3 recherche sur le mot-clé 'IL-6'

The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder / Chang-Jiang YANG in Research in Autism Spectrum Disorders, 9 (January 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181 Titre : The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur Année de publication : 2015 Article en page(s) : p.174-181 Langues : Anglais (eng) Mots-clés : Autism spectrum disorders  Stress  Cortisol  IL-6  TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2434 [article] The roles of cortisol and pro-inflammatory cytokines in assisting the diagnosis of autism spectrum disorder [Texte imprimé et/ou numérique] / Chang-Jiang YANG, Auteur ; He-Ping TAN, Auteur ; Fu-Yi YANG, Auteur ; Chun-Ling LIU, Auteur ; Biao SANG, Auteur ; Xiao-Mei ZHU, Auteur ; Yi-Jie DU, Auteur . - 2015 . - p.174-181. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 9 (January 2015) . - p.174-181 Mots-clés : Autism spectrum disorders  Stress  Cortisol  IL-6  TNF-? Index. décimale : PER Périodiques Résumé : Abstract Autism spectrum disorders (ASD) is a severe neurodevelopmental disorder characterized by impairments in social interaction and repetitive behaviors. Diagnosis of ASD is currently phenotype based with no reliable laboratory test available to assist clinicians. The desire for clinically useful and reliable biomarkers is strong. Researches have shown that individuals with autism often exhibit dysfunction of hypothalamic–pituitary–adrenal (HPA) axis and cytokines. The purpose of this study was to evaluate diurnal variation of cortisol (cortisol VAR), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-?) as potential biomarkers for ASD. The present results demonstrated that in comparison to the healthy controls, the individuals with autism showed a lower level of cortisol VAR, higher level of IL-6 and TNF-?. The levels of cortisol VAR, IL-6 and TNF-? have significantly correlations with the severity of ASD measured by CARS scores. The results of ROC analysis indicated the cortisol VAR, IL-6 and TNF-? were potential biomarkers in diagnosis of ASD. The combination of three factors performed the best sensitivity and specificity for diagnosis of ASD. Therefore, the present study may reveal a simple clinical approach with great potential for assisting the diagnosis of ASD. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.10.012 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2434

Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder / Sarah MARLER in Journal of Autism and Developmental Disorders, 46-3 (March 2016)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130 Titre : Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur Article en page(s) : p.1124-1130 Langues : Anglais (eng) Mots-clés : Serotonin  5-HT  Gastrointestinal (GI)  IL-6  Medical comorbidities  Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2820 [article] Brief Report: Whole Blood Serotonin Levels and Gastrointestinal Symptoms in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Sarah MARLER, Auteur ; Bradley J. FERGUSON, Auteur ; Evon BATEY LEE, Auteur ; Brittany PETERS, Auteur ; Kent C. WILLIAMS, Auteur ; Erin MCDONNELL, Auteur ; Eric A. MACKLIN, Auteur ; Pat LEVITT, Auteur ; Catherine HAGAN GILLESPIE, Auteur ; George M. ANDERSON, Auteur ; Kara Gross MARGOLIS, Auteur ; David Q. BEVERSDORF, Auteur ; Jeremy VEENSTRA-VANDERWEELE, Auteur . - p.1124-1130. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 46-3 (March 2016) . - p.1124-1130 Mots-clés : Serotonin  5-HT  Gastrointestinal (GI)  IL-6  Medical comorbidities  Autism Treatment Network Index. décimale : PER Périodiques Résumé : Elevated whole blood serotonin levels are observed in more than 25 % of children with autism spectrum disorder (ASD). Co-occurring gastrointestinal (GI) symptoms are also common in ASD but have not previously been examined in relationship with hyperserotonemia, despite the synthesis of serotonin in the gut. In 82 children and adolescents with ASD, we observed a correlation between a quantitative measure of lower GI symptoms and whole blood serotonin levels. No significant association was seen between functional constipation diagnosis and serotonin levels in the hyperserotonemia range, suggesting that this correlation is not driven by a single subgroup. More specific assessment of gut function, including the microbiome, will be necessary to evaluate the contribution of gut physiology to serotonin levels in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2646-8 Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=2820

Maternal Immune Activation, Cytokines and Autism / Paul H. PATTERSON

Public ISBD contenu dans Autism / Andrew W. ZIMMERMAN Titre : Maternal Immune Activation, Cytokines and Autism Type de document : Texte imprimé et/ou numérique Auteurs : Paul H. PATTERSON, Auteur ; Wensi XU, Auteur ; Stephen E.P. SMITH, Auteur ; Benjamin E. DEVARMAN, Auteur Année de publication : 2008 Importance : p.289-307 Langues : Anglais (eng) Mots-clés : IL-6  TNF  IL-10  LPS  Poly(I:C)  Influence  Infection maternelle  Immunologie Index. décimale : AUT-B L'Autisme - Ouvrages généraux et scientifiques Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=7046 contenu dans Autism / Andrew W. ZIMMERMAN Maternal Immune Activation, Cytokines and Autism [Texte imprimé et/ou numérique] / Paul H. PATTERSON, Auteur ; Wensi XU, Auteur ; Stephen E.P. SMITH, Auteur ; Benjamin E. DEVARMAN, Auteur . - 2008 . - p.289-307. Langues : Anglais (eng) Mots-clés : IL-6  TNF  IL-10  LPS  Poly(I:C)  Influence  Infection maternelle  Immunologie Index. décimale : AUT-B L'Autisme - Ouvrages généraux et scientifiques Permalink : http://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=7046

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