An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317 Titre : An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk Type de document : texte imprimé Auteurs : Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur Article en page(s) : p.1305-1317 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294 [article] An investigation of child maltreatment and epigenetic mechanisms of mental and physical health risk [texte imprimé] / Dante CICCHETTI, Auteur ; Susan HETZEL, Auteur ; Fred A. ROGOSCH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Sheree L. TOTH, Auteur . - p.1305-1317. Langues : Anglais (eng) in Development and Psychopathology > 28-4 pt2 (November 2016) . - p.1305-1317 Index. décimale : PER Périodiques Résumé : In the present investigation, differential methylation analyses of the whole genome were conducted among a sample of 548 school-aged low-income children (47.8% female, 67.7% Black, M age = 9.40 years), 54.4% of whom had a history of child maltreatment. In the context of a summer research camp, DNA samples via saliva were obtained. Using GenomeStudio, Methylation Module, and the Illumina Custom Model, differential methylation analyses revealed a pattern of greater methylation at low methylation sites (n = 197 sites) and medium methylation sites (n = 730 sites) and less methylation at high methylation sites (n = 907 sites) among maltreated children. The mean difference in methylation between the maltreated and nonmaltreated children was 6.2%. The relative risk of maltreatment with known disease biomarkers was also investigated using GenoGo MetaCore Software. A large number of network objects previously associated with mental health, cancer, cardiovascular systems, and immune functioning were identified evidencing differential methylation among maltreated and nonmaltreated children. Site-specific analyses were also conducted for aldehyde dehydrogenase 2 (ALDH2), ankyrin repeat and kinase domain containing 1 (ANKK1), and nuclear receptor subfamily 3, group C, member 1 (NR3C1) genes, and the results highlight the importance of considering gender and the developmental timing of maltreatment. For ALDH2, the results indicated that maltreated girls evidenced significantly lower methylation compared to nonmaltreated girls, and maltreated boys evidenced significantly higher methylation compared to nonmaltreated boys. Moreover, early onset–not recently maltreated boys evidenced significantly higher methylation at ALDH2 compared to nonmaltreated boys. Similarly, children with early onset–nonrecent maltreatment evidenced significantly higher methylation compared to nonmaltreated children at ANKK1. The site-specific results were not altered by controlling for genotypic variation of respective genes. The findings demonstrate increased risk for adverse physical and mental health outcomes associated with differences in methylation in maltreated children and indicate differences among maltreated children related to developmental timing of maltreatment and gender in genes involved in mental health functioning. En ligne : http://dx.doi.org/10.1017/s0954579416000869 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=294

Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers / Danielle J. GUILD in Development and Psychopathology, 29-2 (May 2017)  

Public ISBD [article]  inDevelopment and Psychopathology > 29-2 (May 2017) . - p.587-600 Titre : Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers Type de document : texte imprimé Auteurs : Danielle J. GUILD, Auteur ; Sheree L. TOTH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.587-600 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Numerous investigations have demonstrated that child–parent psychotherapy (CPP) promotes secure attachment between mothers and offspring. However, the role of postintervention attachment security as it relates to long-term child outcomes has never been evaluated. The present study therefore examined postintervention attachment status as a mediator of the association between CPP for depressed mothers and their offspring and subsequent peer relations among offspring. Depressed mothers and their toddlers were randomized to receive CPP (n = 45) or to a control group (n = 55). A prior investigation with this sample indicated that offspring who received CPP attained significantly higher rates of secure attachment postintervention, whereas insecure attachment continued to predominate for offspring in the control group. The present study examined follow-up data of teachers’ reports on participants’ competence with classroom peers when they were approximately 9 years old. Findings indicated that children who received CPP were more likely to evidence secure attachments at postintervention, which in turn was associated with more positive peer relationships at age 9. En ligne : http://dx.doi.org/10.1017/s0954579417000207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305 [article] Attachment security mediates the longitudinal association between child–parent psychotherapy and peer relations for toddlers of depressed mothers [texte imprimé] / Danielle J. GUILD, Auteur ; Sheree L. TOTH, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.587-600. Langues : Anglais (eng) in Development and Psychopathology > 29-2 (May 2017) . - p.587-600 Index. décimale : PER Périodiques Résumé : Numerous investigations have demonstrated that child–parent psychotherapy (CPP) promotes secure attachment between mothers and offspring. However, the role of postintervention attachment security as it relates to long-term child outcomes has never been evaluated. The present study therefore examined postintervention attachment status as a mediator of the association between CPP for depressed mothers and their offspring and subsequent peer relations among offspring. Depressed mothers and their toddlers were randomized to receive CPP (n = 45) or to a control group (n = 55). A prior investigation with this sample indicated that offspring who received CPP attained significantly higher rates of secure attachment postintervention, whereas insecure attachment continued to predominate for offspring in the control group. The present study examined follow-up data of teachers’ reports on participants’ competence with classroom peers when they were approximately 9 years old. Findings indicated that children who received CPP were more likely to evidence secure attachments at postintervention, which in turn was associated with more positive peer relationships at age 9. En ligne : http://dx.doi.org/10.1017/s0954579417000207 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=305

Building Healthy Children: A preventive intervention for high-risk young families / Elizabeth M. DEMEUSY in Development and Psychopathology, 33-2 (May 2021)  

Public ISBD [article]  inDevelopment and Psychopathology > 33-2 (May 2021) . - p.598-613 Titre : Building Healthy Children: A preventive intervention for high-risk young families Type de document : texte imprimé Auteurs : Elizabeth M. DEMEUSY, Auteur ; Elizabeth D. HANDLEY, Auteur ; Jody T. MANLY, Auteur ; Robin STURM, Auteur ; Sheree L. TOTH, Auteur Année de publication : 2021 Article en page(s) : p.598-613 Langues : Anglais (eng) Mots-clés : Building Healthy Children  child behavior  home visiting  preventive intervention  young mothers Index. décimale : PER Périodiques Résumé : The Building Healthy Children (BHC) home-visiting preventive intervention was designed to provide concrete support and evidence-based intervention to young mothers and their infants who were at heightened risk for child maltreatment and poor developmental outcomes. This paper presents two studies examining the short- and long-term effectiveness of this program at promoting positive parenting and maternal mental health, while preventing child maltreatment and harsh parenting. It also examines the intervention's sustained effect on child symptomatology and self-regulation. At baseline, young mothers and their infants were randomly assigned to receive BHC or Enhanced Community Standard. Families were assessed longitudinally across four time points. Data were also collected from the child's teacher at follow-up. Mothers who received BHC evidenced significant reductions in depressive symptoms at mid-intervention, which was associated with improvements in parenting self-efficacy and stress as well as decreased child internalizing and externalizing symptoms at postintervention. The follow-up study found that BHC mothers exhibited less harsh and inconsistent parenting, and marginally less psychological aggression. BHC children also exhibited less externalizing behavior and self-regulatory difficulties across parent and teacher report. Following the impactful legacy of Dr. Edward Zigler, these findings underline the importance of early, evidence-based prevention to promote well-being in high-risk children and families. En ligne : http://dx.doi.org/10.1017/s0954579420001625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444 [article] Building Healthy Children: A preventive intervention for high-risk young families [texte imprimé] / Elizabeth M. DEMEUSY, Auteur ; Elizabeth D. HANDLEY, Auteur ; Jody T. MANLY, Auteur ; Robin STURM, Auteur ; Sheree L. TOTH, Auteur . - 2021 . - p.598-613. Langues : Anglais (eng) in Development and Psychopathology > 33-2 (May 2021) . - p.598-613 Mots-clés : Building Healthy Children  child behavior  home visiting  preventive intervention  young mothers Index. décimale : PER Périodiques Résumé : The Building Healthy Children (BHC) home-visiting preventive intervention was designed to provide concrete support and evidence-based intervention to young mothers and their infants who were at heightened risk for child maltreatment and poor developmental outcomes. This paper presents two studies examining the short- and long-term effectiveness of this program at promoting positive parenting and maternal mental health, while preventing child maltreatment and harsh parenting. It also examines the intervention's sustained effect on child symptomatology and self-regulation. At baseline, young mothers and their infants were randomly assigned to receive BHC or Enhanced Community Standard. Families were assessed longitudinally across four time points. Data were also collected from the child's teacher at follow-up. Mothers who received BHC evidenced significant reductions in depressive symptoms at mid-intervention, which was associated with improvements in parenting self-efficacy and stress as well as decreased child internalizing and externalizing symptoms at postintervention. The follow-up study found that BHC mothers exhibited less harsh and inconsistent parenting, and marginally less psychological aggression. BHC children also exhibited less externalizing behavior and self-regulatory difficulties across parent and teacher report. Following the impactful legacy of Dr. Edward Zigler, these findings underline the importance of early, evidence-based prevention to promote well-being in high-risk children and families. En ligne : http://dx.doi.org/10.1017/s0954579420001625 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=444

Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations / Justin RUSSOTTI in Development and Psychopathology, 32-5 (December 2020)  

Public ISBD [article]  inDevelopment and Psychopathology > 32-5 (December 2020) . - p.1937-1953 Titre : Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations Type de document : texte imprimé Auteurs : Justin RUSSOTTI, Auteur ; Jennifer M. WARMINGHAM, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur Article en page(s) : p.1937-1953 Langues : Anglais (eng) Mots-clés : Adult  African Americans  C-Reactive Protein  Child  *Child Abuse  Humans  Male  Poverty  Prospective Studies  *crp  *adversity  *child maltreatment  *developmental competence  *stress Index. décimale : PER Périodiques Résumé : Few conditions epitomize severe and chronic stress to a greater extent than child maltreatment, which can derail development across multiple domains of functioning and throughout the life course. Furthermore, child maltreatment tends to co-occur with other adversities, such as poverty. Many individuals grow up under the stressful conditions of these adversities and exhibit developmental competence. The current study prospectively charted the developmental progression of economically disadvantaged maltreated and nonmaltreated children from childhood to emerging adulthood, and examined patterns of competence across multiple developmental domains of functioning central to the period of emerging adulthood. The study investigated childhood precursors to these patterns of adaptation and maladaptation, as well as the physiological cost of these patterns of adaptation (i.e., C-reactive protein; CRP). Latent class analysis revealed four distinct classes of functioning: multifaceted competence across domains (Multifaceted Competence); (multifaceted maladaptation across domains (Multi-Problem); (c) and two classes with mixed patterns of competence and maladaptation (Externalizing Problems and Work/School Impairment). Maltreated individuals were less likely than nonmaltreated individuals to demonstrate patterns of multifaceted competence and more likely to demonstrate aggregate maladaptation across domains. Additionally, Black men who demonstrated a pattern of multifaceted psychosocial competence also evidenced higher levels of low-grade inflammation (indexed by CRP), suggesting physiological distress was associated with adaptation in the context of stress among these individuals. Findings demonstrate the heterogenous patterns of functioning and diverse developmental outcomes that follow early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437 [article] Characterizing competence among a high-risk sample of emerging adults: Prospective predictions and biological considerations [texte imprimé] / Justin RUSSOTTI, Auteur ; Jennifer M. WARMINGHAM, Auteur ; Elizabeth D. HANDLEY, Auteur ; Fred A. ROGOSCH, Auteur ; Dante CICCHETTI, Auteur . - p.1937-1953. Langues : Anglais (eng) in Development and Psychopathology > 32-5 (December 2020) . - p.1937-1953 Mots-clés : Adult  African Americans  C-Reactive Protein  Child  *Child Abuse  Humans  Male  Poverty  Prospective Studies  *crp  *adversity  *child maltreatment  *developmental competence  *stress Index. décimale : PER Périodiques Résumé : Few conditions epitomize severe and chronic stress to a greater extent than child maltreatment, which can derail development across multiple domains of functioning and throughout the life course. Furthermore, child maltreatment tends to co-occur with other adversities, such as poverty. Many individuals grow up under the stressful conditions of these adversities and exhibit developmental competence. The current study prospectively charted the developmental progression of economically disadvantaged maltreated and nonmaltreated children from childhood to emerging adulthood, and examined patterns of competence across multiple developmental domains of functioning central to the period of emerging adulthood. The study investigated childhood precursors to these patterns of adaptation and maladaptation, as well as the physiological cost of these patterns of adaptation (i.e., C-reactive protein; CRP). Latent class analysis revealed four distinct classes of functioning: multifaceted competence across domains (Multifaceted Competence); (multifaceted maladaptation across domains (Multi-Problem); (c) and two classes with mixed patterns of competence and maladaptation (Externalizing Problems and Work/School Impairment). Maltreated individuals were less likely than nonmaltreated individuals to demonstrate patterns of multifaceted competence and more likely to demonstrate aggregate maladaptation across domains. Additionally, Black men who demonstrated a pattern of multifaceted psychosocial competence also evidenced higher levels of low-grade inflammation (indexed by CRP), suggesting physiological distress was associated with adaptation in the context of stress among these individuals. Findings demonstrate the heterogenous patterns of functioning and diverse developmental outcomes that follow early adversity. En ligne : http://dx.doi.org/10.1017/s0954579420001467 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=437

Child maltreatment and youth suicide risk: A developmental conceptual model and implications for suicide prevention / Elizabeth D. HANDLEY ; Peter A. WYMAN ; Andrew J. ROSS ; Catherine CERULLI ; Assaf OSHRI in Development and Psychopathology, 35-4 (October 2023)  

Public ISBD [article]  inDevelopment and Psychopathology > 35-4 (October 2023) . - p.1732-1755 Titre : Child maltreatment and youth suicide risk: A developmental conceptual model and implications for suicide prevention Type de document : texte imprimé Auteurs : Elizabeth D. HANDLEY, Auteur ; Peter A. WYMAN, Auteur ; Andrew J. ROSS, Auteur ; Catherine CERULLI, Auteur ; Assaf OSHRI, Auteur Article en page(s) : p.1732-1755 Langues : Anglais (eng) Mots-clés : adverse childhood experiences  child maltreatment  suicide prevention  trauma  youth suicide Index. décimale : PER Périodiques Résumé : Experiences of child abuse and neglect are risk factors for youth suicidal thoughts and behaviors. Accordingly, suicide risk may emerge as a developmental process that is heavily influenced by the rearing environment. We argue that a developmental, theoretical framework is needed to guide future research on child maltreatment and youth (i.e., adolescent and emerging adult) suicide, and to subsequently inform suicide prevention efforts. We propose a developmental model that integrates principles of developmental psychopathology and current theories of suicide to explain the association between child maltreatment and youth suicide risk. This model bears significant implications for future research on child maltreatment and youth suicide risk, and for suicide prevention efforts that target youth with child maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579422000414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515 [article] Child maltreatment and youth suicide risk: A developmental conceptual model and implications for suicide prevention [texte imprimé] / Elizabeth D. HANDLEY, Auteur ; Peter A. WYMAN, Auteur ; Andrew J. ROSS, Auteur ; Catherine CERULLI, Auteur ; Assaf OSHRI, Auteur . - p.1732-1755. Langues : Anglais (eng) in Development and Psychopathology > 35-4 (October 2023) . - p.1732-1755 Mots-clés : adverse childhood experiences  child maltreatment  suicide prevention  trauma  youth suicide Index. décimale : PER Périodiques Résumé : Experiences of child abuse and neglect are risk factors for youth suicidal thoughts and behaviors. Accordingly, suicide risk may emerge as a developmental process that is heavily influenced by the rearing environment. We argue that a developmental, theoretical framework is needed to guide future research on child maltreatment and youth (i.e., adolescent and emerging adult) suicide, and to subsequently inform suicide prevention efforts. We propose a developmental model that integrates principles of developmental psychopathology and current theories of suicide to explain the association between child maltreatment and youth suicide risk. This model bears significant implications for future research on child maltreatment and youth suicide risk, and for suicide prevention efforts that target youth with child maltreatment experiences. En ligne : https://dx.doi.org/10.1017/S0954579422000414 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=515

Child maltreatment, inflammation, and internalizing symptoms: Investigating the roles of C-reactive protein, gene variation, and neuroendocrine regulation / Dante CICCHETTI in Development and Psychopathology, 27-2 (May 2015)  

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Developmental cascades from child maltreatment to negative friend and romantic interactions in emerging adulthood / Elizabeth D. HANDLEY in Development and Psychopathology, 31-5 (December 2019)  

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Developmental cascades: Linking adolescent substance use, affiliation with substance use promoting peers, and academic achievement to adult substance use disorders / Moira HALLER in Development and Psychopathology, 22-4 (November 2010)  

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Developmental pathways from child maltreatment to adolescent marijuana dependence: Examining moderation by FK506 binding protein 5 gene (FKBP5) / Elizabeth D. HANDLEY in Development and Psychopathology, 27-4 (Part 2) (November 2015)  

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From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth / Elizabeth D. HANDLEY in Development and Psychopathology, 29-5 (December 2017)  

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Genetic moderation of interpersonal psychotherapy efficacy for low-income mothers with major depressive disorder: Implications for differential susceptibility / Dante CICCHETTI in Development and Psychopathology, 27-1 (February 2015)  

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Genome-wide DNA methylation in 1-year-old infants of mothers with major depressive disorder / Dante CICCHETTI in Development and Psychopathology, 28-4 pt2 (November 2016)  

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Intimate partner violence as a mechanism underlying the intergenerational transmission of maltreatment among economically disadvantaged mothers and their adolescent daughters / Tangeria R. ADAMS in Development and Psychopathology, 31-1 (February 2019)  

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Investigating multilevel pathways of developmental consequences of maltreatment / Carrie E. DEPASQUALE in Development and Psychopathology, 31-4 (October 2019)  

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Methylation of the glucocorticoid receptor gene, nuclear receptor subfamily 3, group C, member 1 (NR3C1), in maltreated and nonmaltreated children: Associations with behavioral undercontrol, emotional lability/negativity, and externalizing and internalizing symptoms / Dante CICCHETTI in Development and Psychopathology, 29-5 (December 2017)  

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