Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study / Jie CHEN in Journal of Child Psychology and Psychiatry, 56-5 (May 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.586-594 Titre : Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study Type de document : Texte imprimé et/ou numérique Auteurs : Jie CHEN, Auteur ; Jing YU, Auteur ; Xinying LI, Auteur ; Jianxin ZHANG, Auteur Article en page(s) : p.586-594 Langues : Anglais (eng) Mots-clés : Anxiety  Chinese children and adolescents  genetic and environmental influence  heritability  twin study Index. décimale : PER Périodiques Résumé : Background Child and adolescent anxiety has become a major public health concern in China, but little was known about the etiology of anxiety in Chinese children and adolescents. The present study aimed to investigate genetic and environmental influences on trait anxiety among Chinese children and adolescents. Rater, sex, and age differences on these estimates were also examined. Methods Self-reported and parent-reported child's trait anxiety was collected from 1,104 pairs of same-sex twins aged 9–18 years. Genetic models were fitted to data from each informant to determine the genetic (A), shared (C), and non-shared environmental (E) influences on trait anxiety. Results The parameter estimates and 95% confidence intervals (CI) of A, C, E on self-reported trait anxiety were 50% [30%, 60%], 5% [0%, 24%], 45% [40%, 49%]. For parent-reported data, the corresponding parameter estimates were 63% [47%, 78%], 13% [1%, 28%], and 24% [22%, 27%], respectively. The heritability of anxiety was higher in girls for self-reported data, but higher in boys for parent-reported data. There was no significant age difference in genetic and environmental contributions for self-reported data, but a significant increase of heritability with age for parent-reported data. Conclusions The trait anxiety in Chinese children and adolescents was highly heritable. Non-shared environmental factors also played an important role. The estimates of genetic and environmental effects differed by rater, sex and age. Our findings largely suggest the cross-cultural generalizability of the etiological model of child and adolescent anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Genetic and environmental contributions to anxiety among Chinese children and adolescents – a multi-informant twin study [Texte imprimé et/ou numérique] / Jie CHEN, Auteur ; Jing YU, Auteur ; Xinying LI, Auteur ; Jianxin ZHANG, Auteur . - p.586-594. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-5 (May 2015) . - p.586-594 Mots-clés : Anxiety  Chinese children and adolescents  genetic and environmental influence  heritability  twin study Index. décimale : PER Périodiques Résumé : Background Child and adolescent anxiety has become a major public health concern in China, but little was known about the etiology of anxiety in Chinese children and adolescents. The present study aimed to investigate genetic and environmental influences on trait anxiety among Chinese children and adolescents. Rater, sex, and age differences on these estimates were also examined. Methods Self-reported and parent-reported child's trait anxiety was collected from 1,104 pairs of same-sex twins aged 9–18 years. Genetic models were fitted to data from each informant to determine the genetic (A), shared (C), and non-shared environmental (E) influences on trait anxiety. Results The parameter estimates and 95% confidence intervals (CI) of A, C, E on self-reported trait anxiety were 50% [30%, 60%], 5% [0%, 24%], 45% [40%, 49%]. For parent-reported data, the corresponding parameter estimates were 63% [47%, 78%], 13% [1%, 28%], and 24% [22%, 27%], respectively. The heritability of anxiety was higher in girls for self-reported data, but higher in boys for parent-reported data. There was no significant age difference in genetic and environmental contributions for self-reported data, but a significant increase of heritability with age for parent-reported data. Conclusions The trait anxiety in Chinese children and adolescents was highly heritable. Non-shared environmental factors also played an important role. The estimates of genetic and environmental effects differed by rater, sex and age. Our findings largely suggest the cross-cultural generalizability of the etiological model of child and adolescent anxiety. En ligne : http://dx.doi.org/10.1111/jcpp.12310 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study / Jie CHEN in Journal of Child Psychology and Psychiatry, 54-10 (October 2013)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1066-1073 Titre : The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study Type de document : Texte imprimé et/ou numérique Auteurs : Jie CHEN, Auteur ; Xinying LI, Auteur ; Matt MCGUE, Auteur Article en page(s) : p.1066-1073 Langues : Anglais (eng) Mots-clés : Adolescent  depressive symptoms  BDNF Val66Met polymorphism  stressful life events  gene–environment interaction  gene–environment correlation Index. décimale : PER Périodiques Résumé : Background Confounding introduced by gene–environment correlation (rGE) may prevent one from observing a true gene–environment interaction (G × E) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. Methods A total of 780 pairs of Chinese twins, aged 11–17 years (mean = 13.6, SD = 1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. Results After controlling for sex, age, age square, and Time 1 depression, both total SLEs × BDNF Val66Met genotype and independent SLEs × BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. Conclusions There is a true G × E effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression. En ligne : http://dx.doi.org/10.1111/jcpp.12099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212 [article] The interacting effect of the BDNF Val66Met polymorphism and stressful life events on adolescent depression is not an artifact of gene–environment correlation: evidence from a longitudinal twin study [Texte imprimé et/ou numérique] / Jie CHEN, Auteur ; Xinying LI, Auteur ; Matt MCGUE, Auteur . - p.1066-1073. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 54-10 (October 2013) . - p.1066-1073 Mots-clés : Adolescent  depressive symptoms  BDNF Val66Met polymorphism  stressful life events  gene–environment interaction  gene–environment correlation Index. décimale : PER Périodiques Résumé : Background Confounding introduced by gene–environment correlation (rGE) may prevent one from observing a true gene–environment interaction (G × E) effect on psychopathology. The present study investigated the interacting effect of the BDNF Val66Met polymorphism and stressful life events (SLEs) on adolescent depression while controlling for the rGE by two means: separating pure environmental factors (independent SLEs) from the environmental factors under partial genetic control (dependent SLEs) and adopting a prospective longitudinal design. Methods A total of 780 pairs of Chinese twins, aged 11–17 years (mean = 13.6, SD = 1.8) at intake, were followed up twice. Self-reported depression symptoms at Time 1 and Time 2 were assessed by the Children's Depression Inventory (CDI). SLEs occurring between Time 1 and Time 2 were assessed by a self-reported checklist. SLEs were differentiated into independent and dependent ones and were validated by heritability analyses using twin design. The interacting effects between the BDNF Val66Met polymorphism and numbers of SLEs (total SLEs and independent SLEs) on intraindividual change of depression symptoms were examined. Results After controlling for sex, age, age square, and Time 1 depression, both total SLEs × BDNF Val66Met genotype and independent SLEs × BDNF Val66Met genotype significantly predicted Time 2 depression. Val allele carriers (Val/Val and Val/Met) were more susceptible to the detrimental effects of stress. Conclusions There is a true G × E effect underlying the observed interaction between BDNF Val66Met polymorphism and environmental stress on depression. En ligne : http://dx.doi.org/10.1111/jcpp.12099 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=212

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