3 recherche sur le mot-clé 'Nucleus accumbens'

Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents / Barbara RUGGERI in Journal of Child Psychology and Psychiatry, 59-6 (June 2018)  

Public ISBD [article]  inJournal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Titre : Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents Type de document : texte imprimé Auteurs : Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur Article en page(s) : p.650-658 Langues : Anglais (eng) Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363 [article] Methylation of OPRL1 mediates the effect of psychosocial stress on binge drinking in adolescents [texte imprimé] / Barbara RUGGERI, Auteur ; Christine MACARE, Auteur ; Serena STOPPONI, Auteur ; Tianye JIA, Auteur ; Fabiana M. CARVALHO, Auteur ; Gabriel ROBERT, Auteur ; Tobias BANASCHEWSKI, Auteur ; Arun L.W. BOKDE, Auteur ; Uli BROMBERG, Auteur ; C. BUCHEL, Auteur ; Anna CATTRELL, Auteur ; Patricia J. CONROD, Auteur ; S. DESRIVIERES, Auteur ; Herta FLOR, Auteur ; Vincent FROUIN, Auteur ; Juergen GALLINAT, Auteur ; Hugh GARAVAN, Auteur ; Penny GOWLAND, Auteur ; Andreas HEINZ, Auteur ; Bernd ITTERMANN, Auteur ; Jean-Luc MARTINOT, Auteur ; Marie-Laure PAILLERE-MARTINOT, Auteur ; Frauke NEES, Auteur ; Dimitri PAPADOPOULOS ORFANOS, Auteur ; Tomáš PAUS, Auteur ; Luise POUSTKA, Auteur ; Michael N. SMOLKA, Auteur ; Nora C. VETTER, Auteur ; Henrik WALTER, Auteur ; Robert WHELAN, Auteur ; W.H. SOMMER, Auteur ; Georgy BAKALKIN, Auteur ; Roberto CICCOCIOPPO, Auteur ; Gunter SCHUMANN, Auteur . - p.650-658. Langues : Anglais (eng) in Journal of Child Psychology and Psychiatry > 59-6 (June 2018) . - p.650-658 Mots-clés : OPRL1 methylation  adolescence  binge drinking  nucleus accumbens  stressful life events Index. décimale : PER Périodiques Résumé : BACKGROUND: Nociceptin is a key regulator linking environmental stress and alcohol drinking. In a genome-wide methylation analysis, we recently identified an association of a methylated region in the OPRL1 gene with alcohol-use disorders. METHODS: Here, we investigate the biological basis of this observation by analysing psychosocial stressors, methylation of the OPRL1 gene, brain response during reward anticipation and alcohol drinking in 660 fourteen-year-old adolescents of the IMAGEN study. We validate our findings in marchigian sardinian (msP) alcohol-preferring rats that are genetically selected for increased alcohol drinking and stress sensitivity. RESULTS: We found that low methylation levels in intron 1 of OPRL1 are associated with higher psychosocial stress and higher frequency of binge drinking, an effect mediated by OPRL1 methylation. In individuals with low methylation of OPRL1, frequency of binge drinking is associated with stronger BOLD response in the ventral striatum during reward anticipation. In msP rats, we found that stress results in increased alcohol intake and decreased methylation of OPRL1 in the nucleus accumbens. CONCLUSIONS: Our findings describe an epigenetic mechanism that helps to explain how psychosocial stress influences risky alcohol consumption and reward processing, thus contributing to the elucidation of biological mechanisms underlying risk for substance abuse. En ligne : http://dx.doi.org/10.1111/jcpp.12843 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=363

Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder / J. Anthony RICHEY in Journal of Autism and Developmental Disorders, 45-11 (November 2015)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3409-3423 Titre : Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder Type de document : texte imprimé Auteurs : J. Anthony RICHEY, Auteur ; Cara R. DAMIANO, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; Alison RITTENBERG, Auteur ; Chris PETTY, Auteur ; Joshua BIZZELL, Auteur ; James VOYVODIC, Auteur ; Aaron S. HELLER, Auteur ; Marika C. COFFMAN, Auteur ; Moria SMOSKI, Auteur ; Richard J. DAVIDSON, Auteur ; Gabriel S. DICHTER, Auteur Article en page(s) : p.3409-3423 Langues : Anglais (eng) Mots-clés : Autism spectrum disorder  Dorsolateral prefrontal cortex  Amygdala  Nucleus accumbens  Emotion regulation  Eyetracking Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2359-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270 [article] Neural Mechanisms of Emotion Regulation in Autism Spectrum Disorder [texte imprimé] / J. Anthony RICHEY, Auteur ; Cara R. DAMIANO, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; Alison RITTENBERG, Auteur ; Chris PETTY, Auteur ; Joshua BIZZELL, Auteur ; James VOYVODIC, Auteur ; Aaron S. HELLER, Auteur ; Marika C. COFFMAN, Auteur ; Moria SMOSKI, Auteur ; Richard J. DAVIDSON, Auteur ; Gabriel S. DICHTER, Auteur . - p.3409-3423. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 45-11 (November 2015) . - p.3409-3423 Mots-clés : Autism spectrum disorder  Dorsolateral prefrontal cortex  Amygdala  Nucleus accumbens  Emotion regulation  Eyetracking Index. décimale : PER Périodiques Résumé : Autism spectrum disorder (ASD) is characterized by high rates of comorbid internalizing and externalizing disorders. One mechanistic account of these comorbidities is that ASD is characterized by impaired emotion regulation (ER) that results in deficits modulating emotional responses. We assessed neural activation during cognitive reappraisal of faces in high functioning adults with ASD. Groups did not differ in looking time, pupilometry, or subjective ratings of faces during reappraisal. However, instructions to increase positive and negative emotional responses resulted in less increase in nucleus accumbens and amygdala activations (respectively) in the ASD group, and both regulation instructions resulted in less change in dorsolateral prefrontal cortex activation in the ASD group. Results suggest a potential mechanistic account of impaired ER in ASD. En ligne : http://dx.doi.org/10.1007/s10803-015-2359-z Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=270

Reward Circuitry Function in Autism During Face Anticipation and Outcomes / Gabriel S. DICHTER in Journal of Autism and Developmental Disorders, 42-2 (February 2012)  

Public ISBD [article]  inJournal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.147-160 Titre : Reward Circuitry Function in Autism During Face Anticipation and Outcomes Type de document : texte imprimé Auteurs : Gabriel S. DICHTER, Auteur ; J. Anthony RICHEY, Auteur ; Alison RITTENBERG, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; James W. BODFISH, Auteur Année de publication : 2012 Article en page(s) : p.147-160 Langues : Anglais (eng) Mots-clés : Autism  Nucleus accumbens  Anticipation  Functional magnetic resonance imaging  Social cognition  Reward Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate reward circuitry responses in autism during reward anticipation and outcomes for monetary and social rewards. During monetary anticipation, participants with autism spectrum disorders (ASDs) showed hypoactivation in right nucleus accumbens and hyperactivation in right hippocampus, whereas during monetary outcomes, participants with ASDs showed hyperactivation in left midfrontal and anterior cingulate gyrus. Groups did not differ in nucleus accumbens responses to faces. The ASD group demonstrated hyperactivation in bilateral amygdala during face anticipation that predicted social symptom severity and in bilateral insular cortex during face outcomes. These results add to the growing body of evidence that autism is characterized by altered functioning of reward circuitry. Additionally, atypical amygdala activation during the processing of social rewards may contribute to the development or expression of autistic features. En ligne : http://dx.doi.org/10.1007/s10803-011-1221-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151 [article] Reward Circuitry Function in Autism During Face Anticipation and Outcomes [texte imprimé] / Gabriel S. DICHTER, Auteur ; J. Anthony RICHEY, Auteur ; Alison RITTENBERG, Auteur ; Antoinette SABATINO-DICRISCIO, Auteur ; James W. BODFISH, Auteur . - 2012 . - p.147-160. Langues : Anglais (eng) in Journal of Autism and Developmental Disorders > 42-2 (February 2012) . - p.147-160 Mots-clés : Autism  Nucleus accumbens  Anticipation  Functional magnetic resonance imaging  Social cognition  Reward Index. décimale : PER Périodiques Résumé : The aim of this study was to investigate reward circuitry responses in autism during reward anticipation and outcomes for monetary and social rewards. During monetary anticipation, participants with autism spectrum disorders (ASDs) showed hypoactivation in right nucleus accumbens and hyperactivation in right hippocampus, whereas during monetary outcomes, participants with ASDs showed hyperactivation in left midfrontal and anterior cingulate gyrus. Groups did not differ in nucleus accumbens responses to faces. The ASD group demonstrated hyperactivation in bilateral amygdala during face anticipation that predicted social symptom severity and in bilateral insular cortex during face outcomes. These results add to the growing body of evidence that autism is characterized by altered functioning of reward circuitry. Additionally, atypical amygdala activation during the processing of social rewards may contribute to the development or expression of autistic features. En ligne : http://dx.doi.org/10.1007/s10803-011-1221-1 Permalink : https://www.cra-rhone-alpes.org/cid/opac_css/index.php?lvl=notice_display&id=151