Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study / Elizabeth A. LI ; Christopher H. LEGERE ; Jared M. SALETIN ; Noah S. PHILIP ; Daniel P. DICKSTEIN in Autism Research, 18-6 (June 2025)  

Public ISBD [article]  inAutism Research > 18-6 (June 2025) . - p.1182-1186 Titre : Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study Type de document : Texte imprimé et/ou numérique Auteurs : Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur Article en page(s) : p.1182-1186 Langues : Anglais (eng) Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558 [article] Estimated Nutrient Intake and Association With Psychiatric and Sleep Problems in Autistic Youth in the Adolescent Brain Cognitive DevelopmentSM Study [Texte imprimé et/ou numérique] / Elizabeth A. LI, Auteur ; Christopher H. LEGERE, Auteur ; Jared M. SALETIN, Auteur ; Noah S. PHILIP, Auteur ; Daniel P. DICKSTEIN, Auteur . - p.1182-1186. Langues : Anglais (eng) in Autism Research > 18-6 (June 2025) . - p.1182-1186 Mots-clés : ABCD (adolescent brain cognitive development) study  autism  CBCL (child behavior checklist)  macronutrients  micronutrients  sleep Index. décimale : PER Périodiques Résumé : ABSTRACT Autistic children often consume less varied diets, experience sleep difficulties, and have higher rates of mental health problems as compared to neurotypical peers. Yet, the direct relationship between all of these domains is not well characterized. We leveraged the Adolescent Brain Cognitive DevelopmentSM study (ABCD study) dataset to explore whether estimated levels of consumption of specific macro- and micronutrients correlated with the severity of mental health and sleep problems in autistic youth. We found that low vitamin B3, B6, C, and iron intake was associated with more severe psychiatric problems in autistic children in the ABCD cohort, though these findings did not reach statistical significance after correction for multiple comparisons. In a post hoc analysis, we found that the severity of sleep difficulties was correlated with estimated levels of Vitamins B3, B6, C, and iron intake and with the severity of anxiety/depressive symptoms and/or thought problems. Our analysis on a large number of nutrients, psychiatric symptoms, and sleep serves as an exploratory, initial analysis to identify specific nutrients and psychiatric symptoms that could be the focus of future (confirmatory) studies on the relationship between nutrition, sleep, and mental health in autistic individuals. En ligne : https://doi.org/10.1002/aur.70040 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=558

Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children / Audrey R. TYRKA in Development and Psychopathology, 27-2 (May 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-2 (May 2015) . - p.577-585 Titre : Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children Type de document : Texte imprimé et/ou numérique Auteurs : Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Nicole M. ESLINGER, Auteur ; Carmen J. MARSIT, Auteur ; Corina LESSEUR, Auteur ; David A. ARMSTRONG, Auteur ; Noah S. PHILIP, Auteur ; Brittney JOSEFSON, Auteur ; Ronald SEIFER, Auteur Article en page(s) : p.577-585 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic–pituitary–adrenal axis as well as a broad range of physiological systems including metabolic and immune function. One hundred eighty-four families participated, including n = 74 with child welfare documentation of moderate-severe maltreatment in the past 6 months. Children ranged in age from 3 to 5 years, and were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors, and a composite variable assessed the number exposures to these adversities. Methylation of regions 1D, 1F, and 1H of the GR gene was measured via sodium bisulfite pyrosequencing. The composite measure of adversity was positively correlated with methylation at exons 1D and 1F in the promoter of the GR gene. Individual stress measures were significantly associated with a several CpG sites in these regions. GR gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257 [article] Methylation of exons 1D, 1F, and 1H of the glucocorticoid receptor gene promoter and exposure to adversity in preschool-aged children [Texte imprimé et/ou numérique] / Audrey R. TYRKA, Auteur ; Stephanie H. PARADE, Auteur ; Nicole M. ESLINGER, Auteur ; Carmen J. MARSIT, Auteur ; Corina LESSEUR, Auteur ; David A. ARMSTRONG, Auteur ; Noah S. PHILIP, Auteur ; Brittney JOSEFSON, Auteur ; Ronald SEIFER, Auteur . - p.577-585. Langues : Anglais (eng) in Development and Psychopathology > 27-2 (May 2015) . - p.577-585 Index. décimale : PER Périodiques Résumé : Epigenetic modifications to the genome are a key mechanism involved in the biological encoding of experience. Animal studies and a growing body of literature in humans have shown that early adversity is linked to methylation of the gene for the glucocorticoid receptor (GR), which is a key regulator of the hypothalamic–pituitary–adrenal axis as well as a broad range of physiological systems including metabolic and immune function. One hundred eighty-four families participated, including n = 74 with child welfare documentation of moderate-severe maltreatment in the past 6 months. Children ranged in age from 3 to 5 years, and were racially and ethnically diverse. Structured record review and interviews in the home were used to assess a history of maltreatment, other traumas, and contextual life stressors, and a composite variable assessed the number exposures to these adversities. Methylation of regions 1D, 1F, and 1H of the GR gene was measured via sodium bisulfite pyrosequencing. The composite measure of adversity was positively correlated with methylation at exons 1D and 1F in the promoter of the GR gene. Individual stress measures were significantly associated with a several CpG sites in these regions. GR gene methylation may be a mechanism of the biobehavioral effects of adverse exposures in young children. En ligne : http://dx.doi.org/10.1017/S0954579415000176 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=257

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