Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Titre : Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur Article en page(s) : p.954-963 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281 [article] Atypical Neural Activity in Males But Not Females with Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Matthew E. HUGHES, Auteur ; Susan L. ROSSELL, Auteur ; Paul B. FITZGERALD, Auteur . - p.954-963. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.954-963 Mots-clés : Autism spectrum disorder  Theory of mind  Mentalizing network  Sex differences  Medial prefrontal cortex  Temporo-parietal junction  Superior temporal sulcus  Functional magnetic resonance imaging Index. décimale : PER Périodiques Résumé : The medial prefrontal cortex (mPFC) and the right temporo-parietal junction (rTPj) are highly involved in social understanding, a core area of impairment in autism spectrum disorder (ASD). We used fMRI to investigate sex differences in the neural correlates of social understanding in 27 high-functioning adults with ASD and 23 matched controls. There were no differences in neural activity in the mPFC or rTPj between groups during social processing. Whole brain analysis revealed decreased activity in the posterior superior temporal sulcus in males with ASD compared to control males while processing social information. This pattern was not observed in the female sub-sample. The current study indicates that sex mediates the neurobiology of ASD, particularly with respect to processing social information. En ligne : http://dx.doi.org/10.1007/s10803-015-2639-7 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=281

A Review of the Role of Female Gender in Autism Spectrum Disorders / Melissa KIRKOVSKI in Journal of Autism and Developmental Disorders, 43-11 (November 2013)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2584-2603 Titre : A Review of the Role of Female Gender in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Paul B. FITZGERALD, Auteur Article en page(s) : p.2584-2603 Langues : Anglais (eng) Mots-clés : Gender  Symptomatology  Diagnosis  Etiology Index. décimale : PER Périodiques Résumé : This paper reviews the literature exploring gender differences associated with the clinical presentation of autism spectrum disorders (ASD). The potentially mediating effect of comorbid psychopathology, biological and neurodevelopmental implications on these gender differences is also discussed. A vastly heterogeneous condition, while females on the lower-functioning end of the spectrum appear to be more severely affected, an altered clinical manifestation of the disorder among high-functioning females may consequently result in many being un or misdiagnosed. To date, there is strong bias in the literature towards the clinical presentation of ASD in males. It is imperative that future research explores gender differences across the autism spectrum, in order to improve researchers’, clinicians’ and the publics’ understanding of this debilitating disorder. En ligne : http://dx.doi.org/10.1007/s10803-013-1811-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217 [article] A Review of the Role of Female Gender in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Melissa KIRKOVSKI, Auteur ; Peter G. ENTICOTT, Auteur ; Paul B. FITZGERALD, Auteur . - p.2584-2603. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 43-11 (November 2013) . - p.2584-2603 Mots-clés : Gender  Symptomatology  Diagnosis  Etiology Index. décimale : PER Périodiques Résumé : This paper reviews the literature exploring gender differences associated with the clinical presentation of autism spectrum disorders (ASD). The potentially mediating effect of comorbid psychopathology, biological and neurodevelopmental implications on these gender differences is also discussed. A vastly heterogeneous condition, while females on the lower-functioning end of the spectrum appear to be more severely affected, an altered clinical manifestation of the disorder among high-functioning females may consequently result in many being un or misdiagnosed. To date, there is strong bias in the literature towards the clinical presentation of ASD in males. It is imperative that future research explores gender differences across the autism spectrum, in order to improve researchers’, clinicians’ and the publics’ understanding of this debilitating disorder. En ligne : http://dx.doi.org/10.1007/s10803-013-1811-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=217

---

1 (1 - 2 / 2)