Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility / Michael J. SULIK in Development and Psychopathology, 27-3 (August 2015)  

Public ISBD [article]  inDevelopment and Psychopathology > 27-3 (August 2015) . - p.709-723 Titre : Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility Type de document : Texte imprimé et/ou numérique Auteurs : Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Gregory SWANN, Auteur ; Kassondra M. SILVA, Auteur ; Mark REISER, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur Article en page(s) : p.709-723 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : We used sex, observed parenting quality at 18 months, and three variants of the catechol-O-methyltransferase gene (Val158Met [rs4680], intron1 [rs737865], and 3?-untranslated region [rs165599]) to predict mothers' reports of inhibitory and attentional control (assessed at 42, 54, 72, and 84 months) and internalizing symptoms (assessed at 24, 30, 42, 48, and 54 months) in a sample of 146 children (79 male). Although the pattern for all three variants was very similar, Val158Met explained more variance in both outcomes than did intron1, the 3?-untranslated region, or a haplotype that combined all three catechol-O-methyltransferase variants. In separate models, there were significant three-way interactions among each of the variants, parenting, and sex, predicting the intercepts of inhibitory control and internalizing symptoms. Results suggested that Val158Met indexes plasticity, although this effect was moderated by sex. Parenting was positively associated with inhibitory control for methionine–methionine boys and for valine–valine/valine–methionine girls, and was negatively associated with internalizing symptoms for methionine–methionine boys. Using the “regions of significance” technique, genetic differences in inhibitory control were found for children exposed to high-quality parenting, whereas genetic differences in internalizing were found for children exposed to low-quality parenting. These findings provide evidence in support of testing for differential susceptibility across multiple outcomes. En ligne : http://dx.doi.org/10.1017/S0954579414000807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263 [article] Interactions among catechol-O-methyltransferase genotype, parenting, and sex predict children's internalizing symptoms and inhibitory control: Evidence for differential susceptibility [Texte imprimé et/ou numérique] / Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Gregory SWANN, Auteur ; Kassondra M. SILVA, Auteur ; Mark REISER, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur . - p.709-723. Langues : Anglais (eng) in Development and Psychopathology > 27-3 (August 2015) . - p.709-723 Index. décimale : PER Périodiques Résumé : We used sex, observed parenting quality at 18 months, and three variants of the catechol-O-methyltransferase gene (Val158Met [rs4680], intron1 [rs737865], and 3?-untranslated region [rs165599]) to predict mothers' reports of inhibitory and attentional control (assessed at 42, 54, 72, and 84 months) and internalizing symptoms (assessed at 24, 30, 42, 48, and 54 months) in a sample of 146 children (79 male). Although the pattern for all three variants was very similar, Val158Met explained more variance in both outcomes than did intron1, the 3?-untranslated region, or a haplotype that combined all three catechol-O-methyltransferase variants. In separate models, there were significant three-way interactions among each of the variants, parenting, and sex, predicting the intercepts of inhibitory control and internalizing symptoms. Results suggested that Val158Met indexes plasticity, although this effect was moderated by sex. Parenting was positively associated with inhibitory control for methionine–methionine boys and for valine–valine/valine–methionine girls, and was negatively associated with internalizing symptoms for methionine–methionine boys. Using the “regions of significance” technique, genetic differences in inhibitory control were found for children exposed to high-quality parenting, whereas genetic differences in internalizing were found for children exposed to low-quality parenting. These findings provide evidence in support of testing for differential susceptibility across multiple outcomes. En ligne : http://dx.doi.org/10.1017/S0954579414000807 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=263

Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes / Yi LI in Development and Psychopathology, 28-1 (February 2016)  

Public ISBD [article]  inDevelopment and Psychopathology > 28-1 (February 2016) . - p.199-212 Titre : Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes Type de document : Texte imprimé et/ou numérique Auteurs : Yi LI, Auteur ; Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur Article en page(s) : p.199-212 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Children's observed effortful control (EC) at 30, 42, and 54 months (n = 145) was predicted from the interaction between mothers' observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3?-untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3?-UTR VNTR-10, or intron13-G/3?-UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis–stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children's sensitivity/responsivity to early parenting. En ligne : http://dx.doi.org/10.1017/S0954579415000383 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278 [article] Predicting childhood effortful control from interactions between early parenting quality and children's dopamine transporter gene haplotypes [Texte imprimé et/ou numérique] / Yi LI, Auteur ; Michael J. SULIK, Auteur ; Nancy EISENBERG, Auteur ; Tracy L. SPINRAD, Auteur ; Kathryn LEMERY-CHALFANT, Auteur ; Daryn A. STOVER, Auteur ; Brian C. VERRELLI, Auteur . - p.199-212. Langues : Anglais (eng) in Development and Psychopathology > 28-1 (February 2016) . - p.199-212 Index. décimale : PER Périodiques Résumé : Children's observed effortful control (EC) at 30, 42, and 54 months (n = 145) was predicted from the interaction between mothers' observed parenting with their 30-month-olds and three variants of the solute carrier family C6, member 3 (SLC6A3) dopamine transporter gene (single nucleotide polymorphisms in intron8 and intron13, and a 40 base pair variable number tandem repeat [VNTR] in the 3?-untranslated region [UTR]), as well as haplotypes of these variants. Significant moderating effects were found. Children without the intron8-A/intron13-G, intron8-A/3?-UTR VNTR-10, or intron13-G/3?-UTR VNTR-10 haplotypes (i.e., haplotypes associated with the reduced SLC6A3 gene expression and thus lower dopamine functioning) appeared to demonstrate altered levels of EC as a function of maternal parenting quality, whereas children with these haplotypes demonstrated a similar EC level regardless of the parenting quality. Children with these haplotypes demonstrated a trade-off, such that they showed higher EC, relative to their counterparts without these haplotypes, when exposed to less supportive maternal parenting. The findings revealed a diathesis–stress pattern and suggested that different SLC6A3 haplotypes, but not single variants, might represent different levels of young children's sensitivity/responsivity to early parenting. En ligne : http://dx.doi.org/10.1017/S0954579415000383 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=278

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