Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 12 (April 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Titre : Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.1-9 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260 [article] Interaction between GSTT1 and GSTP1 allele variants as a risk modulating-factor for autism spectrum disorders [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Katherine A. LOVELAND, Auteur ; Manouchehr HESSABI, Auteur ; Aisha S. DICKERSON, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.1-9. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 12 (April 2015) . - p.1-9 Mots-clés : Autism spectrum disorder  Oxidative stress  Glutathione S-transferase (GST) genes  Modulating-factor  Gene–gene interaction Index. décimale : PER Périodiques Résumé : Abstract We investigated the role of glutathione S-transferase (GST) genes in Autism Spectrum Disorder (ASD). We used data from 111 pairs of age- and sex-matched ASD cases and typically developing (TD) controls between 2 and 8 years of age from Jamaica to investigate the role of GST pi 1 (GSTP1), GST theta 1 (GSTT1), and GST mu 1 (GSTM1) polymorphisms in susceptibility to ASD. In univariable conditional logistic regression models we did not observe significant associations between ASD status and GSTT1, GSTM1, or GSTP1 genotype (all P > 0.15). However, in multivariable conditional logistic regression models, we identified a significant interaction between GSTP1 and GSTT1 in relation to ASD. Specifically, in children heterozygous for the GSTP1 Ile105Val polymorphism, the odds of ASD was significantly higher in those with the null GSTT1 genotype than those with the other genotypes [matched odds ratio (MOR) = 2.97, 95% CI (1.09, 8.01), P = 0.03]. Replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2014.12.008 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=260

Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder / Mohammad H. RAHBAR in Research in Autism Spectrum Disorders, 18 (October 2015)  

Public ISBD [article]  inResearch in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82 Titre : Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur Article en page(s) : p.73-82 Langues : Anglais (eng) Mots-clés : Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268 [article] Synergic effect of GSTP1 and blood manganese concentrations in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / Mohammad H. RAHBAR, Auteur ; Maureen SAMMS-VAUGHAN, Auteur ; Jianzhong MA, Auteur ; Jan BRESSLER, Auteur ; Aisha S. DICKERSON, Auteur ; Manouchehr HESSABI, Auteur ; Katherine A. LOVELAND, Auteur ; Megan L. GROVE, Auteur ; Sydonnie SHAKESPEARE-PELLINGTON, Auteur ; Compton BEECHER, Auteur ; Wayne MCLAUGHLIN, Auteur ; Eric BOERWINKLE, Auteur . - p.73-82. Langues : Anglais (eng) in Research in Autism Spectrum Disorders > 18 (October 2015) . - p.73-82 Mots-clés : Manganese  Autism Spectrum Disorder (ASD)  Glutathione-S-transferase (GST) genes  Oxidative stress  Interactions  Jamaica Index. décimale : PER Périodiques Résumé : Abstract We used data from 100 age- and sex-matched case-control pairs (age 2–8 years) from Jamaica to investigate whether there is an interaction between glutathione-S-transferase (GST) genes and blood manganese concentrations (BMC) in relation to Autism Spectrum Disorder (ASD). Our findings, indicate that among children who had the Ile/Ile genotype for GST pi 1 (GSTP1), those with BMC ? 12 ?g/L had about 4 times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.03) under a co-dominant genetic model. After adjusting for potential confounders, among the subgroup of children with genotype Ile/Ile, those with BMC ? 12 ?g/L had about six times higher odds of ASD than those with BMC < 12 ?g/L, (P = 0.04). The results were similar when a recessive genetic model was used. These findings suggest a possible synergic effect of BMC and GSTP1 in ASD. Since our analysis included a variety of genetic models and was not adjusted for multiple testing, replication in other populations is warranted. En ligne : http://dx.doi.org/10.1016/j.rasd.2015.08.001 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=268

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