10 recherche sur le mot-clé 'constipation'

Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders / Carrie CUFFMAN in Research in Autism Spectrum Disorders, 80 (February 2021)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 80 (February 2021) . - p.101710 Titre : Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders Type de document : Texte imprimé et/ou numérique Auteurs : Carrie CUFFMAN, Auteur ; Kimberly BURKHART, Auteur Article en page(s) : p.101710 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Constipation  Gastrointestinal disorders  Developmental disorders Index. décimale : PER Périodiques Résumé : Background Few studies have compared youth constipation in autism spectrum disorder (ASD) to constipation in other developmental-behavioral (DB) disorders. Methods Children and caregivers presenting to a DB pediatrics and psychology clinic completed written questionnaires on constipation. Comparison groups were ASD vs without ASD and caregiver vs child responses. Binary logistic regression were conducted to compare categorical variables. Results Caregivers of 169 toilet trained children and 26 non-toilet trained children completed the survey; 30 % of the toilet trained and 62 % of the non-toilet trained children had ASD. 88 toilet trained children completed the survey. Based on caregiver response, toilet trained youth with ASD were more likely to have been constipated in the past and to currently or previously taken medication to manage constipation. In both the total toilet trained and non-toilet trained sample, more caregivers endorsed their child meeting Rome IV criteria for functional constipation than endorsed current constipation. 37 % of parent/child pairs disagreed on whether the child met the Rome IV criteria. Caregivers of toilet trained youth with ASD were more likely to endorse specific barriers and impairment due to managing constipation in comparison to caregivers of youth without ASD. Conclusions Children with ASD may be at a higher lifetime risk of constipation and of needing medication compared to children with other DB disorders. Providers should use thorough questions to identify constipation and gather information from both caregiver and child when possible. Clinicians should consider targeting behavioral treatment recommendations to perceived caregiver concerns. En ligne : https://doi.org/10.1016/j.rasd.2020.101710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438 [article] Constipation prevalence and perceptions: Comparison of children and adolescents with ASD and other developmental-behavioral disorders [Texte imprimé et/ou numérique] / Carrie CUFFMAN, Auteur ; Kimberly BURKHART, Auteur . - p.101710. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 80 (February 2021) . - p.101710 Mots-clés : Autism spectrum disorder  Constipation  Gastrointestinal disorders  Developmental disorders Index. décimale : PER Périodiques Résumé : Background Few studies have compared youth constipation in autism spectrum disorder (ASD) to constipation in other developmental-behavioral (DB) disorders. Methods Children and caregivers presenting to a DB pediatrics and psychology clinic completed written questionnaires on constipation. Comparison groups were ASD vs without ASD and caregiver vs child responses. Binary logistic regression were conducted to compare categorical variables. Results Caregivers of 169 toilet trained children and 26 non-toilet trained children completed the survey; 30 % of the toilet trained and 62 % of the non-toilet trained children had ASD. 88 toilet trained children completed the survey. Based on caregiver response, toilet trained youth with ASD were more likely to have been constipated in the past and to currently or previously taken medication to manage constipation. In both the total toilet trained and non-toilet trained sample, more caregivers endorsed their child meeting Rome IV criteria for functional constipation than endorsed current constipation. 37 % of parent/child pairs disagreed on whether the child met the Rome IV criteria. Caregivers of toilet trained youth with ASD were more likely to endorse specific barriers and impairment due to managing constipation in comparison to caregivers of youth without ASD. Conclusions Children with ASD may be at a higher lifetime risk of constipation and of needing medication compared to children with other DB disorders. Providers should use thorough questions to identify constipation and gather information from both caregiver and child when possible. Clinicians should consider targeting behavioral treatment recommendations to perceived caregiver concerns. En ligne : https://doi.org/10.1016/j.rasd.2020.101710 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=438

Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study / L. TURRIZIANI in Autism Research, 15-1 (January 2022)  

Public ISBD [article]  inAutism Research > 15-1 (January 2022) . - p.56-69 Titre : Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study Type de document : Texte imprimé et/ou numérique Auteurs : L. TURRIZIANI, Auteur ; A. RICCIARDELLO, Auteur ; F. CUCINOTTA, Auteur ; F. BELLOMO, Auteur ; G. TURTURO, Auteur ; M. BONCODDO, Auteur ; S. MIRABELLI, Auteur ; M. L. SCATTONI, Auteur ; M. ROSSI, Auteur ; A. M. PERSICO, Auteur Article en page(s) : p.56-69 Langues : Anglais (eng) Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8?years old were evaluated before (T0), 1?month (T1), and 6?months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450 [article] Gut mobilization improves behavioral symptoms and modulates urinary p-cresol in chronically constipated autistic children: A prospective study [Texte imprimé et/ou numérique] / L. TURRIZIANI, Auteur ; A. RICCIARDELLO, Auteur ; F. CUCINOTTA, Auteur ; F. BELLOMO, Auteur ; G. TURTURO, Auteur ; M. BONCODDO, Auteur ; S. MIRABELLI, Auteur ; M. L. SCATTONI, Auteur ; M. ROSSI, Auteur ; A. M. PERSICO, Auteur . - p.56-69. Langues : Anglais (eng) in Autism Research > 15-1 (January 2022) . - p.56-69 Mots-clés : Autism Spectrum Disorder/complications  Autistic Disorder/complications  Behavioral Symptoms  Child  Child, Preschool  Constipation/complications  Cresols/urine  Gastrointestinal Microbiome  Gastrointestinal Motility  Humans  Prospective Studies  4-cresol  anxiety  autism  autism spectrum disorder  biomarkers  constipation  microbiota Index. décimale : PER Périodiques Résumé : Chronic constipation is common among children with ASD and is associated with more severe hyperactivity, anxiety, irritability, and repetitive behaviors. Young autistic children with chronic constipation display higher urinary, and foecal concentrations of p-cresol, an aromatic compound produced by gut bacteria, known to negatively affect brain function. Acute p-cresol administration to BTBR mice enhances anxiety, hyperactivity and stereotypic behaviors, while blunting social interaction. This study was undertaken to prospectively assess the behavioral effects of gut mobilization in young autistic children with chronic constipation, and to verify their possible correlation with urinary p-cresol. To this aim, 21 chronically constipated autistic children 2-8?years old were evaluated before (T0), 1?month (T1), and 6?months (T2) after intestinal mobilization, recording Bristol stool scale scores, urinary p-cresol concentrations, and behavioral scores for social interaction deficits, stereotypic behaviors, anxiety, and hyperactivity. Gut mobilization yielded a progressive and highly significant decrease in all behavioral symptoms over the 6-month study period. Urinary p-cresol levels displayed variable trends not significantly correlated with changes in behavioral parameters, mainly increasing at T1 and decreasing at T2. These results support gut mobilization as a simple strategy to ameliorate ASD symptoms, as well as comorbid anxiety and hyperactivity, in chronically constipated children. Variation in p-cresol absorption seemingly provides limited contributions, if any, to these behavioral changes. Further research will be needed to address the relative role of reduced abdominal discomfort following mobilization, as compared to specific modifications in microbiome composition and in gut bacteria-derived neuroactive compounds. En ligne : http://dx.doi.org/10.1002/aur.2639 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=450

Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors / Phillip GORRINDO in Autism Research, 5-2 (April 2012)  

Public ISBD [article]  inAutism Research > 5-2 (April 2012) . - p.101-108 Titre : Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors Type de document : Texte imprimé et/ou numérique Auteurs : Phillip GORRINDO, Auteur ; Dean C. WILLIAMS, Auteur ; Evon B. LEE, Auteur ; Lynn S. WALKER, Auteur ; Susan G. MCGREW, Auteur ; Pat LEVITT, Auteur Année de publication : 2012 Article en page(s) : p.101-108 Langues : Anglais (eng) Mots-clés : autism  constipation  diet  functional gastrointestinal disorders  nonverbal communication  social behavior Index. décimale : PER Périodiques Résumé : The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child's behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.54–56.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors. En ligne : http://dx.doi.org/10.1002/aur.237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155 [article] Gastrointestinal Dysfunction in Autism: Parental Report, Clinical Evaluation, and Associated Factors [Texte imprimé et/ou numérique] / Phillip GORRINDO, Auteur ; Dean C. WILLIAMS, Auteur ; Evon B. LEE, Auteur ; Lynn S. WALKER, Auteur ; Susan G. MCGREW, Auteur ; Pat LEVITT, Auteur . - 2012 . - p.101-108. Langues : Anglais (eng) in Autism Research > 5-2 (April 2012) . - p.101-108 Mots-clés : autism  constipation  diet  functional gastrointestinal disorders  nonverbal communication  social behavior Index. décimale : PER Périodiques Résumé : The objectives of this study were to characterize gastrointestinal dysfunction (GID) in autism spectrum disorder (ASD), to examine parental reports of GID relative to evaluations by pediatric gastroenterologists, and to explore factors associated with GID in ASD. One hundred twenty-one children were recruited into three groups: co-occurring ASD and GID, ASD without GID, and GID without ASD. A pediatric gastroenterologist evaluated both GID groups. Parents in all three groups completed questionnaires about their child's behavior and GI symptoms, and a dietary journal. Functional constipation was the most common type of GID in children with ASD (85.0%). Parental report of any GID was highly concordant with a clinical diagnosis of any GID (92.1%). Presence of GID in children with ASD was not associated with distinct dietary habits or medication status. Odds of constipation were associated with younger age, increased social impairment, and lack of expressive language (adjusted odds ratio in nonverbal children: 11.98, 95% confidence interval 2.54–56.57). This study validates parental concerns for GID in children with ASD, as parents were sensitive to the existence, although not necessarily the nature, of GID. The strong association between constipation and language impairment highlights the need for vigilance by health-care providers to detect and treat GID in children with ASD. Medications and diet, commonly thought to contribute to GID in ASD, were not associated with GID status. These findings are consistent with a hypothesis that GID in ASD represents pleiotropic expression of genetic risk factors. En ligne : http://dx.doi.org/10.1002/aur.237 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=155

Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder / Bradley J. FERGUSON in Autism Research, 10-2 (February 2017)  

Public ISBD [article]  inAutism Research > 10-2 (February 2017) . - p.276-288 Titre : Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Bradley J. FERGUSON, Auteur ; Sarah MARLER, Auteur ; Lily L. ALTSTEIN, Auteur ; Evon BATEY LEE, Auteur ; Jill AKERS, Auteur ; Kristin SOHL, Auteur ; Aaron MCLAUGHLIN, Auteur ; Kaitlyn HARTNETT, Auteur ; Briana KILLE, Auteur ; Micah MAZUREK, Auteur ; Eric A. MACKLIN, Auteur ; Erin MCDONNELL, Auteur ; Mariah BARSTOW, Auteur ; Margaret L. BAUMAN, Auteur ; Kara Gross MARGOLIS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; David Q. BEVERSDORF, Auteur Article en page(s) : p.276-288 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  gastrointestinal  autonomic nervous system  sympathetic  parasympathetic  anxiety  constipation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often accompanied by gastrointestinal disturbances, which also may impact behavior. Alterations in autonomic nervous system functioning are also frequently observed in ASD. The relationship between these findings in ASD is not known. We examined the relationship between gastrointestinal symptomatology, examining upper and lower gastrointestinal tract symptomatology separately, and autonomic nervous system functioning, as assessed by heart rate variability and skin conductance level, in a sample of 120 individuals with ASD. Relationships with co-occurring medical and psychiatric symptoms were also examined. While the number of participants with significant upper gastrointestinal tract problems was small in this sample, 42.5% of participants met criteria for functional constipation, a disorder of the lower gastrointestinal tract. Heart rate variability, a measure of parasympathetic modulation of cardiac activity, was found to be positively associated with lower gastrointestinal tract symptomatology at baseline. This relationship was particularly strong for participants with co-occurring diagnoses of anxiety disorder and for those with a history of regressive ASD or loss of previously acquired skills. These findings suggest that autonomic function and gastrointestinal problems are intertwined in children with ASD; although it is not possible to assess causality in this data set. Future work should examine the impact of treatment of gastrointestinal problems on autonomic function and anxiety, as well as the impact of anxiety treatment on gastrointestinal problems. Clinicians should be aware that gastrointestinal problems, anxiety, and autonomic dysfunction may cluster in children with ASD and should be addressed in a multidisciplinary treatment plan. En ligne : http://dx.doi.org/10.1002/aur.1646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303 [article] Psychophysiological Associations with Gastrointestinal Symptomatology in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Bradley J. FERGUSON, Auteur ; Sarah MARLER, Auteur ; Lily L. ALTSTEIN, Auteur ; Evon BATEY LEE, Auteur ; Jill AKERS, Auteur ; Kristin SOHL, Auteur ; Aaron MCLAUGHLIN, Auteur ; Kaitlyn HARTNETT, Auteur ; Briana KILLE, Auteur ; Micah MAZUREK, Auteur ; Eric A. MACKLIN, Auteur ; Erin MCDONNELL, Auteur ; Mariah BARSTOW, Auteur ; Margaret L. BAUMAN, Auteur ; Kara Gross MARGOLIS, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur ; David Q. BEVERSDORF, Auteur . - p.276-288. Langues : Anglais (eng) in Autism Research > 10-2 (February 2017) . - p.276-288 Mots-clés : autism spectrum disorder  gastrointestinal  autonomic nervous system  sympathetic  parasympathetic  anxiety  constipation Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is often accompanied by gastrointestinal disturbances, which also may impact behavior. Alterations in autonomic nervous system functioning are also frequently observed in ASD. The relationship between these findings in ASD is not known. We examined the relationship between gastrointestinal symptomatology, examining upper and lower gastrointestinal tract symptomatology separately, and autonomic nervous system functioning, as assessed by heart rate variability and skin conductance level, in a sample of 120 individuals with ASD. Relationships with co-occurring medical and psychiatric symptoms were also examined. While the number of participants with significant upper gastrointestinal tract problems was small in this sample, 42.5% of participants met criteria for functional constipation, a disorder of the lower gastrointestinal tract. Heart rate variability, a measure of parasympathetic modulation of cardiac activity, was found to be positively associated with lower gastrointestinal tract symptomatology at baseline. This relationship was particularly strong for participants with co-occurring diagnoses of anxiety disorder and for those with a history of regressive ASD or loss of previously acquired skills. These findings suggest that autonomic function and gastrointestinal problems are intertwined in children with ASD; although it is not possible to assess causality in this data set. Future work should examine the impact of treatment of gastrointestinal problems on autonomic function and anxiety, as well as the impact of anxiety treatment on gastrointestinal problems. Clinicians should be aware that gastrointestinal problems, anxiety, and autonomic dysfunction may cluster in children with ASD and should be addressed in a multidisciplinary treatment plan. En ligne : http://dx.doi.org/10.1002/aur.1646 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=303

Rigid–Compulsive Behaviors are Associated with Mixed Bowel Symptoms in Autism Spectrum Disorder / Brittany PETERS in Journal of Autism and Developmental Disorders, 44-6 (June 2014)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1425-1432 Titre : Rigid–Compulsive Behaviors are Associated with Mixed Bowel Symptoms in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Phillip GORRINDO, Auteur ; Daniel ROSENBERG, Auteur ; Evon BATEY LEE, Auteur ; Pat LEVITT, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1425-1432 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Repetitive behavior  Constipation  Encopresis Index. décimale : PER Périodiques Résumé : Based on clinical experience, we hypothesized that rigid–compulsive behaviors are associated with severe constipation and co-occurring diarrhea or underwear staining in children with autism spectrum disorder. Using data from the Autism Treatment Network, we evaluated the association between these gastrointestinal symptoms and measures of rigid compulsive behavior in children ages 2–17. Following statistical correction, four of five primary measures were significantly associated with constipation and diarrhea or underwear staining, including parental report of repetitive behavior, parental report of compulsive behavior, clinician diagnosis of obsessive–compulsive disorder, and report of rituals observed on the autism diagnostic observation schedule. This association could point to a causal connection between these symptoms or to a common biological pathway that impacts both gut and brain. En ligne : http://dx.doi.org/10.1007/s10803-013-2009-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233 [article] Rigid–Compulsive Behaviors are Associated with Mixed Bowel Symptoms in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Phillip GORRINDO, Auteur ; Daniel ROSENBERG, Auteur ; Evon BATEY LEE, Auteur ; Pat LEVITT, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1425-1432. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 44-6 (June 2014) . - p.1425-1432 Mots-clés : Autism spectrum disorder  Repetitive behavior  Constipation  Encopresis Index. décimale : PER Périodiques Résumé : Based on clinical experience, we hypothesized that rigid–compulsive behaviors are associated with severe constipation and co-occurring diarrhea or underwear staining in children with autism spectrum disorder. Using data from the Autism Treatment Network, we evaluated the association between these gastrointestinal symptoms and measures of rigid compulsive behavior in children ages 2–17. Following statistical correction, four of five primary measures were significantly associated with constipation and diarrhea or underwear staining, including parental report of repetitive behavior, parental report of compulsive behavior, clinician diagnosis of obsessive–compulsive disorder, and report of rituals observed on the autism diagnostic observation schedule. This association could point to a causal connection between these symptoms or to a common biological pathway that impacts both gut and brain. En ligne : http://dx.doi.org/10.1007/s10803-013-2009-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=233

Slow intestinal transit contributes to elevate urinary p-cresol level in Italian autistic children / Stefano GABRIELE in Autism Research, 9-7 (July 2016)  

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An elevated anxiety level among prepubertal autistic boys with non-treatment-seeking functional gastrointestinal disorders: A case-control study / O. W. H. WONG in Autism Research, 14-10 (October 2021)  

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Overall severities of gastrointestinal symptoms in pediatric outpatients with and without autism spectrum disorder / V. THULASI in Autism, 23-2 (February 2019)  

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Toilet training in children with a functional defecation disorder and concomitant symptoms of autism spectrum disorder / Babette PEETERS in Research in Autism Spectrum Disorders, 26 (June 2016)  

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Towards Identifying Genetic Biomarkers for Gastrointestinal Dysfunction in Autism / A. E. SHINDLER in Journal of Autism and Developmental Disorders, 50-1 (January 2020)  

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