Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-3 (March 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.321-323 Titre : Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.321-323 Langues : Anglais (eng) Mots-clés : Brain development  neuropsychiatric disorders  neuroimaging  connectome  DOHad Index. décimale : PER Périodiques Résumé : Vértes and Bullmore's article lays a framework for applying connectomics, the study of brain function from the perspective of underlying network organization, to advance understanding of healthy and maladaptive brain development. They elucidate the power of connectomics for bridging both different levels of analysis (e.g. from synapses to brain regions) and multiple academic fields. In this commentary, we highlight important themes and remaining questions stemming from Vértes and Bullmore's work, including: (a) the application of connectomics in the context of integrating analyses across multiple spatial and temporal dimensions, (b) the extent to which connectomics might be applied in translational and clinical studies of development, (c) growth connectomics and the Developmental Origins of Health and Disease (DOHaD) hypothesis, and (d) the importance and complexity of sound methodological practices in applying connectomics to developmental and clinical science. Ongoing work in these areas will be important for fulfilling the promise of connectomics as a bridge between neuroscience, developmental science, and translational and clinical research. En ligne : http://dx.doi.org/10.1111/jcpp.12400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development – a commentary on Vértes and Bullmore () [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Damien A. FAIR, Auteur . - p.321-323. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-3 (March 2015) . - p.321-323 Mots-clés : Brain development  neuropsychiatric disorders  neuroimaging  connectome  DOHad Index. décimale : PER Périodiques Résumé : Vértes and Bullmore's article lays a framework for applying connectomics, the study of brain function from the perspective of underlying network organization, to advance understanding of healthy and maladaptive brain development. They elucidate the power of connectomics for bridging both different levels of analysis (e.g. from synapses to brain regions) and multiple academic fields. In this commentary, we highlight important themes and remaining questions stemming from Vértes and Bullmore's work, including: (a) the application of connectomics in the context of integrating analyses across multiple spatial and temporal dimensions, (b) the extent to which connectomics might be applied in translational and clinical studies of development, (c) growth connectomics and the Developmental Origins of Health and Disease (DOHaD) hypothesis, and (d) the importance and complexity of sound methodological practices in applying connectomics to developmental and clinical science. Ongoing work in these areas will be important for fulfilling the promise of connectomics as a bridge between neuroscience, developmental science, and translational and clinical research. En ligne : http://dx.doi.org/10.1111/jcpp.12400 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1837-1848 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1837-1848. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1837-1848 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques Résumé : High levels of early emotionality (of either negative or positive valence) are hypothesized to be important precursors to early psychopathology, with attention-deficit/hyperactivity disorder (ADHD) a prime early target. The positive and negative affect domains are prime examples of Research Domain Criteria (RDoC) concepts that may enrich a multilevel mechanistic map of psychopathology risk. Utilizing both variable-centered and person-centered approaches, the current study examined whether levels and trajectories of infant negative and positive emotionality, considered either in isolation or together, predicted children's ADHD symptoms at 4 to 8 years of age. In variable-centered analyses, higher levels of infant negative affect (at as early as 3 months of age) were associated with childhood ADHD symptoms. Findings for positive affect failed to reach statistical threshold. Results from person-centered trajectory analyses suggest that additional information is gained by simultaneously considering the trajectories of positive and negative emotionality. Specifically, only when exhibiting moderate, stable or low levels of positive affect did negative affect and its trajectory relate to child ADHD symptoms. These findings add to a growing literature that suggests that infant negative emotionality is a promising early life marker of future ADHD risk and suggest secondarily that moderation by positive affectivity warrants more consideration. En ligne : http://dx.doi.org/10.1017/S0954579421001012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM / Hanna C. GUSTAFSSON in Development and Psychopathology, 33-5 (December 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Titre : Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM Type de document : Texte imprimé et/ou numérique Auteurs : Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur Article en page(s) : p.1882-1882 Langues : Anglais (eng) Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458 [article] Early development of negative and positive affect: Implications for ADHD symptomatology across three birth cohorts – CORRIGENDUM [Texte imprimé et/ou numérique] / Hanna C. GUSTAFSSON, Auteur ; Saara NOLVI, Auteur ; Elinor L. SULLIVAN, Auteur ; Jerod M. RASMUSSEN, Auteur ; Lauren E. GYLLENHAMMER, Auteur ; Sonja ENTRINGER, Auteur ; Pathik D. WADHWA, Auteur ; Thomas G. O'CONNOR, Auteur ; Linnea KARLSSON, Auteur ; Hasse KARLSSON, Auteur ; Riikka KORJA, Auteur ; Claudia BUSS, Auteur ; Alice M. GRAHAM, Auteur ; Joel T. NIGG, Auteur . - p.1882-1882. Langues : Anglais (eng) in Development and Psychopathology > 33-5 (December 2021) . - p.1882-1882 Mots-clés : ADHD symptomatology  infant temperament  negative affect  positive affect  trajectory analysis Index. décimale : PER Périodiques En ligne : http://dx.doi.org/10.1017/S0954579421001425 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=458

Early life stress is associated with default system integrity and emotionality during infancy / Alice M. GRAHAM in Journal of Child Psychology and Psychiatry, 56-11 (November 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Titre : Early life stress is associated with default system integrity and emotionality during infancy Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur Article en page(s) : p.1212-1222 Langues : Anglais (eng) Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Early life stress is associated with default system integrity and emotionality during infancy [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Jennifer H. PFEIFER, Auteur ; Philip A. FISHER, Auteur ; Samuel CARPENTER, Auteur ; Damien A. FAIR, Auteur . - p.1212-1222. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-11 (November 2015) . - p.1212-1222 Mots-clés : Functional MRI  infancy  stress  family functioning  brain development Index. décimale : PER Périodiques Résumé : Background Extensive animal research has demonstrated the vulnerability of the brain to early life stress (ELS) with consequences for emotional development and mental health. However, the influence of moderate and common forms of stress on early human brain development is less well-understood and precisely characterized. To date, most work has focused on severe forms of stress, and/or on brain functioning years after stress exposure. Methods In this report we focused on conflict between parents (interparental conflict), a common and relatively moderate form of ELS that is highly relevant for children's mental health outcomes. We used resting state functional connectivity MRI to examine the coordinated functioning of the infant brain (N = 23; 6–12-months-of-age) in the context of interparental conflict. We focused on the default mode network (DMN) due to its well-characterized developmental trajectory and implications for mental health. We further examined DMN strength as a mediator between conflict and infants’ negative emotionality. Results Higher interparental conflict since birth was associated with infants showing stronger connectivity between two core DMN regions, the posterior cingulate cortex (PCC) and the anterior medial prefrontal cortex (aMPFC). PCC to amygdala connectivity was also increased. Stronger PCC-aMPFC connectivity mediated between higher conflict and higher negative infant emotionality. Conclusions The developing DMN may be an important marker for effects of ELS with relevance for emotional development and subsequent mental health. Increasing understanding of the associations between common forms of family stress and emerging functional brain networks has potential to inform intervention efforts to improve mental health outcomes. En ligne : http://dx.doi.org/10.1111/jcpp.12409 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Effects of a school readiness intervention on hypothalamus–pituitary–adrenal axis functioning and school adjustment for children in foster care / Alice M. GRAHAM in Development and Psychopathology, 30-2 (May 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-2 (May 2018) . - p.651-664 Titre : Effects of a school readiness intervention on hypothalamus–pituitary–adrenal axis functioning and school adjustment for children in foster care Type de document : Texte imprimé et/ou numérique Auteurs : Alice M. GRAHAM, Auteur ; Katherine C. PEARS, Auteur ; Hyoun K. KIM, Auteur ; Jacqueline BRUCE, Auteur ; Philip A. FISHER, Auteur Article en page(s) : p.651-664 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Maltreated children in foster care are at high risk for dysregulated hypothalamus–pituitary–adrenal (HPA) axis functioning and educational difficulties. The present study examined the effects of a short-term school readiness intervention on HPA axis functioning in response to the start of kindergarten, a critical transition marking entry to formal schooling, and whether altered HPA axis functioning influenced children's school adjustment. Compared to a foster care comparison group, children in the intervention group showed a steeper diurnal cortisol slope on the first day of school, a pattern previously observed among nonmaltreated children. A steeper first day of school diurnal cortisol slope predicted teacher ratings of better school adjustment (i.e., academic performance, appropriate classroom behaviors, and engagement in learning) in the fall of kindergarten. Furthermore, the children's HPA axis response to the start of school mediated the effect of the intervention on school adjustment. These findings support the potential for ameliorative effects of interventions targeting critical transitional periods, such as the transition of formal schooling. This school readiness intervention appears to influence stress neurobiology, which in turn facilitates positive engagement with the school environment and better school adjustment in children who have experienced significant early adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359 [article] Effects of a school readiness intervention on hypothalamus–pituitary–adrenal axis functioning and school adjustment for children in foster care [Texte imprimé et/ou numérique] / Alice M. GRAHAM, Auteur ; Katherine C. PEARS, Auteur ; Hyoun K. KIM, Auteur ; Jacqueline BRUCE, Auteur ; Philip A. FISHER, Auteur . - p.651-664. Langues : Anglais (eng) in Development and Psychopathology > 30-2 (May 2018) . - p.651-664 Index. décimale : PER Périodiques Résumé : Maltreated children in foster care are at high risk for dysregulated hypothalamus–pituitary–adrenal (HPA) axis functioning and educational difficulties. The present study examined the effects of a short-term school readiness intervention on HPA axis functioning in response to the start of kindergarten, a critical transition marking entry to formal schooling, and whether altered HPA axis functioning influenced children's school adjustment. Compared to a foster care comparison group, children in the intervention group showed a steeper diurnal cortisol slope on the first day of school, a pattern previously observed among nonmaltreated children. A steeper first day of school diurnal cortisol slope predicted teacher ratings of better school adjustment (i.e., academic performance, appropriate classroom behaviors, and engagement in learning) in the fall of kindergarten. Furthermore, the children's HPA axis response to the start of school mediated the effect of the intervention on school adjustment. These findings support the potential for ameliorative effects of interventions targeting critical transitional periods, such as the transition of formal schooling. This school readiness intervention appears to influence stress neurobiology, which in turn facilitates positive engagement with the school environment and better school adjustment in children who have experienced significant early adversity. En ligne : http://dx.doi.org/10.1017/S0954579417001171 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=359

Patterns of brain activation in foster children and nonmaltreated children during an inhibitory control task / Jacqueline BRUCE in Development and Psychopathology, 25-4 (November 2013)  

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