The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Titre : The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Article en page(s) : p.12-20 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] The cortisol, serotonin and oxytocin are associated with repetitive behavior in autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; He-Ping WANG, Auteur ; Chun-Ling LIU, Auteur ; Hui-Zhong HE, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - p.12-20. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.12-20 Mots-clés : Autism spectrum disorders  Repetitive behaviors  Cortisol  Serotonin  Oxytocin Index. décimale : PER Périodiques Résumé : Abstract Repetitive behaviors (RBs) are a core feature of autism spectrum disorders (ASD). They constitute a major barrier to learning and social adaptation. Research on potential causes of RBs is still at an early stage. However, promising new ideas and evidence are emerging from neurobiology. Instead of testing single neurotransmitter or hormone, the present study examined the associations of cortisol, serotonin, and oxytocin on subscales of repetitive behavior scales-revised (RBS-R). The results demonstrated that the individuals with ASD showed higher levels of cortisol areas under curve (cortisol AUC), higher levels of serotonin, and lower level of oxytocin compared with the typically developing (TD) individuals. For individuals with ASD, the levels of cortisol AUC, serotonin and oxytocin were all significantly associated with total scores measured by RBS-R. In addition, the cortisol AUC was positively associated with the stereotyped and restricted behavior subscales scores. The level of serotonin was positively associated with the stereotyped and self-injurious behavior subscales scores. The level of oxytocin was negatively associated with compulsive, sameness and restricted behavior subscales scores. Therefore, cortisol, serotonin and oxytocin may all be involved in the occurrence of RBs in ASD. The occurrence of RBs in ASD may due to a variety of pathological factors, not just one factor. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.07.002 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 9 (January 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181 Titre : The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Année de publication : 2015 Article en page(s) : p.174-181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Stress  Cortisol  IL-6  TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - 2015 . - p.174-181. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181 Mots-clés : Autism spectrum disorders  Stress  Cortisol  IL-6  TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

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