Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and Motor Deficits in Children with Autism Spectrum Disorder: A Diffusion Tensor Imaging Study / Ryuzo HANAIE in Journal of Autism and Developmental Disorders, 44-9 (September 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2209-2220 Titre : Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and Motor Deficits in Children with Autism Spectrum Disorder: A Diffusion Tensor Imaging Study Type de document : Texte imprimé et/ou numérique Auteurs : Ryuzo HANAIE, Auteur ; Ikuko MOHRI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; Masaya TACHIBANA, Auteur ; Junko MATSUZAKI, Auteur ; Yoshiyuki WATANABE, Auteur ; Norihiko FUJITA, Auteur ; Masako TANIIKE, Auteur Article en page(s) : p.2209-2220 Langues : Anglais (eng) Mots-clés : Diffusion tensor imaging  Tractography  Corpus callosum  Autism spectrum disorder  Motor function Index. décimale : PER Périodiques Résumé : In addition to social and communicative deficits, many studies have reported motor deficits in autism spectrum disorder (ASD). This study investigated the macro and microstructural properties of the corpus callosum (CC) of 18 children with ASD and 12 typically developing controls using diffusion tensor imaging tractography. We aimed to explore whether abnormalities of the CC were related to motor deficits, as well as social and communication deficits in children with ASD. The ASD group displayed abnormal macro and microstructure of the total CC and its subdivisions and its structural properties were related to socio-communicative deficits, but not to motor deficits in ASD. These findings advance our understanding of the contributions of the CC to ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-014-2096-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238 [article] Abnormal Corpus Callosum Connectivity, Socio-communicative Deficits, and Motor Deficits in Children with Autism Spectrum Disorder: A Diffusion Tensor Imaging Study [Texte imprimé et/ou numérique] / Ryuzo HANAIE, Auteur ; Ikuko MOHRI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; Masaya TACHIBANA, Auteur ; Junko MATSUZAKI, Auteur ; Yoshiyuki WATANABE, Auteur ; Norihiko FUJITA, Auteur ; Masako TANIIKE, Auteur . - p.2209-2220. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-9 (September 2014) . - p.2209-2220 Mots-clés : Diffusion tensor imaging  Tractography  Corpus callosum  Autism spectrum disorder  Motor function Index. décimale : PER Périodiques Résumé : In addition to social and communicative deficits, many studies have reported motor deficits in autism spectrum disorder (ASD). This study investigated the macro and microstructural properties of the corpus callosum (CC) of 18 children with ASD and 12 typically developing controls using diffusion tensor imaging tractography. We aimed to explore whether abnormalities of the CC were related to motor deficits, as well as social and communication deficits in children with ASD. The ASD group displayed abnormal macro and microstructure of the total CC and its subdivisions and its structural properties were related to socio-communicative deficits, but not to motor deficits in ASD. These findings advance our understanding of the contributions of the CC to ASD symptoms. En ligne : http://dx.doi.org/10.1007/s10803-014-2096-8 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=238

Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies / Min LI in Autism Research, 15-9 (September 2022)  

Public ISBD [article]  inAutism Research > 15-9 (September 2022) . - p.1585-1602 Titre : Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Min LI, Auteur ; Yide WANG, Auteur ; Masaya TACHIBANA, Auteur ; Shafiur RAHMAN, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur Article en page(s) : p.1585-1602 Langues : Anglais (eng) Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Child Development Disorders, Pervasive/diagnosis  Diffusion Tensor Imaging  Humans  White Matter/diagnostic imaging  autism spectrum disorder  language networks  meta-analysis  white matter connectivity Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) often show pervasive and complex language impairments that are closely associated with aberrant structural connectivity of language networks. However, the characteristics of white matter connectivity in ASD have remained inconclusive in previous diffusion tensor imaging (DTI) studies. The current meta-analysis aimed to comprehensively elucidate the abnormality in language-related white matter connectivity in individuals with ASD. We searched PubMed, Web of Science, Scopus, and Medline databases to identify relevant studies. The standardized mean difference was calculated to measure the pooled difference in DTI metrics in each tract between the ASD and typically developing (TD) groups. The moderating effects of age, sex, language ability, and symptom severity were investigated using subgroup and meta-regression analysis. Thirty-three DTI studies involving 831 individuals with ASD and 836 TD controls were included in the meta-analysis. ASD subjects showed significantly lower fractional anisotropy or higher mean diffusivity across language-associated tracts than TD controls. These abnormalities tended to be more prominent in the left language networks than in the right. In addition, children with ASD exhibit more pronounced and pervasive disturbances in white matter connectivity than adults. These results support the under-connectivity hypothesis and demonstrate the widespread abnormal microstructure of language-related tracts in patients with ASD. Otherwise, white matter abnormalities in the autistic brain could vary depending on the developmental stage and hemisphere. LAY SUMMARY: This meta-analysis explored abnormalities in white matter connectivity in language networks of individuals with ASD. Significantly reduced white matter integrity was found in all language-associated tracts in subjects with ASD compared with TD controls. In addition, structural disturbances of language networks in the autistic brain exhibit a leftward tendency, and more prominent abnormalities are observed in younger people with ASD than in adults. En ligne : http://dx.doi.org/10.1002/aur.2789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483 [article] Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies [Texte imprimé et/ou numérique] / Min LI, Auteur ; Yide WANG, Auteur ; Masaya TACHIBANA, Auteur ; Shafiur RAHMAN, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur . - p.1585-1602. Langues : Anglais (eng) in Autism Research > 15-9 (September 2022) . - p.1585-1602 Mots-clés : Adult  Autism Spectrum Disorder/diagnostic imaging  Brain/diagnostic imaging  Child  Child Development Disorders, Pervasive/diagnosis  Diffusion Tensor Imaging  Humans  White Matter/diagnostic imaging  autism spectrum disorder  language networks  meta-analysis  white matter connectivity Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) often show pervasive and complex language impairments that are closely associated with aberrant structural connectivity of language networks. However, the characteristics of white matter connectivity in ASD have remained inconclusive in previous diffusion tensor imaging (DTI) studies. The current meta-analysis aimed to comprehensively elucidate the abnormality in language-related white matter connectivity in individuals with ASD. We searched PubMed, Web of Science, Scopus, and Medline databases to identify relevant studies. The standardized mean difference was calculated to measure the pooled difference in DTI metrics in each tract between the ASD and typically developing (TD) groups. The moderating effects of age, sex, language ability, and symptom severity were investigated using subgroup and meta-regression analysis. Thirty-three DTI studies involving 831 individuals with ASD and 836 TD controls were included in the meta-analysis. ASD subjects showed significantly lower fractional anisotropy or higher mean diffusivity across language-associated tracts than TD controls. These abnormalities tended to be more prominent in the left language networks than in the right. In addition, children with ASD exhibit more pronounced and pervasive disturbances in white matter connectivity than adults. These results support the under-connectivity hypothesis and demonstrate the widespread abnormal microstructure of language-related tracts in patients with ASD. Otherwise, white matter abnormalities in the autistic brain could vary depending on the developmental stage and hemisphere. LAY SUMMARY: This meta-analysis explored abnormalities in white matter connectivity in language networks of individuals with ASD. Significantly reduced white matter integrity was found in all language-associated tracts in subjects with ASD compared with TD controls. In addition, structural disturbances of language networks in the autistic brain exhibit a leftward tendency, and more prominent abnormalities are observed in younger people with ASD than in adults. En ligne : http://dx.doi.org/10.1002/aur.2789 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=483

Lesser suppression of response to bright visual stimuli and visual abnormality in children with autism spectrum disorder: a magnetoencephalographic study / S. AOKI in Journal of Neurodevelopmental Disorders, 11-1 (December 2019)  

Public ISBD [article]  inJournal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 9 p. Titre : Lesser suppression of response to bright visual stimuli and visual abnormality in children with autism spectrum disorder: a magnetoencephalographic study Type de document : Texte imprimé et/ou numérique Auteurs : S. AOKI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; J. MATSUZAKI, Auteur ; R. HANAIE, Auteur ; M. NAKANISHI, Auteur ; K. TOMINAGA, Auteur ; Y. NAGAI, Auteur ; I. MOHRI, Auteur ; M. TANIIKE, Auteur Article en page(s) : 9 p. Langues : Anglais (eng) Mots-clés : Autism spectrum disorders (ASD)  Bright visual stimuli  Magnetoencephalography (MEG)  Neural suppression  Supramarginal gyrus (SMG)  Visual abnormality Index. décimale : PER Périodiques Résumé : BACKGROUND: Visual abnormality is a common sensory impairment in autism spectrum disorder (ASD), which may cause behavioral problems. However, only a few studies exist on the neural features corresponding to the visual symptoms in ASD. The purpose of this study was to investigate the relationship between cortical responses to visual stimuli and visual abnormality to examine the neurophysiological mechanisms of the visual abnormality in ASD. METHODS: Twenty-two high-functioning children with ASD (10.95 +/- 2.01 years old) and 23 age-matched typically developing (TD) children (10.13 +/- 2.80 years old) participated in this study. We measured the cortical responses (i.e., activated intensity and attenuation ratio) elicited by the Original visual image and other two types of bright images (the Dot noise or Blind image, which includes overlapped particles onto the Original image or the enhanced-brightness version of the Original image, respectively) using magnetoencephalography. RESULTS: The severity of visual abnormalities was significantly associated with behavioral problems in children with ASD. In addition, we found the increased cortical activation in response to the Original image in the left supramarginal gyrus (SMG) and middle temporal gyrus in children with ASD. However, there were no inter-group differences in the primary visual and medial orbitofrontal cortices. Furthermore, when we compared cortical responses according to the type of images, children with ASD showed lesser attenuation of the activated intensities than children with TD in response to the bright images compared with the Original image in the right SMG. These attenuation ratios (Dot noise/Original and Blind/Original) were also associated with the severity of visual abnormalities. CONCLUSIONS: Our results show that dysfunction of stimulus-driven neural suppression plays a crucial role in the neural mechanism of visual abnormality in children with ASD. To the best of our knowledge, this is the first magnetoencephalography study to demonstrate the association between the severity of visual abnormality and lower attenuation ratios in children with ASD. Our results contribute to the knowledge of the mechanisms underlying visual abnormality in children with ASD, and may therefore lead to more effective diagnosis and earlier intervention. En ligne : https://dx.doi.org/10.1186/s11689-019-9266-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409 [article] Lesser suppression of response to bright visual stimuli and visual abnormality in children with autism spectrum disorder: a magnetoencephalographic study [Texte imprimé et/ou numérique] / S. AOKI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; J. MATSUZAKI, Auteur ; R. HANAIE, Auteur ; M. NAKANISHI, Auteur ; K. TOMINAGA, Auteur ; Y. NAGAI, Auteur ; I. MOHRI, Auteur ; M. TANIIKE, Auteur . - 9 p. Langues : Anglais (eng) in Journal of Neurodevelopmental Disorders > 11-1 (December 2019) . - 9 p. Mots-clés : Autism spectrum disorders (ASD)  Bright visual stimuli  Magnetoencephalography (MEG)  Neural suppression  Supramarginal gyrus (SMG)  Visual abnormality Index. décimale : PER Périodiques Résumé : BACKGROUND: Visual abnormality is a common sensory impairment in autism spectrum disorder (ASD), which may cause behavioral problems. However, only a few studies exist on the neural features corresponding to the visual symptoms in ASD. The purpose of this study was to investigate the relationship between cortical responses to visual stimuli and visual abnormality to examine the neurophysiological mechanisms of the visual abnormality in ASD. METHODS: Twenty-two high-functioning children with ASD (10.95 +/- 2.01 years old) and 23 age-matched typically developing (TD) children (10.13 +/- 2.80 years old) participated in this study. We measured the cortical responses (i.e., activated intensity and attenuation ratio) elicited by the Original visual image and other two types of bright images (the Dot noise or Blind image, which includes overlapped particles onto the Original image or the enhanced-brightness version of the Original image, respectively) using magnetoencephalography. RESULTS: The severity of visual abnormalities was significantly associated with behavioral problems in children with ASD. In addition, we found the increased cortical activation in response to the Original image in the left supramarginal gyrus (SMG) and middle temporal gyrus in children with ASD. However, there were no inter-group differences in the primary visual and medial orbitofrontal cortices. Furthermore, when we compared cortical responses according to the type of images, children with ASD showed lesser attenuation of the activated intensities than children with TD in response to the bright images compared with the Original image in the right SMG. These attenuation ratios (Dot noise/Original and Blind/Original) were also associated with the severity of visual abnormalities. CONCLUSIONS: Our results show that dysfunction of stimulus-driven neural suppression plays a crucial role in the neural mechanism of visual abnormality in children with ASD. To the best of our knowledge, this is the first magnetoencephalography study to demonstrate the association between the severity of visual abnormality and lower attenuation ratios in children with ASD. Our results contribute to the knowledge of the mechanisms underlying visual abnormality in children with ASD, and may therefore lead to more effective diagnosis and earlier intervention. En ligne : https://dx.doi.org/10.1186/s11689-019-9266-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=409

White matter volume in the brainstem and inferior parietal lobule is related to motor performance in children with autism spectrum disorder: A voxel-based morphometry study / Ryuzo HANAIE in Autism Research, 9-9 (September 2016)  

Public ISBD [article]  inAutism Research > 9-9 (September 2016) . - p.981-992 Titre : White matter volume in the brainstem and inferior parietal lobule is related to motor performance in children with autism spectrum disorder: A voxel-based morphometry study Type de document : Texte imprimé et/ou numérique Auteurs : Ryuzo HANAIE, Auteur ; Ikuko MOHRI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; Masaya TACHIBANA, Auteur ; Junko MATSUZAKI, Auteur ; Ikuko HIRATA, Auteur ; Fumiyo NAGATANI, Auteur ; Yoshiyuki WATANABE, Auteur ; Norihiko FUJITA, Auteur ; Masako TANIIKE, Auteur Article en page(s) : p.981-992 Langues : Anglais (eng) Mots-clés : voxel-based morphometry  white matter  brainstem  autism spectrum disorder  motor Index. décimale : PER Périodiques Résumé : Many studies have reported poor motor performance in autism spectrum disorder (ASD); however, the underlying brain mechanisms remain unclear. Recent neuroimaging studies have suggested that abnormalities of the white matter (WM) are related to the features of ASD. In this study, we used voxel-based morphometry (VBM) to investigate which WM regions correlate with motor performance in children with ASD, and whether the WM volume in those brain regions differed between children with ASD and typically developing (TD) children. The subjects included 19 children with ASD and 20 TD controls. Motor performance was assessed using the Movement Assessment Battery for Children 2 (M-ABC 2). Children with ASD showed poorer motor performance than did the controls. There was a significant positive correlation between the total test score on the M-ABC 2 and the volume of WM in the brainstem and WM adjacent to the left supramarginal gyrus (SMG). In addition, compared with the TD controls, children with ASD had a decreased volume of WM in the brainstem and adjacent to the left intraparietal sulcus, which is close to the SMG. These findings suggest that structural changes in the WM in the brainstem and left inferior parietal lobule may contribute to poor motor performance in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] White matter volume in the brainstem and inferior parietal lobule is related to motor performance in children with autism spectrum disorder: A voxel-based morphometry study [Texte imprimé et/ou numérique] / Ryuzo HANAIE, Auteur ; Ikuko MOHRI, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur ; Masaya TACHIBANA, Auteur ; Junko MATSUZAKI, Auteur ; Ikuko HIRATA, Auteur ; Fumiyo NAGATANI, Auteur ; Yoshiyuki WATANABE, Auteur ; Norihiko FUJITA, Auteur ; Masako TANIIKE, Auteur . - p.981-992. Langues : Anglais (eng) in Autism Research > 9-9 (September 2016) . - p.981-992 Mots-clés : voxel-based morphometry  white matter  brainstem  autism spectrum disorder  motor Index. décimale : PER Périodiques Résumé : Many studies have reported poor motor performance in autism spectrum disorder (ASD); however, the underlying brain mechanisms remain unclear. Recent neuroimaging studies have suggested that abnormalities of the white matter (WM) are related to the features of ASD. In this study, we used voxel-based morphometry (VBM) to investigate which WM regions correlate with motor performance in children with ASD, and whether the WM volume in those brain regions differed between children with ASD and typically developing (TD) children. The subjects included 19 children with ASD and 20 TD controls. Motor performance was assessed using the Movement Assessment Battery for Children 2 (M-ABC 2). Children with ASD showed poorer motor performance than did the controls. There was a significant positive correlation between the total test score on the M-ABC 2 and the volume of WM in the brainstem and WM adjacent to the left supramarginal gyrus (SMG). In addition, compared with the TD controls, children with ASD had a decreased volume of WM in the brainstem and adjacent to the left intraparietal sulcus, which is close to the SMG. These findings suggest that structural changes in the WM in the brainstem and left inferior parietal lobule may contribute to poor motor performance in children with ASD. En ligne : http://dx.doi.org/10.1002/aur.1605 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

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