833

High Rates of Psychiatric Co-Morbidity in PDD-NOS / Esther I. DE BRUIN in Journal of Autism and Developmental Disorders, 37-5 (May 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.877-886 Titre : High Rates of Psychiatric Co-Morbidity in PDD-NOS Type de document : Texte imprimé et/ou numérique Auteurs : Esther I. DE BRUIN, Auteur ; Robert F. FERDINAND, Auteur ; Sjifra MEESTER, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur Année de publication : 2007 Article en page(s) : p.877-886 Langues : Anglais (eng) Mots-clés : PDD-NOS Autistic-disorder Psychiatric-co-morbidity Index. décimale : PER Périodiques Résumé : Rates of co-morbid psychiatric conditions in children with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) are hardly available, although these conditions are often considered as more responsive to treatment than the core symptoms of PDD-NOS. Ninety-four children with PDD-NOS, aged 6–12 years were included. The DISC-IV-P was administered. At least one co-morbid psychiatric disorder was present in 80.9% of the children; 61.7% had a co-morbid disruptive behavior disorder, and 55.3% fulfilled criteria of an anxiety disorder. Compared to those without co-morbid psychiatric disorders, children with a co-morbid disorder had more deficits in social communication. Co-morbid disorders occur very frequently in children with PDD-NOS, and therefore clinical assessment in those children should include assessment of co-morbid DSM-IV disorders. En ligne : http://dx.doi.org/10.1007/s10803-006-0215-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140 [article] High Rates of Psychiatric Co-Morbidity in PDD-NOS [Texte imprimé et/ou numérique] / Esther I. DE BRUIN, Auteur ; Robert F. FERDINAND, Auteur ; Sjifra MEESTER, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur . - 2007 . - p.877-886. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-5 (May 2007) . - p.877-886 Mots-clés : PDD-NOS Autistic-disorder Psychiatric-co-morbidity Index. décimale : PER Périodiques Résumé : Rates of co-morbid psychiatric conditions in children with Pervasive Developmental Disorder-Not Otherwise Specified (PDD-NOS) are hardly available, although these conditions are often considered as more responsive to treatment than the core symptoms of PDD-NOS. Ninety-four children with PDD-NOS, aged 6–12 years were included. The DISC-IV-P was administered. At least one co-morbid psychiatric disorder was present in 80.9% of the children; 61.7% had a co-morbid disruptive behavior disorder, and 55.3% fulfilled criteria of an anxiety disorder. Compared to those without co-morbid psychiatric disorders, children with a co-morbid disorder had more deficits in social communication. Co-morbid disorders occur very frequently in children with PDD-NOS, and therefore clinical assessment in those children should include assessment of co-morbid DSM-IV disorders. En ligne : http://dx.doi.org/10.1007/s10803-006-0215-x Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=140

Multiple Complex Developmental Disorder Delineated from PDD-NOS / Esther I. DE BRUIN in Journal of Autism and Developmental Disorders, 37-6 (July 2007)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 37-6 (July 2007) . - p.1181-1191 Titre : Multiple Complex Developmental Disorder Delineated from PDD-NOS Type de document : Texte imprimé et/ou numérique Auteurs : Esther I. DE BRUIN, Auteur ; Catharina A. HARTMAN, Auteur ; Robert F. FERDINAND, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur Année de publication : 2007 Article en page(s) : p.1181-1191 Langues : Anglais (eng) Mots-clés : MCDD Pervasive-developmental-disorders PDD-NOS Thought-problems Index. décimale : PER Périodiques Résumé : The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6–12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity, psychotic thought problems and social contact problems using the child behavior checklist/4–18, the Dutch version of the diagnostic interview schedule for children—Version IV, the child and adolescent functional assessment scale, and the autism diagnostic observation schedule-generic. MCDD was associated with anxiety disorders, disruptive behavior, and psychotic thought problems. PDD-NOS was associated with deficits in social contact. MCDD differs from autistic disorder, and can also be delineated from PDD-NOS. En ligne : http://dx.doi.org/10.1007/s10803-006-0261-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Multiple Complex Developmental Disorder Delineated from PDD-NOS [Texte imprimé et/ou numérique] / Esther I. DE BRUIN, Auteur ; Catharina A. HARTMAN, Auteur ; Robert F. FERDINAND, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur . - 2007 . - p.1181-1191. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 37-6 (July 2007) . - p.1181-1191 Mots-clés : MCDD Pervasive-developmental-disorders PDD-NOS Thought-problems Index. décimale : PER Périodiques Résumé : The objective of this study was to identify behavioral differences between children with multiple complex developmental disorder (MCDD) and those with pervasive developmental disorder-not otherwise specified (PDD-NOS). Twenty-five children (6–12 years) with MCDD and 86 children with PDD-NOS were compared with respect to psychiatric co-morbidity, psychotic thought problems and social contact problems using the child behavior checklist/4–18, the Dutch version of the diagnostic interview schedule for children—Version IV, the child and adolescent functional assessment scale, and the autism diagnostic observation schedule-generic. MCDD was associated with anxiety disorders, disruptive behavior, and psychotic thought problems. PDD-NOS was associated with deficits in social contact. MCDD differs from autistic disorder, and can also be delineated from PDD-NOS. En ligne : http://dx.doi.org/10.1007/s10803-006-0261-4 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

The association of quality of social relations, symptom severity and intelligence with anxiety in children with autism spectrum disorders / Mart L.J.M. EUSSEN in Autism, 17-6 (November 2013)  

Public ISBD [article]  inAutism > 17-6 (November 2013) . - p.723-735 Titre : The association of quality of social relations, symptom severity and intelligence with anxiety in children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mart L.J.M. EUSSEN, Auteur ; Arthur R. VAN GOOL, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur ; Frank C. VERHULST, Auteur ; Kirstin GREAVES-LORD, Auteur Année de publication : 2013 Article en page(s) : p.723-735 Langues : Anglais (eng) Mots-clés : anxiety  autism spectrum disorders  intelligence  social relations  symptom severity Index. décimale : PER Périodiques Résumé : Limited quality of social relations, milder symptom severity and higher intelligence were shown to account for higher anxiety levels in autism spectrum disorders. The current study replicated and extended earlier findings by combining these three determinants of anxiety in autism spectrum disorders in one study. The sample consisted of 134 school-aged children with autism spectrum disorders, of whom 58 (43%) had a co-morbid anxiety disorder according to the Diagnostic Interview Schedule for Children–Parent version. In this sample, we tested associations between these determinants and anxiety univariately and multivariately to clarify the unique contribution of all determinants. Since we hypothesized that the association between limited quality of social relations and anxiety would be amplified by low symptom severity and/or high intelligence, we additionally tested for moderating effects. We found that higher anxiety levels were associated with a lower quality of social relations and lower symptom severity. In this mainly high-functioning sample, intelligence was not related to anxiety levels. No moderation effects were found. Since lower quality of social relations and lower symptom severity are associated with higher anxiety levels in children with autism spectrum disorders, therapeutic interventions aimed at reducing anxiety in autism spectrum disorders should pay attention to improving social relations, and presumably children with a lower symptom severity could benefit most from such interventions. En ligne : http://dx.doi.org/10.1177/1362361312453882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218 [article] The association of quality of social relations, symptom severity and intelligence with anxiety in children with autism spectrum disorders [Texte imprimé et/ou numérique] / Mart L.J.M. EUSSEN, Auteur ; Arthur R. VAN GOOL, Auteur ; Fop VERHEIJ, Auteur ; Pieter F.A. DE NIJS, Auteur ; Frank C. VERHULST, Auteur ; Kirstin GREAVES-LORD, Auteur . - 2013 . - p.723-735. Langues : Anglais (eng) in Autism > 17-6 (November 2013) . - p.723-735 Mots-clés : anxiety  autism spectrum disorders  intelligence  social relations  symptom severity Index. décimale : PER Périodiques Résumé : Limited quality of social relations, milder symptom severity and higher intelligence were shown to account for higher anxiety levels in autism spectrum disorders. The current study replicated and extended earlier findings by combining these three determinants of anxiety in autism spectrum disorders in one study. The sample consisted of 134 school-aged children with autism spectrum disorders, of whom 58 (43%) had a co-morbid anxiety disorder according to the Diagnostic Interview Schedule for Children–Parent version. In this sample, we tested associations between these determinants and anxiety univariately and multivariately to clarify the unique contribution of all determinants. Since we hypothesized that the association between limited quality of social relations and anxiety would be amplified by low symptom severity and/or high intelligence, we additionally tested for moderating effects. We found that higher anxiety levels were associated with a lower quality of social relations and lower symptom severity. In this mainly high-functioning sample, intelligence was not related to anxiety levels. No moderation effects were found. Since lower quality of social relations and lower symptom severity are associated with higher anxiety levels in children with autism spectrum disorders, therapeutic interventions aimed at reducing anxiety in autism spectrum disorders should pay attention to improving social relations, and presumably children with a lower symptom severity could benefit most from such interventions. En ligne : http://dx.doi.org/10.1177/1362361312453882 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=218

Using the Child Behavior Checklist and the Teacher’s Report Form for identification of children with autism spectrum disorders / Pety SO in Autism, 17-5 (September 2013)  

Public ISBD [article]  inAutism > 17-5 (September 2013) . - p.595-607 Titre : Using the Child Behavior Checklist and the Teacher’s Report Form for identification of children with autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Pety SO, Auteur ; Kirstin GREAVES-LORD, Auteur ; Jan VAN DER ENDE, Auteur ; Frank C. VERHULST, Auteur ; Leslie RESCORLA, Auteur ; Pieter F.A. DE NIJS, Auteur Article en page(s) : p.595-607 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  Child Behavior Checklist  screening  Teacher’s Report Form Index. décimale : PER Périodiques Résumé : This study evaluated the ability of the Child Behavior Checklist and the Teacher’s Report Form to identify children with autism spectrum disorders (ASD), using a sample of children with ASD (n = 458), referred children without ASD (n = 1109) and children from the general population (n = 999). A ten items ASD scale was constructed using half of the sample and the ability of this scale to discriminate between children with ASD and the other children was tested for the CBCL and the TRF separately and together in the other half of the sample. Using a cut-off score of 8 the combined CBCL/TRF ASD scale demonstrated high predictive values (NPV 95%, PPV 73%) in identifying children with ASD and children in the general population sample. This might be an acceptable percentage of false positives in general screening, considering the chance that these children might have other behavioural, emotional, and developmental problems which also need psychiatric evaluation. In the referred population, using a cut-off of 13, PPV was 49% and NPV was 85%. The high NPV indicates that in a referred population the scale is especially good at identifying children who do not need evaluation with a more ASD-specific instrument. En ligne : http://dx.doi.org/10.1177/1362361312448855 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211 [article] Using the Child Behavior Checklist and the Teacher’s Report Form for identification of children with autism spectrum disorders [Texte imprimé et/ou numérique] / Pety SO, Auteur ; Kirstin GREAVES-LORD, Auteur ; Jan VAN DER ENDE, Auteur ; Frank C. VERHULST, Auteur ; Leslie RESCORLA, Auteur ; Pieter F.A. DE NIJS, Auteur . - p.595-607. Langues : Anglais (eng) in Autism > 17-5 (September 2013) . - p.595-607 Mots-clés : autism spectrum disorder  Child Behavior Checklist  screening  Teacher’s Report Form Index. décimale : PER Périodiques Résumé : This study evaluated the ability of the Child Behavior Checklist and the Teacher’s Report Form to identify children with autism spectrum disorders (ASD), using a sample of children with ASD (n = 458), referred children without ASD (n = 1109) and children from the general population (n = 999). A ten items ASD scale was constructed using half of the sample and the ability of this scale to discriminate between children with ASD and the other children was tested for the CBCL and the TRF separately and together in the other half of the sample. Using a cut-off score of 8 the combined CBCL/TRF ASD scale demonstrated high predictive values (NPV 95%, PPV 73%) in identifying children with ASD and children in the general population sample. This might be an acceptable percentage of false positives in general screening, considering the chance that these children might have other behavioural, emotional, and developmental problems which also need psychiatric evaluation. In the referred population, using a cut-off of 13, PPV was 49% and NPV was 85%. The high NPV indicates that in a referred population the scale is especially good at identifying children who do not need evaluation with a more ASD-specific instrument. En ligne : http://dx.doi.org/10.1177/1362361312448855 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=211

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