[article]
| Titre : |
Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children |
| Type de document : |
texte imprimé |
| Auteurs : |
Stefano GABRIELE, Auteur ; Roberto SACCO, Auteur ; Laura ALTIERI, Auteur ; Cristina NERI, Auteur ; Andrea URBANI, Auteur ; Carmela BRAVACCIO, Auteur ; Maria Pia RICCIO, Auteur ; Maria Rosaria IOVENE, Auteur ; Francesca BOMBACE, Auteur ; Laura DE MAGISTRIS, Auteur ; Antonio M. PERSICO, Auteur |
| Article en page(s) : |
p.752-759 |
| Langues : |
Anglais (eng) |
| Mots-clés : |
autism autism spectrum disorder biomarker constipation gut intestinal transit organic contaminants neurotoxicity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The uremic toxin p-cresol (4-methylphenol) is either of environmental origin or can be synthetized from tyrosine by cresol-producing bacteria present in the gut lumen. Elevated p-cresol amounts have been previously found in the urines of Italian and French autism spectrum disorder (ASD) children up until 8 years of age, and may be associated with autism severity or with the intensity of abnormal behaviors. This study aims to investigate the mechanism producing elevated urinary p-cresol in ASD. Urinary p-cresol levels were thus measured by High Performance Liquid Chromatography in a sample of 53 Italian ASD children assessed for (a) presence of Clostridium spp. strains in the gut by means of an in vitro fecal stool test and of Clostridium difficile-derived toxin A/B in the feces, (b) intestinal permeability using the lactulose/mannitol (LA/MA) test, (c) frequent use of antibiotics due to recurrent infections during the first 2 years of postnatal life, and (d) stool habits with the Bristol Stool Form Scale. Chronic constipation was the only variable significantly associated with total urinary p-cresol concentration (P < 0.05). No association was found with presence of Clostridium spp. in the gut flora (P = 0.92), augmented intestinal permeability (P = 0.18), or frequent use of antibiotics in early infancy (P = 0.47). No ASD child was found to carry C. difficile in the gut or to release toxin A/B in the feces. In conclusion, urinary p-cresol levels are elevated in young ASD children with increased intestinal transit time and chronic constipation. Autism Res 2016, 9: 752–759. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1571 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 |
in Autism Research > 9-7 (July 2016) . - p.752-759
[article] Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children [texte imprimé] / Stefano GABRIELE, Auteur ; Roberto SACCO, Auteur ; Laura ALTIERI, Auteur ; Cristina NERI, Auteur ; Andrea URBANI, Auteur ; Carmela BRAVACCIO, Auteur ; Maria Pia RICCIO, Auteur ; Maria Rosaria IOVENE, Auteur ; Francesca BOMBACE, Auteur ; Laura DE MAGISTRIS, Auteur ; Antonio M. PERSICO, Auteur . - p.752-759. Langues : Anglais ( eng) in Autism Research > 9-7 (July 2016) . - p.752-759
| Mots-clés : |
autism autism spectrum disorder biomarker constipation gut intestinal transit organic contaminants neurotoxicity |
| Index. décimale : |
PER Périodiques |
| Résumé : |
The uremic toxin p-cresol (4-methylphenol) is either of environmental origin or can be synthetized from tyrosine by cresol-producing bacteria present in the gut lumen. Elevated p-cresol amounts have been previously found in the urines of Italian and French autism spectrum disorder (ASD) children up until 8 years of age, and may be associated with autism severity or with the intensity of abnormal behaviors. This study aims to investigate the mechanism producing elevated urinary p-cresol in ASD. Urinary p-cresol levels were thus measured by High Performance Liquid Chromatography in a sample of 53 Italian ASD children assessed for (a) presence of Clostridium spp. strains in the gut by means of an in vitro fecal stool test and of Clostridium difficile-derived toxin A/B in the feces, (b) intestinal permeability using the lactulose/mannitol (LA/MA) test, (c) frequent use of antibiotics due to recurrent infections during the first 2 years of postnatal life, and (d) stool habits with the Bristol Stool Form Scale. Chronic constipation was the only variable significantly associated with total urinary p-cresol concentration (P < 0.05). No association was found with presence of Clostridium spp. in the gut flora (P = 0.92), augmented intestinal permeability (P = 0.18), or frequent use of antibiotics in early infancy (P = 0.47). No ASD child was found to carry C. difficile in the gut or to release toxin A/B in the feces. In conclusion, urinary p-cresol levels are elevated in young ASD children with increased intestinal transit time and chronic constipation. Autism Res 2016, 9: 752–759. © 2015 International Society for Autism Research, Wiley Periodicals, Inc. |
| En ligne : |
http://dx.doi.org/10.1002/aur.1571 |
| Permalink : |
https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=292 |
|  |
Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children in Autism Research, 9-7 (July 2016)
