Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents / Justine Nienke PANNEKOEK in Journal of Child Psychology and Psychiatry, 55-12 (December 2014)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Titre : Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents Type de document : texte imprimé Auteurs : Justine Nienke PANNEKOEK, Auteur ; S.J.A. VAN DER WERFF, Auteur ; Paul H.F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Serge A.R.B. ROMBOUTS, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur Article en page(s) : p.1317-1327 Langues : Anglais (eng) Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243 [article] Aberrant resting-state functional connectivity in limbic and salience networks in treatment-naïve clinically depressed adolescents [texte imprimé] / Justine Nienke PANNEKOEK, Auteur ; S.J.A. VAN DER WERFF, Auteur ; Paul H.F. MEENS, Auteur ; Bianca G. VAN DEN BULK, Auteur ; Dietsje D. JOLLES, Auteur ; Ilya M. VEER, Auteur ; Natasja D.J. VAN LANG, Auteur ; Serge A.R.B. ROMBOUTS, Auteur ; Nic J.A. VAN DER WEE, Auteur ; Robert R.J.M. VERMEIREN, Auteur . - p.1317-1327. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 55-12 (December 2014) . - p.1317-1327 Mots-clés : Resting-state  adolescents  depression  anxiety Index. décimale : PER Périodiques Résumé : Background Depression is prevalent and typically has its onset in adolescence. Resting-state fMRI could help create a better understanding of the underlying neurobiological mechanisms during this critical period. In this study, resting-state functional connectivity (RSFC) is examined using seed regions-of-interest (ROIs) associated with three networks: the limbic network, the default mode network (DMN) and the salience network. Methods Twenty-six treatment-naïve, clinically depressed adolescents of whom 18 had comorbid anxiety, and 26 pair-wise matched healthy controls underwent resting-state fMRI. The three networks were investigated using a seed-based ROI approach with seeds in the bilateral amygdala (limbic network), bilateral dorsal anterior cingulate cortex (dACC; salience network) and bilateral posterior cingulate cortex (default mode network). Results Compared to healthy controls, clinically depressed adolescents showed increased RSFC of the left amygdala with right parietal cortical areas, and decreased right amygdala RSFC with left frontal cortical areas including the ACC, as well as with right occipito-parietal areas. The bilateral dACC showed decreased RSFC with the right middle frontal gyrus, frontal pole, and inferior frontal gyrus in clinically depressed adolescents. No abnormalities in DMN RSFC were found, and differences in RSFC did not correlate with clinical measures. Conclusions The aberrant RSFC of the amygdala network and the dACC network may be related to altered emotion processing and regulation in depressed adolescents. Our results provide new insights into RSFC in clinically depressed adolescents and future models on adolescent depression may include abnormalities in the connectivity of salience network. En ligne : http://dx.doi.org/10.1111/jcpp.12266 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=243

Conduct disorder with limited prosocial emotions: a multimethod study in criminal justice-involved boys / Olivier F. COLINS in Journal of Child Psychology and Psychiatry, 67-7 (July 2026)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1062-1072 Titre : Conduct disorder with limited prosocial emotions: a multimethod study in criminal justice-involved boys Type de document : texte imprimé Auteurs : Olivier F. COLINS, Auteur ; Thomas CASSART, Auteur ; Emmely DELAMILLIEURE, Auteur ; Kostas A. FANTI, Auteur ; Melina Nicole KYRANIDES, Auteur ; Maria SIKKI, Auteur ; Maria PETRIDOU, Auteur ; Paul H.F. MEENS, Auteur Article en page(s) : p.1062-1072 Langues : Anglais (eng) Mots-clés : Callous-unemotional  Clinical Assessment of Prosocial Emotions  conduct disorder  subtyping Index. décimale : PER Périodiques Résumé : Background More than 10?years after its introduction in DSM-5, support for the ?limited prosocial emotions? specifier (LPE) for the diagnosis of conduct disorder (CD) remains scarce, possibly because studies failed to comprehensively assess the specifier and to include important characteristics. This study was designed to tackle both major limitations. Methods In a sample of 323 criminal justice-involved male adolescents (ages 16?17?years), diagnostic interviews were used to differentiate between males who meet criteria for both CD and the DSM-5 specifier (CD?+?LPE) and males who only meet criteria for CD (CD Only). Individual and environmental characteristics were measured by means of questionnaires and computerized tasks. Results The CD?+?LPE (vs. CD Only) group exhibited higher levels of aggression, delay discounting, and boldness, was more likely to be expelled from school, and had significantly more delinquent friends. Levels of treatment engagement and empathy also were lower in the CD?+?LPE group. The DSM-5 LPE specifier significantly added to the prediction of various of these characteristics beyond indices of CD severity (i.e., total number of CD symptoms and childhood-onset CD) and features of attention-deficit/hyperactivity disorder. However, no significant group differences emerged for other characteristics (e.g., emotion recognition accuracy, anxiety, sensation seeking, response inhibition, and warm parenting). Conclusions Findings provide important and novel evidence to support the utility of the DSM-5 LPE specifier for CD. Some findings were unexpected, though, underscoring the need to replicate and extend the current results when testing the viability of this specifier. En ligne : https://doi.org/10.1111/jcpp.70118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588 [article] Conduct disorder with limited prosocial emotions: a multimethod study in criminal justice-involved boys [texte imprimé] / Olivier F. COLINS, Auteur ; Thomas CASSART, Auteur ; Emmely DELAMILLIEURE, Auteur ; Kostas A. FANTI, Auteur ; Melina Nicole KYRANIDES, Auteur ; Maria SIKKI, Auteur ; Maria PETRIDOU, Auteur ; Paul H.F. MEENS, Auteur . - p.1062-1072. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 67-7 (July 2026) . - p.1062-1072 Mots-clés : Callous-unemotional  Clinical Assessment of Prosocial Emotions  conduct disorder  subtyping Index. décimale : PER Périodiques Résumé : Background More than 10?years after its introduction in DSM-5, support for the ?limited prosocial emotions? specifier (LPE) for the diagnosis of conduct disorder (CD) remains scarce, possibly because studies failed to comprehensively assess the specifier and to include important characteristics. This study was designed to tackle both major limitations. Methods In a sample of 323 criminal justice-involved male adolescents (ages 16?17?years), diagnostic interviews were used to differentiate between males who meet criteria for both CD and the DSM-5 specifier (CD?+?LPE) and males who only meet criteria for CD (CD Only). Individual and environmental characteristics were measured by means of questionnaires and computerized tasks. Results The CD?+?LPE (vs. CD Only) group exhibited higher levels of aggression, delay discounting, and boldness, was more likely to be expelled from school, and had significantly more delinquent friends. Levels of treatment engagement and empathy also were lower in the CD?+?LPE group. The DSM-5 LPE specifier significantly added to the prediction of various of these characteristics beyond indices of CD severity (i.e., total number of CD symptoms and childhood-onset CD) and features of attention-deficit/hyperactivity disorder. However, no significant group differences emerged for other characteristics (e.g., emotion recognition accuracy, anxiety, sensation seeking, response inhibition, and warm parenting). Conclusions Findings provide important and novel evidence to support the utility of the DSM-5 LPE specifier for CD. Some findings were unexpected, though, underscoring the need to replicate and extend the current results when testing the viability of this specifier. En ligne : https://doi.org/10.1111/jcpp.70118 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=588

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