Adding to the neuroimmune network model: A commentary on Nusslock et al. (2024) / Aaron S. HELLER in Journal of Child Psychology and Psychiatry, 65-5 (May 2024)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.733-735 Titre : Adding to the neuroimmune network model: A commentary on Nusslock et al. (2024) Type de document : Texte imprimé et/ou numérique Auteurs : Aaron S. HELLER, Auteur Article en page(s) : p.733-735 Langues : Anglais (eng) Index. décimale : PER Périodiques Résumé : Work by many groups demonstrate links between peripheral markers of inflammation and symptoms of depression. Here, Nusslock and colleagues present an update to their neuroimmune network model to incorporate a developmental lens. They propose that specific neural circuits may be responsible for causing heightened inflammation. One principal circuit includes the amygdala and prefrontal cortex and is proposed to be involved in threat detection. Thus, heightened threat sensitivity resulting from early life stress is suggested to cause increases in inflammatory signaling. Second, the authors suggest that reward circuits, including the striatum, may be targets of increased inflammation leading to symptoms of anhedonia. In this commentary, I add context to the model proposed by Nusslock et al., suggesting that taking a learning perspective and considering additional circuits, including the hippocampus and midline structures may be necessary to more fully account for the phenomena described by the authors. En ligne : https://doi.org/10.1111/jcpp.13978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526 [article] Adding to the neuroimmune network model: A commentary on Nusslock et al. (2024) [Texte imprimé et/ou numérique] / Aaron S. HELLER, Auteur . - p.733-735. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 65-5 (May 2024) . - p.733-735 Index. décimale : PER Périodiques Résumé : Work by many groups demonstrate links between peripheral markers of inflammation and symptoms of depression. Here, Nusslock and colleagues present an update to their neuroimmune network model to incorporate a developmental lens. They propose that specific neural circuits may be responsible for causing heightened inflammation. One principal circuit includes the amygdala and prefrontal cortex and is proposed to be involved in threat detection. Thus, heightened threat sensitivity resulting from early life stress is suggested to cause increases in inflammatory signaling. Second, the authors suggest that reward circuits, including the striatum, may be targets of increased inflammation leading to symptoms of anhedonia. In this commentary, I add context to the model proposed by Nusslock et al., suggesting that taking a learning perspective and considering additional circuits, including the hippocampus and midline structures may be necessary to more fully account for the phenomena described by the authors. En ligne : https://doi.org/10.1111/jcpp.13978 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=526

Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder / J. Anthony RICHEY in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3409-3423 Titre : Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder Type de document : Texte imprimé et/ou numérique Auteurs : J. Anthony RICHEY, Auteur ; Cara R. DAMIANO, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; Alison RITTENBERG, Auteur ; Chris PETTY, Auteur ; Josh BIZZELL, Auteur ; James VOYVODIC, Auteur ; Aaron S. HELLER, Auteur ; Marika C. COFFMAN, Auteur ; Moria SMOSKI, Auteur ; Richard J. DAVIDSON, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.3409-3423 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Dorsolateral prefrontal cortex  Amygdala  Nucleus accumbens  Emotion regulation  Eyetracking Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2359-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder [Texte imprimé et/ou numérique] / J. Anthony RICHEY, Auteur ; Cara R. DAMIANO, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; Alison RITTENBERG, Auteur ; Chris PETTY, Auteur ; Josh BIZZELL, Auteur ; James VOYVODIC, Auteur ; Aaron S. HELLER, Auteur ; Marika C. COFFMAN, Auteur ; Moria SMOSKI, Auteur ; Richard J. DAVIDSON, Auteur ; Gabriel S. DICHTER, Auteur . - p.3409-3423. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3409-3423 Mots-clés : Autism spectrum disorder  Dorsolateral prefrontal cortex  Amygdala  Nucleus accumbens  Emotion regulation  Eyetracking Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2359-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

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