Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children / Mark WADE in Development and Psychopathology, 30-1 (February 2018)  

Public ISBD [article]  inDevelopment and Psychopathology > 30-1 (February 2018) . - p.203-211 Titre : Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur Article en page(s) : p.203-211 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336 [article] Birth weight interacts with a functional variant of the oxytocin receptor gene (OXTR) to predict executive functioning in children [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Heather PRIME, Auteur ; Thomas J. HOFFMANN, Auteur ; Louis A. SCHMIDT, Auteur ; Thomas G. O'CONNOR, Auteur ; Jennifer M. JENKINS, Auteur . - p.203-211. Langues : Anglais (eng) in Development and Psychopathology > 30-1 (February 2018) . - p.203-211 Index. décimale : PER Périodiques Résumé : Genetic variation in the oxytocin receptor gene (OXTR) is associated with several psychiatric conditions characterized by deficits in executive functioning (EF). A specific OXTR variant, rs2254298, has previously been associated with brain functioning in regions implicated in EF. Moreover, birth weight variation across the entire range is associated with individual differences in cortical structure and function that underlie EF. This is the first study to examine the main and interactive effect between rs2254298 and birth weight on EF in children. The sample consisted of 310 children from an ongoing longitudinal study. EF was measured at age 4.5 using observational tasks indexing working memory, cognitive flexibility, and inhibitory control. A family-based design that controlled for population admixture, stratification, and nongenomic confounds was employed. A significant genetic association between rs2254298 and EF was observed, with more copies of the major allele (G) associated with higher EF. There was also a significant interaction between rs2254298 and birth weight, such that more copies of the major allele in combination with higher birth weight predicted better EF. Findings suggest that OXTR may be associated with discrete neurocognitive abilities in childhood, and these effects may be modulated by intrauterine conditions related to fetal growth and development. En ligne : https://doi.org/10.1017/S0954579417000578 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=336

Cumulative contextual risk, maternal responsivity, and social cognition at 18 months / Mark WADE in Development and Psychopathology, 27-1 (February 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-1 (February 2015) . - p.189-203 Titre : Cumulative contextual risk, maternal responsivity, and social cognition at 18 months Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Chris MOORE, Auteur ; Janet Wilde ASTINGTON, Auteur ; Kristen FRAMPTON, Auteur ; Jennifer M. JENKINS, Auteur Article en page(s) : p.189-203 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : By 18 months children demonstrate a range of social–cognitive skills that can be considered important precursors to more advanced forms of social understanding such as theory of mind. Although individual differences in social cognition have been linked to neurocognitive maturation, sociocultural models of development suggest that environmental influences operate in the development of children's social–cognitive outcomes. In the current study of 501 children and their mothers, we tested and found support for a model in which distal environmental risk, assessed when children were newborns, was indirectly associated with children's social–cognitive competency at 18 months through mothers' responsivity at 18 months. Part of this effect also operated through children's concomitant language skills, suggesting both a language-mediated and a language-independent mechanism of social–cognitive development. These findings are discussed with respect to the Vygotskian themes of internalization and semiotic mediation. En ligne : http://dx.doi.org/10.1017/S0954579414000674 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Cumulative contextual risk, maternal responsivity, and social cognition at 18 months [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Chris MOORE, Auteur ; Janet Wilde ASTINGTON, Auteur ; Kristen FRAMPTON, Auteur ; Jennifer M. JENKINS, Auteur . - p.189-203. Langues : Anglais (eng) in Development and Psychopathology > 27-1 (February 2015) . - p.189-203 Index. décimale : PER Périodiques Résumé : By 18 months children demonstrate a range of social–cognitive skills that can be considered important precursors to more advanced forms of social understanding such as theory of mind. Although individual differences in social cognition have been linked to neurocognitive maturation, sociocultural models of development suggest that environmental influences operate in the development of children's social–cognitive outcomes. In the current study of 501 children and their mothers, we tested and found support for a model in which distal environmental risk, assessed when children were newborns, was indirectly associated with children's social–cognitive competency at 18 months through mothers' responsivity at 18 months. Part of this effect also operated through children's concomitant language skills, suggesting both a language-mediated and a language-independent mechanism of social–cognitive development. These findings are discussed with respect to the Vygotskian themes of internalization and semiotic mediation. En ligne : http://dx.doi.org/10.1017/S0954579414000674 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events / Mark WADE in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1732-1742 Titre : Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Margaret A. SHERIDAN, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Katie A. MCLAUGHLIN, Auteur Article en page(s) : p.1732-1742 Langues : Anglais (eng) Mots-clés : Adolescent  Child  *Child, Institutionalized  Foster Home Care  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  *Pituitary-Adrenal System  Psychosocial Deprivation  Stress, Psychological  *HPA-axis  *developmental psychobiology  *institutional rearing  *neglect  *stress reactivity  *sympathetic nervous system Index. décimale : PER Périodiques Résumé : Children who spend their early lives in institutions experience profound psychosocial deprivation that is associated with altered stress response system development. Here, we used data from a longitudinal randomized controlled trial of foster care for institutionally reared children to examine whether caregiving quality and stressful life events (SLEs) in early adolescence (age 12) influence patterns of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity. Controlling for the effect of institutional care, higher caregiving quality at age 12 was associated with heightened cortisol and SNS reactivity. However, moderation analysis revealed that the latter effect was only observed among never-institutionalized children, whereas ever-institutionalized children demonstrated a persistently blunted SNS response regardless of recent caregiving quality. Among institutionally reared children, SLEs interacted with prior random assignment to foster care, such that those placed in foster care early in development had a SNS response that approximated never-institutionalized children when SLEs at age 12 were low. In contrast, SNS reactivity was persistently blunted among those with prolonged deprivation, regardless of recent SLEs. Early-life deprivation is associated with persistent blunting of stress response systems, but normalization may be achievable if SLEs are limited following placement into enriched family-based care. En ligne : http://dx.doi.org/10.1017/s0954579420001327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Environmental determinants of physiological reactivity to stress: The interacting effects of early life deprivation, caregiving quality, and stressful life events [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Margaret A. SHERIDAN, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur ; Katie A. MCLAUGHLIN, Auteur . - p.1732-1742. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1732-1742 Mots-clés : Adolescent  Child  *Child, Institutionalized  Foster Home Care  Humans  Hydrocortisone  Hypothalamo-Hypophyseal System  *Pituitary-Adrenal System  Psychosocial Deprivation  Stress, Psychological  *HPA-axis  *developmental psychobiology  *institutional rearing  *neglect  *stress reactivity  *sympathetic nervous system Index. décimale : PER Périodiques Résumé : Children who spend their early lives in institutions experience profound psychosocial deprivation that is associated with altered stress response system development. Here, we used data from a longitudinal randomized controlled trial of foster care for institutionally reared children to examine whether caregiving quality and stressful life events (SLEs) in early adolescence (age 12) influence patterns of hypothalamic-pituitary-adrenal (HPA) axis and sympathetic nervous system (SNS) reactivity. Controlling for the effect of institutional care, higher caregiving quality at age 12 was associated with heightened cortisol and SNS reactivity. However, moderation analysis revealed that the latter effect was only observed among never-institutionalized children, whereas ever-institutionalized children demonstrated a persistently blunted SNS response regardless of recent caregiving quality. Among institutionally reared children, SLEs interacted with prior random assignment to foster care, such that those placed in foster care early in development had a SNS response that approximated never-institutionalized children when SLEs at age 12 were low. In contrast, SNS reactivity was persistently blunted among those with prolonged deprivation, regardless of recent SLEs. Early-life deprivation is associated with persistent blunting of stress response systems, but normalization may be achievable if SLEs are limited following placement into enriched family-based care. En ligne : http://dx.doi.org/10.1017/s0954579420001327 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Pathways to social-emotional functioning in the preschool period: The role of child temperament and maternal anxiety in boys and girls / Hannah F. BEHRENDT in Development and Psychopathology, 32-3 (August 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-3 (August 2020) . - p.961-974 Titre : Pathways to social-emotional functioning in the preschool period: The role of child temperament and maternal anxiety in boys and girls Type de document : Texte imprimé et/ou numérique Auteurs : Hannah F. BEHRENDT, Auteur ; Mark WADE, Auteur ; Laurie BAYET, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur Article en page(s) : p.961-974 Langues : Anglais (eng) Mots-clés : maternal anxiety  path model  sex differences  social-emotional development  temperament Index. décimale : PER Périodiques Résumé : Individual differences in social-emotional functioning emerge early and have long-term implications for developmental adaptation and competency. Research is needed that specifies multiple early risk factors and outcomes simultaneously to demonstrate specificity. Using multigroup longitudinal path analysis in a sample of typically developing children (N = 541), we examined child temperament dimensions (surgency, negative affectivity, and regulation/effortful control) and maternal anxiety in infancy and age 2 as predictors of child externalizing, internalizing, dysregulation, and competence behaviors at age 3. Four primary patterns emerged. First, there was stability in temperament dimensions and maternal anxiety from infancy to age 3. Second, negative affectivity was implicated in internalizing problems and surgency in externalizing problems. Third, effortful control at age 2 was a potent mediator of maternal anxiety in infancy on age 3 outcomes. Fourth, there was suggestive evidence for transactional effects between maternal anxiety and child effortful control. Most pathways operated similarly for boys and girls, with some differences, particularly for surgency. These findings expand our understanding of the roles of specific temperamental domains and postnatal maternal anxiety in a range of social-emotional outcomes in the preschool period, and have implications for efforts to enhance the development of young children's social-emotional functioning and reduce risk for later psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579419000853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Pathways to social-emotional functioning in the preschool period: The role of child temperament and maternal anxiety in boys and girls [Texte imprimé et/ou numérique] / Hannah F. BEHRENDT, Auteur ; Mark WADE, Auteur ; Laurie BAYET, Auteur ; Charles A. NELSON, Auteur ; Michelle BOSQUET ENLOW, Auteur . - p.961-974. Langues : Anglais (eng) in Development and Psychopathology > 32-3 (August 2020) . - p.961-974 Mots-clés : maternal anxiety  path model  sex differences  social-emotional development  temperament Index. décimale : PER Périodiques Résumé : Individual differences in social-emotional functioning emerge early and have long-term implications for developmental adaptation and competency. Research is needed that specifies multiple early risk factors and outcomes simultaneously to demonstrate specificity. Using multigroup longitudinal path analysis in a sample of typically developing children (N = 541), we examined child temperament dimensions (surgency, negative affectivity, and regulation/effortful control) and maternal anxiety in infancy and age 2 as predictors of child externalizing, internalizing, dysregulation, and competence behaviors at age 3. Four primary patterns emerged. First, there was stability in temperament dimensions and maternal anxiety from infancy to age 3. Second, negative affectivity was implicated in internalizing problems and surgency in externalizing problems. Third, effortful control at age 2 was a potent mediator of maternal anxiety in infancy on age 3 outcomes. Fourth, there was suggestive evidence for transactional effects between maternal anxiety and child effortful control. Most pathways operated similarly for boys and girls, with some differences, particularly for surgency. These findings expand our understanding of the roles of specific temperamental domains and postnatal maternal anxiety in a range of social-emotional outcomes in the preschool period, and have implications for efforts to enhance the development of young children's social-emotional functioning and reduce risk for later psychopathology. En ligne : http://dx.doi.org/10.1017/s0954579419000853 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Social communication deficits following early-life deprivation and relation to psychopathology: a randomized clinical trial of foster care / Mark WADE in Journal of Child Psychology and Psychiatry, 61-12 (December 2020)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1360-1369 Titre : Social communication deficits following early-life deprivation and relation to psychopathology: a randomized clinical trial of foster care Type de document : Texte imprimé et/ou numérique Auteurs : Mark WADE, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur Article en page(s) : p.1360-1369 Langues : Anglais (eng) Mots-clés : Institutional rearing  foster care intervention  maltreatment  psychopathology  severe early neglect  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Children reared in institutions experience profound deprivation that is linked to impairments in social communication (SC). However, little is known about the long-term consequences of institutional rearing on SC through adolescence, and how SC deficits relate to broad-spectrum psychopathology. It is also unclear whether early removal from deprivation and placement into socially enriched environments remediates these difficulties. METHODS: Children reared in Romanian institutions from the Bucharest Early Intervention Project were randomly assigned to care as usual or foster care intervention in early childhood. An age- and sex-matched group of never-institutionalized children was also recruited. SC data from 208 children at age 8 and 129 children at 16 were collected using the Social Communication Questionnaire. Psychopathology was assessed as saved factor scores for general (P) and specific internalizing (INT) and externalizing (EXT) problems. We examined (a) whether institutional rearing is associated with continued SC deficits into adolescence; (b) whether early placement into foster care mitigates risk for SC problems; and (c) associations between SC and psychopathology from middle childhood (age 8) to adolescence (age 16). RESULTS: Findings suggest that: (a) institutionally-reared children have significantly more SC problems than never-institutionalized children at age 16; (b) children placed into foster care early in life have fewer problems with reciprocal social interaction compared to those with prolonged institutional rearing; and (c) deficits in SC at age 8 partially account for the link between institutional rearing and general psychopathology at age 16. CONCLUSIONS: Early deprivation is associated with impairments in SC that persist into adolescence, with evidence for the remedial benefit of family-based care in the domain of reciprocal social interaction. Moreover, deficits in SC among ever-institutionalized children in middle childhood may increase the risk of broad-spectrum psychopathology in adolescence, thus providing one putative target for early intervention to safeguard against later psychiatric problems. En ligne : http://dx.doi.org/10.1111/jcpp.13222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434 [article] Social communication deficits following early-life deprivation and relation to psychopathology: a randomized clinical trial of foster care [Texte imprimé et/ou numérique] / Mark WADE, Auteur ; Charles H. ZEANAH, Auteur ; Nathan A. FOX, Auteur ; Charles A. NELSON, Auteur . - p.1360-1369. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 61-12 (December 2020) . - p.1360-1369 Mots-clés : Institutional rearing  foster care intervention  maltreatment  psychopathology  severe early neglect  social communication Index. décimale : PER Périodiques Résumé : BACKGROUND: Children reared in institutions experience profound deprivation that is linked to impairments in social communication (SC). However, little is known about the long-term consequences of institutional rearing on SC through adolescence, and how SC deficits relate to broad-spectrum psychopathology. It is also unclear whether early removal from deprivation and placement into socially enriched environments remediates these difficulties. METHODS: Children reared in Romanian institutions from the Bucharest Early Intervention Project were randomly assigned to care as usual or foster care intervention in early childhood. An age- and sex-matched group of never-institutionalized children was also recruited. SC data from 208 children at age 8 and 129 children at 16 were collected using the Social Communication Questionnaire. Psychopathology was assessed as saved factor scores for general (P) and specific internalizing (INT) and externalizing (EXT) problems. We examined (a) whether institutional rearing is associated with continued SC deficits into adolescence; (b) whether early placement into foster care mitigates risk for SC problems; and (c) associations between SC and psychopathology from middle childhood (age 8) to adolescence (age 16). RESULTS: Findings suggest that: (a) institutionally-reared children have significantly more SC problems than never-institutionalized children at age 16; (b) children placed into foster care early in life have fewer problems with reciprocal social interaction compared to those with prolonged institutional rearing; and (c) deficits in SC at age 8 partially account for the link between institutional rearing and general psychopathology at age 16. CONCLUSIONS: Early deprivation is associated with impairments in SC that persist into adolescence, with evidence for the remedial benefit of family-based care in the domain of reciprocal social interaction. Moreover, deficits in SC among ever-institutionalized children in middle childhood may increase the risk of broad-spectrum psychopathology in adolescence, thus providing one putative target for early intervention to safeguard against later psychiatric problems. En ligne : http://dx.doi.org/10.1111/jcpp.13222 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=434

The development of a measure of maternal cognitive sensitivity appropriate for use in primary care health settings / Heather PRIME in Journal of Child Psychology and Psychiatry, 56-4 (April 2015)  

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The prospective association between stressful life events and inflammation among adolescents with a history of early institutional rearing / Alva TANG in Development and Psychopathology, 32-5 (December 2020)  

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