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Auteur Louis A. SCHMIDT |
Documents disponibles écrits par cet auteur (20)



Adolescent females exposed to child maltreatment exhibit atypical EEG coherence and psychiatric impairment: Linking early adversity, the brain, and psychopathology / Vladimir MISKOVIC in Development and Psychopathology, 22-2 (May 2010)
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Titre : Adolescent females exposed to child maltreatment exhibit atypical EEG coherence and psychiatric impairment: Linking early adversity, the brain, and psychopathology Type de document : Texte imprimé et/ou numérique Auteurs : Vladimir MISKOVIC, Auteur ; Katholiki GEORGIADES, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur ; Harriet L. MACMILLAN, Auteur Année de publication : 2010 Article en page(s) : p.419-432 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Although the relation between child maltreatment and psychiatric impairment is well documented and preliminary evidence has linked child maltreatment with aberrant cortical connectivity of the left hemisphere, no investigations have attempted to examine these relations in the same study. Here, we examined the links among early adversity, brain connectivity, and functional outcomes. We collected resting regional EEG intra- and interhemispheric α-band (7.5–12.5 Hz) coherence and measures of general psychiatric impairment from a cohort of 38 adolescent females exposed to child maltreatment (M age = 14.47) and 24 adolescent females not exposed to child maltreatment (M age = 14.00). Maltreated youths exhibited more left hemisphere EEG coherence than the control youths, suggesting a suboptimal organization of cortical networks. Maltreated participants also showed reduced frontal (anterior) interhemispheric coherence. These differences in brain circuitry remained statistically significant even after controlling for group differences in pubertal status and socioeconomic status. Measures of functional brain connectivity were associated with several subtypes of abuse and neglect. It was important that atypical left hemisphere EEG coherence mediated the effects of child maltreatment on levels of psychiatric impairment. The findings are discussed in the context of models linking early adversity to brain function and psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579410000155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102
in Development and Psychopathology > 22-2 (May 2010) . - p.419-432[article] Adolescent females exposed to child maltreatment exhibit atypical EEG coherence and psychiatric impairment: Linking early adversity, the brain, and psychopathology [Texte imprimé et/ou numérique] / Vladimir MISKOVIC, Auteur ; Katholiki GEORGIADES, Auteur ; Michael H. BOYLE, Auteur ; Louis A. SCHMIDT, Auteur ; Harriet L. MACMILLAN, Auteur . - 2010 . - p.419-432.
Langues : Anglais (eng)
in Development and Psychopathology > 22-2 (May 2010) . - p.419-432
Index. décimale : PER Périodiques Résumé : Although the relation between child maltreatment and psychiatric impairment is well documented and preliminary evidence has linked child maltreatment with aberrant cortical connectivity of the left hemisphere, no investigations have attempted to examine these relations in the same study. Here, we examined the links among early adversity, brain connectivity, and functional outcomes. We collected resting regional EEG intra- and interhemispheric α-band (7.5–12.5 Hz) coherence and measures of general psychiatric impairment from a cohort of 38 adolescent females exposed to child maltreatment (M age = 14.47) and 24 adolescent females not exposed to child maltreatment (M age = 14.00). Maltreated youths exhibited more left hemisphere EEG coherence than the control youths, suggesting a suboptimal organization of cortical networks. Maltreated participants also showed reduced frontal (anterior) interhemispheric coherence. These differences in brain circuitry remained statistically significant even after controlling for group differences in pubertal status and socioeconomic status. Measures of functional brain connectivity were associated with several subtypes of abuse and neglect. It was important that atypical left hemisphere EEG coherence mediated the effects of child maltreatment on levels of psychiatric impairment. The findings are discussed in the context of models linking early adversity to brain function and psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579410000155 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=102 Affect and gaze responses during an Emotion-Evoking Task in infants at an increased likelihood for autism spectrum disorder / Lori-Ann R. SACREY in Molecular Autism, 12 (2021)
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Titre : Affect and gaze responses during an Emotion-Evoking Task in infants at an increased likelihood for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; V. ARMSTRONG, Auteur ; S. RAZA, Auteur ; T. VAILLANCOURT, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : 63 p. Langues : Anglais (eng) Mots-clés : Affect Autism Emotion regulation Gaze Increased likelihood cohort Temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research examining emotional difficulties in autism spectrum disorder (ASD) prior to age 2 relies on parent report. METHODS: We examined behavioral responses (affect and gaze) during emotionally salient tasks designed to elicit mildly positive and negative emotional states in infants. At 12 and 18 months, infants at an increased likelihood for an ASD diagnosis (IL; have an older sibling with ASD; n = 60) and low likelihood (LL; no family history of ASD; n = 21) completed the Emotion-Evoking (EE) Task and parents completed the Infant Behavior Questionnaire-Revised (IBQ-R). All children received an Autism Diagnostic Observation Scale-second Edition assessment for ASD symptomatology at 24 months. RESULTS: The main findings were (1) the IL group displayed higher rates of negative affect and spent less time looking at the task objects compared to the LL group, and (2) affect and gaze scores at 12 and 18 months, but not scores on the IBQ-R, predicted ASD symptoms at 24 months. LIMITATIONS: The data were drawn from an IL sample and may not be generalizable to the general ASD population, and the children were not followed to determine a diagnosis of ASD. CONCLUSION: These results suggest that behavioral responses can provide important information that complements parent reports of emotional regulation in IL infants as early as 12 months of age. En ligne : http://dx.doi.org/10.1186/s13229-021-00468-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459
in Molecular Autism > 12 (2021) . - 63 p.[article] Affect and gaze responses during an Emotion-Evoking Task in infants at an increased likelihood for autism spectrum disorder [Texte imprimé et/ou numérique] / Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica BRIAN, Auteur ; I. M. SMITH, Auteur ; V. ARMSTRONG, Auteur ; S. RAZA, Auteur ; T. VAILLANCOURT, Auteur ; Louis A. SCHMIDT, Auteur . - 63 p.
Langues : Anglais (eng)
in Molecular Autism > 12 (2021) . - 63 p.
Mots-clés : Affect Autism Emotion regulation Gaze Increased likelihood cohort Temperament Index. décimale : PER Périodiques Résumé : BACKGROUND: The majority of research examining emotional difficulties in autism spectrum disorder (ASD) prior to age 2 relies on parent report. METHODS: We examined behavioral responses (affect and gaze) during emotionally salient tasks designed to elicit mildly positive and negative emotional states in infants. At 12 and 18 months, infants at an increased likelihood for an ASD diagnosis (IL; have an older sibling with ASD; n = 60) and low likelihood (LL; no family history of ASD; n = 21) completed the Emotion-Evoking (EE) Task and parents completed the Infant Behavior Questionnaire-Revised (IBQ-R). All children received an Autism Diagnostic Observation Scale-second Edition assessment for ASD symptomatology at 24 months. RESULTS: The main findings were (1) the IL group displayed higher rates of negative affect and spent less time looking at the task objects compared to the LL group, and (2) affect and gaze scores at 12 and 18 months, but not scores on the IBQ-R, predicted ASD symptoms at 24 months. LIMITATIONS: The data were drawn from an IL sample and may not be generalizable to the general ASD population, and the children were not followed to determine a diagnosis of ASD. CONCLUSION: These results suggest that behavioral responses can provide important information that complements parent reports of emotional regulation in IL infants as early as 12 months of age. En ligne : http://dx.doi.org/10.1186/s13229-021-00468-0 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=459 Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication / Karen J. MATHEWSON in Autism Research, 4-2 (April 2011)
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Titre : Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication Type de document : Texte imprimé et/ou numérique Auteurs : Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur Année de publication : 2011 Article en page(s) : p.98-108 Langues : Anglais (eng) Mots-clés : autism spectrum disorders (ASD) heart period respiratory sinus arrhythmia (RSA) Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121
in Autism Research > 4-2 (April 2011) . - p.98-108[article] Behavioral and cardiac responses to emotional stroop in adults with autism spectrum disorders: influence of medication [Texte imprimé et/ou numérique] / Karen J. MATHEWSON, Auteur ; Irene E. DRMIC, Auteur ; Michelle K. JETHA, Auteur ; Susan E. BRYSON, Auteur ; Joel O. GOLDBERG, Auteur ; Geoffrey B. C. HALL, Auteur ; Diane L. SANTESSO, Auteur ; Sidney SEGALOWITZ, Auteur ; Louis A. SCHMIDT, Auteur . - 2011 . - p.98-108.
Langues : Anglais (eng)
in Autism Research > 4-2 (April 2011) . - p.98-108
Mots-clés : autism spectrum disorders (ASD) heart period respiratory sinus arrhythmia (RSA) Stroop task Index. décimale : PER Périodiques Résumé : Researchers have recently hypothesized that autism spectrum disorders (ASD) may be partly characterized by physiological over-arousal. One way to assess physiological arousal is through autonomic measures. Here heart period (HP) and parasympathetic activity measured by respiratory sinus arrhythmia (RSA) were examined in adults with ASD and matched controls at rest and during performance of an emotional Stroop task. Resting HP and RSA were lower in adults with ASD than in matched controls, consistent with hypothesized over-arousal in ASD. However, dividing the ASD group on the basis of antipsychotic medication usage revealed that group differences in autonomic arousal may be related to the effects of these medications or their correlates. Autonomic adjustments for Stroop performance were comparable across groups, but in the control group, larger RSA reductions were correlated with faster responding (i.e., better performance). This relation was reversed in the unmedicated ASD group and absent in the medicated ASD group. Findings highlight the importance of considering medication status in the recently burgeoning area of psychophysiological studies of autism. En ligne : http://dx.doi.org/10.1002/aur.176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=121 Behavioral and physiological differences during an emotion-evoking task in children at increased likelihood for autism spectrum disorder / Lori-Ann R. SACREY in Development and Psychopathology, 36-1 (February 2024)
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Titre : Behavioral and physiological differences during an emotion-evoking task in children at increased likelihood for autism spectrum disorder Type de document : Texte imprimé et/ou numérique Auteurs : Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica A. BRIAN, Auteur ; Isabel M. SMITH, Auteur ; Vickie ARMSTRONG, Auteur ; Tracy VAILLANCOURT, Auteur ; Louis A. SCHMIDT, Auteur Article en page(s) : p.404-414 Langues : Anglais (eng) Mots-clés : ASD affect autism baby sibling gaze heart rate physiology Index. décimale : PER Périodiques Résumé : Literature examining emotional regulation in infants with autism spectrum disorder (ASD) has focused on parent report. We examined behavioral and physiological responses during an emotion-evoking task designed to elicit emotional states in infants. Infants at an increased likelihood for ASD (IL; have an older sibling with ASD; 96 not classified; 29 classified with ASD at age two) and low likelihood (LL; no family history of ASD; n = 61) completed the task at 6, 12, and 18 months. The main findings were (1) the IL-ASD group displayed higher levels of negative affect during toy removal and negative tasks compared to the IL non-ASD and LL groups, respectively, (2) the IL-ASD group spent more time looking at the baseline task compared to the other two groups, and (3) the IL-ASD group showed a greater increase in heart rate from baseline during the toy removal and negative tasks compared to the LL group. These results suggest that IL children who are classified as ASD at 24 months show differences in affect, gaze, and heart rate during an emotion-evoking task, with potential implications for understanding mechanisms related to emerging ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523
in Development and Psychopathology > 36-1 (February 2024) . - p.404-414[article] Behavioral and physiological differences during an emotion-evoking task in children at increased likelihood for autism spectrum disorder [Texte imprimé et/ou numérique] / Lori-Ann R. SACREY, Auteur ; Lonnie ZWAIGENBAUM, Auteur ; Jessica A. BRIAN, Auteur ; Isabel M. SMITH, Auteur ; Vickie ARMSTRONG, Auteur ; Tracy VAILLANCOURT, Auteur ; Louis A. SCHMIDT, Auteur . - p.404-414.
Langues : Anglais (eng)
in Development and Psychopathology > 36-1 (February 2024) . - p.404-414
Mots-clés : ASD affect autism baby sibling gaze heart rate physiology Index. décimale : PER Périodiques Résumé : Literature examining emotional regulation in infants with autism spectrum disorder (ASD) has focused on parent report. We examined behavioral and physiological responses during an emotion-evoking task designed to elicit emotional states in infants. Infants at an increased likelihood for ASD (IL; have an older sibling with ASD; 96 not classified; 29 classified with ASD at age two) and low likelihood (LL; no family history of ASD; n = 61) completed the task at 6, 12, and 18 months. The main findings were (1) the IL-ASD group displayed higher levels of negative affect during toy removal and negative tasks compared to the IL non-ASD and LL groups, respectively, (2) the IL-ASD group spent more time looking at the baseline task compared to the other two groups, and (3) the IL-ASD group showed a greater increase in heart rate from baseline during the toy removal and negative tasks compared to the LL group. These results suggest that IL children who are classified as ASD at 24 months show differences in affect, gaze, and heart rate during an emotion-evoking task, with potential implications for understanding mechanisms related to emerging ASD. En ligne : https://dx.doi.org/10.1017/S0954579422001286 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=523 Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children / Mark WADE in Development and Psychopathology, 30-1 (February 2018)
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Titre : Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur Article en page(s) : p.203-211 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336
in Development and Psychopathology > 30-1 (February 2018) . - p.203-211[article] Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur . - p.203-211.
Langues : Anglais (eng)
in Development and Psychopathology > 30-1 (February 2018) . - p.203-211
Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 Developmental programming of shyness: A longitudinal, prospective study across four decades / Kristie L. POOLE in Development and Psychopathology, 32-2 (May 2020)
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PermalinkDNA methylation profiles in adults born at extremely low birth weight / Karen J. MATHEWSON in Development and Psychopathology, 34-1 (February 2022)
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PermalinkDynamic changes in postnatal growth predict adolescent mental health problems in survivors of extremely low birth weight (ELBW) / Karen J. MATHEWSON in Development and Psychopathology, 36-3 (August 2024)
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PermalinkEarly developmental influences on self-esteem trajectories from adolescence through adulthood: Impact of birth weight and motor skills / Kristie L. POOLE in Development and Psychopathology, 30-1 (February 2018)
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PermalinkEvidence for a gene–gene interaction in predicting children's behavior problems: Association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7-year-olds / Louis A. SCHMIDT in Development and Psychopathology, 19-4 (Fall 2007)
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PermalinkExtremely low birth weight babies grown up: Gene–environment interaction predicts internalizing problems in the third and fourth decades of life / Ayelet LAHAT in Development and Psychopathology, 29-3 (August 2017)
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PermalinkFrontal brain delta-beta correlation, salivary cortisol, and social anxiety in children / K. L. POOLE in Journal of Child Psychology and Psychiatry, 60-6 (June 2019)
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PermalinkFrontal EEG asymmetry moderates the relation between borderline personality disorder features and feelings of social rejection in adolescents / Victoria E. STEAD in Development and Psychopathology, 35-2 (May 2023)
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PermalinkHow do childhood intelligence and early psychosocial adversity influence income attainment among adult extremely low birth weight survivors? A test of the cognitive reserve hypothesis / Kathleen G. DOBSON in Development and Psychopathology, 30-4 (October 2018)
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PermalinkImpact of extremely low-birth-weight status on risk and resilience for depression and anxiety in adulthood / R. J. VAN LIESHOUT in Journal of Child Psychology and Psychiatry, 59-5 (May 2018)
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