Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children / Mark WADE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.203-211 Titre : Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur Article en page(s) : p.203-211 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur . - p.203-211. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.203-211 Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Empirical support for a model of risk and resilience in children and families during COVID-19: A systematic review & narrative synthesis / Melissa KIMBER ; Heather PRIME ; Gillian SHOYCHET ; Jonathan WEISS in Development and Psychopathology, 35-5 (December 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-5 (December 2023) . - p.2464-2481 Titre : Empirical support for a model of risk and resilience in children and families during COVID-19: A systematic review & narrative synthesis Type de document : Texte imprimé et/ou numérique Auteurs : Melissa KIMBER, Auteur ; Heather PRIME, Auteur ; Gillian SHOYCHET, Auteur ; Jonathan WEISS, Auteur Article en page(s) : p.2464-2481 Mots-clés : COVID-19  Child functioning  family functioning  family systems  risk and resilience Index. décimale : PER Périodiques Résumé : Background.The COVID-19 Family Disruption Model (FDM) describes the cascading effects of pandemic-related social disruptions on child and family psychosocial functioning. The current systematic review assesses the empirical support for the model.Methods.Study eligibility: 1) children between 2?18 years (and/or their caregivers); 2) a quantitative longitudinal design; 3) published findings during the first 2.5 years of COVID-19; 4) an assessment of caregiver and/or family functioning; 5) an assessment of child internalizing, externalizing, or positive adjustment; and 6) an examination of a COVID-19 FDM pathway. Following a search of PsycINFO and MEDLINE in August 2022, screening, full-text assessments, and data extraction were completed by two reviewers. Study quality was examined using an adapted NIH risk-of- bias tool.Results.Findings from 47 studies were summarized using descriptive statistics, tables, and a narrative synthesis. There is emerging support for bidirectional pathways linking caregiver-child functioning and family-child functioning, particularly for child internalizing problems. Quality assessments indicated issues with attrition and power justification.Discussion.We provide a critical summary of the empirical support for the model, highlighting themes related to family systems theory and risk/resilience. We outline future directions for research on child and family well-being during COVID-19. Systematic review registration. PROSPERO [CRD42022327191]. En ligne : https://dx.doi.org/10.1017/S0954579423000767 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519 [article] Empirical support for a model of risk and resilience in children and families during COVID-19: A systematic review & narrative synthesis [Texte imprimé et/ou numérique] / Melissa KIMBER, Auteur ; Heather PRIME, Auteur ; Gillian SHOYCHET, Auteur ; Jonathan WEISS, Auteur . - p.2464-2481. in Development and Psychopathology > 35-5 (December 2023) . - p.2464-2481 Mots-clés : COVID-19  Child functioning  family functioning  family systems  risk and resilience Index. décimale : PER Périodiques Résumé : Background.The COVID-19 Family Disruption Model (FDM) describes the cascading effects of pandemic-related social disruptions on child and family psychosocial functioning. The current systematic review assesses the empirical support for the model.Methods.Study eligibility: 1) children between 2?18 years (and/or their caregivers); 2) a quantitative longitudinal design; 3) published findings during the first 2.5 years of COVID-19; 4) an assessment of caregiver and/or family functioning; 5) an assessment of child internalizing, externalizing, or positive adjustment; and 6) an examination of a COVID-19 FDM pathway. Following a search of PsycINFO and MEDLINE in August 2022, screening, full-text assessments, and data extraction were completed by two reviewers. Study quality was examined using an adapted NIH risk-of- bias tool.Results.Findings from 47 studies were summarized using descriptive statistics, tables, and a narrative synthesis. There is emerging support for bidirectional pathways linking caregiver-child functioning and family-child functioning, particularly for child internalizing problems. Quality assessments indicated issues with attrition and power justification.Discussion.We provide a critical summary of the empirical support for the model, highlighting themes related to family systems theory and risk/resilience. We outline future directions for research on child and family well-being during COVID-19. Systematic review registration. PROSPERO [CRD42022327191]. En ligne : https://dx.doi.org/10.1017/S0954579423000767 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=519

The development of a measure of maternal cognitive sensitivity appropriate for use in primary care health settings / Heather PRIME in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.488-495 Titre : The development of a measure of maternal cognitive sensitivity appropriate for use in primary care health settings Type de document : Texte imprimé et/ou numérique Auteurs : Heather PRIME, Auteur ; Dillon BROWNE, Auteur ; Emis AKBARI, Auteur ; Mark WADE, Auteur ; Sheri MADIGAN, Auteur ; Jennifer M. JENKINS, Auteur Article en page(s) : p.488-495 Langues : Anglais (eng) Mots-clés : Maternal responsivity  child cognitive development  parent–child interaction  primary healthcare  thin slice methodology Index. décimale : PER Périodiques Résumé : Background Parental responsivity is important to children's cognitive and socioemotional development, yet is under-represented in primary healthcare, because the measurement is specialized and time-consuming. Methods The current study developed a measure of maternal cognitive sensitivity (CS), which uses impressionistic ratings based on brief observations of parent–child interaction when children are 3 years old. Results Using data from a longitudinal cohort (Time 1, N = 501), the CS measure had good psychometric properties, was significantly related to a gold-standard maternal responsivity measure, and was predicted by the same socio-demographic factors predictive of other measures of parental responsivity. Finally, a well-established pathway from socioeconomic risk (child age 2 months) to compromised parenting (child age 3 years) to negative child outcome (child age 4.5 years) was demonstrated with CS as the mediator. Conclusion The maternal CS measure is brief, can be easily trained, and takes 8 min to administer and code, making it potentially useful in primary healthcare settings. En ligne : http://dx.doi.org/10.1111/jcpp.12322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] The development of a measure of maternal cognitive sensitivity appropriate for use in primary care health settings [Texte imprimé et/ou numérique] / Heather PRIME, Auteur ; Dillon BROWNE, Auteur ; Emis AKBARI, Auteur ; Mark WADE, Auteur ; Sheri MADIGAN, Auteur ; Jennifer M. JENKINS, Auteur . - p.488-495. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 56-4 (April 2015) . - p.488-495 Mots-clés : Maternal responsivity  child cognitive development  parent–child interaction  primary healthcare  thin slice methodology Index. décimale : PER Périodiques Résumé : Background Parental responsivity is important to children's cognitive and socioemotional development, yet is under-represented in primary healthcare, because the measurement is specialized and time-consuming. Methods The current study developed a measure of maternal cognitive sensitivity (CS), which uses impressionistic ratings based on brief observations of parent–child interaction when children are 3 years old. Results Using data from a longitudinal cohort (Time 1, N = 501), the CS measure had good psychometric properties, was significantly related to a gold-standard maternal responsivity measure, and was predicted by the same socio-demographic factors predictive of other measures of parental responsivity. Finally, a well-established pathway from socioeconomic risk (child age 2 months) to compromised parenting (child age 3 years) to negative child outcome (child age 4.5 years) was demonstrated with CS as the mediator. Conclusion The maternal CS measure is brief, can be easily trained, and takes 8 min to administer and code, making it potentially useful in primary healthcare settings. En ligne : http://dx.doi.org/10.1111/jcpp.12322 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

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