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4 recherche sur le mot-clé 'White Matter/diagnostic imaging'




Connecting the dots: social networks in the classroom and white matter connections in the brain / Rosa H. MULDER in Journal of Child Psychology and Psychiatry, 63-12 (December 2022)
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Titre : Connecting the dots: social networks in the classroom and white matter connections in the brain Type de document : Texte imprimé et/ou numérique Auteurs : Rosa H. MULDER, Auteur ; Monica LOPEZ-VICENTE, Auteur ; Andrea P. CORTES HIDALGO, Auteur ; Lisa R. STEENKAMP, Auteur ; Berna GUROÄŽLU, Auteur ; Henning TIEMEIER, Auteur ; Ryan L. MUETZEL, Auteur Article en page(s) : p.1622-1630 Langues : Anglais (eng) Mots-clés : Child Humans White Matter/diagnostic imaging Diffusion Tensor Imaging Cross-Sectional Studies Brain/diagnostic imaging Social Networking Bullying behavior Generation R Study brain imaging peer acceptance peer rejection peer victimization white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Peer connections in school classrooms play an important role in social-emotional development and mental health. However, research on the association between children's peer relationships and white matter connections in the brain is scarce. We studied associations between peer relationships in the classroom and white matter structural connectivity in a pediatric population-based sample. METHODS: Bullying and victimization, as well as rejection and acceptance, were assessed in classrooms in 634 children at age 7. White matter microstructure (fractional anisotropy (FA), mean diffusivity (MD)) was measured with diffusion tensor imaging at age 10. We examined global metrics of white matter microstructure and used Tract-Based Spatial Statistics (TBSS) for voxel-wise associations. RESULTS: Peer victimization was associated with higher global FA and lower global MD and peer rejection was associated with lower global MD; however, these associations did not remain after multiple testing correction. Voxel-wise TBSS results for peer victimization and rejection were in line with global metrics both in terms of direction and spatial extent of the associations, with associated voxels (p(FWE) <.05) observed throughout the brain (including corpus callosum, corona radiata, sagittal stratum and superior longitudinal fasciculi). CONCLUSIONS: Although based only on cross-sectional data, the findings could indicate accelerated white matter microstructure maturation in certain brain areas of children who are victimized or rejected more often. However, repeated measurements are essential to unravel this complex interplay of peer connections, maturation and brain development over time. En ligne : http://dx.doi.org/10.1111/jcpp.13647 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4904
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1622-1630[article] Connecting the dots: social networks in the classroom and white matter connections in the brain [Texte imprimé et/ou numérique] / Rosa H. MULDER, Auteur ; Monica LOPEZ-VICENTE, Auteur ; Andrea P. CORTES HIDALGO, Auteur ; Lisa R. STEENKAMP, Auteur ; Berna GUROÄŽLU, Auteur ; Henning TIEMEIER, Auteur ; Ryan L. MUETZEL, Auteur . - p.1622-1630.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-12 (December 2022) . - p.1622-1630
Mots-clés : Child Humans White Matter/diagnostic imaging Diffusion Tensor Imaging Cross-Sectional Studies Brain/diagnostic imaging Social Networking Bullying behavior Generation R Study brain imaging peer acceptance peer rejection peer victimization white matter microstructure Index. décimale : PER Périodiques Résumé : BACKGROUND: Peer connections in school classrooms play an important role in social-emotional development and mental health. However, research on the association between children's peer relationships and white matter connections in the brain is scarce. We studied associations between peer relationships in the classroom and white matter structural connectivity in a pediatric population-based sample. METHODS: Bullying and victimization, as well as rejection and acceptance, were assessed in classrooms in 634 children at age 7. White matter microstructure (fractional anisotropy (FA), mean diffusivity (MD)) was measured with diffusion tensor imaging at age 10. We examined global metrics of white matter microstructure and used Tract-Based Spatial Statistics (TBSS) for voxel-wise associations. RESULTS: Peer victimization was associated with higher global FA and lower global MD and peer rejection was associated with lower global MD; however, these associations did not remain after multiple testing correction. Voxel-wise TBSS results for peer victimization and rejection were in line with global metrics both in terms of direction and spatial extent of the associations, with associated voxels (p(FWE) <.05) observed throughout the brain (including corpus callosum, corona radiata, sagittal stratum and superior longitudinal fasciculi). CONCLUSIONS: Although based only on cross-sectional data, the findings could indicate accelerated white matter microstructure maturation in certain brain areas of children who are victimized or rejected more often. However, repeated measurements are essential to unravel this complex interplay of peer connections, maturation and brain development over time. En ligne : http://dx.doi.org/10.1111/jcpp.13647 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4904 Individual differences in white matter of the uncinate fasciculus and inferior fronto-occipital fasciculus: possible early biomarkers for callous-unemotional behaviors in young children with disruptive behavior problems / P. A. GRAZIANO in Journal of Child Psychology and Psychiatry, 63-1 (January 2022)
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Titre : Individual differences in white matter of the uncinate fasciculus and inferior fronto-occipital fasciculus: possible early biomarkers for callous-unemotional behaviors in young children with disruptive behavior problems Type de document : Texte imprimé et/ou numérique Auteurs : P. A. GRAZIANO, Auteur ; D. GARIC, Auteur ; A. S. DICK, Auteur Article en page(s) : p.19-33 Langues : Anglais (eng) Mots-clés : Biomarkers Child Child, Preschool Diffusion Tensor Imaging Female Humans Individuality Male Problem Behavior Uncinate Fasciculus White Matter/diagnostic imaging Callous-unemotional behaviors Dti conduct problems imaging preschool uncinate fasciculus Index. décimale : PER Périodiques Résumé : BACKGROUND: Callous-unemotional (CU) behaviors are important for identifying severe patterns of conduct problems (CP). One major fiber tract implicated in the development of CP is the uncinate fasciculus (UF), which connects amygdala and orbitofrontal cortex (OFC). The goals of the current study were to (a) explore differences in the white matter microstructure in the UF and other major fiber tracks between young typically developing (TD) children and those with a disruptive behavior disorder (DBD) and (b) explore, within the DBD group, whether individual differences in these white matter tracts relate to co-occurring CP and CU behaviors. METHODS: Participants included 198 young children (69% boys, M(age) ?=?5.66?years; 80% Latinx; 48.5% TD). CU behaviors and CP were measured via a combination of teacher/parent ratings. Non-invasive diffusion-weighted imaging (DWI) was used to measure fractional anisotropy (FA), an indirect indicator of white matter properties. RESULTS: Relative to TD children, children in the DBD group had reduced FA on four out of the five fiber tracks we examined (except for cingulum and right ILF), even after accounting for whole brain FA, sex, movement, parental income, and IQ. Within the DBD group, no associations were found between CP and reduced white matter integrity across any of the fiber tracks examined. However, we found that even after accounting for CP, ADHD symptomology, and a host of covariates (whole brain FA, sex, movement, parental income, and IQ), CU behaviors were independently related to reduced FA in bilateral UF and left inferior fronto-occipital fasciculus (IFOF) in the DBD group, but this was not the case for TD children. CONCLUSIONS: Alterations in the white matter microstructure within bilateral UF and left IFOF may be biomarkers of CU behaviors, even in very young children. En ligne : http://dx.doi.org/10.1111/jcpp.13444 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4569
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.19-33[article] Individual differences in white matter of the uncinate fasciculus and inferior fronto-occipital fasciculus: possible early biomarkers for callous-unemotional behaviors in young children with disruptive behavior problems [Texte imprimé et/ou numérique] / P. A. GRAZIANO, Auteur ; D. GARIC, Auteur ; A. S. DICK, Auteur . - p.19-33.
Langues : Anglais (eng)
in Journal of Child Psychology and Psychiatry > 63-1 (January 2022) . - p.19-33
Mots-clés : Biomarkers Child Child, Preschool Diffusion Tensor Imaging Female Humans Individuality Male Problem Behavior Uncinate Fasciculus White Matter/diagnostic imaging Callous-unemotional behaviors Dti conduct problems imaging preschool uncinate fasciculus Index. décimale : PER Périodiques Résumé : BACKGROUND: Callous-unemotional (CU) behaviors are important for identifying severe patterns of conduct problems (CP). One major fiber tract implicated in the development of CP is the uncinate fasciculus (UF), which connects amygdala and orbitofrontal cortex (OFC). The goals of the current study were to (a) explore differences in the white matter microstructure in the UF and other major fiber tracks between young typically developing (TD) children and those with a disruptive behavior disorder (DBD) and (b) explore, within the DBD group, whether individual differences in these white matter tracts relate to co-occurring CP and CU behaviors. METHODS: Participants included 198 young children (69% boys, M(age) ?=?5.66?years; 80% Latinx; 48.5% TD). CU behaviors and CP were measured via a combination of teacher/parent ratings. Non-invasive diffusion-weighted imaging (DWI) was used to measure fractional anisotropy (FA), an indirect indicator of white matter properties. RESULTS: Relative to TD children, children in the DBD group had reduced FA on four out of the five fiber tracks we examined (except for cingulum and right ILF), even after accounting for whole brain FA, sex, movement, parental income, and IQ. Within the DBD group, no associations were found between CP and reduced white matter integrity across any of the fiber tracks examined. However, we found that even after accounting for CP, ADHD symptomology, and a host of covariates (whole brain FA, sex, movement, parental income, and IQ), CU behaviors were independently related to reduced FA in bilateral UF and left inferior fronto-occipital fasciculus (IFOF) in the DBD group, but this was not the case for TD children. CONCLUSIONS: Alterations in the white matter microstructure within bilateral UF and left IFOF may be biomarkers of CU behaviors, even in very young children. En ligne : http://dx.doi.org/10.1111/jcpp.13444 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4569 Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies / Min LI in Autism Research, 15-9 (September 2022)
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Titre : Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies Type de document : Texte imprimé et/ou numérique Auteurs : Min LI, Auteur ; Yide WANG, Auteur ; Masaya TACHIBANA, Auteur ; Shafiur RAHMAN, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur Article en page(s) : p.1585-1602 Langues : Anglais (eng) Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Child Development Disorders, Pervasive/diagnosis Diffusion Tensor Imaging Humans White Matter/diagnostic imaging autism spectrum disorder language networks meta-analysis white matter connectivity Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) often show pervasive and complex language impairments that are closely associated with aberrant structural connectivity of language networks. However, the characteristics of white matter connectivity in ASD have remained inconclusive in previous diffusion tensor imaging (DTI) studies. The current meta-analysis aimed to comprehensively elucidate the abnormality in language-related white matter connectivity in individuals with ASD. We searched PubMed, Web of Science, Scopus, and Medline databases to identify relevant studies. The standardized mean difference was calculated to measure the pooled difference in DTI metrics in each tract between the ASD and typically developing (TD) groups. The moderating effects of age, sex, language ability, and symptom severity were investigated using subgroup and meta-regression analysis. Thirty-three DTI studies involving 831 individuals with ASD and 836 TD controls were included in the meta-analysis. ASD subjects showed significantly lower fractional anisotropy or higher mean diffusivity across language-associated tracts than TD controls. These abnormalities tended to be more prominent in the left language networks than in the right. In addition, children with ASD exhibit more pronounced and pervasive disturbances in white matter connectivity than adults. These results support the under-connectivity hypothesis and demonstrate the widespread abnormal microstructure of language-related tracts in patients with ASD. Otherwise, white matter abnormalities in the autistic brain could vary depending on the developmental stage and hemisphere. LAY SUMMARY: This meta-analysis explored abnormalities in white matter connectivity in language networks of individuals with ASD. Significantly reduced white matter integrity was found in all language-associated tracts in subjects with ASD compared with TD controls. In addition, structural disturbances of language networks in the autistic brain exhibit a leftward tendency, and more prominent abnormalities are observed in younger people with ASD than in adults. En ligne : http://dx.doi.org/10.1002/aur.2789 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836
in Autism Research > 15-9 (September 2022) . - p.1585-1602[article] Atypical structural connectivity of language networks in autism spectrum disorder: A meta-analysis of diffusion tensor imaging studies [Texte imprimé et/ou numérique] / Min LI, Auteur ; Yide WANG, Auteur ; Masaya TACHIBANA, Auteur ; Shafiur RAHMAN, Auteur ; Kuriko KAGITANI-SHIMONO, Auteur . - p.1585-1602.
Langues : Anglais (eng)
in Autism Research > 15-9 (September 2022) . - p.1585-1602
Mots-clés : Adult Autism Spectrum Disorder/diagnostic imaging Brain/diagnostic imaging Child Child Development Disorders, Pervasive/diagnosis Diffusion Tensor Imaging Humans White Matter/diagnostic imaging autism spectrum disorder language networks meta-analysis white matter connectivity Index. décimale : PER Périodiques Résumé : Patients with autism spectrum disorder (ASD) often show pervasive and complex language impairments that are closely associated with aberrant structural connectivity of language networks. However, the characteristics of white matter connectivity in ASD have remained inconclusive in previous diffusion tensor imaging (DTI) studies. The current meta-analysis aimed to comprehensively elucidate the abnormality in language-related white matter connectivity in individuals with ASD. We searched PubMed, Web of Science, Scopus, and Medline databases to identify relevant studies. The standardized mean difference was calculated to measure the pooled difference in DTI metrics in each tract between the ASD and typically developing (TD) groups. The moderating effects of age, sex, language ability, and symptom severity were investigated using subgroup and meta-regression analysis. Thirty-three DTI studies involving 831 individuals with ASD and 836 TD controls were included in the meta-analysis. ASD subjects showed significantly lower fractional anisotropy or higher mean diffusivity across language-associated tracts than TD controls. These abnormalities tended to be more prominent in the left language networks than in the right. In addition, children with ASD exhibit more pronounced and pervasive disturbances in white matter connectivity than adults. These results support the under-connectivity hypothesis and demonstrate the widespread abnormal microstructure of language-related tracts in patients with ASD. Otherwise, white matter abnormalities in the autistic brain could vary depending on the developmental stage and hemisphere. LAY SUMMARY: This meta-analysis explored abnormalities in white matter connectivity in language networks of individuals with ASD. Significantly reduced white matter integrity was found in all language-associated tracts in subjects with ASD compared with TD controls. In addition, structural disturbances of language networks in the autistic brain exhibit a leftward tendency, and more prominent abnormalities are observed in younger people with ASD than in adults. En ligne : http://dx.doi.org/10.1002/aur.2789 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=4836 Diffusional kurtosis imaging of the corpus callosum in autism / Y. V. SUI in Molecular Autism, 9 (2018)
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Titre : Diffusional kurtosis imaging of the corpus callosum in autism Type de document : Texte imprimé et/ou numérique Auteurs : Y. V. SUI, Auteur ; J. DONALDSON, Auteur ; L. MILES, Auteur ; James S. BABB, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; M. LAZAR, Auteur Article en page(s) : 62 p. Langues : Anglais (eng) Mots-clés : Adolescent Adult Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Corpus Callosum/*diagnostic imaging Humans Magnetic Resonance Imaging Wechsler Scales White Matter/diagnostic imaging *Autism *Corpus callosum *Diffusional kurtosis imaging *Interhemispheric connectivity *Processing speed Medicine. All participants provided informed consent at the time of their visit.The authors give consent for this manuscript to be published.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The corpus callosum is implicated in the pathophysiology of autism spectrum disorder (ASD). However, specific structural deficits and underlying mechanisms are yet to be well defined. Methods: We employed diffusional kurtosis imaging (DKI) metrics to characterize white matter properties within five discrete segments of the corpus callosum in 17 typically developing (TD) adults and 16 age-matched participants with ASD without co-occurring intellectual disability (ID). The DKI metrics included axonal water fraction (f axon) and intra-axonal diffusivity (D axon), which reflect axonal density and caliber, and extra-axonal radial (RDextra) and axial (ADextra) diffusivities, which reflect myelination and microstructural organization of the extracellular space. The relationships between DKI metrics and processing speed, a cognitive feature known to be impaired in ASD, were also examined. Results: ASD group had significantly decreased callosal f axon and D axon (p = .01 and p = .045), particularly in the midbody, isthmus, and splenium. Regression analysis showed that variation in DKI metrics, primarily in the mid and posterior callosal regions explained up to 70.7% of the variance in processing speed scores for TD (p = .001) but not for ASD (p > .05). Conclusion: Decreased DKI metrics suggested that ASD may be associated with axonal deficits such as reduced axonal caliber and density in the corpus callosum, especially in the mid and posterior callosal areas. These data suggest that impaired interhemispheric connectivity may contribute to decreased processing speed in ASD participants. En ligne : https://dx.doi.org/10.1186/s13229-018-0245-1 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3892
in Molecular Autism > 9 (2018) . - 62 p.[article] Diffusional kurtosis imaging of the corpus callosum in autism [Texte imprimé et/ou numérique] / Y. V. SUI, Auteur ; J. DONALDSON, Auteur ; L. MILES, Auteur ; James S. BABB, Auteur ; Francisco Xavier CASTELLANOS, Auteur ; M. LAZAR, Auteur . - 62 p.
Langues : Anglais (eng)
in Molecular Autism > 9 (2018) . - 62 p.
Mots-clés : Adolescent Adult Autistic Disorder/*diagnostic imaging/physiopathology Case-Control Studies Corpus Callosum/*diagnostic imaging Humans Magnetic Resonance Imaging Wechsler Scales White Matter/diagnostic imaging *Autism *Corpus callosum *Diffusional kurtosis imaging *Interhemispheric connectivity *Processing speed Medicine. All participants provided informed consent at the time of their visit.The authors give consent for this manuscript to be published.The authors declare that they have no competing interests.Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Index. décimale : PER Périodiques Résumé : Background: The corpus callosum is implicated in the pathophysiology of autism spectrum disorder (ASD). However, specific structural deficits and underlying mechanisms are yet to be well defined. Methods: We employed diffusional kurtosis imaging (DKI) metrics to characterize white matter properties within five discrete segments of the corpus callosum in 17 typically developing (TD) adults and 16 age-matched participants with ASD without co-occurring intellectual disability (ID). The DKI metrics included axonal water fraction (f axon) and intra-axonal diffusivity (D axon), which reflect axonal density and caliber, and extra-axonal radial (RDextra) and axial (ADextra) diffusivities, which reflect myelination and microstructural organization of the extracellular space. The relationships between DKI metrics and processing speed, a cognitive feature known to be impaired in ASD, were also examined. Results: ASD group had significantly decreased callosal f axon and D axon (p = .01 and p = .045), particularly in the midbody, isthmus, and splenium. Regression analysis showed that variation in DKI metrics, primarily in the mid and posterior callosal regions explained up to 70.7% of the variance in processing speed scores for TD (p = .001) but not for ASD (p > .05). Conclusion: Decreased DKI metrics suggested that ASD may be associated with axonal deficits such as reduced axonal caliber and density in the corpus callosum, especially in the mid and posterior callosal areas. These data suggest that impaired interhemispheric connectivity may contribute to decreased processing speed in ASD participants. En ligne : https://dx.doi.org/10.1186/s13229-018-0245-1 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=3892