Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges / Fae B. KAYARIAN in Autism Research, 13-7 (July 2020)  

Public ISBD [article]  inAutism Research > 13-7 (July 2020) . - p.1051-1071 Titre : Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges Type de document : Texte imprimé et/ou numérique Auteurs : Fae B. KAYARIAN, Auteur ; Ali JANNATI, Auteur ; Alexander ROTENBERG, Auteur ; Emiliano SANTARNECCHI, Auteur Article en page(s) : p.1051-1071 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  gamma  transcranial alternating current stimulation  transcranial direct current stimulation  transcranial electrical stimulation Index. décimale : PER Périodiques Résumé : A range of scalp electroencephalogram (EEG) abnormalities correlates with the core symptoms of autism spectrum disorder (ASD). Among these are alterations of brain oscillations in the gamma-frequency EEG band in adults and children with ASD, whose origin has been linked to dysfunctions of inhibitory interneuron signaling. While therapeutic interventions aimed to modulate gamma oscillations are being tested for neuropsychiatric disorders such as schizophrenia, Alzheimer's disease, and frontotemporal dementia, the prospects for therapeutic gamma modulation in ASD have not been extensively studied. Accordingly, we discuss gamma-related alterations in the setting of ASD pathophysiology, as well as potential interventions that can enhance gamma oscillations in patients with ASD. Ultimately, we argue that transcranial electrical stimulation modalities capable of entraining gamma oscillations, and thereby potentially modulating inhibitory interneuron circuitry, are promising methods to study and mitigate gamma alterations in ASD. Autism Res 2020, 13: 1051-1071. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain functions are mediated by various oscillatory waves of neuronal activity, ranging in amplitude and frequency. In certain neuropsychiatric disorders, such as schizophrenia and Alzheimer's disease, reduced high-frequency oscillations in the "gamma" band have been observed, and therapeutic interventions to enhance such activity are being explored. Here, we review and comment on evidence of reduced gamma activity in ASD, arguing that modalities used in other disorders may benefit individuals with ASD as well. En ligne : http://dx.doi.org/10.1002/aur.2312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429 [article] Targeting Gamma-Related Pathophysiology in Autism Spectrum Disorder Using Transcranial Electrical Stimulation: Opportunities and Challenges [Texte imprimé et/ou numérique] / Fae B. KAYARIAN, Auteur ; Ali JANNATI, Auteur ; Alexander ROTENBERG, Auteur ; Emiliano SANTARNECCHI, Auteur . - p.1051-1071. Langues : Anglais (eng) in Autism Research > 13-7 (July 2020) . - p.1051-1071 Mots-clés : autism spectrum disorder  gamma  transcranial alternating current stimulation  transcranial direct current stimulation  transcranial electrical stimulation Index. décimale : PER Périodiques Résumé : A range of scalp electroencephalogram (EEG) abnormalities correlates with the core symptoms of autism spectrum disorder (ASD). Among these are alterations of brain oscillations in the gamma-frequency EEG band in adults and children with ASD, whose origin has been linked to dysfunctions of inhibitory interneuron signaling. While therapeutic interventions aimed to modulate gamma oscillations are being tested for neuropsychiatric disorders such as schizophrenia, Alzheimer's disease, and frontotemporal dementia, the prospects for therapeutic gamma modulation in ASD have not been extensively studied. Accordingly, we discuss gamma-related alterations in the setting of ASD pathophysiology, as well as potential interventions that can enhance gamma oscillations in patients with ASD. Ultimately, we argue that transcranial electrical stimulation modalities capable of entraining gamma oscillations, and thereby potentially modulating inhibitory interneuron circuitry, are promising methods to study and mitigate gamma alterations in ASD. Autism Res 2020, 13: 1051-1071. © 2020 International Society for Autism Research, Wiley Periodicals, Inc. LAY SUMMARY: Brain functions are mediated by various oscillatory waves of neuronal activity, ranging in amplitude and frequency. In certain neuropsychiatric disorders, such as schizophrenia and Alzheimer's disease, reduced high-frequency oscillations in the "gamma" band have been observed, and therapeutic interventions to enhance such activity are being explored. Here, we review and comment on evidence of reduced gamma activity in ASD, arguing that modalities used in other disorders may benefit individuals with ASD as well. En ligne : http://dx.doi.org/10.1002/aur.2312 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=429

Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research / Lindsay M. OBERMAN in Autism Research, 9-2 (February 2016)  

Public ISBD [article]  inAutism Research > 9-2 (February 2016) . - p.184-203 Titre : Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay M. OBERMAN, Auteur ; Peter G. ENTICOTT, Auteur ; Manuel F. CASANOVA, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; James T. MCCRACKEN, Auteur ; T. M. S. IN A. S. D. CONSENSUS GROUP, THE, Auteur Article en page(s) : p.184-203 Langues : Anglais (eng) Mots-clés : autism spectrum disorder  transcranial magnetic stimulation  consensus  review  treatment Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282 [article] Transcranial magnetic stimulation in autism spectrum disorder: Challenges, promise, and roadmap for future research [Texte imprimé et/ou numérique] / Lindsay M. OBERMAN, Auteur ; Peter G. ENTICOTT, Auteur ; Manuel F. CASANOVA, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur ; James T. MCCRACKEN, Auteur ; T. M. S. IN A. S. D. CONSENSUS GROUP, THE, Auteur . - p.184-203. Langues : Anglais (eng) in Autism Research > 9-2 (February 2016) . - p.184-203 Mots-clés : autism spectrum disorder  transcranial magnetic stimulation  consensus  review  treatment Index. décimale : PER Périodiques Résumé : Autism Spectrum Disorder (ASD) is a behaviorally defined complex neurodevelopmental syndrome characterized by impairments in social communication, by the presence of restricted and repetitive behaviors, interests and activities, and by abnormalities in sensory reactivity. Transcranial magnetic stimulation (TMS) is a promising, emerging tool for the study and potential treatment of ASD. Recent studies suggest that TMS measures provide rapid and noninvasive pathophysiological ASD biomarkers. Furthermore, repetitive TMS (rTMS) may represent a novel treatment strategy for reducing some of the core and associated ASD symptoms. However, the available literature on the TMS use in ASD is preliminary, composed of studies with methodological limitations. Thus, off-label clinical rTMS use for therapeutic interventions in ASD without an investigational device exemption and outside of an IRB approved research trial is premature pending further, adequately powered and controlled trials. Leaders in this field have gathered annually for a two-day conference (prior to the 2014 and 2015 International Meeting for Autism Research, IMFAR) to share recent progress, promote collaboration across laboratories, and establish consensus on protocols. Here we review the literature in the use of TMS in ASD in the context of the unique challenges required for the study and exploration of treatment strategies in this population. We also suggest future directions for this field of investigations. While its true potential in ASD has yet to be delineated, TMS represents an innovative research tool and a novel, possibly transformative approach to the treatment of neurodevelopmental disorders. En ligne : http://dx.doi.org/10.1002/aur.1567 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=282

Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders / Lindsay M. OBERMAN in Journal of Autism and Developmental Disorders, 45-2 (February 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.524-536 Titre : Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders Type de document : Texte imprimé et/ou numérique Auteurs : Lindsay M. OBERMAN, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur Article en page(s) : p.524-536 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Transcranial magnetic stimulation  TMS  Diagnosis  Therapy Index. décimale : PER Périodiques Résumé : The clinical, social and financial burden of autism spectrum disorder (ASD) is staggering. We urgently need valid and reliable biomarkers for diagnosis and effective treatments targeting the often debilitating symptoms. Transcranial magnetic stimulation (TMS) is beginning to be used by a number of centers worldwide and may represent a novel technique with both diagnostic and therapeutic potential. Here we critically review the current scientific evidence for the use of TMS in ASD. Though preliminary data suggests promise, there is simply not enough evidence yet to conclusively support the clinical widespread use of TMS in ASD, neither diagnostically nor therapeutically. Carefully designed and properly controlled clinical trials are warranted to evaluate the true potential of TMS in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1960-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258 [article] Use of Transcranial Magnetic Stimulation in Autism Spectrum Disorders [Texte imprimé et/ou numérique] / Lindsay M. OBERMAN, Auteur ; Alexander ROTENBERG, Auteur ; Alvaro PASCUAL-LEONE, Auteur . - p.524-536. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-2 (February 2015) . - p.524-536 Mots-clés : Autism spectrum disorder  Transcranial magnetic stimulation  TMS  Diagnosis  Therapy Index. décimale : PER Périodiques Résumé : The clinical, social and financial burden of autism spectrum disorder (ASD) is staggering. We urgently need valid and reliable biomarkers for diagnosis and effective treatments targeting the often debilitating symptoms. Transcranial magnetic stimulation (TMS) is beginning to be used by a number of centers worldwide and may represent a novel technique with both diagnostic and therapeutic potential. Here we critically review the current scientific evidence for the use of TMS in ASD. Though preliminary data suggests promise, there is simply not enough evidence yet to conclusively support the clinical widespread use of TMS in ASD, neither diagnostically nor therapeutically. Carefully designed and properly controlled clinical trials are warranted to evaluate the true potential of TMS in ASD. En ligne : http://dx.doi.org/10.1007/s10803-013-1960-2 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=258

---

1 (1 - 3 / 3)