Commentary: The dynamic panel model: a promising approach to clarify sources of influence in developmental psychopathology – a commentary on Wichstrøm et al. (2017) / Annette M. KLEIN in Journal of Child Psychology and Psychiatry, 58-11 (November 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-11 (November 2017) . - p.1248-1250 Titre : Commentary: The dynamic panel model: a promising approach to clarify sources of influence in developmental psychopathology – a commentary on Wichstrøm et al. (2017) Type de document : Texte imprimé et/ou numérique Auteurs : Annette M. KLEIN, Auteur ; Sarah BERGMANN, Auteur ; Lars O. WHITE, Auteur Article en page(s) : p.1248-1250 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In their study, Wichstrøm et al. (2017) have proposed a novel groundbreaking approach for developmental psychopathology that undoubtedly will inspire other research. Applying the dynamic panel model (DPM), the authors were able to show that within-disorder (homotypic) and between-disorder (heterotypic) continuities of psychiatric symptoms are mostly due to unmeasured time-invariant factors while only few effects of earlier symptoms on later symptoms remained significant after accounting for these factors. The DPM calls for future applications of this approach to samples across different countries, diverse developmental phases, and in various settings – community samples and clinical samples alike. En ligne : http://dx.doi.org/10.1111/jcpp.12820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326 [article] Commentary: The dynamic panel model: a promising approach to clarify sources of influence in developmental psychopathology – a commentary on Wichstrøm et al. (2017) [Texte imprimé et/ou numérique] / Annette M. KLEIN, Auteur ; Sarah BERGMANN, Auteur ; Lars O. WHITE, Auteur . - p.1248-1250. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-11 (November 2017) . - p.1248-1250 Index. décimale : PER Périodiques Résumé : In their study, Wichstrøm et al. (2017) have proposed a novel groundbreaking approach for developmental psychopathology that undoubtedly will inspire other research. Applying the dynamic panel model (DPM), the authors were able to show that within-disorder (homotypic) and between-disorder (heterotypic) continuities of psychiatric symptoms are mostly due to unmeasured time-invariant factors while only few effects of earlier symptoms on later symptoms remained significant after accounting for these factors. The DPM calls for future applications of this approach to samples across different countries, diverse developmental phases, and in various settings – community samples and clinical samples alike. En ligne : http://dx.doi.org/10.1111/jcpp.12820 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=326

Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Titre : Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) Type de document : Texte imprimé et/ou numérique Auteurs : Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÜLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur Article en page(s) : p.1011-1013 Langues : Anglais (eng) Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017) [Texte imprimé et/ou numérique] / Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Bertram MÜLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur . - p.1011-1013. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.1011-1013 Mots-clés : Maltreatment  psychopathology Index. décimale : PER Périodiques Résumé : We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view. En ligne : http://dx.doi.org/10.1111/jcpp.12770 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

Depressive comorbidity in preschool anxiety disorder / Kai VON KLITZING in Journal of Child Psychology and Psychiatry, 55-10 (October 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1107-1116 Titre : Depressive comorbidity in preschool anxiety disorder Type de document : Texte imprimé et/ou numérique Auteurs : Kai VON KLITZING, Auteur ; Lars O. WHITE, Auteur ; Yvonne OTTO, Auteur ; Sandra FUCHS, Auteur ; Helen L. EGGER, Auteur ; Annette M. KLEIN, Auteur Article en page(s) : p.1107-1116 Langues : Anglais (eng) Mots-clés : Anxiety  depression  comorbidity  preschool children Index. décimale : PER Périodiques Résumé : Background The threshold for clinical relevance of preschool anxiety has recently come under increasing scrutiny in view of large variations in prevalence estimates. We studied the impact of presence/absence of additional depressive comorbidity (symptoms and/or diagnosis) on preschoolers with anxiety disorders in relation to clinical phenomenology, family, and peer problems compared to healthy controls. Method A population of 1738 preschoolers were screened and oversampled for internalizing symptoms from community sites, yielding a sample of 236 children. Results Using a multi-informant approach (mother, father, teacher, child), we found evidence that children with anxiety disorders and depressive comorbidity display a greater internalizing symptom-load, more peer problems and live in families with more psychosocial impairment (poor family functioning, family adversity, maternal mental health problems). The pure anxiety group was merely dissociable from controls with regard to internalizing symptoms and family adversity. Conclusion The presence of depressive comorbidity in anxiety disorders may mark the transition to a more detrimental and impairing disorder at preschool age. En ligne : http://dx.doi.org/10.1111/jcpp.12222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239 [article] Depressive comorbidity in preschool anxiety disorder [Texte imprimé et/ou numérique] / Kai VON KLITZING, Auteur ; Lars O. WHITE, Auteur ; Yvonne OTTO, Auteur ; Sandra FUCHS, Auteur ; Helen L. EGGER, Auteur ; Annette M. KLEIN, Auteur . - p.1107-1116. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-10 (October 2014) . - p.1107-1116 Mots-clés : Anxiety  depression  comorbidity  preschool children Index. décimale : PER Périodiques Résumé : Background The threshold for clinical relevance of preschool anxiety has recently come under increasing scrutiny in view of large variations in prevalence estimates. We studied the impact of presence/absence of additional depressive comorbidity (symptoms and/or diagnosis) on preschoolers with anxiety disorders in relation to clinical phenomenology, family, and peer problems compared to healthy controls. Method A population of 1738 preschoolers were screened and oversampled for internalizing symptoms from community sites, yielding a sample of 236 children. Results Using a multi-informant approach (mother, father, teacher, child), we found evidence that children with anxiety disorders and depressive comorbidity display a greater internalizing symptom-load, more peer problems and live in families with more psychosocial impairment (poor family functioning, family adversity, maternal mental health problems). The pure anxiety group was merely dissociable from controls with regard to internalizing symptoms and family adversity. Conclusion The presence of depressive comorbidity in anxiety disorders may mark the transition to a more detrimental and impairing disorder at preschool age. En ligne : http://dx.doi.org/10.1111/jcpp.12222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=239

Latent trajectories of internalizing symptoms from preschool to school age: A multi-informant study in a high-risk sample / Annette M. KLEIN in Development and Psychopathology, 31-2 (May 2019)  

Public ISBD [article]  inDevelopment and Psychopathology > 31-2 (May 2019) . - p.657-681 Titre : Latent trajectories of internalizing symptoms from preschool to school age: A multi-informant study in a high-risk sample Type de document : Texte imprimé et/ou numérique Auteurs : Annette M. KLEIN, Auteur ; Andrea SCHLESIER-MICHEL, Auteur ; Yvonne OTTO, Auteur ; Lars O. WHITE, Auteur ; Anna ANDREAS, Auteur ; Susan SIERAU, Auteur ; Sarah BERGMANN, Auteur ; Sonja PERREN, Auteur ; Kai VON KLITZING, Auteur Article en page(s) : p.657-681 Langues : Anglais (eng) Mots-clés : anxiety/depression internalizing symptoms preschool age risk factors trajectories Index. décimale : PER Périodiques Résumé : Recent proposals suggest early adversity sets in motion particularly chronic and neurobiologically distinct trajectories of internalizing symptoms. However, few prospective studies in high-risk samples delineate distinct trajectories of internalizing symptoms from preschool age onward. We examined trajectories in a high-risk cohort, oversampled for internalizing symptoms, several preschool risk/maintenance factors, and school-age outcomes. Parents of 325 children completed the Strengths and Difficulties Questionnaire on up to four waves of data collection from preschool (3–5 years) to school age (8–9 years) and Preschool Age Psychiatric Assessment interviews at both ages. Multi-informant data were collected on risk factors and symptoms. Growth mixture modelling identified four trajectory classes of internalizing symptoms with stable low, rising low-to-moderate, stable moderate, and stable high symptoms. Children in the stable high symptom trajectory manifested clinically relevant internalizing symptoms, mainly diagnosed with anxiety disorders/depression at preschool and school age. Trajectories differed regarding loss/separation experience, maltreatment, maternal psychopathology, temperament, and stress-hormone regulation with loss/separation, temperament, maternal psychopathology, and stress-hormone regulation (trend) significantly contributing to explained variance. At school age, trajectories continued to differ on symptoms, disorders, and impairment. Our study is among the first to show that severe early adversity may trigger a chronic and neurobiologically distinct internalizing trajectory from preschool age onward. En ligne : http://dx.doi.org/10.1017/S0954579418000214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393 [article] Latent trajectories of internalizing symptoms from preschool to school age: A multi-informant study in a high-risk sample [Texte imprimé et/ou numérique] / Annette M. KLEIN, Auteur ; Andrea SCHLESIER-MICHEL, Auteur ; Yvonne OTTO, Auteur ; Lars O. WHITE, Auteur ; Anna ANDREAS, Auteur ; Susan SIERAU, Auteur ; Sarah BERGMANN, Auteur ; Sonja PERREN, Auteur ; Kai VON KLITZING, Auteur . - p.657-681. Langues : Anglais (eng) in Development and Psychopathology > 31-2 (May 2019) . - p.657-681 Mots-clés : anxiety/depression internalizing symptoms preschool age risk factors trajectories Index. décimale : PER Périodiques Résumé : Recent proposals suggest early adversity sets in motion particularly chronic and neurobiologically distinct trajectories of internalizing symptoms. However, few prospective studies in high-risk samples delineate distinct trajectories of internalizing symptoms from preschool age onward. We examined trajectories in a high-risk cohort, oversampled for internalizing symptoms, several preschool risk/maintenance factors, and school-age outcomes. Parents of 325 children completed the Strengths and Difficulties Questionnaire on up to four waves of data collection from preschool (3–5 years) to school age (8–9 years) and Preschool Age Psychiatric Assessment interviews at both ages. Multi-informant data were collected on risk factors and symptoms. Growth mixture modelling identified four trajectory classes of internalizing symptoms with stable low, rising low-to-moderate, stable moderate, and stable high symptoms. Children in the stable high symptom trajectory manifested clinically relevant internalizing symptoms, mainly diagnosed with anxiety disorders/depression at preschool and school age. Trajectories differed regarding loss/separation experience, maltreatment, maternal psychopathology, temperament, and stress-hormone regulation with loss/separation, temperament, maternal psychopathology, and stress-hormone regulation (trend) significantly contributing to explained variance. At school age, trajectories continued to differ on symptoms, disorders, and impairment. Our study is among the first to show that severe early adversity may trigger a chronic and neurobiologically distinct internalizing trajectory from preschool age onward. En ligne : http://dx.doi.org/10.1017/S0954579418000214 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=393

Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence / Lars O. WHITE in Journal of Child Psychology and Psychiatry, 58-9 (September 2017)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.998-1007 Titre : Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence Type de document : Texte imprimé et/ou numérique Auteurs : Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Anna ANDREAS, Auteur ; Jan KEIL, Auteur ; Leonhard QUINTERO, Auteur ; Bertram MÜLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Ruth GAUSCHE, Auteur ; Jody T. MANLY, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur Article en page(s) : p.998-1007 Langues : Anglais (eng) Mots-clés : Hair cortisol  maltreatment  neglect  externalizing symptoms Index. décimale : PER Périodiques Résumé : Background The enduring impact of childhood maltreatment on biological systems and ensuing psychopathology remains incompletely understood. Long-term effects of stress may be reflected in cumulative cortisol secretion over several months, which is now quantifiable via hair cortisol concentrations (HCC). We conducted a first comprehensive investigation utilizing the potential of hair cortisol analysis in a large sample of maltreated and nonmaltreated children and adolescents. Method Participants included 537 children and adolescents (3–16 years; 272 females) with maltreatment (n = 245) or without maltreatment histories (n = 292). Maltreated subjects were recruited from child protection services (CPS; n = 95), youth psychiatric services (n = 56), and the community (n = 94). Maltreatment was coded using the Maltreatment Classification System drawing on caregiver interviews and complemented with CPS records. Caregivers and teachers reported on child mental health. HCC were assessed in the first 3 cm hair segment. Results Analyses uniformly supported that maltreatment coincides with a gradual and dose-dependent reduction in HCC from 9 to 10 years onwards relative to nonmaltreated controls. This pattern emerged consistently from both group comparisons between maltreated and nonmaltreated subjects (27.6% HCC reduction in maltreated 9–16-year-olds) and dimensional analyses within maltreated subjects, with lower HCC related to greater maltreatment chronicity and number of subtypes. Moreover, both group comparisons and dimensional analyses within maltreated youth revealed that relative HCC reduction mediates the effect of maltreatment on externalizing symptoms. Conclusions From middle childhood onwards, maltreatment coincides with a relative reduction in cortisol secretion, which, in turn, may predispose to externalizing symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317 [article] Reduced hair cortisol after maltreatment mediates externalizing symptoms in middle childhood and adolescence [Texte imprimé et/ou numérique] / Lars O. WHITE, Auteur ; Marcus ISING, Auteur ; Kai VON KLITZING, Auteur ; Susan SIERAU, Auteur ; Andrea MICHEL, Auteur ; Annette M. KLEIN, Auteur ; Anna ANDREAS, Auteur ; Jan KEIL, Auteur ; Leonhard QUINTERO, Auteur ; Bertram MÜLLER-MYHSOK, Auteur ; Manfred UHR, Auteur ; Ruth GAUSCHE, Auteur ; Jody T. MANLY, Auteur ; Michael J. CROWLEY, Auteur ; Clemens KIRSCHBAUM, Auteur ; Tobias STALDER, Auteur . - p.998-1007. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 58-9 (September 2017) . - p.998-1007 Mots-clés : Hair cortisol  maltreatment  neglect  externalizing symptoms Index. décimale : PER Périodiques Résumé : Background The enduring impact of childhood maltreatment on biological systems and ensuing psychopathology remains incompletely understood. Long-term effects of stress may be reflected in cumulative cortisol secretion over several months, which is now quantifiable via hair cortisol concentrations (HCC). We conducted a first comprehensive investigation utilizing the potential of hair cortisol analysis in a large sample of maltreated and nonmaltreated children and adolescents. Method Participants included 537 children and adolescents (3–16 years; 272 females) with maltreatment (n = 245) or without maltreatment histories (n = 292). Maltreated subjects were recruited from child protection services (CPS; n = 95), youth psychiatric services (n = 56), and the community (n = 94). Maltreatment was coded using the Maltreatment Classification System drawing on caregiver interviews and complemented with CPS records. Caregivers and teachers reported on child mental health. HCC were assessed in the first 3 cm hair segment. Results Analyses uniformly supported that maltreatment coincides with a gradual and dose-dependent reduction in HCC from 9 to 10 years onwards relative to nonmaltreated controls. This pattern emerged consistently from both group comparisons between maltreated and nonmaltreated subjects (27.6% HCC reduction in maltreated 9–16-year-olds) and dimensional analyses within maltreated subjects, with lower HCC related to greater maltreatment chronicity and number of subtypes. Moreover, both group comparisons and dimensional analyses within maltreated youth revealed that relative HCC reduction mediates the effect of maltreatment on externalizing symptoms. Conclusions From middle childhood onwards, maltreatment coincides with a relative reduction in cortisol secretion, which, in turn, may predispose to externalizing symptoms. En ligne : http://dx.doi.org/10.1111/jcpp.12700 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=317

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